Effects of extracts, flavonoids and iridoids from Penstemon gentianoides (Plantaginaceae) on inhibition of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) in LPS-Activated RAW 264.7 macrophage cells and their antioxidant activity¥;Efectos de extractos, flavonoides e iridoides de Penstemon gentianoides (Plantaginaceae) sobre la inhibición de oxido nitrico sintasa inducible (iNOS), ciclooxigenasa-2 (COX-2) celulas de macrofagos murinos RAW 264.7 activadas con LPS y sus actividades antioxidantes

Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas

Volumn 9, Issue 5, 2010, Pages 397-413

  Dominguez, Mariana ^a   Keck, Anna S ^b   Jeffery, Elizabeth H ^b   Cespedes, Carlos L ^c  

^a INSTITUTO DE FISIOLOGÍA CELULAR   (Mexico)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c UNIVERSIDAD DEL BÍO BÍO   (Chile)

Author keywords

Anti inflammatory activity; Antioxidant activity; COX 2 Inhibitors; NO inhibitors; Penstemon gentianoides; Plantaginaceae

Indexed keywords

ACTEOSIDE; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; DIOSMETIN; FLAVONOID; GLOBULARISICIN; INDUCIBLE NITRIC OXIDE SYNTHASE; IRIDOID; LIPOPOLYSACCHARIDE; LUTEOLIN; MARTYNOSIDE; PENSTEMINOSIDE; PENSTEMON GENTIANOIDES EXTRACT; PLANT EXTRACT; PLANTARENALOSIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; MACROPHAGE; NONHUMAN; PENSTEMON; PENSTEMON GENTIANOIDES; PROTEIN EXPRESSION; SOLVENT EXTRACTION;

MURINAE; PENSTEMON; PLANTAGINACEAE;

