Phthalates: Toxicogenomics and inferred human diseases

Genomics

Volumn 97, Issue 3, 2011, Pages 148-157

  Singh, Sher ^a   Li, Steven Shoei Lung ^b,c  

^a NATIONAL TAIWAN NORMAL UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

BBP; DBP; DEHP; Diseases; Genes; MBP; MEHP; Phthalates; Proteins; Toxicity

Indexed keywords

ANDROGEN RECEPTOR; AROMATASE; AROMATIC HYDROCARBON RECEPTOR; BIOLOGICAL MARKER; CARRIER PROTEIN; CELL NUCLEUS RECEPTOR; EARLY GROWTH RESPONSE FACTOR 1; ESTROGEN RECEPTOR ALPHA; FATTY ACID BINDING PROTEIN; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; LOW DENSITY LIPOPROTEIN RECEPTOR; METALLOTHIONEIN I; METALLOTHIONEIN II; MYC PROTEIN; NUCLEAR RECEPTOR NR1I2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHTHALIC ACID 2 ETHYLHEXYL MONOESTER; PHTHALIC ACID BENZYL BUTYL ESTER; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; PHTHALIC ACID BUTYL ESTER; PHTHALIC ACID DERIVATIVE; PHTHALIC ACID DIBUTYL ESTER; PROTEIN SLC27A1; PROTEIN SLC5A5; SCAVENGER RECEPTOR BI; STEROIDOGENIC ACUTE REGULATORY PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN A;

ADVERSE OUTCOME; ARTICLE; CARDIOTOXICITY; CARDIOVASCULAR DISEASE; DISEASE ASSOCIATION; ENDOCRINE DISEASE; ENVIRONMENTAL EXPOSURE; GENE INTERACTION; GENITAL SYSTEM DISEASE; HUMAN; LIVER TOXICITY; NEPHROTOXICITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TOXICOGENETICS; URINARY TRACT DISEASE;

DATABASES, GENETIC; DIETHYLHEXYL PHTHALATE; DISEASE; ENVIRONMENTAL EXPOSURE; GENETIC MARKERS; HUMANS; METAGENOMICS; PHTHALIC ACIDS; PLASTICIZERS;

RODENTIA;

EID: 79951579030     PISSN: 08887543     EISSN: 10898646     Source Type: Journal    
DOI: 10.1016/j.ygeno.2010.11.008     Document Type: Article

References (37)

