-
1
-
-
27244436276
-
Clinically significant cancer evolves from transient mutated and/or aneuploid neoplasia by cell fusion to form unstable syncytia that give rise to ecologically viable parasite species
-
Parris, G. E. Clinically significant cancer evolves from transient mutated and/or aneuploid neoplasia by cell fusion to form unstable syncytia that give rise to ecologically viable parasite species. Med. Hypotheses 65:846-850; 2005.
-
(2005)
Med. Hypotheses
, vol.65
, pp. 846-850
-
-
Parris, G.E.1
-
2
-
-
73249139727
-
Susceptibility of mantle cell lymphomas to reovirus oncolysis
-
Alain, T.; Muzik, H.; Otsuka, S.; Chan, S.; Magliocco, T.; Diaz, R.; Forsyth, P. A.; Morris, D.; Bebb, G. Susceptibility of mantle cell lymphomas to reovirus oncolysis. Leuk. Res. 34:100-108; 2010.
-
(2010)
Leuk. Res.
, vol.34
, pp. 100-108
-
-
Alain, T.1
Muzik, H.2
Otsuka, S.3
Chan, S.4
Magliocco, T.5
Diaz, R.6
Forsyth, P.A.7
Morris, D.8
Bebb, G.9
-
3
-
-
18844365357
-
p12CDK2-AP1 gene therapy strategy inhibits tumor growth in an in vivo mouse model of head and neck cancer
-
Figueiredo, M. L.; Kim, Y.; St John, M. A.; Wong, D. T. p12CDK2-AP1 gene therapy strategy inhibits tumor growth in an in vivo mouse model of head and neck cancer. Clin. Cancer Res. 11:3939-3948; 2005.
-
(2005)
Clin. Cancer Res.
, vol.11
, pp. 3939-3948
-
-
Figueiredo, M.L.1
Kim, Y.2
St John, M.A.3
Wong, D.T.4
-
4
-
-
75349106759
-
MicroRNAs: Oncogenes, tumor suppressors or master regulators of cancer heterogeneity?
-
Voorhoeve, P. M. MicroRNAs: Oncogenes, tumor suppressors or master regulators of cancer heterogeneity? Biochim. Biophys. Acta 1805:72-86; 2010.
-
(2010)
Biochim. Biophys. Acta
, vol.1805
, pp. 7286
-
-
Voorhoeve, P.M.1
-
5
-
-
79951525591
-
Phase Ib study of PTC299, a novel oral inhibitor of tumor VEGF expression, in patients with advanced cancer
-
Schwartz, G. K.; Dickson, M. A.; Callahan, L. A.; Darby, C. H.; Llorente, M.; Cao, Y.; Dials, H. J.; Miller, L. L.; Miao, H. H. Phase Ib study of PTC299, a novel oral inhibitor of tumor VEGF expression, in patients with advanced cancer. J. Clin. Oncol. 28:7s; 2010.
-
(2010)
J. Clin. Oncol.
, vol.28
-
-
Schwartz, G.K.1
Dickson, M.A.2
Callahan, L.A.3
Darby, C.H.4
Llorente, M.5
Cao, Y.6
Dials, H.J.7
Miller, L.L.8
Miao, H.H.9
-
6
-
-
75349091269
-
Structure-function analysis of VEGF receptor activation and the role of coreceptors in angiogenic signaling
-
Granewald, F. S.; Prota, A. E.; Giese, A.; Ballmer-Hofer, K. Structure-function analysis of VEGF receptor activation and the role of coreceptors in angiogenic signaling. Biochim. Biophys. Acta 1804:567-580; 2010.
-
(2010)
Biochim. Biophys. Acta
, vol.1804
, pp. 567-580
-
-
Granewald, F.S.1
Prota, A.E.2
Giese, A.3
Ballmer-Hofer, K.4
-
7
-
-
70449567429
-
Production of beta-globin and adult haemoglobin following G418 treatment of erythroid precursor cells from homozygous beta(0)39 thalassemia patients
-
Salvatori, F.; Breveglieri, G.; Zuccato, C.; Finotti, A.; Bianchi, N.; Borgatti, M.; Feriotto, G.; Destro, F.; Canella, A.; Brognara, E.; Lampronti, I.; Breda, L.; Rivella, S.; Gambari, R. Production of beta-globin and adult haemoglobin following G418 treatment of erythroid precursor cells from homozygous beta(0)39 thalassemia patients. Am. J. Hematol. 84:720-728; 2009.
-
(2009)
Am. J. Hematol.
, vol.84
, pp. 720-728
-
-
Salvatori, F.1
Breveglieri, G.2
Zuccato, C.3
Finotti, A.4
Bianchi, N.5
Borgatti, M.6
Feriotto, G.7
Destro, F.8
Canella, A.9
Brognara, E.10
Lampronti, I.11
Breda, L.12
Rivella, S.13
Gambari, R.14
-
8
-
-
0033929810
-
Aminoglycoside antibiotics mediate context-dependent suppression of termination codons in a mammalian translation system
-
Manuvakhova, M.; Keeling, K.; Bedwell, D. M. Aminoglycoside antibiotics mediate context-dependent suppression of termination codons in a mammalian translation system. RNA 6:1044-1055; 2000.
-
(2000)
RNA
, vol.6
, pp. 1044-1055
-
-
Manuvakhova, M.1
Keeling, K.2
Bedwell, D.M.3
-
9
-
-
14844348264
-
Molecular insights into aminoglycoside action and resistance
-
Magnet, S.; Blanchard, J. S. Molecular insights into aminoglycoside action and resistance. Chem. Rev. 105: 477-498; 2005.
-
(2005)
Chem. Rev.
, vol.105
, pp. 477-498
-
-
Magnet, S.1
Blanchard, J.S.2
-
10
-
-
33947529670
-
Safety, tolerability and pharmacokinetics of PTC124, a nonaminoglycoside nonsense mutation suppressor, following single and multiple dose administration to healthy male and female volunteers
-
Hirawat, S.; Welch, E. M.; Elfring, G. L.; Northcutt, V.J.; Paushkin, S.; Hwang, S.; Leonard, E. M.; Almstead, N. G.; Ju, W.; Peltz, S. W.; Miller, L. L. Safety, tolerability and pharmacokinetics of PTC124, a nonaminoglycoside nonsense mutation suppressor, following single and multiple dose administration to healthy male and female volunteers. J. Clin. Pharmacol. 47:430-444; 2007.
