The human fetal immune response to hepatitis C virus exposure in utero

Journal of Infectious Diseases

Volumn 203, Issue 2, 2011, Pages 196-206

  Babik, Jennifer M ^a   Cohan, Deborah ^a   Monto, Alexander ^b   Hartigan O'Connor, Dennis J ^a   McCune, Joseph M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; GRANZYME; HLA DR ANTIGEN; IMMUNOGLOBULIN M ANTIBODY; INDOLEAMINE 2,3 DIOXYGENASE; VIRUS RNA;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; FEMALE; FETUS; HEPATITIS C VIRUS; HUMAN; IMMUNE RESPONSE; IMMUNOPHENOTYPING; MALE; MONONUCLEAR CELL; NEWBORN; PRENATAL EXPOSURE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SEROLOGY; STAINING; T LYMPHOCYTE ACTIVATION; UMBILICAL CORD BLOOD;

ADULT; CYTOKINES; FEMALE; FETAL BLOOD; FETAL DISEASES; GRANZYMES; HEPACIVIRUS; HEPATITIS C; HEPATITIS C ANTIBODIES; HUMANS; IMMUNE TOLERANCE; IMMUNOGLOBULIN M; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; INFANT, NEWBORN; INFLAMMATION; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE SUBSETS; MALE; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS;

EID: 79851477292     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jiq044     Document Type: Article

References (46)

