RNA interference targeting CITRON can significantly inhibit the proliferation of hepatocellular carcinoma cells

Molecular Biology Reports

Volumn 38, Issue 2, 2011, Pages 693-702

  Fu, Yinghui ^a,b   Huang, Jian ^b   Wang, Ke Sheng ^b   Zhang, Xin ^b   Han, Ze Guang ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b CHINESE NATIONAL HUMAN GENOME CENTER AT SHANGHAI   (China)

Author keywords

CITRON; Cytokinesis; Hepatocellular carcinoma; RNA interference

Indexed keywords

ADENOVIRUS VECTOR; PROTEIN SERINE THREONINE KINASE; RHO INTERACTING SERINE THREONINE KINASE 21; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CARCINOGENICITY; CELL PROLIFERATION; COLONY FORMATION; CONTROLLED STUDY; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL CARCINOMA; MOUSE; MULTINUCLEAR CELL; NONHUMAN; PROTEIN EXPRESSION; PROTEIN TARGETING; RNA INTERFERENCE; UPREGULATION;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL CYCLE; CELL PROLIFERATION; CYTOKINESIS; HUMANS; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER NEOPLASMS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; PROTEIN-SERINE-THREONINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE;

ADENOVIRIDAE; MUS MUSCULUS;

EID: 79951577813     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-010-0156-5     Document Type: Article

References (36)