-
(2007)
J. Clin. Pharmacol.
, vol.47
, pp. 430-444
-
-
Hirawat, S.1
Welch, E.M.2
Elfring, G.L.3
Northcutt, V.J.4
Paushkin, S.5
Hwang, S.6
Leonard, E.M.7
Almstead, N.G.8
Ju, W.9
Peltz, S.W.10
Miller, L.L.11
-
11
-
-
68649089108
-
Pharmaceuticals targeting nonsense mutations in genetic diseases: Progress in development
-
Rowe, S. M.; Clancy, J. P. Pharmaceuticals targeting nonsense mutations in genetic diseases: Progress in development. BioDrugs 23:165-174; 2009.
-
(2009)
BioDrugs
, vol.23
, pp. 165-174
-
-
Rowe, S.M.1
Clancy, J.P.2
-
12
-
-
34247588271
-
PTC124 targets genetic disorders caused by nonsense mutations
-
Welch, E. M.; Barton, E. R.; Zhuo, J.; Tomizawa, Y.; Friesen, W. J.; Trifillis, P.; Paushkin, S.; Patel, M.; Trotta, C. R.; Hwang, S.; Wilde, R. G.; Karp, G.; Takasugi, J.; Chen, G.; Jones, S.; Ren, H.; Moon, Y. C.; Corson, D.; Turpoff, A. A.; Campbell, J. A.; Conn, M. M.; Khan, A.; Almstead, N. G.; Hedrick, J.; Mollin, A.; Risher, N.; Weetall, M.; Yeh, S.; Branstrom, A. A.; Colacino, J. M.; Babiak, J.; Ju, W. D.; Hirawat, S.; Northcutt, V. J.; Miller, L. L.; Spatrick, P.; He, F.; Kawana, M.; Feng, H.; Jacobson, A.; Peltz, S. W.; Sweeney, H. L. PTC124 targets genetic disorders caused by nonsense mutations. Nature 447: 87-91; 2007.
-
(2007)
Nature
, vol.447
, pp. 87-91
-
-
Welch, E.M.1
Barton, E.R.2
Zhuo, J.3
Tomizawa, Y.4
Friesen, W.J.5
Trifillis, P.6
Paushkin, S.7
Patel, M.8
Trotta, C.R.9
Hwang, S.10
Wilde, R.G.11
Karp, G.12
Takasugi, J.13
Chen, G.14
Jones, S.15
Ren, H.16
Moon, Y.C.17
Corson, D.18
Turpoff, A.A.19
Campbell, J.A.20
Conn, M.M.21
Khan, A.22
Almstead, N.G.23
Hedrick, J.24
Mollin, A.25
Risher, N.26
Weetall, M.27
Yeh, S.28
Branstrom, A.A.29
Colacino, J.M.30
Babiak, J.31
Ju, W.D.32
Hirawat, S.33
Northcutt, V.J.34
Miller, L.L.35
Spatrick, P.36
He, F.37
Kawana, M.38
Feng, H.39
Jacobson, A.40
Peltz, S.W.41
Sweeney, H.L.42
more..
-
13
-
-
77249176209
-
Cystic fibrosis transmembrane conductance regulator modulators for personalized drug treatment of cystic fibrosis: Progress to date
-
Becq, F. Cystic fibrosis transmembrane conductance regulator modulators for personalized drug treatment of cystic fibrosis: Progress to date. Drugs 70:241-259; 2010.
-
(2010)
Drugs
, vol.70
, pp. 241-259
-
-
Becq, F.1
-
14
-
-
0035997219
-
Clinically relevant aminoglycosides can suppress disease-associated premature stop mutations in the IDUA and P53 cDNAs in a mammalian translation system
-
Keeling, K. M.; Bedwell, D. M. Clinically relevant aminoglycosides can suppress disease-associated premature stop mutations in the IDUA and P53 cDNAs in a mammalian translation system. J. Mol. Med. 80:367-376; 2002.
-
(2002)
J. Mol. Med.
, vol.80
, pp. 367-376
-
-
Keeling, K.M.1
Bedwell, D.M.2
-
16
-
-
33751064254
-
Drug evaluation: PTC-124 - A potential treatment of cystic fibrosis and Duchenne muscular dystrophy
-
Hamed, S. A. Drug evaluation: PTC-124 - a potential treatment of cystic fibrosis and Duchenne muscular dystrophy. Drugs 9:783-789; 2006.
-
(2006)
Drugs
, vol.9
, pp. 783-789
-
-
Hamed, S.A.1
-
17
-
-
0028241478
-
Mutations to nonsense codons in human genetic disease: Implications for gene therapy by nonsense suppressor tRNAs
-
Atkinson, J.; Martin, R. Mutations to nonsense codons in human genetic disease: Implications for gene therapy by nonsense suppressor tRNAs. Nucleic Acids Res. 22:1327-1334; 1994.
-
(1994)
Nucleic Acids Res.
, vol.22
, pp. 1327-1334
-
-
Atkinson, J.1
Martin, R.2
-
18
-
-
49149098054
-
A meta-analysis of nonsense mutations causing human genetic disease
-
Mort, M.; Ivanov, D.; Cooper, D. N.; Chuzhanova, N. A. A meta-analysis of nonsense mutations causing human genetic disease. Hum. Mutat. 29:1037-1047; 2008.
-
(2008)
Hum. Mutat.
, vol.29
, pp. 1037-1047
-
-
Mort, M.1
Ivanov, D.2
Cooper, D.N.3
Chuzhanova, N.A.4
-
20
-
-
0031737407
-
Overview of RB gene mutations in patients with retinoblastoma. Implications for clinical genetic screening
-
Harbour, J. W. Overview of RB gene mutations in patients with retinoblastoma. Implications for clinical genetic screening. Ophthalmology 105:1442-1447; 1998.