1. Wasley A, Alter MJ. Epidemiology of hepatitis C: Geographic differences and temporal trends. Semin Liver Dis 2000; 20:1-16. (Pubitemid 30421405)
2. Indolfi G, Resti M. Perinatal transmission of hepatitis C virus infection. J Med Virol 2009; 81:836-43.
3. Yeung LT, King SM, Roberts EA. Mother-to-infant transmission of hepatitis C virus. Hepatology 2001; 34:223-9. (Pubitemid 32702332)
4. Mok J, Pembrey L, Tovo PA, Newell ML. European Paediatric Hepatitis C Virus Network. When does mother to child transmission of hepatitis C virus occur? Arch Dis Child Fetal Neonatal Ed 2005; 90:F156-60.
5. European Paediatric Hepatitis C Virus Network. A significant sex-but not elective cesarean section-effect on mother-to-child transmission of hepatitis C virus infection. J Infect Dis 2005; 192:1872-9.
6. Bosi I, Ancora G, Mantovani W, et al. HLA DR13 and HCV vertical infection. Pediatr Res 2002; 51:746-9. (Pubitemid 34547339)
7. Mold JE, Michaëlsson J, Burt TD, et al. Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero. Science 2008; 322:1562-5.
8. Gammill HS, Nelson JL. Naturally acquired microchimerism. Int J Dev Biol 2010; 54:531-43.
9. Browne JC, Veall N. The maternal placental blood flow in normotensive and hypertensive women. J Obstet Gynaecol Br Emp 1953; 60:141-7.
10. Holt P. Functionally mature virus-specific CD8 T memory cells in congenitally infected newborns: Proof of principle for neonatal vaccination? J Clin Invest 2003; 111:1645-7.
11. Trowsdale J, Betz AG. Mother's little helpers: Mechanisms of maternalfetal tolerance. Nat Immunol 2006; 7:241-6.
12. Levy O. Innate immunity of the newborn: Basic mechanisms and clinical correlates. Nat Rev Immunol 2007; 7:379-90. (Pubitemid 46674489)
13. Munn DH, Zhou M, Attwood JT, et al. Prevention of allogeneic fetal rejection by tryptophan catabolism. Science 1998; 281:1191-3. (Pubitemid 28406294)
14. Fuss IJ, Kanof ME, Smith PD, Zola H. Isolation of whole mononuclear cells from peripheral blood and cord blood. Curr Protoc Immunol 2009; 85:7.1.1-.8.
15. H17 to regulatory T cells in HIV disease. Sci Transl Med 2010; 2:32ra36.
16. Baecher-Allan C, Wolf E, Hafler DA. MHC class II expression identifies functionally distinct human regulatory T cells. J Immunol 2006; 176:4622-31.
17. Emu B, Sinclair E, Favre D, et al. Phenotypic, functional, and kinetic parameters associated with apparent T-cell control of human immunodeficiency virus replication in individuals with and without antiretroviral treatment. J Virol 2005; 79:14169-78. (Pubitemid 41552715)
18. Quinti I, Hassan NF, El Salman D, et al. Hepatitis C virus-specific B cell activation: IgG and IgM detection in acute and chronic hepatitis C. J Hepatol 1995; 23:640-7. (Pubitemid 26013273)
19. Pawlotsky JM, Darthuy F, Rémiré J, et al. Significance of anti-hepatitis C virus core IgM antibodies in patients with chronic hepatitis C. J Med Virol 1995; 47:285-91.
20. Nikolaeva LI, Blokhina NP, Tsurikova NN, et al. Virus-specific antibody titres in different phases of hepatitis C virus infection. J Viral Hepat 2002; 9:429-37. (Pubitemid 35373764)
21. Avrech OM, Samra Z, Lazarovich Z, Caspi E, Jacobovich A, Sompolinsky D. Efficacy of the placental barrier for immunoglobulins: Correlations between maternal, paternal and fetal immunoglobulin levels. Int Arch Allergy Immunol 1994; 103:160-5. (Pubitemid 24038202)
22. Landor M. Maternal-fetal transfer of immunoglobulins. Ann Allergy Asthma Immunol 1995; 74:279-83.
23. McDonagh S, Maidji E, Ma W, Chang HT, Fisher S, Pereira L. Viral and bacterial pathogens at the maternal-fetal interface. J Infect Dis 2004; 190:826-34. (Pubitemid 39050014)
24. Dye JF, Jablenska R, Donnelly JL, et al. Phenotype of the endothelium in the human term placenta. Placenta 2001; 22:32-43. (Pubitemid 32124094)
25. Ethier-Chiasson M, Duchesne A, Forest JC, et al. Influence of maternal lipid profile on placental protein expression of LDLr and SR-BI. Biochem Biophys Res Commun 2007; 359:8-14. (Pubitemid 46836663)
26. Soilleux EJ, Barten R, Trowsdale J. DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13. J Immunol 2000; 165:2937-42.
27. Yao ZQ, Eisen-Vandervelde A, Waggoner SN, Cale EM, Hahn YS. Direct binding of hepatitis C virus core to gC1qR on CD4+ and CD8+ T cells leads to impaired activation of Lck and Akt. J Virol 2004; 78:6409-19. (Pubitemid 38715939)
28. Kimball P, Verbeke S, Shiffman M. HCV core protein augments cyclosporine immunosuppression. Transplant Proc 2005; 37:652-3. (Pubitemid 40590659)
29. Hygino J, Lima PG, Filho RG, et al. Altered immunological reactivity in HIV-1-exposed uninfected neonates. Clin Immunol 2008; 127:340-7.
30. Vanderbeeken Y, Sarfati M, Bose R, Delespesse G. In utero immunization of the fetus to tetanus by maternal vaccination during pregnancy. Am J Reprod Immunol Microbiol 1985; 8:39-42.
31. Hahn-Zoric M, Carlsson B, Björkander J, Osterhaus AD, Mellander L, Hanson LA. Presence of non-maternal antibodies in newborns of mothers with antibody deficiencies. Pediatr Res 1992; 32:150-4.
32. Fainboim L, Cherñavsky A, Paladino N, Flores AC, Arruvito L. Cytokines and chronic liver disease. Cytokine Growth Factor Rev 2007; 18:143-57. (Pubitemid 46420550)
33. Joshi D, James A, Quaglia A, Westbrook RH, Heneghan MA. Liver disease in pregnancy. Lancet 2010; 375:594-605.
34. Vermijlen D, Brouwer M, Donner C, et al. Human cytomegalovirus elicits fetal cd T cell responses in utero. J Exp Med 2010; 207:807-21.
35. Fievet N, Varani S, Ibitokou S, et al. Plasmodium falciparum exposure in utero, maternal age and parity influence the innate activation of foetal antigen presenting cells. Malar J 2009; 8:251.
36. Hermann E, Alonso-Vega C, Berthe A, et al. Human congenital infection with Trypanosoma cruzi induces phenotypic and functional modifications of cord blood NK cells. Pediatr Res 2006; 60:38-43. (Pubitemid 44297610)
37. Ricci E, Malacrida S, Zanchetta M, et al. Toll-like receptor 9 polymorphisms influence mother-to-child transmission of human immunodeficiency virus type 1. J Transl Med 2010; 8:49.
38. Renneson J, Dutta B, Goriely S, et al. IL-12 and type I IFN response of neonatal myeloid DC to human CMV infection. Eur J Immunol 2009; 39:2789-99.
39. Vekemans J, Truyens C, Torrico F, et al. Maternal Trypanosoma cruzi infection upregulates capacity of uninfected neonate cells to produce pro- and anti-inflammatory cytokines. Infect Immun 2000; 68:5430-4.
40. Kuhn L, Coutsoudis A, Moodley D, et al. Interferon-gamma and interleukin-10 production among HIV-1-infected and uninfected infants of HIV-1-infected mothers. Pediatr Res 2001; 50:412-6. (Pubitemid 32801968)
41. Flanagan KL, Halliday A, Burl S, et al. The effect of placental malaria infection on cord blood and maternal immunoregulatory responses at birth. Eur J Immunol 2010; 40:1062-72.
42. Falconer K, Gonzalez VD, Reichard O, Sandberg JK, Alaeus A. Spontaneous HCV clearance in HCV/HIV-1 coinfection associated with normalized CD4 counts, low level of chronic immune activation and high level of T cell function. J Clin Virol 2008; 41:160-3.
43. White GP, Watt PM, Holt BJ, Holt PG. Differential patterns of methylation of the IFN-c promoter at CpG and non-CpG sites underlie differences in IFN-c gene expression between human neonatal and adult CD45RO- T cells. J Immunol 2002; 168:2820-7. (Pubitemid 34211661)
44. Prescott SL, Holt PG. Abnormalities in cord blood mononuclear cytokine production as a predictor of later atopic disease in childhood. Clin Exp Allergy 1998; 28:1313-6. (Pubitemid 28559002)
45. Kondo N, Kobayashi Y, Shinoda S, et al. Reduced interferon gamma production by antigen-stimulated cord blood mononuclear cells is a risk factor of allergic disorders - 6-year follow-up study. Clin Exp Allergy 1998; 28:1340-4. (Pubitemid 28559007)
46. Dauby N, Alonso-Vega C, Suarez E, et al. Maternal infection with Trypanosoma cruzi and congenital Chagas disease induce a trend to a type 1 polarization of infant immune responses to vaccines. PLoS Negl Trop Dis 2009; 3:e571.