Increased vascular endothelial growth factor may account for elevated level of plasminogen activator inhibitor-1 via activating ERK1/2 in keloid fibroblasts

American Journal of Physiology - Cell Physiology

Volumn 286, Issue 4 55-4, 2004, Pages

  Wu, Yidi ^a   Zhang, Qunzhou ^a   Ann, David K ^b   Akhondzadeh, Anita ^a   Duong, Hai S ^c   Messadi, Diana V ^c   Le, Anh D ^a,c  

^a CHARLES R DREW UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Extracellular matrix; Fibrosis; Urokinase plasminogen activator

Indexed keywords

MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; PLASMINOGEN ACTIVATOR INHIBITOR 1; UROKINASE; VASCULOTROPIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 3; VASCULOTROPIN A;

ANGIOGENESIS; ARTICLE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GENE EXPRESSION; HUMAN; HUMAN CELL; INFLAMMATION; KELOID; PRIORITY JOURNAL; SCAR FORMATION; SKIN FIBROBLAST; SKIN FIBROSIS; FIBROBLAST; GENETICS; HOMEOSTASIS; METABOLISM; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

EXTRACELLULAR MATRIX; FIBROBLASTS; GENE EXPRESSION; HOMEOSTASIS; HUMANS; KELOID; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; PLASMINOGEN ACTIVATOR INHIBITOR 1; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 2142657200     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.00200.2003     Document Type: Article

References (67)

