Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on neural correlates of affective processing

Biological Psychology

Volumn 79, Issue 1, 2008, Pages 118-125

  Canli, Turhan ^a   Congdon, Eliza ^a   Todd Constable, R ^b   Lesch, Klaus Peter ^c  

^a STONY BROOK UNIVERSITY   (United States)

^b YALE UNIVERSITY   (United States)

^c UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Affect; Amygdala; Emotion; fMRI; Functional magnetic resonance imaging; Genetics; Imaging; Polymorphism; Putamen; Serotonin transporter; Striatum; Tryptophan hydroxylase 2

Indexed keywords

SEROTONIN TRANSPORTER; TRYPTOPHAN HYDROXYLASE 2;

ADULT; AMYGDALOID NUCLEUS; ARTICLE; BRAIN CORTEX; BRAIN REGION; CORPUS STRIATUM; DEPTH PERCEPTION; EMOTION; FACIAL EXPRESSION; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENE CONTROL; GENE FUNCTION; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN EXPERIMENT; MALE; NERVE CELL NETWORK; NORMAL HUMAN; PRIORITY JOURNAL; PUTAMEN; SEROTONINERGIC SYSTEM; STIMULUS RESPONSE; TASK PERFORMANCE; VERBALIZATION;

ADULT; AFFECT; AMYGDALA; BRAIN CHEMISTRY; EMOTIONS; FEMALE; GENOTYPE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; PSYCHOMOTOR PERFORMANCE; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SOCIAL PERCEPTION; TRYPTOPHAN HYDROXYLASE; VARIATION (GENETICS);

EID: 46649117930     PISSN: 03010511     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsycho.2008.01.004     Document Type: Article

References (43)

