The porcine TBC1D1 gene: Mapping, SNP identification, and association study with meat, carcass and production traits in Italian heavy pigs

Molecular Biology Reports

Volumn 38, Issue 2, 2011, Pages 1425-1431

  Fontanesi, Luca ^a   Colombo, Michela ^a   Tognazzi, Lucia ^a   Scotti, Emilio ^a   Buttazzoni, Luca ^b   Dall'Olio, Stefania ^a   Davoli, Roberta ^a   Russo, Vincenzo ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b Associazione Nazionale Allevatori Suini ANAS   (Italy)

Author keywords

Association study; Candidate gene; Meat production; Pig; SNP; TBC1D1

Indexed keywords

ADENINE; GUANINE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; PROTEIN TBC1D1; RAB PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BODY FAT; BREEDING; CARCASS; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE MAPPING; GENETIC ASSOCIATION; GENETIC IDENTIFICATION; GENETIC TRAIT; GENOTYPE; ITALY; LEAN BODY WEIGHT; MALE; MEAT; MEAT INDUSTRY; MELTING POINT; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM; SWINE; THICKNESS;

ALLELES; ANIMALS; FEMALE; GENE FREQUENCY; GENOTYPE; GTPASE-ACTIVATING PROTEINS; ITALY; MALE; MODELS, BIOLOGICAL; MUTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; SWINE;

PIERIS BRASSICAE; SUIDAE; SUS;

EID: 79951577924     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-010-0247-3     Document Type: Article

References (19)