EID: 79951489822     PISSN: None     EISSN: 07177917     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Aldini G, Piccoli A, Beretta G, Morazzoni P, Riva A, Marinello C, Maffei M, Facino R. 2006. Antioxidant activity of polyphenols from solid olive residues of c.v. Coratina. Fitoterapia 77: 121-128.
2. Alice HL, Michael JB, Robert RG. 1989. Regulation of prostaglandin H systhase mRNA levels and prostaglandin biosynthesis by platelet-derived growth factor. J Biol Chem 264: 17379-17383.
3. Amiram R, Angela W, Ned S, Philip N. 1988. Regulation of fibroblast cyclooxygenase synthesis by interleukin-1. J Biol Chem 263: 3022-3024.
4. Babior BM, Kipnes RS, Carnutte JT. 1973. Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent. J Clin Invest 52: 741-744.
5. Bowers MD. 1983. The role of inflammatory glycosides in host-plant specificity of checkerspot butterflies. J Chem Ecol 9: 475-493.
6. Cao Y, Prescott SM. 2002. Many actions of cyclooxygenase-2 in cellular dynamics and cancer. J Cell Physiol 190: 279-286
7. Cespedes CL, Lemus A, Salazar JR, Cabrera A, Sharma P. 2003. Herbicidal, plant growth inhibitory, and cytotoxic activities of bismuthines containing aromatic heterocycles. J Agric Food Chem 51: 2923-2929.
8. Cespedes CL, Uchoa A, Salazar JR, Perich F, Pardo F. 2002. Plant growth inhibitory activity of p-hydroxyacetophenones and tremetones from Chilean endemic Baccharis species and some analogous: a comparative study. J Agric Food Chem 50: 2283-2292.
9. Cespedes CL, El-Hafidi M, Pavon N, Alarcon J. 2008. Antioxidant and cardioprotective activities of phenolic extracts from fruits of Chilean blackberry Aristotelia chilensis (Elaeocarpaceae), Maqui. Food Chemistry 107: 820-829.
10. Chiang YM, Lo CP, Chen YP, Wang SY, Yang NS, Kuo YH, Shyur LF. 2005. Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin. Br J Pharmacol 146: 352-363.
11. De Nardin E. 2001. The role of inflammatory and immunological mediators in periodontitis and cardiovascular disease. Ann Periodontol 6: 30-40.
12. Dean AK, Bradley SF, Brian CV, Robert WL, Harvey RH. 1991. TIS 10, a phorbol ester tumor promoter inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. J Biol Chem 266: 12866-12872.
13. Dedon P, Tannenbaum R. 2004. Reactive nitrogen species in the chemical biology of inflammation. Arch Biochem Biophys 423: 12-22.
14. Dominguez M, Nieto A, Marin JC, Keck AS, Jeffery E, Cespedes CL. 2005. Antioxidants activities of extracts from Barkleyanthus salicifolius (Asteraceae) and Penstemon gentianoides (Scrophulariaceae). J Agric Food Chem 53: 5889-5895.
15. Dominguez M, Marin JC, Esquivel B, Cespedes CL. 2007. Pensteminoside, an unusual catalpol-type iridoids from Penstemon gentianoides HBK (Plantaginaceae). Phytochemistry 68: 1762-1766.
16. Dominguez M, Avila JG, Nieto A, Cespedes CL. 2010. Anti-inflammatory Activity of Penstemon gentianoides and P. campanulatus (Plantaginaceae). Pharm Biol 48: xxx-xxx (in press).
17. Jimenez-Estrada M, Saad I, Sanchez-Contreras A, Reyes-Chilpa R. 2006. Estudios sobre monoterpenos e iridoides. In: Quimica de la Flora Mexicana Investigaciones en el Instituto de Quimica, UNAM. A. Romo de Vivar R., Ed. Soc. Quim. Mexico. Mexico D.F. pp: 39-62.
18. Funk CD. 2001. Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 294: 1871-1875.
19. Kim HK, Cheon BS, Kim YH, Kim SY, Kim HP. 1999. Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships. Biochem Pharmacol 58: 759-765.
20. Kim YH, Lee SH, Lee JY, Choi SW, Park JW, Kwon TK. 2004. Triptolide inhibits murine-inducible nitric oxide synthase expression by down-regulating lipopolysaccharide-induced activity of nuclear factor-kappa B and c-Jun NH2-terminal kinase. Eur J Pharmacol. 494: 1-9.
21. Li J, Huang X, Du X, Sun W, Zhang Y (2009): Study of chemical composition and antimicrobial activity of leaves and roots of Scrophularia ningpoensis. Natural Product Research: Formerly Natural Product Letters 23: 775-780.
22. MacMicking J, Xie QW, Nathan C. 1997. Nitric oxide and macrophage function. Annu Rev Immunol 15: 323-350.
23. Marletta MA. 1993. Nitric oxide synthase structure and mechanism. J Biol Chem 268: 12231-12234.
24. Mordan LJ, Burnett TS, Zhang LX, Tom J, Cooney RV. 1993. Inhibitors of endogenous nitrogen oxide formation block the promotion of neoplastic transformation in C3H10T1/2 fibro-blasts. Carcinogenesis 14: 1555-1559.
25. Nathan C. 2002. Points of control in inflammation. Nature 420: 846-852.
26. Ng TB, Liu F, Wang ZT. 2000. Antioxidative activity of natural products from plants. Life Sciences 66: 709-723.
27. Oshima H, Bartsch H, 1994. Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis. Mutat Res 305: 253-264.
28. Paul A, Pendreigh RH Plevin R. 1995. Protein kinase C and tyrosine kinase pathway regulate lipopolysaccharide-induced nitric oxide synthase activity in RAW 264.7 murine macrophages. Br J Pharmacol 114: 482-488.
29. Park YC, Rimbach G, Saliou C, Valacchi G, Packer L. 2000. Activity of monomeric, dimeric, and trimeric flavonoids on NO production, TNF-R secretion, and NF-κBdependent gene expression in RAW 264.7 macrophages. FEBS Lett 464: 93-97.
30. Peñuelas J, Sardans J, Stefanescu C, Parella T, Filella I. 2006. Lonicera Implexa Leaves Bearing Naturally Laid Eggs of the Specialist Herbivore Euphydryas Aurinia have Dramatically Greater Concentrations of Iridoid Glycosides thanother Leaves. J Chem Ecol 32: 1925-1933.
31. Rosen GM, Tsai P, Pou S. 2002. Mechanism of free-radical generation by nitric oxide synthase. Chem Rev. 102: 1191-1199.
32. Schmidt HHHW, Walter U, 1994. NO at work. Cell 78: 919-925.
33. Seigler DS 1998. Plant Secondary Metabolism. Kluwer Academic Publishers, Norwell, MA.
34. Sheu F, Lai HH, Yen GC. 2001. Suppression effect of soy isoflavones on nitric oxide production in RAW 264.7 macrophages. J Agric Food Chem 49: 1767-1772.
35. Singleton VL, Orthofer R, Lamuela-Raventos RM. 1999. Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent. Methods Enzymol 299: 152-178.
36. Szabo C. 1995. Alterations in nitric oxide production in various forms of circulatory shock. New Hortz 3: 2-32.
37. Subbaramaiah K, Telang N, Ramonetti JT, Araki R, Devito B, Weksker BB, Dannenberg AJ. 1996. Transcription of cyclooxygenase-2 is enhanced in transformed mammary epithelial cells. Cancer Res 56: 4424-4429.
38. Surh Y, Chun K, Cha H, Han S, Keum Y, Park K, Lee S. 2001. Molecular mechanisms underlying chemo-preventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-κB activation. Mutat Res 480-481: 243-268.