-
(1998)
Ophthalmology
, vol.105
, pp. 1442-1447
-
-
Harbour, J.W.1
-
21
-
-
47049115051
-
The NMD mRNA surveillance pathway down regulates aberrant E-cadherin transcripts in gastric cancer cells and CDH1 mutation carriers
-
Karam, R.; Carvalho, J.; Bruno, I.; Graziadio, C.; Senz, J.; Huntsman, D.; Carneiro, F.; Seruca, R.; Wilkinson, M. F.; Oliveira, C. The NMD mRNA surveillance pathway down regulates aberrant E-cadherin transcripts in gastric cancer cells and CDH1 mutation carriers. Oncogene 27:4255-4260; 2008.
-
(2008)
Oncogene
, vol.27
, pp. 4255-4260
-
-
Karam, R.1
Carvalho, J.2
Bruno, I.3
Graziadio, C.4
Senz, J.5
Huntsman, D.6
Carneiro, F.7
Seruca, R.8
Wilkinson, M.F.9
Oliveira, C.10
-
22
-
-
77955982168
-
Tumor-stromal interactions in bone metastasis
-
Nannuru, K. C.; Singh, R. K. Tumor-stromal interactions in bone metastasis. Curr. Osteoporos. Rep. 8:105-113; 2010.
-
(2010)
Curr. Osteoporos. Rep.
, vol.8
, pp. 105-113
-
-
Nannuru, K.C.1
Singh, R.K.2
-
23
-
-
34250174504
-
The role of epithelial-mesenchymal transition in cancer pathology
-
Guarino, M.; Rubino, B.; Ballabio, G. The role of epithelial-mesenchymal transition in cancer pathology. Pathology 39:305-318; 2007.
-
(2007)
Pathology
, vol.39
, pp. 305-318
-
-
Guarino, M.1
Rubino, B.2
Ballabio, G.3
-
24
-
-
77951155224
-
Gain of oncogenic function of p53 mutants regulates E-cadherin expression uncoupled from cell invasion in colon cancer cells
-
Roger, L.; Jullien, L.; Gire, V.; Roux, P. Gain of oncogenic function of p53 mutants regulates E-cadherin expression uncoupled from cell invasion in colon cancer cells. J. Cell Sci. 123:1295-1305; 2010.
-
(2010)
J. Cell Sci.
, vol.123
, pp. 1295-1305
-
-
Roger, L.1
Jullien, L.2
Gire, V.3
Roux, P.4
-
25
-
-
70350064307
-
The role of VHL in clear-cell renal cell carcinoma and its relation to targeted therapy
-
Clark, P. E. The role of VHL in clear-cell renal cell carcinoma and its relation to targeted therapy. Kidney Int. 76: 939-945; 2009.
-
(2009)
Kidney Int.
, vol.76
, pp. 939-945
-
-
Clark, P.E.1
-
26
-
-
76549111028
-
NF-kappaB-dependent plasticity of the epithelial to mesenchymal transition induced by Von Hippel-Lindau inactivation in renal cell carcinomas
-
Pantuck, A. J.; An, J.; Liu, H.; Rettig, M. B. NF-kappaB-dependent plasticity of the epithelial to mesenchymal transition induced by Von Hippel-Lindau inactivation in renal cell carcinomas. Cancer Res. 70:752-761; 2010.
-
(2010)
Cancer Res.
, vol.70
, pp. 752-761
-
-
Pantuck, A.J.1
An, J.2
Liu, H.3
Rettig, M.B.4
-
27
-
-
0035054565
-
Genotype-phenotype correlation in von Hippel-Lindau syndrome
-
Friedrich, C. A. Genotype-phenotype correlation in von Hippel-Lindau syndrome. Hum. Mol. Genet. 10:763-767; 2001.
-
(2001)
Hum. Mol. Genet.
, vol.10
, pp. 763-767
-
-
Friedrich, C.A.1
-
28
-
-
16344369067
-
Gastric juvenile polyposis associated with germline SMAD4 mutation
-
Shikata, K.; Kukita, Y.; Matsumoto, T.; Esaki, M.; Yao, T.; Mochizuki, Y.; Hayashi, K.; Iida, M. Gastric juvenile polyposis associated with germline SMAD4 mutation. Am. J. Med. Genet. 134:326-329; 2005.
-
(2005)
Am. J. Med. Genet.
, vol.134
, pp. 326-329
-
-
Shikata, K.1
Kukita, Y.2
Matsumoto, T.3
Esaki, M.4
Yao, T.5
Mochizuki, Y.6
Hayashi, K.7
Iida, M.8
-
29
-
-
28744441903
-
Truncating mutations in the ACVR2 gene attenuates activin signaling in prostate cancer cells
-
Rossi, M.; Ionov, Y.; Bakin, A.; Cowell, J. Truncating mutations in the ACVR2 gene attenuates activin signaling in prostate cancer cells. Cancer Genet. Cytogenet. 163: 123-129; 2005.
-
(2005)
Cancer Genet. Cytogenet.
, vol.163
, pp. 123-129
-
-
Rossi, M.1
Ionov, Y.2
Bakin, A.3
Cowell, J.4
-
30
-
-
33745253118
-
A common nonsense mutation in EphB2 is associated with prostate cancer risk in African American men with a positive family history
-
Kittles, R. A.; Baffoe-Bonnie, A. B.; Moses, T. Y.; Robbins, C. M.; Ahaghotu, C.; Huusko, P.; Pettaway, C.; Vijayakumar, S.; Bennett, J.; Hoke, G.; Mason, T.; Weinrich, S.; Trent, J. M.; Collins, F. S.; Mousses, S.; Bailey-Wilson, J.; Furbert-Harris, P.; Dunston, G.; Powell, I. J.; Carpten, J. D. A common nonsense mutation in EphB2 is associated with prostate cancer risk in African American men with a positive family history. J. Med. Genet. 43: 507-511; 2006.