1. Heudorf U., Mersch-Sundermann V., Angerer J.g. Phthalates: toxicology and exposure. Int. J. Hyg. Environ. Health 2007, 210:623-634.
2. Silva M.J., Barr D.B., Reidy J.A., Malek N.A., Hodge C.C., Caudill S.P., Brock J.W., Needham L.L., Calafat A.M. Urinary levels of seven phthalate metabolites in the U.S. population from the National Health and Nutrition Examination Survey (NHANES) 1999-2000. Environ. Health Perspect. 2004, 112:331-338.
3. Wormuth Matthias, Scheringer Martin, Vollenweider Meret, Hungerbühler Konrad What are the sources of exposure to eight frequently used phthalic acid esters in Europeans?. Risk Anal. 2006, 26:803-824.
4. Tickner Joel A., Schettler Ted, Guidotti Tee, McCally Michael, Rossi Mark Health risks posed by use of di-2-ethylhexyl phthalate (DEHP) in PVC medical devices: a critical review. Am. J. Ind. Med. 2001, 39:100-111.
5. Thomas J.A., Thomas M.J., Gangolli S.D. Biological effects of di-(2-ethylhexyl) phthalate and other phthalic acid esters. Crit. Rev. Toxicol. 1984, 13:283-317.
6. National Toxicology Program NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di(2-ethylhexyl) Phthalate (DEHP) 2006, NIH Pub. No. 06-4476.
7. Davis A.P., Murphy C.G., Saraceni-Richards C.A., Rosenstein M.C., Wiegers T.C., Mattingly C.J. Comparative Toxicogenomics Database: a knowledgebase and discovery tool for chemical-gene-disease networks. Nucl. Acids Res. 2009, 37:D786-D792.
8. Davis A., Murphy C., Rosenstein M., Wiegers T., Mattingly C. The Comparative Toxicogenomics Database facilitates identification and understanding of chemical-gene-disease associations: arsenic as a case study. BMC Med. Genet. 2008, 1:48.
9. Bility M.T., Thompson J.T., McKee R.H., David R.M., Butala J.H., Vanden Heuvel J.P., Peters J.M. Activation of mouse and human peroxisome proliferator-activated receptors (PPARs) by phthalate monoesters. Toxicol. Sci. 2004, 82:170-182.
10. Desvergne B., Feige J.N., Casals-Casas C. PPAR-mediated activity of phthalates: a link to the obesity epidemic?. Mol. Cell. Endocrinol. 2009, 304:43-48.
11. van Dartel D.A.M., Pennings J.L.A., Hendriksen P.J.M., van Schooten F.J., Piersma A.H. Early gene expression changes during embryonic stem cell differentiation into cardiomyocytes and their modulation by monobutyl phthalate. Reprod. Toxicol. 2009, 27:93-102.
12. Hatch E., Nelson J., Qureshi M.M., Weinberg J., Moore L., Singer M., Webster T. Association of urinary phthalate metabolite concentrations with body mass index and waist circumference: a cross-sectional study of NHANES data, 1999-2002. Environ. Health 2008, 7:27.
13. Stahlhut R.W., van Wijngaarden E., Dye T.D., Cook S., Swan S.H. Concentrations of urinary phthalate metabolites are associated with increased waist circumference and insulin resistance in adult U.S. males. Environ. Health Perspect. 2007, 115:876-882.
14. Doull J., Cattley R., Elcombe C., Lake B.G., Swenberg J., Wilkinson C., Williams G., van Gemert M. A cancer risk assessment of di(2-ethylhexyl)phthalate: application of the New U.S. EPA Risk Assessment Guidelines. Regul. Toxicol. Pharmacol. 1999, 29:327-357.
15. Ito Y., Yamanoshita O., Asaeda N., Tagawa Y., Lee C.-H., Aoyama T., Ichihara G., Furuhashi K., Kamijima M., Gonzalez F.J., Nakajima T. Di(2-ethylhexyl)phthalate induces hepatic tumorigenesis through a peroxisome proliferator-activated receptor ?-independent pathway. J. Occup. Health 2007, 49:172-182.
16. Eveillard A., Mselli-Lakhal L., Mogha A., Lasserre F., Polizzi A., Pascussi J.-M., Guillou H., Martin P.G.P., Pineau T. Di-(2-ethylhexyl)-phthalate (DEHP) activates the constitutive androstane receptor (CAR): a novel signalling pathway sensitive to phthalates. Biochem. Pharmacol. 2009, 77:1735-1746.
17. Takashima K., Ito Y., Gonzalez F.J., Nakajima T. Different mechanisms of DEHP-induced hepatocellular adenoma tumorigenesis in wild-type and Ppar?-null mice. J. Occup. Health 2008, 50:169-180.
18. Rothenbacher K.-P., Kimmel R., Hildenbrand S., Schmahl F.W., Dartsch P.C. Nephrotoxic effects of di-(2-ethylhexyl)phthalate (DEHP) hydrolysis products on cultured kidney epithelial cells. Hum. Exp. Toxicol. 1998, 17:336-342.