1. DM Parkin F Bray J Ferlay P Pisani 2005 Global cancer statistics, 2002 CA Cancer J Clin 55 2 74 108 10.3322/canjclin.55.2.74 10.3322/canjclin.55.2.74 15761078 (Pubitemid 40372904)
2. M Shimizu K Takai H Moriwaki 2009 Strategy and mechanism for the prevention of hepatocellular carcinoma: phosphorylated retinoid X receptor alpha is a critical target for hepatocellular carcinoma chemoprevention Cancer Sci 100 3 369 374 10.1111/j.1349-7006.2008.01045.x 1:CAS:528:DC%2BD1MXjt1Wrt7k%3D 10.1111/j.1349-7006.2008.01045.x 19068086
3. MB Thomas AX Zhu 2005 Hepatocellular carcinoma: the need for progress J Clin Oncol 23 13 2892 2899 10.1200/JCO.2005.03.196 10.1200/JCO.2005.03.196 15860847 (Pubitemid 46224106)
4. M Huang G Liu 1999 The study of innate drug resistance of human hepatocellular carcinoma Bel7402 cell line Cancer Lett 135 1 97 105 10.1016/S0304-3835(98)00280-8 1:CAS:528:DyaK1MXht1Smtrc%3D 10.1016/S0304- 3835(98)00280-8 10077227
5. A Kato M Miyazaki S Ambiru, et al. 2001 Multidrug resistance gene (MDR-1) expression as a useful prognostic factor in patients with human hepatocellular carcinoma after surgical resection J Surg Oncol 78 2 110 115 10.1002/jso.1129 1:STN:280:DC%2BD3Mrjt1Gqtg%3D%3D 10.1002/jso.1129 11579388 (Pubitemid 32906122)
6. GK Abou-Alfa L Schwartz S Ricci, et al. 2006 Phase II study of sorafenib in patients with advanced hepatocellular carcinoma J Clin Oncol 24 26 4293 4300 10.1200/JCO.2005.01.3441 1:CAS:528:DC%2BD28XhtVGju7jE 10.1200/JCO.2005.01.3441 16908937 (Pubitemid 46630787)
7. MB Thomas JS Morris R Chadha, et al. 2009 Phase II trial of the combination of bevacizumab and erlotinib in patients who have advanced hepatocellular carcinoma J Clin Oncol 27 6 843 850 10.1200/JCO.2008.18.3301 1:CAS:528:DC%2BD1MXjs1Kntr4%3D 10.1200/JCO.2008.18.3301 19139433
8. J Zhang PL Yang NS Gray 2009 Targeting cancer with small molecule kinase inhibitors Nat Rev Cancer 9 1 28 39 10.1038/nrc2559 10.1038/nrc2559 19104514
9. RD Carvajal A Tse GK Schwartz 2006 Aurora kinases: new targets for cancer therapy Clin Cancer Res 12 23 6869 6875 10.1158/1078-0432.CCR-06-1405 1:CAS:528:DC%2BD28Xht1Kns7rK 10.1158/1078-0432.CCR-06-1405 17145803 (Pubitemid 44974478)
10. O Gautschi J Heighway PC Mack, et al. 2008 Aurora kinases as anticancer drug targets Clin Cancer Res 14 6 1639 1648 10.1158/1078-0432.CCR-07-2179 1:CAS:528:DC%2BD1cXjtlejtrY%3D 10.1158/1078-0432.CCR-07-2179 18347165 (Pubitemid 351471713)
11. G Mountzios E Terpos MA Dimopoulos 2008 Aurora kinases as targets for cancer therapy Cancer Treat Rev 34 2 175 182 10.1016/j.ctrv.2007.09.005 1:CAS:528:DC%2BD1cXjtl2jtrw%3D 18023292 (Pubitemid 351372885)
12. Q Lang H Zhang J Li, et al. 2010 3-Hydroxyflavone inhibits endogenous Aurora B and induces growth inhibition of cancer cell line Mol Biol Rep 37 3 1577 1583 10.1007/s11033-009-9562-y 1:CAS:528:DC%2BC3cXhtlajsL0%3D 10.1007/s11033-009-9562-y 19437133
13. XR Xu J Huang ZG Xu, et al. 2001 Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver Proc Natl Acad Sci USA 98 26 15089 15094 10.1073/pnas.241522398 1:CAS:528: DC%2BD38XpsVSr 10.1073/pnas.241522398 11752456 (Pubitemid 34013974)
14. P Madaule M Eda N Watanabe, et al. 1998 Role of citron kinase as a target of the small GTPase rho in cytokinesis Nature 394 6692 491 494 10.1038/28873 1:CAS:528:DyaK1cXltVGqtrs%3D 10.1038/28873 9697773 (Pubitemid 28373961)
15. M Paramasivam YJ Chang JJ LoTurco 2007 ASPM and citron kinase co-localize to the midbody ring during cytokinesis Cell Cycle 6 13 1605 1612 1:CAS:528:DC%2BD2sXhtFWlsr3I 10.4161/cc.6.13.4356 17534152 (Pubitemid 47327947)
16. S Yamashiro G Totsukawa Y Yamakita, et al. 2003 Citron kinase, a rho-dependent kinase, induces di-phosphorylation of regulatory light chain of myosin II Mol Biol Cell 14 5 1745 1756 10.1091/mbc.E02-07-0427 1:CAS:528:DC%2BD3sXktFKiur4%3D 10.1091/mbc.E02-07-0427 12802051 (Pubitemid 36583529)
17. A De Lozanne JA Spudich 1987 Disruption of the dictyostelium myosin heavy chain gene by homologous recombination Science 236 4805 1086 1091 10.1126/science.3576222 10.1126/science.3576222 3576222 (Pubitemid 17113250)
18. H Liu F Di Cunto S Imarisio LM Reid 2003 Citron kinase is a cell cycle-dependent, nuclear protein required for G2/M transition of hepatocytes J Biol Chem 278 4 2541 2548 10.1074/jbc.M210391200 1:CAS:528: DC%2BD3sXksFamtw%3D%3D 10.1074/jbc.M210391200 12411428 (Pubitemid 36801331)
19. F Di Cunto S Imarisio E Hirsch, et al. 2000 Defective neurogenesis in citron kinase knockout mice by altered cytokinesis and massive apoptosis Neuron 28 1 115 127 10.1016/S0896-6273(00)00090-8 1:CAS:528:DC%2BD3cXnvVGlt7Y%3D 10.1016/S0896-6273(00)00090-8 11086988