-
(2006)
J. Med. Genet.
, vol.43
, pp. 507-511
-
-
Kittles, R.A.1
Baffoe-Bonnie, A.B.2
Moses, T.Y.3
Robbins, C.M.4
Ahaghotu, C.5
Huusko, P.6
Pettaway, C.7
Vijayakumar, S.8
Bennett, J.9
Hoke, G.10
Mason, T.11
Weinrich, S.12
Trent, J.M.13
Collins, F.S.14
Mousses, S.15
Bailey-Wilson, J.16
Furbert-Harris, P.17
Dunston, G.18
Powell, I.J.19
Carpten, J.D.20
more..
-
31
-
-
0030807905
-
The Eph family: A multitude of receptors that mediate cell recognition signals
-
Zisch, A. H.; Pasquale, E. B. The Eph family: A multitude of receptors that mediate cell recognition signals. Cell Tissue Res. 290:217-226; 1997.
-
(1997)
Cell Tissue Res.
, vol.290
, pp. 217-226
-
-
Zisch, A.H.1
Pasquale, E.B.2
-
32
-
-
49549091736
-
Silibinin impairs constitutively active TGFalpha-EGFR autocrine loop in advanced human prostate carcinoma cells
-
Tyagi, A.; Sharma, Y.; Agarwal, C.; Agarwal, R. Silibinin impairs constitutively active TGFalpha-EGFR autocrine loop in advanced human prostate carcinoma cells. Pharm. Res. 9:2143-2150; 2008.
-
(2008)
Pharm. Res.
, vol.9
, pp. 2143-2150
-
-
Tyagi, A.1
Sharma, Y.2
Agarwal, C.3
Agarwal, R.4
-
33
-
-
67649876132
-
Acquired mutations in TET2 are common in myelodysplastic syndromes
-
Langemeijer, S. M.; Kuiper, R. P.; Berends, M.; Knops, R.; Aslanyan, M. G.; Massop, M.; Stevens-Linders, E.; van Hoogen, P.; van Kessel, A. G.; Raymakers, R. A.; Kamping, E. J.; Verhoef, G. E.; Verburgh, E.; Hagemeijer, A.; Vandenberghe, P.; de Witte, T.; van der Reijden, B. A.; Jansen, J. H. Acquired mutations in TET2 are common in myelodysplastic syndromes. Nat. Genet. 41:838-842; 2009.
-
(2009)
Nat. Genet.
, vol.41
, pp. 838-842
-
-
Langemeijer, S.M.1
Kuiper, R.P.2
Berends, M.3
Knops, R.4
Aslanyan, M.G.5
Massop, M.6
Stevens-Linders, E.7
Van Hoogen, P.8
Van Kessel, A.G.9
Raymakers, R.A.10
Kamping, E.J.11
Verhoef, G.E.12
Verburgh, E.13
Hagemeijer, A.14
Vandenberghe, P.15
De Witte, T.16
Van Der Reijden, B.A.17
Jansen, J.H.18
-
34
-
-
68949124841
-
Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms
-
Sanada, M.; Suzuki, T.; Shih, L. Y.; Otsu, M.; Kato, M.; Yamazaki, S.; Tamura, A.; Honda, H.; Sakata-Yanagimoto, M.; Kumano, K.; Oda, H.; Yamagata, T.; Takita, J.; Gotoh, N.; Nakazaki, K.; Kawamata, N.; Onodera, M.; Nobuyoshi, M.; Hayashi, Y.; Harada, H.; Kurokawa, M.; Chiba, S.; Mori, H.; Ozawa, K.; Omine, M.; Hirai, H.; Nakauchi, H.; Koeffler, H. P.; Ogawa, S. Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. Nature 460:904-908; 2009.
-
(2009)
Nature
, vol.460
, pp. 904-908
-
-
Sanada, M.1
Suzuki, T.2
Shih, L.Y.3
Otsu, M.4
Kato, M.5
Yamazaki, S.6
Tamura, A.7
Honda, H.8
Sakata-Yanagimoto, M.9
Kumano, K.10
Oda, H.11
Yamagata, T.12
Takita, J.13
Gotoh, N.14
Nakazaki, K.15
Kawamata, N.16
Onodera, M.17
Nobuyoshi, M.18
Hayashi, Y.19
Harada, H.20
Kurokawa, M.21
Chiba, S.22
Mori, H.23
Ozawa, K.24
Omine, M.25
Hirai, H.26
Nakauchi, H.27
Koeffler, H.P.28
Ogawa, S.29
more..
-
35
-
-
0034618439
-
Detection of PTEN nonsense mutation and psiPTEN expression in central nervous system high-grade astrocytic tumors by a yeast-based stop codon assay
-
Zhang, C. L.; Tada, M.; Kobayashi, H.; Nozaki, M.; Moriuchi, T.; Abe, H. Detection of PTEN nonsense mutation and psiPTEN expression in central nervous system high-grade astrocytic tumors by a yeast-based stop codon assay. Oncogene 19:4346-4353; 2000.
-
(2000)
Oncogene
, vol.19
, pp. 4346-4353
-
-
Zhang, C.L.1
Tada, M.2
Kobayashi, H.3
Nozaki, M.4
Moriuchi, T.5
Abe, H.6
-
36
-
-
75549087826
-
COSMIC (the Catalogue of Somatic Mutations in Cancer): A resource to investigate acquired mutations in human cancer
-
Forbes, S. A.; Tang, G.; Bindal, N.; Bamford, S.; Dawson, E.; Cole, C.; Kok, C. Y.; Jia, M.; Ewing, R.; Menzies, A.; Teague, J. W.; Stratton, M. R.; Futreal, P. A. COSMIC (the Catalogue of Somatic Mutations in Cancer): A resource to investigate acquired mutations in human cancer. Nucleic Acids Res. 38:D652-657; 2010.
-
(2010)
Nucleic Acids Res.
, vol.38
-
-
Forbes, S.A.1
Tang, G.2
Bindal, N.3
Bamford, S.4
Dawson, E.5
Cole, C.6
Kok, C.Y.7
Jia, M.8
Ewing, R.9
Menzies, A.10
Teague, J.W.11
Stratton, M.R.12
Futreal, P.A.13
-
37
-
-
17344363637
-
Inherited mutations in PTEN that are associated with breast cancer, Cowden disease and juvenile polyposis
-
Lynch, E.; Ostermeyer, E.; Lee, M.; Arena, J.; Ji, H.; Dann, J.; Swisshelm, K.; Suchard, D.; MacLeod, P.; Kvinnsland, S. Inherited mutations in PTEN that are associated with breast cancer, Cowden disease and juvenile polyposis. Am. J. Hum. Genet. 61:1254-1260; 1997.
