The putative lipid transporter, Arv1, is required for activating pheromone-induced MAP kinase signaling in Saccharomyces cerevisiae

Genetics

Volumn 187, Issue 2, 2011, Pages 455-465

  Villasmil, Michelle L ^a,b   Ansbach, Alison ^b   Nickels Jr , Joseph T ^a,b  

^a Medical Diagnostic Laboratories LLC   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FILIPIN; GLYCOSYLPHOSPHATIDYLINOSITOL; LIPID TRANSFER PROTEIN; LIPID TRANSFER PROTEIN ARV1; MITOGEN ACTIVATED PROTEIN KINASE; PHEROMONE; SPHINGOLIPID; STEROL; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL MEMBRANE; LIPID TRANSPORT; MATING; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

CELL CYCLE; CELL MEMBRANE; GENE EXPRESSION; GENE EXPRESSION REGULATION, FUNGAL; MEMBRANE LIPIDS; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; PHEROMONES; REPRODUCTION; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION;

SACCHAROMYCES CEREVISIAE;

EID: 79951525332     PISSN: 00166731     EISSN: 00166731     Source Type: Journal    
DOI: 10.1534/genetics.110.120725     Document Type: Article

References (58)

1. BAGNAT, M., and K. SIMONS, 2002a Cell surface polarization during yeast mating. Proc. Natl. Acad. Sci. USA 99: 14183-14188.
2. BAGNAT, M., and K. SIMONS, 2002b Lipid rafts in protein sorting and cell polarity in budding yeast Saccharomyces cerevisiae. Biol. Chem. 383: 1475-1480.
3. BEH, C. T., and J. RINE, 2004 A role for yeast oxysterol-binding protein homologs in endocytosis and in the maintenance of intracellular sterol-lipid distribution. J. Cell Sci. 117: 2983-2996.
4. BERLIN, V., J. BRILL, J. TRUEHEART, J. D. BOEKE and G. R. FINK, 1991 Genetic screens and selections for cell and nuclear fusion mutants. Methods Enzymol. 194: 774-792.
5. BIDLINGMAIER, S., and M. SNYDER, 2004 Regulation of polarized growth initiation and termination cycles by the polarisome and Cdc42 regulators. J. Cell Biol. 164: 207-218.
6. BROWN, D. A., and E. LONDON, 1998 Functions of lipid rafts in biological membranes. Annu. Rev. Cell Dev. Biol. 14: 111-136.
7. BURKHOLDER, A. C., and L. H. HARTWELL, 1985 The yeast α-factor receptor: structural properties deduced from the sequence of the STE2 gene. Nucleic Acids Res. 13: 8463-8475.
8. CARTWRIGHT, C. P., and D. J. TIPPER, 1991 In vivo topological analysis of Ste2, a yeast plasma membrane protein, by using beta-lactamase gene fusions. Mol. Cell. Biol. 11: 2620-2628.
9. CHANG, F., and M. PETER, 2003 Yeasts make their mark. Nat. Cell Biol. 5: 294.
10. CHANT, J., 1999 Cell polarity in yeast. Annu. Rev. Cell Dev. Biol. 15: 365-391.
11. CHENEVERT, J., N. VALTZ and I. HERSKOWITZ, 1994 Identification of genes required for normal pheromone-induced cell polarization in Saccharomyces cerevisiae. Genetics 136: 1287-1297.
12. CLONTECH LABORATORIES, 2001 Yeast Protocols Handbook. Clontech, Palo Alto, CA.
13. DOLAN, J. W., and S. FIELDS, 1990 Overproduction of the yeast STE12 protein leads to constitutive transcriptional induction. Genes Dev. 4: 492-502.
14. DOLAN, J. W., C. KIRKMAN and S. FIELDS, 1989 The yeast STE12 protein binds to the DNA sequence mediating pheromone induction. Proc. Natl. Acad. Sci. USA 86: 5703-5707.
15. ELION, E. A., 1995 Ste5: a meeting place for MAP kinases and their associates. Trends Cell Biol. 5: 322-327.
16. FEI, W., G. ALFARO, B.-P. MUTHUSAMY, Z. KLAASSEN, T. R. GRAHAM et al., 2008 Genome-wide analysis of sterol-lipid storage and trafficking in Saccharomyces cerevisiae. Eukaryot. Cell 7: 401-414.
17. FORES, O., M. ARRO, A. PAHISSA, S. FERRERO, M. GERMANN et al., 2006 Arabidopsis thaliana expresses two functional isoforms of Arvp, a protein involved in the regulation of cellular lipid homeostasis. Biochim. Biophys. Acta 1761: 725-735.
