Decreased expression of ARV1 results in cholesterol retention in the endoplasmic reticulum and abnormal bile acid metabolism

Journal of Biological Chemistry

Volumn 285, Issue 44, 2010, Pages 33632-33641

  Tong, Fumin ^a   Billheimer, Jeffrey ^a   Shechtman, Caryn F ^b   Liu, Ying ^b   Crooke, Roseann ^c   Graham, Mark ^c   Cohen, David E ^d   Sturley, Stephen L ^b   Rader, Daniel J ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b New York Presbyterian Morgan Stanley Children's Hospital   (United States)

^c ISIS PHARMACEUTICALS   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDES; BILE ACID; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM MEMBRANES; FARNESOID X RECEPTORS; HEPG2 CELLS; HYPERCHOLESTEROLEMIA; KEY COMPONENT; NET IMPACT; OPTIMAL CONCENTRATION; PLASMA MEMBRANES; REGULATORY PATHWAY; STEROL REGULATORY ELEMENT-BINDING PROTEINS; STEROL TRANSPORTS; YEAST SACCHAROMYCES CEREVISIAE;

ACIDS; ALCOHOLS; CELL MEMBRANES; CHOLESTEROL; LAWS AND LEGISLATION; LIVER; MAMMALS; METABOLISM; OLIGONUCLEOTIDES; PHYSIOLOGY; YEAST;

BODY FLUIDS;

ALANINE AMINOTRANSFERASE; ANTISENSE OLIGONUCLEOTIDE; CHOLESTEROL; CHOLESTEROL ESTER; FARNESOID X RECEPTOR; FATTY ACID; MEMBRANE PROTEIN; PROTEIN ARV1; STEROL REGULATORY ELEMENT BINDING PROTEIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BILE ACID BLOOD LEVEL; BILE ACID METABOLISM; CHOLESTEROL BILE LEVEL; CHOLESTEROL ESTERIFICATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; FATTY ACID BLOOD LEVEL; GENE CONTROL; GENE EXPRESSION; HUMAN; HUMAN CELL; HYPERCHOLESTEROLEMIA; LIPID METABOLISM; LIVER WEIGHT; MALE; MOUSE; NONHUMAN; PHOSPHOLIPID BLOOD LEVEL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; RNA ISOLATION; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; BILE ACIDS AND SALTS; CARRIER PROTEINS; CHO CELLS; CHOLESTEROL; CRICETINAE; CRICETULUS; ENDOPLASMIC RETICULUM; HUMANS; INTESTINES; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

MAMMALIA; MURINAE; SACCHAROMYCES CEREVISIAE;

EID: 77958552402     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.165761     Document Type: Article

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