-
(1997)
Am. J. Hum. Genet.
, vol.61
, pp. 1254-1260
-
-
Lynch, E.1
Ostermeyer, E.2
Lee, M.3
Arena, J.4
Ji, H.5
Dann, J.6
Swisshelm, K.7
Suchard, D.8
MacLeod, P.9
Kvinnsland, S.10
-
38
-
-
0035476883
-
A non-sense mutation in MLH1 causes exon skipping in three unrelated HNPCC families
-
Stella, A.; Wagner, A.; Shito, K.; Lipkin, S. M.; Watson, P.; Guanti, G.; Lynch, H. T.; Fodde, R.; Liu, B. A non-sense mutation in MLH1 causes exon skipping in three unrelated HNPCC families. Cancer Res. 61:7020-7024; 2001.
-
(2001)
Cancer Res.
, vol.61
, pp. 7020-7024
-
-
Stella, A.1
Wagner, A.2
Shito, K.3
Lipkin, S.M.4
Watson, P.5
Guanti, G.6
Lynch, H.T.7
Fodde, R.8
Liu, B.9
-
39
-
-
53749096775
-
A novel EGFR nonsense mutation in a non-small-cell lung cancer (NSCLC) patient who did not derive any clinical benefit with combination chemotherapy and erlotinib
-
Manzano, R. G.; Navarro, E. M.; Eugenieva, E.; Morejón, F. J. F.; Farré, J.; Brugarolas, A. A novel EGFR nonsense mutation in a non-small-cell lung cancer (NSCLC) patient who did not derive any clinical benefit with combination chemotherapy and erlotinib. Clin. Transl. Oncol. 10:442-444; 2008.
-
(2008)
Clin. Transl. Oncol.
, vol.10
, pp. 442-444
-
-
Manzano, R.G.1
Navarro, E.M.2
Eugenieva, E.3
Morejón, F.J.F.4
Farré, J.5
Brugarolas, A.6
-
40
-
-
0036848138
-
The nonsense-mediated mRNA decay pathway triggers degradation of most BRCA1 mRNAs bearing premature termination codons
-
Perrin-Vidoz, L.; Sinilnikova, O. M.; Stoppa-Lyonnet, D.; Lenoir, G. M.; Mazoyer, S. The nonsense-mediated mRNA decay pathway triggers degradation of most BRCA1 mRNAs bearing premature termination codons. Hum. Mol. Genet. 11:2805-2814; 2002.
-
(2002)
Hum. Mol. Genet.
, vol.11
, pp. 2805-2814
-
-
Perrin-Vidoz, L.1
Sinilnikova, O.M.2
Stoppa-Lyonnet, D.3
Lenoir, G.M.4
Mazoyer, S.5
-
41
-
-
30544452112
-
Does non-sense-mediated mRNA decay explain the ovarian cancer cluster region of the BRCA2 gene?
-
Ware, M. D.; DeSilva, D.; Sinilnikova, O. M.; Stoppa-Lyonnet, D.; Tavtigian, S. V.; Mazoyer, S. Does non-sense-mediated mRNA decay explain the ovarian cancer cluster region of the BRCA2 gene? Oncogene 25:323-328; 2006.
-
(2006)
Oncogene
, vol.25
, pp. 323-328
-
-
Ware, M.D.1
DeSilva, D.2
Sinilnikova, O.M.3
Stoppa-Lyonnet, D.4
Tavtigian, S.V.5
Mazoyer, S.6
-
42
-
-
0030957558
-
New nonsense mutation in the breast cancer-1 gene in a French site-specific breast cancer family
-
Laplace-Marieze, V.; Presneau, N.; Girodet, C.; Vidal, V.; Vaurs, C.; Rio, P.; Bignon, Y-J. New nonsense mutation in the breast cancer-1 gene in a French site-specific breast cancer family. Hum. Mutat. 9:474-475; 1999.
-
(1999)
Hum. Mutat.
, vol.9
, pp. 474-475
-
-
Laplace-Marieze, V.1
Presneau, N.2
Girodet, C.3
Vidal, V.4
Vaurs, C.5
Rio, P.6
Bignon, Y.-J.7
-
43
-
-
73649122504
-
Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor
-
Patsialou, A.; Wyckoff, J.; Wang, Y.; Goswami, S.; Stanley, E. R.; Condeelis, J. S. Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor. Cancer Res. 69:9498-9506; 2009.
-
(2009)
Cancer Res.
, vol.69
, pp. 9498-9506
-
-
Patsialou, A.1
Wyckoff, J.2
Wang, Y.3
Goswami, S.4
Stanley, E.R.5
Condeelis, J.S.6
-
44
-
-
0028822526
-
Intragenic mutations of CDKN2B and CDKN2A in primary human esophageal cancers
-
Suzuki, H.; Zhou, X.; Yin, J.; Lei, J.; Jiang, H. Y.; Suzuki, Y.; Chan, T.; Hannon, G. J.; Mergner, W. J.; Abraham, J. M.; Melzer, S. J. Intragenic mutations of CDKN2B and CDKN2A in primary human esophageal cancers. Hum. Mol. Genet. 4:1883-1887; 1995.
-
(1995)
Hum. Mol. Genet.
, vol.4
, pp. 1883-1887
-
-
Suzuki, H.1
Zhou, X.2
Yin, J.3
Lei, J.4
Jiang, H.Y.5
Suzuki, Y.6
Chan, T.7
Hannon, G.J.8
Mergner, W.J.9
Abraham, J.M.10
Melzer, S.J.11
-
45
-
-
3042821085
-
Identification of a transcriptionally inactive p53 mutant by functional analysis of separated alleles in yeasts (FASAY) in a child osteosarcoma tumor: A case report
-
Dekairelle, A. F.; Brichard, B.; Delhez, H.; Gala, J. L. Identification of a transcriptionally inactive p53 mutant by functional analysis of separated alleles in yeasts (FASAY) in a child osteosarcoma tumor: A case report. Pediatr. Hematol. Oncol. 21:321-328; 2004.
