Genistein enhances relaxation of the spontaneously hypertensive rat aorta by transactivation of epidermal growth factor receptor following binding to membrane estrogen receptors-α and activation of a G protein-coupled, endothelial nitric oxide synthase-dependent pathway

Pharmacological Research

Volumn 63, Issue 3, 2011, Pages 181-189

  Lin, Amanda H Y ^a   Leung, George P H ^a   Leung, Susan W S ^a   Vanhoutte, Paul M ^a   Man, Ricky Y K ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

eNOS; Epidermal growth factor receptor transactivation; G protein activation; Genistein; Membrane estrogen receptor

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; ACETYLCHOLINE; CALCIMYCIN; CYCLOHEXIMIDE; DACTINOMYCIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; EPIDERMAL GROWTH FACTOR RECEPTOR; ESTROGEN RECEPTOR ALPHA; FULVESTRANT; GENISTEIN; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; PROTEIN G; TYRPHOSTIN;

ACETYLCHOLINE RELEASE; ANIMAL TISSUE; AORTA; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG RECEPTOR BINDING; ENZYME ACTIVATION; ENZYME INHIBITION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; RECEPTOR BINDING; VASCULAR ENDOTHELIUM; VASOCONSTRICTION; VASODILATATION;

ANIMALS; AORTA, THORACIC; ENZYME ACTIVATION; ESTROGEN RECEPTOR ALPHA; GENISTEIN; GTP-BINDING PROTEINS; HYPERTENSION; MALE; NITRIC OXIDE SYNTHASE TYPE III; ORGAN CULTURE TECHNIQUES; PROTEIN BINDING; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; VASODILATION;

EID: 79751528958     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2010.11.007     Document Type: Article

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