20. FD Cunto S Imarisio P Camera, et al. 2002 Essential role of citron kinase in cytokinesis of spermatogenic precursors J Cell Sci 115 Pt 24 4819 4826 10.1242/jcs.00163 10.1242/jcs.00163 12432070 (Pubitemid 36054635)
21. CD Atreya S Kulkarni KV Mohan 2004 Rubella virus P90 associates with the cytokinesis regulatory protein citron-K kinase and the viral infection and constitutive expression of P90 protein both induce cell cycle arrest following S phase in cell culture Arch Virol 149 4 779 789 10.1007/s00705-003-0267-6 1:CAS:528:DC%2BD2cXisVGltbs%3D 10.1007/s00705-003-0267-6 15045564 (Pubitemid 38459135)
22. CD Atreya KV Mohan S Kulkarni 2004 Rubella virus and birth defects: molecular insights into the viral teratogenesis at the cellular level Birth Defects Res A Clin Mol Teratol 70 7 431 437 10.1002/bdra.20045 1:CAS:528:DC%2BD2cXmtlKhs7c%3D 10.1002/bdra.20045 15259032 (Pubitemid 38998792)
23. RJ Loomis DA Holmes A Elms, et al. 2006 Citron kinase, a rho A effector, enhances HIV-1 virion production by modulating exocytosis Traffic 7 12 1643 1653 10.1111/j.1600-0854.2006.00503.x 1:CAS:528:DC%2BD28XhtlSitrvN 10.1111/j.1600-0854.2006.00503.x 17118119 (Pubitemid 44742367)
24. J Huang YL Zhang XM Teng, et al. 2007 Down-regulation of SFRP1 as a putative tumor suppressor gene can contribute to human hepatocellular carcinoma BMC Cancer 7 126 10.1186/1471-2407-7-126 10.1186/1471-2407-7-126 17626620 (Pubitemid 47226095)
25. KJ Livak TD Schmittgen 2001 Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method Methods 25 4 402 408 10.1006/meth.2001.1262 1:CAS:528:DC%2BD38XhtFelt7s%3D 10.1006/meth.2001.1262 11846609 (Pubitemid 34164012)
26. N Wettschureck S Offermanns 2002 Rho/rho-kinase mediated signaling in physiology and pathophysiology J Mol Med 80 10 629 638 10.1007/s00109-002-0370-2 1:CAS:528:DC%2BD38XotVClt7s%3D 10.1007/s00109-002-0370-2 12395147 (Pubitemid 35471727)
27. Z Zhang L Han Y Liu X Liang W Sun 2009 Up-regulation of tropomyosin related kinase B contributes to resistance to detachment-induced apoptosis in hepatoma multicellular aggregations Mol Biol Rep 36 5 1211 1216 10.1007/s11033-008-9299-z 1:CAS:528:DC%2BD1MXjvFejs70%3D 10.1007/s11033-008- 9299-z 18595003
28. H Li X Fu Y Chen, et al. 2005 Use of adenovirus-delivered siRNA to target oncoprotein p28GANK in hepatocellular carcinoma Gastroenterology 128 7 2029 2041 10.1053/j.gastro.2005.03.001 1:CAS:528:DC%2BD2MXlvFKltrY%3D 10.1053/j.gastro.2005.03.001 15940635 (Pubitemid 40824711)
29. Chen G, Qiao Y, Yao J et al. Construction of NF-kappaB-targeting RNAi adenovirus vector and the effect of NF-kappaB pathway on proliferation and apoptosis of vascular endothelial cells. Mol Biol Rep. doi: 10.1007/s11033-010- 9977-5
30. F Di Cunto E Calautti J Hsiao, et al. 1998 Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the rho-Rac-binding protein citron J Biol Chem 273 45 29706 29711 10.1074/jbc.273.45.29706 1:CAS:528:DyaK1cXntlKqtbk%3D 10.1074/jbc.273.45.29706 9792683 (Pubitemid 28509981)
31. T Genda M Sakamoto T Ichida, et al. 1999 Cell motility mediated by rho and rho-associated protein kinase plays a critical role in intrahepatic metastasis of human hepatocellular carcinoma Hepatology 30 4 1027 1036 10.1002/hep.510300420 1:CAS:528:DyaK1MXmslWgtb4%3D 10.1002/hep.510300420 10498656 (Pubitemid 29458293)
32. AV Somlyo D Bradshaw S Ramos, et al. 2000 Rho-kinase inhibitor retards migration and in vivo dissemination of human prostate cancer cells Biochem Biophys Res Commun 269 3 652 659 10.1006/bbrc.2000.2343 1:CAS:528: DC%2BD3cXhsleqtbc%3D 10.1006/bbrc.2000.2343 10720471 (Pubitemid 30440356)
33. DR Croft E Sahai G Mavria, et al. 2004 Conditional ROCK activation in vivo induces tumor cell dissemination and angiogenesis Cancer Res 64 24 8994 9001 1:CAS:528:DC%2BD2cXhtVOmsLvL 10.1158/0008-5472.CAN-04-2052 15604264 (Pubitemid 39665509)
34. K Kaneko K Satoh A Masamune A Satoh T Shimosegawa 2002 Expression of ROCK-1 in human pancreatic cancer: its down-regulation by morpholino oligo antisense can reduce the migration of pancreatic cancer cells in vitro Pancreas 24 3 251 257 10.1097/00006676-200204000-00007 11893932 (Pubitemid 34260649)
35. Wang L, Xue L, Yan H, Li J, Lu Y (2009) Effects of ROCK inhibitor, Y-27632, on adhesion and mobility in esophageal squamous cell cancer cells. Mol Biol Rep. doi: 10.1007/s11033-009-9645-9
36. T Ishizaki M Uehata I Tamechika, et al. 2000 Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases Mol Pharmacol 57 5 976 983 1:CAS:528:DC%2BD3cXjtVegu74%3D 10779382 (Pubitemid 30253382)