1. Ball D., Hill L., Freeman B., Eley T.C., Strelau J., Riemann R., et al. The serotonin transporter gene and peer-rated neuroticism. Neuroreport 8 (1997) 1301-1304
2. Becerra L., Breiter H.C., Wise R., Gonzalez R.G., and Borsook D. Reward circuitry activation by noxious thermal stimuli. Neuron 32 (2001) 927-946
3. Bradley M.M., and Lang P.J. Affective Norms for English Words (ANEW) (1999), The NIMH Center for the Study of Emotion and Attention, University of Florida, Gainesville, FL
4. Breiter H.C., Aharon I., Kahneman D., Dale A., and Shizgal P. Functional imaging of neural responses to expectancy and experience of monetary gains and losses. Neuron 30 (2001) 619-639
5. Brown S.M., Peet E., Manuck S.B., Williamson D.E., Dahl R.E., Ferrell R.E., et al. A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity. Molecular Psychiatry 10 (2005) pp. 884-888, 805
6. Canli T. Functional brain mapping of extraversion and neuroticism: learning from individual differences in emotion processing. Journal of Personality 72 (2004) 1105-1132
7. Canli T., and Lesch K.P. Long story short: the serotonin transporter in emotion regulation and social cognition. Nature Neuroscience 10 (2007) 1103-1109
8. Canli T., Zhao Z., Desmond J.E., Kang E., Gross J., and Gabrieli J.D.E. An fMRI study of personality influences on brain reactivity to emotional stimuli. Behavioral Neuroscience 115 (2001) 33-42
9. Canli T., Amin Z., Haas B.W., Omura K., and Constable RT. A double dissociation between mood states and personality traits in the anterior cingulated. Behavioral Neuroscience 118 (2004) 897-904
10. Canli T., Congdon E., Gutknecht L., Constable R.T., and Lesch K.P. Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation. Journal of Neural Transmission 112 (2005) 1479-1485
11. Canli T., Omura K., Haas B.W., Fallgatter A.J., Constable R.T., and Lesch K.P. Beyond affect: a role for genetic variation of the serotonin transporter in neural activation during a cognitive attention task. Proceedings of the National Academy of Science USA 102 (2005) 12224-12229
12. Canli T., Qiu M., Omura K., Congdon E., Haas B.W., Amin Z., et al. Neural correlates of epigenesis. Proceedings of the National Academy of Science USA 103 (2006) 16033-16038
13. Cannon D.M., Ichise M., Fromm S.J., Nugent A.C., Rollis D., Gandhi S.K., et al. Serotonin transporter binding in bipolar disorder assessed using [11C]DASB and positron emission tomography. Biological Psychiatry 60 (2006) 207-217
14. Costa Jr. P.T., and McCrae R.R. Professional Manual of the Revised NEO Personality Inventory and NEO Five-Factor Inventory (1992), PAR Inc., Odessa, FL
15. Dilalla L.F., Gottesman II (Eds.) 2004. Behavior Genetics Principles: Perspectives in Development, Personality, and Psychopathology American Psychological Association.
16. Dreary I.J., Battersby S., Whiteman M.C., Connor J.M., Fowkes F.G., and Harmar A. Neuroticism and polymorphisms in the serotonin transporter gene. Psychological Medicine 29 (1999) 735-739
17. Friston K.J. Statistical parametric mapping. In: Thatcher R. (Ed). Functional Neuroimaging: Technical foundations (1994), Academic Press, San Diego, CA 79-93
18. Furmark T., Tillfors M., Garpenstrand H., Marteinsdottir I., Langstrom B., Oreland L., et al. Serotonin transporter polymorphism related to amygdala excitability and symptom severity in patients with social phobia. Neuroscience Letters 362 (2004) 189-192
19. Hariri A.R., Bookheimer S.Y., and Mazziotta J.C. Modulating emotional responses: effects of a neocortical network on the limbic system. Neuroreport 11 (2000) 43-48
20. Hariri A.R., Mattay V.S., Tessitore A., Kolachana B., Fera F., Goldman D., et al. Serotonin transporter genetic variation and the response of the human amygdala. Science 297 (2002) 400-403
21. Hariri A.R., Drabant E.M., Munoz K.E., Kolachana B.S., Mattay V.S., Egan M.F., et al. A susceptibility gene for affective disorders and the response of the human amygdala. Archives of General Psychiatry 62 (2005) 146-152
22. Hasler G., Fromm S., Alvarez R.P., Luckenbaugh D.A., Drevets W.C., and Grillon C. Cerebral blood flow in immediate and sustained anxiety. Journal of Neuroscience 27 (2007) 6313-6319
23. Heinz A., Braus D.F., Smolka M.N., Wrase J., Puls I., Hermann D., et al. Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter. Nature Neuroscience 8 (2005) 20-21
24. Herrmann M.J., Huter T., Muller F., Muhlberger A., Pauli P., Reif A., et al. Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on emotional processing. Cerebral Cortex 17 (2007) 1160-1163
25. Holmes A.P., and Friston K.J. Generalisability random effects and population inference. Neuroimage 7 (1998) S754
26. Jensen J., McIntosh A.R., Crawley A.P., Mikulis D.J., Remington G., and Kapur S. Direct activation of the ventral striatum in anticipation of aversive stimuli. Neuron 40 (2003) 1251-1257
27. Knutson B., Adams C.M., Fong G.W., and Hommer D. Anticipation of increasing monetary reward selectively recruits nucleus accumbens. Journal of Neuroscience 21 (2001) RC159
28. Lesch K.P., Bengel D., Heils A., Sabol S.Z., Greenberg B.D., Petri S., et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274 (1996) 1527-1531
29. Lundberg J., Odano I., Olsson H., Halldin C., and Farde L. Quantification of 11C-MADAM binding to the serotonin transporter in the human brain. Journal of Nuclear Medicine 46 (2005) 1505-1515
30. McNair M.L., Lorr M., and Droppleman L.F. POMS manual: Profile of Mood States (1992), Edits, San Diego, CA
31. Meyer J.H., Houle S., Sagrati S., Carella A., Hussey D.F., Ginovart N., et al. Brain serotonin transporter binding potential measured with carbon 11-labeled DASB positron emission tomography: effects of major depressive episodes and severity of dysfunctional attitudes. Archives of General Psychiatry 61 (2004) 1271-1279
32. Middeldorp C.M., de Geus E.J., Beem A.L., Lakenberg N., Hottenga J.J., Slagboom P.E., et al. Family based association analyses between the serotonin transporter gene polymorphism (5-HTTLPR) and neuroticism, anxiety and depression. Behavior Genetics 37 (2007) 294-301
33. Munafo M.R., Clark T., and Flint J. Does measurement instrument moderate the association between the serotonin transporter gene and anxiety-related personality traits? A meta-analysis. Molecular Psychiatry 10 (2005) 415-419
34. Munafo M.R., Clark T.G., and Flint J. Promise and pitfalls in the meta-analysis of genetic association studies: a response to Sen and Shinka. Molecular Psychiatry 10 (2005) 895-897
35. Munafo M.R., Brown S.M., Hariri A.R., 2007. Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis. Biological Psychiatry.
36. Pezawas L., Meyer-Lindenberg A., Drabant E.M., Verchinski B.A., Munoz K.E., Kolachana B.S., et al. 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nature Neuroscience 8 (2005) 828-834 Epub 2005 May 2008
37. Plomin R., DeFries J.C., McClearn G.E., and McGuffin P. Behavioral Genetics. 5th ed. (2008), Worth Publishers
38. Reif A., and Lesch K.P. Toward a molecular architecture of personality. Behavioral and Brain Research 139 (2003) 1-20
39. Sakowski S.A., Geddes T.J., Thomas D.M., Levi E., Hatfield J.S., and Kuhn D.M. Differential tissue distribution of tryptophan hydroxylase isoforms 1 and 2 as revealed with monospecific antibodies. Brain Research 1085 (2006) 11-18
40. Schinka J.A., Busch R.M., and Robichaux-Keene N. A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety. Molecular Psychiatry 9 (2004) 197-202
41. Sen S., Burmeister M., and Ghosh D. Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits. American Journal of Medical Genetics B Neuropsychiatry Genetics 127 (2004) 85-89
42. Sirota L.A., Greenberg B.D., Murphy D.L., and Hamer D.H. Non-linear association between the serotonin transporter promoter polymorphism and neuroticism: a caution against using extreme samples to identify quantitative trait loci. Psychiatric Genetics 9 (1999) 35-38
43. Walitza S., Renner T.J., Dempfle A., Konrad K., Wewetzer C., Halbach A., et al. Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder. Molecular Psychiatry 10 (2005) 1126-1132