1. Akimoto S, Ishikawa O, Iijima C, and Miyachi Y. Expression of basic fibroblast growth factor and its receptor by fibroblast, macrophages and mast cells in hypertrophic scar. Eur J Dermatol 9: 357-362, 1999.
2. Appleton I, Brown NJ, and Willoughby DA. Apoptosis, necrosis, and proliferation: possible implications in the etiology of keloids. Am J Pathol 149: 1441-1447, 1996.
3. Babu M, Dlegelmann R, and Oliver N. Fibronectin is overproduced by keloid fibroblasts during abnormal wound healing. Mol Cell Biol 9: 1642-50, 1989.
4. Babu M, Diegelmann R, and Oliver N. Keloid fibroblasts exhibit an altered response to TGF-β. J Invest Dermatol 99: 650-655, 1992.
5. Banfi C, Eriksson P, Giandomenico G, Mussoni M, Sironi L, Hamsten A, and Tremoli E. Transcriptional regulation of plasminogen activator inhibitor type-1 gene by insulin. Diabetes 50: 1522-1530, 2001.
6. Bernatchez PN, Allen BG, Gélinas DS, Guillemette G, and Sirois MG. Regulation of VEGF-induced endothelial cell PAF synthesis: role of p42/44 MAPK, p38 MAPK and PI3K pathways. Br J Pharmacol 134: 1253-1262, 2001.
7. Brown LF, Berse B, Jackman RW, Tognazzi K, Manseau EJ, Senger DR, and Dvorak HF. Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract. Cancer Res 53: 4727-4735, 1993.
8. Brown LF and Yeo K. Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing. J Exp Med 176: 1375-1379, 1992.
9. Carmeliet P and Rerreira V. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380: 435-439, 1996.
10. Chin GS, Liu W, Steinbrech D, Hsu M, Levinson H, and Longaker MT. Cellular signaling by tyrosine phosphorylation in keloid and normal human dermal fibroblasts. Plast Reconstr Surg 106: 1532-1540, 2000.
11. Connolly DT, Heuvelman DM, Nelson R, Olander JV, Eppley BL, Delfino JJ, Siegel NR, Leimgruber RM, and Feder J. Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis. J Clin Invest 84: 1470-1478, 1989.
12. Fattal PG, Schneider DJ, Sobel BE, and Billadello JJ. Post-transcriptional regulation of expression of plasminogen activator inhibitor-1 mRNA by insulin and insulin like growth factor-1. J Biol Chem 267: 12412-12415, 1992.
13. Fava R, Olsen N, Spencer-Green G, Yeo KT, Berse B, Jackman R, Senger D, Dvorak H, and Brown L. Vascular permeability factor/ endothelial growth factor (VPF/VEGF): accumulation and expression in human synovial fluids and rheumatoid synovial tissue. J Exp Med 180: 341-346, 1994.
14. Ferrara N and Carver-Moore K. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380: 439-442, 1996.
15. Ferrara N and Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev 18: 4-25, 1997.
16. Fink T, Kazlauskas A, Poellinger L, Ebbesen P, and Zachar V. Identification of a tightly regulated hypoxia-response element in the promoter of human plasminogen activator inhibitor-1. Blood 99: 2077-2083, 2002.
17. Fitzpatrick TE and Graham CH. Stimulation of plasminogen activator inhibitor-1 expression in immortalized human trophoblast cells cultured under low levels of oxygen. Exp Cell Res 245: 155-162, 1998.
18. Forsythe JA, Jiang BH, Iyer NV, Agani F, Leung SW, Koos RD, and Semenza GL. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 16: 4604-4613, 1996.
19. Gerber HP, McMurtrey A, Kowalski J, Yan M, Keyt BA, Dixit V, and Ferrara N. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. J Biol Chem 273: 30336-30343, 1998.
20. 2+. Biochem J 353: 503-512, 2001.
21. Goldman CK, Kim J, Wong WL, King V, Brock T, and Gillespie GY. Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: a model of glioblastoma multiforme pathophysiology. Mol Biol Cell 4: 121-133, 1993.
22. Guo D, Jia Q, Song HY, Warren RS, and Donner DB. Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domain. Association with endothelial cell proliferation. J Biol Chem 270: 6729-6733, 1995.
23. Higgins PJ, Slack JK, Diegelmann RF, and Staiano-Coico L. Differential regulation of PAI-1 gene expression in human fibroblasts predisposed to a fibrotic phenotype. Exp Cell Res 248: 634-642, 1999.
24. Ikeda E, Achen MG, Breier G, and Risau W. Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells. J Biol Chem 270: 19761-19766, 1995.