18. GARRENTON, L. S., C. J. STEFAN, M. A. MCMURRAY, S. D. EMR and J. THORNER, 2010 Pheromone-induced anisotropy in yeast plasma membrane phosphatidylinositol-4,5-bisphosphate distribution is required for MAPK signaling. Proc. Natl. Acad. Sci. USA 107: 11805-11810.
19. GARRENTON, L. S., S. L. YOUNG and J. THORNER, 2006 Function of the MAPK scaffold protein, Ste5, requires a cryptic PH domain. Genes Dev. 20: 1946-1958.
20. HARDER, T., P. SCHEIFFELE, P. VERKADE and K. SIMONS, 1998 Lipid domain structure of the plasma membrane revealed by patching of membrane components. J. Cell Biol. 141: 929-942.
21. HOEKSTRA, D., O. MAIER, J. M. VAN DER WOUDEN, T. A. SLIMANE and S. C. D. VAN IJZENDOORN, 2003 Membrane dynamics and cell polarity: the role of sphingolipids. J. Lipid Res. 44: 869-877.
22. HURLEY, J. H., and T. MEYER, 2001 Subcellular targeting by membrane lipids. Curr. Opin. Cell Biol. 13: 146-152.
23. ITO, H., Y. FUKUDA, K. MURATA and A. KIMURA, 1983 Transformation of intact yeast cells treated with alkali cations. J. Bacteriol. 153: 163-168.
24. JACKSON, C. L., J. B. KONOPKA and L. H. HARTWELL, 1991 S. cerevisiae alpha pheromone receptors activate a novel signal transduction pathway for mating partner discrimination. Cell 67: 389-402.
25. JIN, H., J. M. MCCAFFERY and E. GROTE, 2008 Ergosterol promotes pheromone signaling and plasma membrane fusion in mating yeast. J. Cell Biol. 180: 813-826.
26. JONES, E. W., 1984 The synthesis and function of proteases in Saccharomyces: genetic approaches. Annu. Rev. Genet. 18: 233-270.
27. KAJIWARA, K., R. WATANABE, H. PICHLER, K. IHARA, S. MURAKAMI et al., 2008 Yeast ARV1 is required for efficient delivery of an early GPI intermediate to the first mannosyltransferase during GPI assembly and controls lipid flow from the endoplasmic reticulum. Mol. Biol. Cell 19: 2069-2082.
28. KAWASAKI, S., M. RAMGOPAL, J. CHIN and K. BLOCH, 1985 Sterol control of the phosphatidylethanolamine-phosphatidylcholine conversion in the yeast mutant GL7. Proc. Natl. Acad. Sci. USA 82: 5715-5719.
29. KONOPKA, J. B., D. D. JENNESS and L. H. HARTWELL, 1988 The C-terminus of the S. cerevisiae alpha-pheromone receptormediates an adaptive response to pheromone. Cell 54: 609-620.
30. KRONSTAD, J. W., J. A. HOLLY and V. L. MACKAY, 1987 A yeast operator overlaps an upstream activation site. Cell 50: 369-377.
31. LAMSON, R. E., S. TAKAHASHI, M. J. WINTERS and P. M. PRYCIAK, 2006 Dual role for membrane localization in yeast MAP kinase cascade activation and its contribution to signaling fidelity. Curr. Biol. 16: 618-623.
32. LEMMON, M. A., and K. M. FERGUSON, 2000 Signal-dependent membrane targeting by pleckstrin homology (PH) domains. Biochem. J. 350: 1-18.
33. MADDEN, K., and M. SNYDER, 1998 Cell polarity and morphogenesis in budding yeast. Annu. Rev. Microbiol. 52: 687-744.
34. MITCHELL, A. P., 1994 Control of meiotic gene expression in Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 58: 56-70.
35. MOSKOW, J. J., A. S. GLADFELTER, R. E. LAMSON, P. M. PRYCIAK and D. J. LEW, 2000 Role of Cdc42p in pheromone-stimulated signal transduction in Saccharomyces cerevisiae. Mol. Cell. Biol. 20: 7559-7571.
36. NAKAYAMA, N., A. MIYAJIMA and K. ARAI, 1985 Nucleotide sequences of STE2 and STE3, cell type-specific sterile genes from Saccharomyces cerevisiae. EMBO J. 4: 2643-2648.
37. NAKAYAMA, N., Y. KAZIRO, K. ARAI and K. MATSUMOTO, 1988 Role of STE genes in the mating factor signaling pathway mediated by GPA1 in Saccharomyces cerevisiae. Mol. Cell. Biol. 8: 3777-3783.