-
(2004)
Pediatr. Hematol. Oncol.
, vol.21
, pp. 321-328
-
-
Dekairelle, A.F.1
Brichard, B.2
Delhez, H.3
Gala, J.L.4
-
46
-
-
0037179872
-
High incidence of protein-truncating mutations of the p53 gene in liver metastases of colorectal carcinomas
-
Miyaki, M.; Iijima, T.; Yasuno, M.; Kita, Y.; Hishima, T.; Kuroki, T.; Mori, T. High incidence of protein-truncating mutations of the p53 gene in liver metastases of colorectal carcinomas. Oncogene 21:6689-6693; 2002.
-
(2002)
Oncogene
, vol.21
, pp. 6689-6693
-
-
Miyaki, M.1
Iijima, T.2
Yasuno, M.3
Kita, Y.4
Hishima, T.5
Kuroki, T.6
Mori, T.7
-
47
-
-
0026464556
-
Mutation spectrum of the p53 gene in bone and soft tissue sarcomas
-
Toguchida, J.; Yamaguchi, T.; Ritchie, B.; Beauchamp, R. L.; Dayton, S. H.; Herrera, G. E.; Yamamuro, T.; Kotoura, Y.; Sasaki, M. S.; Little, J. B.; Weichselbaum, R. R.; Ishizaki, K.; Yandell, D. W. Mutation spectrum of the p53 gene in bone and soft tissue sarcomas. Cancer Res. 52:6194-6199; 1992.
-
(1992)
Cancer Res.
, vol.52
, pp. 6194-6199
-
-
Toguchida, J.1
Yamaguchi, T.2
Ritchie, B.3
Beauchamp, R.L.4
Dayton, S.H.5
Herrera, G.E.6
Yamamuro, T.7
Kotoura, Y.8
Sasaki, M.S.9
Little, J.B.10
Weichselbaum, R.R.11
Ishizaki, K.12
Yandell, D.W.13
-
48
-
-
0037141455
-
Investigations on a clinically and functionally unusual and novel germline p53 mutation
-
Rutherford, J.; Chu, C. E.; Duddy, P. M.; Charlton, R. S.; Chumas, P.; Taylor, G. R.; Lu, X.; Barnes, D. M.; Camplejohn, R. S. Investigations on a clinically and functionally unusual and novel germline p53 mutation. Br. J. Cancer 20:1592-1596; 2002.
-
(2002)
Br. J. Cancer
, vol.20
, pp. 1592-1596
-
-
Rutherford, J.1
Chu, C.E.2
Duddy, P.M.3
Charlton, R.S.4
Chumas, P.5
Taylor, G.R.6
Lu, X.7
Barnes, D.M.8
Camplejohn, R.S.9
-
49
-
-
77952597892
-
Expression signatures of TP53 mutations in serous ovarian cancers
-
Bernardini, M. Q.; Baba, T.; Lee, P. S.; Barnett, J. C.; Sfakionos, G. P.; Alvarez Secord, A.; Murphy, S. K.; Iversen, E.; Marks, J. R.; Berchuck, A. Expression signatures of TP53 mutations in serous ovarian cancers. BMC Cancer 10:237; 2010.
-
(2010)
BMC Cancer
, vol.10
, pp. 237
-
-
Bernardini, M.Q.1
Baba, T.2
Lee, P.S.3
Barnett, J.C.4
Sfakionos, G.P.5
Alvarez Secord, A.6
Murphy, S.K.7
Iversen, E.8
Marks, J.R.9
Berchuck, A.10
-
50
-
-
55749092776
-
Heparin-binding epidermal growth factor-like growth factor promotes transcoelomic metastasis in ovarian cancer through epithelial-mesenchymal transition
-
Yagi, H.; Yotsumoto, F.; Miyamoto, S. Heparin-binding epidermal growth factor-like growth factor promotes transcoelomic metastasis in ovarian cancer through epithelial-mesenchymal transition. Mol. Cancer Ther. 7:3441-3451; 2008.
-
(2008)
Mol. Cancer Ther.
, vol.7
, pp. 3441-3451
-
-
Yagi, H.1
Yotsumoto, F.2
Miyamoto, S.3
-
51
-
-
0028953433
-
Germline p53 mutations in 15 families with Li-Fraumeni syndrome
-
Frebourg, T.; Barbier, N.; Yan, Y. X.; Garber, J. E.; Dreyfus, M.; Fraumeni, Jr., J.; Li, F. P.; Friend, S. H. Germline p53 mutations in 15 families with Li-Fraumeni syndrome. Am. J. Hum. Genet. 56:608-615; 1995.
-
(1995)
Am. J. Hum. Genet.
, vol.56
, pp. 608-615
-
-
Frebourg, T.1
Barbier, N.2
Yan, Y.X.3
Garber, J.E.4
Dreyfus, M.5
Fraumeni Jr., J.6
Li, F.P.7
Friend, S.H.8
-
52
-
-
77749287000
-
Heterozygous TP53stop146/R72P fibroblasts from a Li-Fraumeni syndrome patient with impaired response to DNA damage
-
De Moura, J.; Kavalec, F. L.; Doghman, M.; Rosati, R.; Custodio, G.; Lalli, E.; Cavallari, G. M.; Santa Maria, J.; Figueiredo, B. C. Heterozygous TP53stop146/R72P fibroblasts from a Li-Fraumeni syndrome patient with impaired response to DNA damage. Int. J. Oncol. 36:983-990; 2010.
-
(2010)
Int. J. Oncol.
, vol.36
, pp. 983-990
-
-
De Moura, J.1
Kavalec, F.L.2
Doghman, M.3
Rosati, R.4
Custodio, G.5
Lalli, E.6
Cavallari, G.M.7
Santa Maria, J.8
Figueiredo, B.C.9
-
53
-
-
77956632519
-
Inactivation of the p53 tumor suppressor gene and activation of the Ras oncogene: Cooperative events in tumorigenesis
-
Solomon, H.; Brosh, R.; Buganim, Y.; Rotter, V. Inactivation of the p53 tumor suppressor gene and activation of the Ras oncogene: Cooperative events in tumorigenesis. Discov. Med. 9:448-454; 2010.