25. Kaneko T, Fujii S, Matsumoto A, Goto D, Ishimori N, Watano K, Furumoto T, Sugawara T, Sobel BE, and Kitabatake A. Induction of plasminogen activator inhibitor-1 in endothelial cells by basis fibroblast growth factor and its modulation by fibric acid. Arterioscler Thromb Vasc Biol 22: 855-860, 2002.
26. Keck PJ, Hauser SD, Krivi G, Sanzo K, Warren T, Feder J, and Connolly DT. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 246: 1309-1312, 1989.
27. Kletzmann T, Roth U, and Jungermann K. Induction of the plasminogen activator inhibitor-1 gene expression by mild hypoxia via a hypoxia response element binding the hypoxia-inducible factor-1 in rat hepatocytes. Blood 94: 4177-4185, 1999.
28. Kischer CW. The microvessels in hypertrophic scars, keloids and related lesions: a review. J Submicrosc Cytol Pathol 24: 281-296, 1992.
29. Kischer CW, Thies AC, and Chvapil M. Perivascular myofibroblasts and microvascular occlusion in hypertrophic scars and keloids. Hum Pathol 13: 819-824, 1982.
30. Knighton DR and Fiegel VD. Regulation of cutaneous wound healing by growth factors and the microenvironment. Invest Radiol 26: 604-611, 1991.
31. Le AD, Zhang QZ, Wu YD, Messadi DV, Akhonzadeh A, Nguyen A, Aghaloo T, Kelly AP, and Bertolami CN. Elevated vascular endothelial growth factor in keloids: relevance to tissue fibrosis. Cells Tissues Organs 176: 87-94, 2004.
32. Lee TY, Chin GS, Kim WJ, Chau D, Gittes GK, and Longaker MT. Expression of transforming growth factor beta1, 2, and 3 proteins in keloids. Ann Plast Surg 43: 179-184, 1999.
33. Levy AP, Levy NS, and Goldberg MA. Post-transcriptional regulation of vascular endothelial growth factor by hypoxia. J Biol Chem 271: 2746-2753, 1996.
34. Levy NS, Chung S, Furneaux H, and Levy AP. Hypoxic stabilization of vascular endothelial growth factor mRNA by the RNA-binding protein HuR. J Biol Chem 273: 6417-6423, 1998.
35. Liu LX, Lu H, Luo YX, Date T, Belanger AJ, Vincent KA, Akita GY, Goldberg M, Cheng SH, Gregory RJ, and Jiang C Stabilization of vascular endothelial growth factor mRNA by hypoxia-inducible factor 1. Biochem Biophys Res Commun 291: 908-914, 2002.
36. Luo S, Benathan M, Raffoul W, Panizzon RG, and Egloff DV. Abnormal balance between proliferation and apoptosis cell death in fibroblasts derived from keloid lesions. Plast Reconstr Surg 107: 87-96, 2001.
37. Mandriota SJ, Seghezzi G, Vassalli JD, Ferrara N, Wasi S, Mazzieri R, Mignatti P, and Pepper MS. Vascular endothelial growth factor increases urokinase receptor expression in vascular endothelial cells. J Biol Chem 270: 9709-9716, 1995.
38. Miele C, Rochford JJ, Filippa N, Giorgetti-Peraldi S, and Obberghen EV. Insulin and insulin-like growth factor-I induce vascular endothelial growth factor mRNA expression via different signaling pathways. J Biol Chem 275: 21695-21702, 2000.
39. Namiki A, Brogi E, Kearney M, Kim EA, Wu T, Couffinhal T, Varticovski L, and Isner JM. Hypoxia induces vascular endothelial growth factor in cultured human endothelial cells. J Biol Chem 270: 31189-31195, 1995.
40. Niessen FB, Spauwen PHM, Schalkwijk J, and Kon M. On the nature of hypertrophic scars and keloids: a review. Plast Reconstr Surg 104: 1435-1458, 1999.
41. Nissen NN, Polverini PJ, Koch AE, Volin MV, Gamelli RL, and Dipietro LA. Vascular endothelial growth factor mediates angiogenesis activity during the proliferative phase of wound healing. Am J Pathol 152: 1445-1452, 1998.
42. Oloffson B, Korpelainen E, Pepper MS, Mandriota SJ, Aase K, Kumar V, Gunji Y, Jeltsch MM, Shibuya M, and Alitano K. Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells. Proc Natl Acad Sci USA 95: 11709-11714, 1998.
43. Pages G, Berra E, Milanini J, Levy AP, and Pouyssegur J. Stress-activated protein kinases (JNK and p38/HOG) are essential for vascular endothelial growth factor mRNA stability. J Biol Chem 275: 26484-26491, 2000.
44. Pepper MS, Ferrara N, Orci L, and Montesano R. Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells. Biochem Biophys Res Commun 181: 902-906, 1991.
45. Plate KH, Breier G, Weich HA, and Risau W. Vascular endothelial growth factor is a potential tumor angiogenesis factor in human gliomas in vivo. Nature 359: 845-848, 1992.
46. Plow EF, Herren T, Redlitz A, Miles LA, and Hoover-Plow JL. The cell biology of the plasminogen systems. EMBO J 9: 939-945, 1995.