1. KS Kim N Larsen T Short G Plastow MF Rothschild 2000 A missense variant of the porcine melanocortin-4 receptor (MC4R) gene is associated with fatness, growth, and feed intake traits Mamm Genome 11 131 135 1:CAS:528: DC%2BD3cXhtFOkur0%3D 10.1007/s003350010025 10656927 (Pubitemid 30054415)
2. L Fontanesi E Scotti L Buttazzoni R Davoli V Russo 2009 The porcine fat mass and obesity associated (FTO) gene is associated with fat deposition in Italian Duroc pigs Anim Genet 40 90 93 1:CAS:528:DC%2BD1MXivVGksbo%3D 10.1111/j.1365-2052.2008.01777.x 18786155
3. L Fontanesi E Scotti L Buttazzoni S Dall'Olio A Bagnato DP Lo Fiego R Davoli V Russo 2010 Confirmed association between a single nucleotide polymorphism in the FTO gene and obesity-related traits in heavy pigs Mol Biol Rep 37 461 466 1:CAS:528:DC%2BC3cXisFSnsQ%3D%3D 10.1007/s11033-009-9638-8 19649729
4. S Stone V Abkevich DL Russell R Riley K Timms T Tran D Trem D Frank S Jammulapati CD Neff D Iliev R Gress G He GC Frech TD Adams MH Skolnick JS Lanchbury A Gutin SC Hunt D Shattuck 2006 TBC1D1 is a candidate for a severe obesity gene and evidence for a gene/gene interaction in obesity predisposition Hum Mol Genet 15 2709 2720 1:CAS:528:DC%2BD28Xps1Gnurs%3D 10.1093/hmg/ddl204 16893906 (Pubitemid 44400398)
5. D Meyre M Farge C Lecoeur C Proenca E Durand F Allegaert J Tichet M Marre B Balkau J Weill J Delplanque P Froguel 2008 R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population Hum Mol Genet 17 1798 1802 1:CAS:528: DC%2BD1cXmsFKju7Y%3D 10.1093/hmg/ddn070 18325908 (Pubitemid 351791506)
6. Diabetes Genetics Initiative of Broad Institute of Harvard and MIT Lund University Novartis Institutes of BioMedical Research R Saxena BF Voight V Lyssenko NP Burtt PI de Bakker H Chen JJ Roix S Kathiresan JN Hirschhorn MJ Daly TE Hughes L Groop D Altshuler P Almgren JC Florez J Meyer K Ardlie K Bengtsson Boström B Isomaa G Lettre U Lindblad HN Lyon O Melander C Newton-Cheh P Nilsson M Orho-Melander L Råstam EK Speliotes MR Taskinen T Tuomi C Guiducci A Berglund J Carlson L Gianniny R Hackett L Hall J Holmkvist E Laurila M Sjögren M Sterner A Surti M Svensson M Svensson R Tewhey B Blumenstiel M Parkin M Defelice R Barry W Brodeur J Camarata N Chia M Fava J Gibbons B Handsaker C Healy K Nguyen C Gates C Sougnez D Gage M Nizzari SB Gabriel GW Chirn Q Ma H Parikh D Richardson D Ricke S Purcell 2007 Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels Science 316 1331 1336 1:CAS:528:DC%2BD2sXmtVyitrk%3D 10.1126/science.1142358 17463246 (Pubitemid 46871653)
7. E Zeggini MN Weedon CM Lindgren TM Frayling KS Elliott H Lango NJ Timpson JR Perry NW Rayner RM Freathy JC Barrett B Shields AP Morris S Ellard CJ Groves LW Harries JL Marchini KR Owen B Knight LR Cardon M Walker GA Hitman AD Morris AS Doney Wellcome Trust Case Control Consortium (WTCCC) MI McCarthy AT Hattersley 2007 Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes Science 316 1336 1341 1:CAS:528: DC%2BD2sXmtVymtb0%3D 10.1126/science.1142364 17463249 (Pubitemid 46871654)
8. A Chadt K Leicht A Deshmukh LQ Jiang S Scherneck U Bernhardt T Dreja H Vogel K Schmolz R Kluge JR Zierath C Hultschig RC Hoeben A Schürmann HG Joost H Al-Hasani 2008 Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity Nat Genet 40 1354 1359 1:CAS:528: DC%2BD1cXhtlSkurnN 10.1038/ng.244 18931681
9. WG Roach JA Chavez CP Mîinea GE Lienhard 2007 Substrate specificity and effect on GLUT4 translocation of the Rab GTPase-activating protein Tbc1d1 Biochem J 403 353 358 1:CAS:528:DC%2BD2sXjsVWrtL8%3D 10.1042/BJ20061798 17274760 (Pubitemid 46596592)
10. S Chen J Murphy R Toth DG Campbell NA Morrice C Mackintosh 2008 Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators Biochem J 409 449 459 1:CAS:528:DC%2BD1cXhtlSrur4%3D 10.1042/BJ20071114 17995453 (Pubitemid 351184963)
11. H Zaid CN Antonescu VK Randhawa A Klip 2008 Insulin action on glucose transporters through molecular switches, tracks and tethers Biochem J 413 201 215 1:CAS:528:DC%2BD1cXnslKhu78%3D 10.1042/BJ20080723 18570632
12. RH Vossen E Aten A Roos JT den Dunnen 2009 High-resolution melting analysis (HRMA): more than just sequence variant screening Hum Mutat 30 860 866 1:CAS:528:DC%2BD1MXpt1Sht74%3D 10.1002/humu.21019 19418555
13. L Fontanesi R Davoli L Nanni Costa F Beretti E Scotti M Tazzoli F Tassone M Colombo L Buttazzoni V Russo 2008 Investigation of candidate genes for glycolytic potential of porcine skeletal muscle: association with meat quality and production traits in Italian Large White pigs Meat Sci 80 780 787 1:CAS:528:DC%2BD1cXhtVKmtbnM 10.1016/j.meatsci.2008.03.022
14. M Yerle P Pinton A Robic A Alfonso Y Palvadeau C Delcros R Hawken L Alexander C Beattie L Schook D Milan J Gellin 1998 Construction of a whole-genome radiation hybrid panel for high-resolution gene mapping in pigs Cytogenet Cell Genet 82 182 188 1:CAS:528:DyaK1MXkslyqtQ%3D%3D 10.1159/000015095 9858812 (Pubitemid 29002460)
15. D Milan R Hawken C Cabau S Leroux C Genet Y Lahbib G Tosser A Robic F Hatey L Alexander C Beattie L Schook M Yerle J Gellin 2000 IMpRH server: an RH mapping server available on the web Bioinformatics 16 558 559 1:CAS:528:DC%2BD3cXnsVelsbk%3D 10.1093/bioinformatics/16.6.558 10980153
16. L Fontanesi E Scotti L Buttazzoni S Dall'Olio R Davoli V Russo 2010 The porcine cathepsin K (CTSK) gene is associated with back fat thickness and production traits in Italian Duroc pigs Mol Biol Rep 37 491 495 1:CAS:528:DC%2BC3cXisFWitQ%3D%3D 10.1007/s11033-009-9678-0 19662513
17. V Russo L Fontanesi E Scotti F Beretti R Davoli L Nanni Costa R Virgili L Buttazzoni 2008 Single nucleotide polymorphisms in several porcine cathepsin genes are associated with growth, carcass, and production traits in Italian Large White pigs J Anim Sci 86 3300 3314 1:CAS:528:DC%2BD1cXhsV2jsb%2FE 10.2527/jas.2008-0920 18708606
18. RJ Hawken J Murtaugh GH Flickinger M Yerle A Robic D Milan J Gellin CW Beattie LB Schook LJ Alexander 1999 A first-generation porcine whole-genome radiation hybrid map Mamm Genome 10 824 830 1:CAS:528:DyaK1MXkvV2msLY%3D 10.1007/s003359901097 10430669 (Pubitemid 29390559)
19. GA Brockmann SW Tsaih C Neuschl GA Churchill R Li 2009 Genetic factors contributing to obesity and body weight can act through mechanisms affecting muscle weight, fat weight, or both Physiol Genomics 36 114 126 1:CAS:528:DC%2BD1MXlsFynsrg%3D 18984673