Tryptase staining of mast cells may differentiate eosinophilic esophagitis from gastroesophageal reflux disease

American Journal of Gastroenterology

Volumn 106, Issue 2, 2011, Pages 264-271

  Dellon, Evan S ^a   Chen, Xiaoxin ^b   Miller, C Ryan ^a   Fritchie, Karen J ^a   Rubinas, Tara C ^a   Woosley, John T ^a   Shaheen, Nicholas J ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b NORTH CAROLINA CENTRAL UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRYPTASE;

ADULT; ARTICLE; CELL DENSITY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; EOSINOPHIL COUNT; EOSINOPHILIC ESOPHAGITIS; ESOPHAGUS BIOPSY; FEMALE; GASTROESOPHAGEAL REFLUX; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MAST CELL; PATHOGENESIS; PRIORITY JOURNAL;

ADULT; AREA UNDER CURVE; BIOPSY; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; EOSINOPHILIC ESOPHAGITIS; FEMALE; GASTROESOPHAGEAL REFLUX; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MAST CELLS; ROC CURVE; TRYPTASES;

EID: 79751524799     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1038/ajg.2010.412     Document Type: Article

References (33)

1. Furuta GT, Liacouras CA, Collins MH et al. Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment. Gastroenterology 2007; 133: 1342-63.
2. Spechler SJ, Genta RM, Souza RF. Th oughts on the complex relationship between gastroesophageal reflux disease and eosinophilic esophagitis. Am J Gastroenterol 2007; 102: 1301-6. (Pubitemid 46802025)
3. Noel RJ, Tipnis NA. Eosinophilic esophagitis - a mimic of GERD. Int J Pediatr Otorhinolaryngol 2006; 70: 1147-53.
4. Sgouros SN, Bergele C, Mantides A. Eosinophilic esophagitis in adults: a systematic review. Eur J Gastroenterol Hepatol 2006; 18: 211-7. (Pubitemid 43361608)
5. Dellon ES, Aderoju A, Woosley JT et al. Variability in diagnostic criteria for eosinophilic esophagitis: a systematic review. Am J Gastroenterol 2007; 102: 2300-13. (Pubitemid 47493837)
6. Molina-Infante J, Ferrando-Lamana L, Mateos-Rodriguez JM et al. Overlap of reflux and eosinophilic esophagitis in two patients requiring diff erent therapies: a review of the literature. World J Gastroenterol 2008; 14: 1463-6. (Pubitemid 351425234)
7. Dellon ES, Gibbs WB, Fritchie KJ et al. Clinical, endoscopic, and histologic findings distinguish eosinophilic esophagitis from gastroesophageal reflux disease. Clin Gastroenterol Hepatol 2009; 104: 2695-703.
8. Ngo P, Furuta GT, Antonioli DA et al. Eosinophils in the esophagus- peptic or allergic eosinophilic esophagitis? Case series of three patients wiThesophageal eosinophilia. Am J Gastroenterol 2006; 101: 1666-70.
9. Rodrigo S, Abboud G, Oh D et al. High intraepithelial eosinophil counts in esophageal squamous epithelium are not specific for eosinophilic esophagitis in adults. Am J Gastroenterol 2008; 103: 435-42. (Pubitemid 351248715)
10. Dellon ES, Farrell TM, Bozymski EM et al. Diagnosis of eosinophilic esophagitis after fundoplication for " refractory reflux ": implications for preoperative evaluation. Dis Esophagus 2009; 23: 191-5.
11. Straumann A, Bauer M, Fischer B et al. Idiopathic eosinophilic esophagitis is associated with a T(H)2-type allergic inflammatory response. J Allergy Clin Immunol 2001; 108: 954-61. (Pubitemid 33151548)
12. Gupta SK, Fitzgerald JF, Kondratyuk T et al. Cytokine expression in normal and inflamed esophageal mucosa: a study into the pathogenesis of allergic eosinophilic esophagitis. J Pediatr Gastroenterol Nutr 2006; 42: 22-6. (Pubitemid 43061005)
13. Blanchard C, Wang N, Stringer KF et al. Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis. J Clin Invest 2006; 116: 536-47. (Pubitemid 43228372)