47. Reilly CF and McFall RC. Platelet-derived growth factor and transforming growth factor-beta regulate plasminogen activator-1 synthesis in vascular smooth muscle cells. J Biol Chem 266: 9419-9427, 1991.
48. Ryuto M, Ono M, Izumi H, Yoshida S, Weich HA, Kohno K, and Kuwano M. Induction of vascular endothelial growth factor by tumor necrosis factor in human glioma cells. Possible roles of SP-1. J Biol Chem 271:28220-28228, 1996.
49. Sawdey MS and Loskutoff DJ. Regulation of murine type 1 plasminogen activator inhibitor gene expression in vivo. Tissue specificity and induction by lipopolysaccharides, tumor necrosis factor-alpha, and transforming growth factor-beta. J Clin Invest 88: 1346-1353, 1991.
50. Semenza GL. Signal transduction to hypoxia-inducible factor 1. Biochem Pharmacol 64: 993-998, 2002.
51. Senger DR. Vascular permeability factor (VEP/VEGF) in tumor biology. Cancer Metastasis Rev 12: 303-324, 1993.
52. Shabsigh A, Ghafar MA, de la Taile A, Burchardt M, Kaplan SA, Anastasiadis AG, and Buttyan R. Biomarker analysis demonstrates a hypoxic environment in the castrated rat ventral prostate gland. J Cell Biochem 81: 437-444, 2001.
53. Shih SC and Claffey KP. Regulation of human vascular endothelial growth factor mRNA stability in hypoxia by heterogeneous nuclear ribonucleoprotein L. J Biol Chem 274: 1359-1365, 1999.
54. Shweiki D, Itin A, Soffer D, and Keshet E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359: 843-845, 1992.
55. Stavri G, Hong Y, Zachary I, Breier G, Baskerville P, Yla-Herttnala S, Risau W, Martin J, and Erusalimsky J. Hypoxia and platelet-derived growth factor-BB synergistically upregulate the expression of vascular endothelial growth factor in vascular smooth muscle cells. FEBS Lett 358: 311-315, 1995.
56. Stavri G, Zachary I, Baskerville P, Martin J, and Erusalimsky J. Basic fibroblast growth factor upregulates the expression of vascular endothelial growth factor in vascular smooth muscle cells. Circulation 92: 5-8, 1995.
57. Suzaki Y, Yoshizumi M, Kagami S, Koyama AH, Taketani Y, Houchi H, Tsuchiya K, Takeda E, and Tamaki T. Hydrogen peroxide stimulates c-Src-mediated big mitogen-activated protein kinase 1(BMK1) and the MEF2C signaling pathway in PV12 cells. J Biol Chem 277: 9614-9621, 2002.
58. Tuan TL and Nichter LS. The molecular basis of keloid and hypertrophic scar formation. Mol Med Today 4: 19-24, 1998.
59. Tuan TL, Song A, Chang S, Younai S, and Nimni ME. In vitro fibroplasia: matrix contraction, cell growth, and collagen production of fibroblasts cultured in fibrin gels. Exp Cell Res 223: 127-134, 1996.
60. Tuan TL, Wu HY, Hang EY, Chong SN, Laug W, Messadi D, Kelley P, and Le A. Increased plasminogen activator inhibitor-1 in keloid fibroblasts may account for their elevated collagen accumulation in fibrin gel cultures. Am J Pathol 162: 1579-1589, 2003.
61. Tuan TL, Zhu JY, Sun B, Nichter LS, Nimni ME, and Laug WE. Elevated levels of plasminogen activator inhibitor-1 may account for the altered fibrinolysis by keloid fibroblasts. J Invest Dermatol 106: 1007-1011, 1996.
62. Wang DG, Huang HJS, Kazlauskas A, and Cavenee WK. Induction of vascular endothelial growth factor expression in endothelial cells by platelet-derived growth factor through the activation of phosphatidylinositol 3-kinase. Cancer Res 59: 1464-1472, 1999.
63. Xue H, McCauley RL, and Zhang W. Elevated interleukin-6 expression in keloid fibroblasts. J Surg Res 89: 74-77, 2000.
64. Yoshimoto H, Ishihara H, Ohtsuru A, Akino K, Murakami R, Kuroo H, Namba H, Ito M, Fujii T, and Yamashita S. Overexpression of insulin-like growth factor-1 (IGF-I) receptor and the invasiveness of cultured keloid fibroblasts. Am J Pathol 154: 883-889, 1999.
65. Zachary I and Gliki G. Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family. Cardiovasc Res 49: 568-581, 2001.
66. Zhang QZ, Wu YD, Ann DK, Messadi DV, Tuan TL, Kelly AP, Bertolami CN, and Le A. Mechanisms of hypoxic regulation of plasminogen activator inhibitor-1 gene expression in keloid fibroblasts. J Invest Dermatol 121: 1005-1012, 2003.
67. Zhang QZ, Wu YD, Chau CH, Ann DK, Bertolami CN, and Le AD. Crosstalk of hypoxia-mediated signaling pathways in upregulating plasminogen activator inhibitor-1 expression in keloid fibroblasts. J Cell Physiol 199: 89-97, 2004.