-
(2010)
Discov. Med.
, vol.9
, pp. 448-454
-
-
Solomon, H.1
Brosh, R.2
Buganim, Y.3
Rotter, V.4
-
54
-
-
0031439763
-
Heritable genetic alterations in a xeroderma pigmentosum group G/Cockayne syndrome pedigree
-
Okinaka, R. T.; Perez-Castro, A. V.; Sena, A.; Laubscher, K.; Strniste, G. F.; Park, M. S.; Hernandez, R.; MacInnes, M. A.; Kraemer, K. H. Heritable genetic alterations in a xeroderma pigmentosum group G/Cockayne syndrome pedigree. Mutat. Res. 385:107-114; 1997.
-
(1997)
Mutat. Res.
, vol.385
, pp. 107-114
-
-
Okinaka, R.T.1
Perez-Castro, A.V.2
Sena, A.3
Laubscher, K.4
Strniste, G.F.5
Park, M.S.6
Hernandez, R.7
MacInnes, M.A.8
Kraemer, K.H.9
-
55
-
-
70350065725
-
Disorders of nucleotide excision repair: The genetic and molecular basis of heterogeneity
-
Cleaver, J. E.; Lam, E. T.; Revet, I. Disorders of nucleotide excision repair: The genetic and molecular basis of heterogeneity. Nat. Rev. Genet. 10:756-768; 2009.
-
(2009)
Nat. Rev. Genet.
, vol.10
, pp. 756-768
-
-
Cleaver, J.E.1
Lam, E.T.2
Revet, I.3
-
56
-
-
33750922149
-
Phenotypic heterogeneity in the XPB DNA helicase gene (ERCC3): Xeroderma pigmentosum without and with Cockayne syndrome
-
Oh, K. S.; Khan, S. G.; Jaspers, N. G.; Raams, A.; Ueda, T.; Lehmann, A.; Friedmann, P. S.; Emmert, S.; Gratchev, A.; Lachlan, K.; Lucassan, A.; Baker, C. C.; Kraemer, K. H. Phenotypic heterogeneity in the XPB DNA helicase gene (ERCC3): Xeroderma pigmentosum without and with Cockayne syndrome. Hum. Mutat. 27:1092-1103; 2006.
-
(2006)
Hum. Mutat.
, vol.27
, pp. 1092-1103
-
-
Oh, K.S.1
Khan, S.G.2
Jaspers, N.G.3
Raams, A.4
Ueda, T.5
Lehmann, A.6
Friedmann, P.S.7
Emmert, S.8
Gratchev, A.9
Lachlan, K.10
Lucassan, A.11
Baker, C.C.12
Kraemer, K.H.13
-
57
-
-
22744442111
-
NMD microarray analysis for rapid genome-wide screen of mutated genes in cancer
-
Wolf, M.; Edgren, H.; Muggerud, A.; Kilpinen, S.; Huusko, P.; Sørlie, T.; Mousses, S.; Kallioniemi, O. NMD microarray analysis for rapid genome-wide screen of mutated genes in cancer. Cell Oncol. 27:169-173; 2005.
-
(2005)
Cell Oncol.
, vol.27
, pp. 169-173
-
-
Wolf, M.1
Edgren, H.2
Muggerud, A.3
Kilpinen, S.4
Huusko, P.5
Sørlie, T.6
Mousses, S.7
Kallioniemi, O.8
-
58
-
-
4444326581
-
Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer
-
Huusko, P.; Ponciano-Jackson, D.; Wolf, M.; Kiefer, J. A.; Azorsa, D. O.; Tuzmen, S.; Weaver, D.; Robbins, C.; Moses, T.; Allinen, M.; Hautaniemi, S.; Chen, Y.; Elkahloun, A.; Basik, M.; Bova, G. S.; Bubendorf, L.; Lugli, A.; Sauter, G.; Schleutker, J.; Ozcelik, H.; Elowe, S.; Pawson, T.; Trent, J. M.; Carpten, J. D.; Kallioniemi, O. P.; Mousses, S. Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer. Nat. Genet. 36:979-983; 2004.
-
(2004)
Nat. Genet.
, vol.36
, pp. 979-983
-
-
Huusko, P.1
Ponciano-Jackson, D.2
Wolf, M.3
Kiefer, J.A.4
Azorsa, D.O.5
Tuzmen, S.6
Weaver, D.7
Robbins, C.8
Moses, T.9
Allinen, M.10
Hautaniemi, S.11
Chen, Y.12
Elkahloun, A.13
Basik, M.14
Bova, G.S.15
Bubendorf, L.16
Lugli, A.17
Sauter, G.18
Schleutker, J.19
Ozcelik, H.20
Elowe, S.21
Pawson, T.22
Trent, J.M.23
Carpten, J.D.24
Kallioniemi, O.P.25
Mousses, S.26
more..
-
59
-
-
79951537038
-
Nonsense-mediated decay microarray analysis identifies potential tumor suppressor genes in neuroblastoma
-
Song, Y. K.; Huusko, P.; Bilke, S.; Greer, B.; Wei, J. S.; Chen, Q-R.; Khan, J. Nonsense-mediated decay microarray analysis identifies potential tumor suppressor genes in neuroblastoma. Proc. Am. Assoc. Cancer Res. 47:3308; 2006.
-
(2006)
Proc. Am. Assoc. Cancer Res.
, vol.47
, pp. 3308
-
-
Song, Y.K.1
Huusko, P.2
Bilke, S.3
Greer, B.4
Wei, J.S.5
Chen, Q.-R.6
Khan, J.7
-
60
-
-
0035005985
-
A strategy for disease gene identification through nonsense-mediated mRNA decay inhibition
-
Noensie, E. N.; Dietz, H. C. A strategy for disease gene identification through nonsense-mediated mRNA decay inhibition. Nat. Biotechnol. 19:434-439; 2001.