14. Kirsch R, Bokhary R, Marcon MA et al. Activated mucosal mast cells diff erentiate eosinophilic (allergic) esophagitis from gastroesophageal reflux disease. J Pediatr Gastroenterol Nutr 2007; 44: 20-6. (Pubitemid 46071787)
15. Lucendo AJ, Navarro M, Comas C et al. Immunophenotypic characterization and quantification of the epithelial inflammatory infi ltrate in eosinophilic esophagitis through stereology: an analysis of the cellular mechanisms of the disease and the immunologic capacity of the esophagus. Am J Surg Pathol 2007; 31: 598-606. (Pubitemid 46569045)
16. Mueller S, Neureiter D, Aigner T et al. Comparison of histological parameters for the diagnosis of eosinophilic oesophagitis versus gastrooesophageal reflux disease on oesophageal biopsy material. Histopathology 2008; 53: 676-84. (Pubitemid 352768719)
17. Chehade M, Sampson HA, Morotti RA et al. Esophageal subepithelial fibrosis in children wiTheosinophilic esophagitis. J Pediatr Gastroenterol Nutr 2007; 45: 319-28. (Pubitemid 47415083)
18. Abonia JP, Blanchard C, Butz BB et al. Involvement of mast cells in eosinophilic esophagitis. J Allergy Clin Immunol 2010; 126: 140-9.
19. Mishra A, Rothenberg ME. Intratracheal IL-13 induces eosinophilic esophagitis by an IL-5, eotaxin-1, and STAT6-dependent mechanism. Gastroenterology 2003; 125: 1419-27. (Pubitemid 37409762)
20. Blanchard C, Mingler MK, Vicario M et al. IL-13 involvement in eosinophilic esophagitis: transcriptome analysis and reversibility with glucocorticoids. J Allergy Clin Immunol 2007; 120: 1292-300. (Pubitemid 350225686)
21. Aceves SS, Newbury RO, Dohil R et al. Esophageal remodeling in pediatric eosinophilic esophagitis. J Allergy Clin Immunol 2007; 119: 206-12. (Pubitemid 46037819)
22. Lucendo AJ, Bellon T, Lucendo B. The role of mast cells in eosinophilic esophagitis. Pediatr Allergy Immunol 2009; 20: 512-8.
23. Wershil BK. Exploring the role of mast cells in eosinophilic esophagitis. Immunol Allergy Clin North Am 2009; 29: 189-95.
24. Dellon ES, Fritchie KJ, Rubinas TC et al. Inter- and intra-observer reliability and validation of a new method for determination of eosinophil counts in patients wiThesophageal eosinophilia. Dig Dis Sci 2009; 55: 1940-9.
25. Rothenberg ME. Biology and treatment of eosinophilic esophagitis. Gastroenterology 2009; 137: 1238-49.
26. Rothenberg ME, Hogan SP. The eosinophil. Annu Rev Immunol 2006; 24: 147-74.
27. Straumann A, Spichtin HP, Grize L et al. Natural history of primary eosinophilic esophagitis: a follow-up of 30 adult patients for up to 11.5 years. Gastroenterology 2003; 125: 1660-9. (Pubitemid 37500430)
28. Liacouras CA, Spergel JM, Ruchelli E et al. Eosinophilic esophagitis: a 10-year experience in 381 children. Clin Gastroenterol Hepatol 2005; 3: 1198-206. (Pubitemid 41797671)
29. Gonsalves N, Policarpio-Nicolas M, Zhang Q et al. Histopathologic variability and endoscopic correlates in adults wiTheosinophilic esophagitis. Gastrointest Endosc 2006; 64: 313-9. (Pubitemid 44233586)
30. Prasad GA, Talley NJ, Romero Y et al. Prevalence and predictive factors of eosinophilic esophagitis in patients presenting with dysphagia: a prospective study. Am J Gastroenterol 2007; 102: 2627-32. (Pubitemid 350179332)
31. Veerappan GR, Perry JL, Duncan TJ et al. Prevalence of eosinophilic esophagitis in an adult population undergoing upper endoscopy: a prospective study. Clin Gastroenterol Hepatol 2009; 7: 420-6.
32. Merwat SN, Spechler SJ. Might the use of acid-suppressive medications predispose to the development of eosinophilic esophagitis? Am J Gastro enterol 2009; 104: 1897-902.
33. Kedika RR, Souza RF, Spechler SJ. Potential anti-inflammatory Effects of proton pump inhibitors: a review and discussion of the clinical implications. Dig Dis Sci 2009; 54: 2312-7 .