Strict 3′ splice site sequence requirements for U2 snRNP recruitment after U2AF binding underlie a genetic defect leading to autoimmune disease

RNA

Volumn 17, Issue 3, 2011, Pages 401-411

  Corrionero, Anna ^a,b   Raker, Veronica A ^a,b   Izquierdo, José María ^a,d   Valcárcel, Juan ^a,b,c  

^a CENTRE FOR GENOMIC REGULATION CRG   (Spain)

^b UNIVERSITAT POMPEU FABRA   (Spain)

^c INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

^d UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

3 splice site; Autoimmune disease; Genetic defect; U2 snRNP; U2AF

Indexed keywords

FAS ANTIGEN; HETERODIMER; POLYPYRIMIDINE TRACT BINDING PROTEIN; SMALL NUCLEAR RIBONUCLEOPROTEIN; SPLICING FACTOR U2AF; UNCLASSIFIED DRUG; URIDINE; CROSS LINKING REAGENT; FAS PROTEIN, HUMAN; NUCLEAR PROTEIN; RIBONUCLEOPROTEIN; RNA PRECURSOR;

ALTERNATIVE RNA SPLICING; ARTICLE; AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME; COMPLEX FORMATION; EXON; EXON SKIPPING; GENE MUTATION; GENE SEQUENCE; GENETIC DISORDER; HELA CELL; INTRON; POINT MUTATION; PRIORITY JOURNAL; SPLICEOSOME; CELL NUCLEUS; GENETICS; HUMAN; IMMUNOPRECIPITATION; METABOLISM; MUTATION; PATHOLOGY; RNA SPLICING;

ANTIGENS, CD95; AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME; CELL NUCLEUS; CROSS-LINKING REAGENTS; HELA CELLS; HUMANS; IMMUNOPRECIPITATION; MUTATION; NUCLEAR PROTEINS; RIBONUCLEOPROTEIN, U2 SMALL NUCLEAR; RIBONUCLEOPROTEINS; RNA PRECURSORS; RNA SPLICING;

EID: 79951528344     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.2444811     Document Type: Article

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