-
(2001)
Nat. Biotechnol.
, vol.19
, pp. 434-439
-
-
Noensie, E.N.1
Dietz, H.C.2
-
61
-
-
0029808405
-
Role of proximal promoter elements in regulation of renin gene transcription
-
Petrovic, N.; Black, T. A.; Fabian, J. R.; Kane, C.; Jones, C. A.; Loudon, J. A.; Abonia, J. P.; Sigmund, C. D.; Gross, K. W. Role of proximal promoter elements in regulation of renin gene transcription. J. Biol. Chem. 271: 22499-22505; 1996.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 22499-22505
-
-
Petrovic, N.1
Black, T.A.2
Fabian, J.R.3
Kane, C.4
Jones, C.A.5
Loudon, J.A.6
Abonia, J.P.7
Sigmund, C.D.8
Gross, K.W.9
-
62
-
-
77953152280
-
Injectable sustained release microparticles of curcumin: A new concept for cancer chemoprevention
-
Shahani, K.; Swaminathan, S. K.; Freeman, D.; Blum, A.; Ma, L.; Panyam, J. Injectable sustained release microparticles of curcumin: A new concept for cancer chemoprevention. Cancer Res. 70:4443-4452; 2010.
-
(2010)
Cancer Res.
, vol.70
, pp. 4443-4452
-
-
Shahani, K.1
Swaminathan, S.K.2
Freeman, D.3
Blum, A.4
Ma, L.5
Panyam, J.6
-
63
-
-
78651327833
-
Evolved for cancer?
-
Zimmer, C. Evolved for cancer? Sci. Am. 18:15-21; 2008.
-
(2008)
Sci. Am.
, vol.18
, pp. 15-21
-
-
Zimmer, C.1
-
64
-
-
79951544288
-
What is this life if, full of care
-
Untermeyer, L., ed. London/ Glasgow: Collins
-
Davies, W. H. What is this life if, full of care. In: Untermeyer, L., ed. Collins Albatross book of verse. London/ Glasgow: Collins; 1974:524.
-
(1974)
Collins Albatross Book of Verse
, pp. 524
-
-
Davies, W.H.1
-
65
-
-
0036645286
-
Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung
-
Sanchez-Cespedes, M.; Parrella, P.; Esteller, M.; Nomoto, S.; Trink, B.; Engles, J. M.; Westra, W. H.; Herman, J. G.; Sidransky, D. Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. Cancer Res. 62:3659-3662; 2002.
-
(2002)
Cancer Res.
, vol.62
, pp. 3659-3662
-
-
Sanchez-Cespedes, M.1
Parrella, P.2
Esteller, M.3
Nomoto, S.4
Trink, B.5
Engles, J.M.6
Westra, W.H.7
Herman, J.G.8
Sidransky, D.9
-
66
-
-
70350448984
-
Nonaminoglycoside compounds induce readthrough of nonsense mutations
-
Du, L.; Damoiseaux, R.; Nahas, S.; Gao, K.; Hu, H.; Pollard, J. M.; Goldstine, J.; Jung, M. E.; Henning, S. M.; Bertoni, C.; Gatti, R. A. Nonaminoglycoside compounds induce readthrough of nonsense mutations. J. Exp. Med. 206:2285-2297; 2009.
-
(2009)
J. Exp. Med.
, vol.206
, pp. 2285-2297
-
-
Du, L.1
Damoiseaux, R.2
Nahas, S.3
Gao, K.4
Hu, H.5
Pollard, J.M.6
Goldstine, J.7
Jung, M.E.8
Henning, S.M.9
Bertoni, C.10
Gatti, R.A.11
-
67
-
-
70349912565
-
A nonsense mutation (E1978X) in the ATM gene is associated with breast cancer
-
Bogdanova, N.; Cybulski, C.; Bermisheva, M.; Datsyuk, I.; Yamini, P.; Hillemanns, P.; Antonenkova, N. N.; Khusnutdinova, E.; Lubinski, J.; Dãrk, T. A nonsense mutation (E1978X) in the ATM gene is associated with breast cancer. Breast Cancer Res Treat. 118:207-211; 2009.
-
(2009)
Breast Cancer Res Treat.
, vol.118
, pp. 207-211
-
-
Bogdanova, N.1
Cybulski, C.2
Bermisheva, M.3
Datsyuk, I.4
Yamini, P.5
Hillemanns, P.6
Antonenkova, N.N.7
Khusnutdinova, E.8
Lubinski, J.9
Dãrk, T.10
-
68
-
-
65449144050
-
PRIMA-1 reactivates mutant p53 by covalent binding to the core domain
-
Lambert, J. M.; Gorzov, P.; Veprintsev, D. B.; Söderqvist, M.; Segerbäck, D.; Bergman, J.; Fersht, A. R.; Hainaut, P.; Wiman, K. G.; Bykov, V. J. PRIMA-1 reactivates mutant p53 by covalent binding to the core domain. Cancer Cell 15:376-388; 2009.
-
(2009)
Cancer Cell
, vol.15
, pp. 376-388
-
-
Lambert, J.M.1
Gorzov, P.2
Veprintsev, D.B.3
Söderqvist, M.4
Segerbäck, D.5
Bergman, J.6
Fersht, A.R.7
Hainaut, P.8
Wiman, K.G.9
Bykov, V.J.10
-
69
-
-
65549113424
-
Regression of progestin-accelerated 7,12-dimethylbenz[a]anthracene- induced mammary tumors in Sprague-Dawley rats by p53 reactivation and induction of massive apoptosis: A pilot study
-
Benakanakere, I.; Besch-Williford, C.; Ellersieck, M. R.; Hyder, S. M. Regression of progestin-accelerated 7,12-dimethylbenz[a]anthracene-induced mammary tumors in Sprague-Dawley rats by p53 reactivation and induction of massive apoptosis: A pilot study. Endocr. Relat. Cancer 16:85-98; 2009.
-
(2009)
Endocr. Relat. Cancer
, vol.16
, pp. 85-98
-
-
Benakanakere, I.1
Besch-Williford, C.2
Ellersieck, M.R.3
Hyder, S.M.4
|