Direct visualization of repair of oxidative damage by OGG1 in the nuclei of live cells

Journal of Biochemical and Molecular Toxicology

Volumn 25, Issue 1, 2011, Pages 1-7

  Zielinska, Agnieszka ^a   Davies, Owain T ^a   Meldrum, Rosalind A ^a   Hodges, Nikolas J ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

DNA Repair; OGG1; Polymorphism; Real Time Imaging

Indexed keywords

8 OXOGUANINE DNA GLYCOSYLASE 1; DNA; DNA GLYCOSYLTRANSFERASE; GREEN FLUORESCENT PROTEIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; EMBRYO; ENZYME ACTIVITY; FIBROBLAST CULTURE; FLUORESCENCE; IRRADIATION; LASER; MOUSE; NONHUMAN; OXIDATIVE STRESS; THREE DIMENSIONAL IMAGING;

ANIMALS; CELL LINE; CELL NUCLEUS; DNA DAMAGE; DNA GLYCOSYLASES; DNA REPAIR; FIBROBLASTS; KINETICS; MICE; MICE, KNOCKOUT; MICROSCOPY, FLUORESCENCE, MULTIPHOTON; MUTAGENESIS; OXIDATIVE STRESS; POLYMORPHISM, GENETIC; REACTIVE OXYGEN SPECIES;

EID: 79951493270     PISSN: 10956670     EISSN: 10990461     Source Type: Journal    
DOI: 10.1002/jbt.20346     Document Type: Article

References (27)

1. Perillo B, Ombra MN, Bertoni A, Cuozzo C, Sacchetti S, Sasso A, Chiariotti L, Malorni A, Abbondanza C, Avvedimento EV. DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression. Science. 2008;319:202-206.
2. Kriaucionis S, Heintz N. The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science. 2009;324:929-930.
3. Mates JM, Segura JA, Alonso FJ, Márquez J. Intracellular redox status and oxidative stress: implications for cell proliferation, apoptosis, and carcinogenesis. Arch Toxicol. 2008;82:273-299.
4. Toyokuni S. Molecular mechanisms of oxidative stress-induced carcinogenesis: from epidemiology to oxygenomics. IUBMB Life. 2008;60:441-447.
5. Gruber J, Schaffer S, Halliwell B. The mitochondrial free radical theory of ageing-where do we stand? Front Biosci. 2008;13:6554-6579.
6. Lu T, Finkel T. Free radicals and senescence. Exp Cell Res. 2008;314:1918-1922.
7. Chen SK, Hsieh WA, Tsai MH, Chen CC, Hong AI, Wei YH, Chang WP. Age-associated decrease of oxidative repair enzymes, human 8-oxoguanine DNA glycosylases (hOgg1), in human aging. J Radiat Res (Tokyo) 2003;44:31-35.
8. Yamane A, Kohno T, Ito K, Sunaga N, Aoki K, Yoshimura K, Murakami H, Nojima Y, Yokota J. Differential ability of polymorphic OGG1 proteins to suppress mutagenesis induced by 8-hydroxyguanine in human cell in vivo. Carcinogenisis. 2004;25:1689-1694.
9. Lee AJ, Hodges NJ, Chipman JK. Interindividual variability in response to sodium dichromate-induced oxidative DNA damage: role of the Ser326Cys polymorphism in the DNA-repair protein of 8-oxo-7, 8-dihydro-2'-deoxyguanosine DNA glycosylase 1. Cancer Epidemiol Biomarkers Prev 2005;14:497-505.
10. Smart DJ, Chipman JK, Hodges NJ. Activity of OGG1 variants in the repair of pro-oxidant-induced 8-oxo-2'-deoxyguanosine. DNA Repair (Amst) 2006;5:1337-1345.
11. Hung RJ, Hall J, Brennan P, Boffetta P. (2005). Genetic polymorphisms in the base excision repair pathway and cancer risk: a HuGE review. Am J Epidemiol 2005;162:925-942.
12. Hazra TK, Das A, Das S, Choudhury S, Kow YW, Roy R. Oxidative DNA damage repair in mammalian cells: a new perspective. DNA Repair (Amst) 2007;6:470-480.
13. Hirano T. Repair system of 7, 8-dihydro-8-oxoguanine as a defense line against carcinogenesis. J Radiat Res (Tokyo) 2008;49:329-340.
14. Li H, Hao X, Zhang W, Wei Q, Chen K. The hOGG1 Ser326Cys polymorphism and lung cancer risk: a meta-analysis. Cancer Epidemiol Biomarkers. 2008;17:1739-1745.
15. Cheng KC, Cahill DS, Kasai H, Nishimura S, Loeb LA. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G - T and A - C substitutions. J Biol Chem 1992;267:166-172.
16. Bjoras M, Lun L. Johnsen B, Hoff E, Haug T, Rognes T, Seeberg E. Opposite base-dependent reactions of a human base excision repair enzyme on DNA containing 7, 8-dihdyro-8-oxoguanine and abasic sites. EMBO J. 1997;16: 6314-6322.
17. Lan L, Nakajima S, Oohata Y, Takao M, Okana S, Matsutani M, Wilson SH, Yasui A. In situ analysis of repair processes for oxidative DNA damage in mammalian cells. PNAS. 2004;101(38):13738-13743.
18. Meldrum RA, Botchway SW, Wharton CW, Hirst GJ. Nanoscale induction of UV photoproducts in cellular DNA by 3-photon near infra-red absorption. EMBO Rep.. 2003;4(12):1144-1149.
19. Green RM, Graham M, O'Donovan MR, Chipman JK, Hodges NJ. Subcellular compartmentalization of glutathione: correlations with parameters of oxidative stress related to genotoxicity. Mutagenesis. 2006;21:383-390.
20. Negishi K, Higashi S, Nakamura T, Otsuka C, Wantanabe M, Negishi T. Oxidative DNA damage induced by 364-nm UVA laser in yeast cells. Genes Environ. 2006;28:74-76.
21. Campalans A, Amourox R, Bravard A, Epe B, Radicella JP. UVA irradiation induces relocalisation of the DNA repair protein hOGG1 to nuclear speckles. J Cell Sci. 2007;120:23-32.
22. Dantzer F, Luna L, Bjoras M, Seeberg E. Human OGG1 undergoes serine phosphorylation and associates with the nuclear matrix and mitotic chromatin in vivo. Nucleic Acids Res. 2002;30:2349-2357.
23. Bravard A, Vacher M, Gouget B, Coutant A, de Boisferon FH, Marsin S, Chevillard S, Radicella JP. Redox regulation of human OGG1 activity in response to cellular oxidative stress. Mol Cell Biol. 2006;26:7430-7436.
24. Bravard A, Vacher M, Moritz E, Vaslin L, Hall J, Epe B, Radicella JP. Oxidation status of human OGG1-S326C polymorphic variant determines cellular DNA repair capacity. Cancer Res. 2009;69:3642-3649.
25. Hill JW, Evans MK. Dimerization and opposite base-dependent catalytic impairment of polymorphic S326C OGG1 glycosylase. Nucleic Acids Res. 2006;34:1620-1632.
26. Mirbahai L, Kershaw M, Meldrum RA, Hodges NJ. Use of a molecular beacon to track the activity of base excision repair protein OGG1 in live cells. DNA 2010 Feb 4;9(2):144-52. Epub 2009 Dec 29.
27. Griffiths LM, Swartzlander D, Meadows KL, Wilkinson KD, Corbett AH, Doetsch PW. Dynamic compartmentalization of base excision repair proteins in response to nuclear and mitochondrial oxidative stress. Mol Cell Biol. 2009;29:794-807.