A facile approach to construct hyaluronic acid shielding polyplexes with improved stability and reduced cytotoxicity

Colloids and Surfaces B: Biointerfaces

Volumn 84, Issue 1, 2011, Pages 259-266

  Wang, Youxiang ^a   Xu, Zhixue ^a   Zhang, Ran ^a   Li, Wenyu ^a   Yang, Lu ^a   Hu, Qiaoling ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Hyaluronic acid; Non viral gene delivery; Reduced cytotoxicity; Ternary complexes

Indexed keywords

ELECTROSTATIC COMPLEXATION; ELECTROSTATIC INTERACTIONS; ETHIDIUM BROMIDE; GENE CARRIER; HEPG2 CELLS; HYALURONIC ACIDS; NEGATIVE CHARGE; NON-VIRAL GENE DELIVERY; PHYSIOLOGICAL CONDITION; POLYPLEXES; POTENTIAL APPLICATIONS; RECEPTOR-MEDIATED ENDOCYTOSIS; REDUCED CYTOTOXICITY; SPHERICAL PARTICLE; TERNARY COMPLEXES; TRANSFECTION EFFICIENCY; TUMOR THERAPY;

BROMINE COMPOUNDS; CYTOTOXICITY; ELECTROSTATICS; GENE THERAPY; GENE TRANSFER; MOLECULAR BIOLOGY; NUCLEIC ACIDS; ORGANIC ACIDS; SHIELDING;

COMPLEXATION;

ETHIDIUM BROMIDE; HYALURONIC ACID; POLYETHYLENEIMINE;

ADSORPTION KINETICS; ANTINEOPLASTIC ACTIVITY; ARTICLE; ATOMIC FORCE MICROSCOPY; CELL STRAIN HEK293; CELL STRAIN HEPG2; CONTROLLED STUDY; DNA DRUG COMPLEX; DRUG COATING; DRUG CYTOTOXICITY; DRUG DNA INTERACTION; DRUG MECHANISM; DRUG STABILITY; DRUG UPTAKE; ENDOCYTOSIS; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; PRIORITY JOURNAL; TARGET CELL;

CELL LINE, TUMOR; CELL SURVIVAL; CELLS, CULTURED; DRUG STABILITY; GENE TRANSFER TECHNIQUES; HUMANS; HYALURONIC ACID; MICROSCOPY, ATOMIC FORCE; POLYMERS;

EID: 79951595657     PISSN: 09277765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.colsurfb.2011.01.007     Document Type: Article

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