19. Lahousse S.A., Wallace D.G., Liu D., Gaido K.W., Johnson K.J. Testicular gene expression profiling following prepubertal rat mono-(2-ethylhexyl) phthalate exposure suggests a common initial genetic response at fetal and prepubertal ages. Toxicol. Sci. 2006, 93:369-381.
20. Saillenfait A.-M., Sabaté J.-P., Gallissot F. Effects of in utero exposure to di-n-hexyl phthalate on the reproductive development of the male rat. Reprod. Toxicol. 2009, 28:468-476.
21. Liu K., Lehmann K.P., Sar M., Young S.S., Gaido K.W. Gene expression profiling following in utero exposure to phthalate esters reveals new gene targets in the etiology of testicular dysgenesis. Biol. Reprod. 2005, 73:180-192.
22. Swan S.H., Main K.M., Liu F., Stewart S.L., Kruse R.L., Calafat A.M., Mao C.S., Redmon J.B., Ternand C.L., Sullivan S., Teague J.L. Decrease in anogenital distance among male infants with prenatal phthalate exposure. Environ. Health Perspect. 2005, 113:1056-1061.
23. Thompson C.J., Ross S.M., Hensley J., Liu K., Heinze S.C., Young S.S., Gaido K.W. Differential steroidogenic gene expression in the fetal adrenal gland versus the testis and rapid and dynamic response of the fetal testis to di(n-butyl) phthalate. Biol. Reprod. 2005, 73:908-917.
24. McKee R.H., Pavkov K.L., Trimmer G.W., Keller L.H., Stump D.G. An assessment of the potential developmental and reproductive toxicity of di-isoheptyl phthalate in rodents. Reprod. Toxicol. 2006, 21:241-252.
25. Martino-Andrade A.J., Chahoud I. Reproductive toxicity of phthalate esters. Mol. Nutr. Food Res. 2010, 54:148-157.
26. Koch H.M., Drexler H., Angerer J. An estimation of the daily intake of di(2-ethylhexyl)phthalate (DEHP) and other phthalates in the general population. Int. J. Hyg. Environ. Health 2003, 206:77-83.
27. Barr D.B., Silva M.J., Kato K., Reidy J.A., Malek N.A., Hurtz D., Sadowski M., Needham L.L., Calafat A.M. Assessing human exposure to phthalates using monoesters and their oxidized metabolites as biomarkers. Environ. Health Perspect. 2003, 111:1148-1151.
28. Andrade A.J.M., Grande S.W., Talsness C.E., Grote K., Golombiewski A., Sterner-Kock A., Chahoud I. A dose-response study following in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP): effects on androgenic status, developmental landmarks and testicular histology in male offspring rats. Toxicology 2006, 225:64-74.
29. Eveillard A., Lasserre F., de Tayrac M., Polizzi A., Claus S., Canlet C., Mselli-Lakhal L., Gotardi G., Paris A., Guillou H., Martin P.G.P., Pineau T. Identification of potential mechanisms of toxicity after di-(2-ethylhexyl)-phthalate (DEHP) adult exposure in the liver using a systems biology approach. Toxicol. Appl. Pharmacol. 2009, 236:282-292.
30. Hauser R., Meeker J.D., Duty S., Silva M.J., Calafat A.M. Altered semen quality in relation to urinary concentrations of phthalate monoester and oxidative metabolites. Epidemiology 2006, 17:682-691.
31. Botelho G., Golin M., Bufalo A., Morais R., Dalsenter P., Martino-Andrade A. Reproductive effects of di(2-ethylhexyl)phthalate in immature male rats and its relation to cholesterol, testosterone, and thyroxin levels. Arch. Environ. Contam. Toxicol. 2009, 57:777-784.
32. Ghisari M., Bonefeld-Jorgensen E.C. Effects of plasticizers and their mixtures on estrogen receptor and thyroid hormone functions. Toxicol. Lett. 2009, 189:67-77.
33. Swan S.H. Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans. Environ. Res. 2008, 108:177-184.
34. Feige J.N., Gerber A., Casals-Casas C., Yang Q., Winkler C., Bedu E., Bueno M., Gelman L., Auwerx J., Gonzales F.J., Desvergne B. The pollutant diethylhexyl phthalate regulate hepatic energy metabolism via species-specific PARRA-dependent mechanisms. Environ. Health Perspect. 2010, 118:234-241.
35. Li S.S.-L., Liu Y.-H., Tseng C.-N., Chung T.-L., Lee T.-Y., Singh S. Characterization and gene expression profiling of five new human embryonic stem cell lines derived in Taiwan. Stem Cells Dev. 2006, 15:532-555.
36. Meeker J.D., Sathyanarayana S., Swan S.H. Phthalates and other additives in plastics: human exposure and associated health outcomes. Philos. Trans. R. Soc. B Biol. Sci. 2009, 364:2097-2113.
37. Braam S.R., Tertoolen L., van de Stolpe A., Meyer T., Passier R., Mummery C.L. Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes. Stem Cell Res. 2010, 4:107-116.