38. PRYCIAK, P. M., and F. A. HUNTRESS, 1998 Membrane recruitment of the kinase cascade scaffold protein Ste5 by the Gbγ complex underlies activation of the yeast pheromone response pathway. Genes Dev. 12: 2684-2697.
39. RAJENDRAN, L., and K. SIMONS, 2005 Lipid rafts and membrane dynamics. J. Cell Sci. 118: 1099-1102.
40. SCHUCK, S., and K. SIMONS, 2004 Polarized sorting in epithelial cells: raft clustering and the biogenesis of the apical membrane. J. Cell. Sci. 117: 5955-5964.
41. SEGALL, J. E., 1993 Polarization of yeast cells in spatial gradients of alpha mating factor. Proc. Natl. Acad. Sci. USA 90: 8332-8336.
42. SIMONS, K., and E. IKONEN, 1997 Functional rafts in cell membranes. Nature 387: 569-572.
43. SIMONS, K., and D. TOOMRE, 2000 Lipid rafts and signal transduction. Nat. Rev. Mol. Cell Biol. 1: 31-39.
44. STEVENSON, B. J., N. RHODES, B. ERREDE and G. F. SPRAGUE, 1992 Constitutive mutants of the protein kinase STE11 activate the yeast pheromone response pathway in the absence of the G protein. Genes Dev. 6: 1293-1304.
45. STRICKFADEN, S. C., and P. M. PRYCIAK, 2008 Distinct roles for two Galpha-Gbeta interfaces in cell polarity control by a yeast heterotrimeric G protein. Mol. Biol. Cell 19: 181-197.
46. STRICKFADEN, S. C., M. J. WINTERS, G. BEN-ARI, R. E. LAMSON, M. TYERS et al., 2007 A mechanism for cell-cycle regulation of MAP kinase signaling in a yeast differentiation pathway. Cell 128: 519-531.
47. SWAIN, E., J. STUKEY, V. MCDONOUGH, M. GERMANN, Y. LIU et al., 2002 Yeast cells lacking the ARV1 gene harbor defects in sphingolipid metabolism. COMPLEMENTATION BY HUMAN ARV1. J. Biol. Chem. 277: 36152-36160.
48. TINKELENBERG, A. H., Y. LIU, F. ALCANTARA, S. KHAN, Z. GUO et al., 2000 Mutations in yeast ARV1 alter intracellular sterol distribution and are complemented by human ARV1. J. Biol. Chem. 275: 40667-40670.
49. TONG, F., J. T. BILHEIMER, C. F. SHECHTMAN, Y. LIU, R. CROOKE et al., 2010 Decreased expression of ARV1 results in cholesterol retention in the endoplasmic reticulum and abnormal bile acid metabolism. J. Biol. Chem. 285: 33632-33641.
50. TRUEHEART, J., J. D. BOEKE and G. R. FINK, 1987 Two genes required for cell fusion during yeast conjugation: evidence for a pheromone-induced surface protein. Mol. Cell. Biol. 7: 2316-2328.
51. TRUEHEART, J., and G. R. FINK, 1989 The yeast cell fusion protein FUS1 is O-glycosylated and spans the plasma membrane. Proc. Natl. Acad. Sci. USA 86: 9916-9920.
52. VALDEZ-TAUBAS, J., and H. R. B. PELHAM, 2003 Slow diffusion of proteins in the yeast plasma membrane allows polarity to be maintained by endocytic cycling. Curr. Biol. 13: 1636-1640.
53. VAN ARSDELL, S. W., G. L. STETLER and J. THORNER, 1987 The yeast repeated element sigma contains a hormone-inducible promoter. Mol. Cell. Biol. 7: 749-759.
54. VAN DROGEN, F., S. M. O'ROURKE, V. M. STUCKE, M. JAQUENOUD, A. M. NEIMAN et al., 2000 Phosphorylation of the MEKK Ste11p by the PAK-like kinase Ste20p is required for MAP kinase signaling in vivo. Curr. Biol. 10: 630-639.
55. WACHTLER, V., and M. K. BALASUBRAMANIAN, 2006 Yeast lipid rafts? An emerging view. Trends Cell. Biol. 16: 1-4.
56. WANG, Y., and H. G. DOHLMAN, 2004 Pheromone signaling mechanisms in yeast: a prototypical sex machine. Science 306: 1508-1509.
57. WINTERS, M. J., R. E. LAMSON, H. NAKANISHI, A. M. NEIMAN and P. M. PRYCIAK, 2005 A membrane binding domain in the Ste5 scaffold synergizes with Gbg binding to control localization and signaling in pheromone response. Mol. Cell 20: 21-32.
58. WU, C., E. LEBERER, D. Y. THOMAS and M. WHITEWAY, 1999 Functional characterization of the interaction of Ste50p with Ste11p MAPKKK in Saccharomyces cerevisiae. Mol. Biol. Cell 10: 2425-2440.