Cytotoxicity of Thymus vulgaris essential oil towards human oral cavity squamous cell carcinoma

Anticancer Research

Volumn 31, Issue 1, 2011, Pages 81-87

  Sertel, Serkan ^a,b,c   Eichhorn, Tolga ^b,c   Plinkert, Peter K ^a   Efferth, Thomas ^b,c  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Head and neck squamous cell carcinoma HNSCC; Natural product; Oral cavity squamous cell carcinoma OCSCC; Pharmacogenomics; Thymus vulgaris L. (thyme)

Indexed keywords

GLYCOPEPTIDASE; MITOGEN ACTIVATED PROTEIN KINASE 7; THYME OIL;

ARTICLE; CANCER CELL; CYTOTOXICITY; DRUG MECHANISM; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MOUTH CARCINOMA; PHARMACOGENOMICS; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA;

APOPTOSIS; CARCINOMA, SQUAMOUS CELL; GENE EXPRESSION PROFILING; HUMANS; INTERFERONS; MITOGEN-ACTIVATED PROTEIN KINASE 7; MOUTH NEOPLASMS; OILS, VOLATILE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHYTOTHERAPY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; THYMUS PLANT; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 79851494647     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J and Thun MJ: Cancer statistics, 2009. CA Cancer J Clin 59: 225-249, 2009.
2. Dobrossy L: Epidemiology of head and neck cancer: magnitude of the problem. Cancer Metastasis Rev 24: 9-17, 2005.
3. Kupferman ME and Myers JN: Molecular biology of oral cavity squamous cell carcinoma. Otolaryngol Clin North Am 39: 229-247, 2006.
4. Newman DJ and Cragg GM: Natural products as sources of new drugs over the last 25 years. J Nat Prod 70: 461-477, 2007. (Pubitemid 46595760)
5. Cosentino S, Tuberoso CI, Pisano B, Satta M, Mascia V, Arzedi E and Palmas F: In vitro antimicrobial activity and chemical composition of Sardinian Thymus essential oils. Lett Appl Microbiol 29: 130-135, 1999.
6. Lai PK and Roy J: Antimicrobial and chemopreventive properties of herbs and spices. Curr Med Chem 11: 1451-1460, 2004. (Pubitemid 38735789)
7. Miura K, Kikuzaki H and Nakatani N: Antioxidant activity of chemical components from sage (Salvia officinalis L.) and thyme (Thymus vulgaris L.) measured by the oil stability index method. J Agric Food Chem 50: 1845-1851, 2002.
8. Zava DT, Dollbaum CM and Blen M: Estrogen and progestin bioactivity of foods, herbs, and spices. Proc Soc Exp Biol Med 217: 369-378, 1998.
9. Ait M'barek L, Ait Mouse H, Jaafari A, Aboufatima R, Benharref A, Kamal M, Benard J, El Abbadi N, Bensalah M, Gamouh A, Chait A, Dalai A and Zyad A: Cytotoxic effect of essential oil of thyme (Thymus broussonettii) on the IGR-OV1 tumor cells resistant to chemotherapy. Braz J Med Biol Res 40: 1537-1544, 2007.
10. Blumenthal M, Busse WR and Goldberg A: In: The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Austin, Tex, American Botanical Council, pp. 219-220, 1998.
11. Clavero J, Baca P, Paloma Gonzalez M and Valderrama MJ: Efficacy of chlorhexidine-thymol varnish (Cervitec) against plaque accumulation and gingival inflammation in a geriatric population. Gerodontology 23: 43-47, 2006.
12. Lin CJ, Grandis JR, Carey TE, Gollin SM, Whiteside TL, Koch WM, Ferris RL and Lai SY: Head and neck squamous cell carcinoma cell lines: established models and rationale for selection. Head Neck 29: 163-188, 2007. (Pubitemid 46167784)
13. Konkimalla VB, Blunder M, Korn B, Soomro SA, Jansen H, Chang W, Posner GH, Bauer R and Efferth T: Effect of artemisinins and other endoperoxides on nitric oxide-related signaling pathway in RAW 264.7 mouse macrophage cells. Nitric Oxide 19: 184-191, 2008.
14. Scudiero DA, Shoemaker RH, Pauli KD, Monks A, Tierney S, Nofziger TH, Currens MJ, Seniff D and Boyd MR: Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines. Cancer Res 48: 4827-4833, 1988.
15. Sikkema J, de Bont JA and Poolman B: Mechanisms of membrane toxicity of hydrocarbons. Microbiol Rev 59: 201-222, 1995.
16. von Ardenne M and Reitnauer PG: The elevation of the leucocyte and thrombocyte counts produced by a thyme extract in the peripheral blood as compared to that caused by 2-cyanoethylurea (author's transl). Pharmazie 36: 703-705, 1981.
17. Medina-Holguin AL, Holguin FO, Micheletto S, Goehle S, Simon JA and O'Connell MA: Chemotypic variation of essential oils in the medicinal plant, Anemopsis californica. Phytochemistry 69: 919-927, 2008.
18. Horvathova E, Turcaniova V and Slamenova D: Comparative study of DNA-damaging and DNA-protective effects of selected components of essential plant oils in human leukemic cells K562. Neoplasma 54: 478-483, 2007.
19. Slamenova D, Horvathova E, Sramkova M and Marsalkova L: DNA-protective effects of two components of essential plant oils carvacrol and thymol on mammalian cells cultured in vitro. Neoplasma 54: 108-112, 2007.
20. Weisenthal LM, Dill PL, Kurnick NB and Lippman ME: Comparison of dye exclusion assays with a clonogenic assay in the determination of drug-induced cytotoxicity. Cancer Res 43: 258-264, 1983. (Pubitemid 13172827)
21. Vichi P and Tritton TR: Stimulation of growth in human and murine cells by adriamycin. Cancer Res 49: 2679-2682, 1989. (Pubitemid 19143398)
22. http://www.genecards.org/index.shtml: Accessed: 01.01.2010.
23. Katsoulidis E, Kaur S and Platanias LC: Deregulation of interferon signaling in malignant cells. Pharmaceuticals 3: 406-418, 2010.
24. Takahashi M, Tsuda T, Ikeda Y, Honke K and Taniguchi N: Role of N-glycans in growth factor signaling. Glycoconj J 20: 207-212, 2004.
25. Lau KS and Dennis JW: N-Glycans in cancer progression. Glycobiology 18: 750-760, 2008.
26. Roberts OL, Holmes K, Muller J, Cross DA and Cross MJ: ERK5 and the regulation of endothelial cell function. Biochem Soc Trans 37: 1254-1259, 2009.