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Guarantor of the article: Jeffery A. Alexander, M.D. Specific author contributions: Ganapathy A. Prasad: study design, manuscript preparation and revision, data extraction, statistical analysis, corresponding author. Nicholas J. Talley: study design and manuscript revision. Yvonne Romero: study design and manuscript revision. Thomas C. Smyrk: interpretation of pathology specimens and manuscript revision. Lori A. Kryzer: data extraction and entry. Amindra S. Arora: study design and manuscript revision. Jeffery A. Alexander: concept, study design, manuscript revision, guarantor, senior author. Financial support: An unrestricted grant was received from GlaxoSmithKline to support this project. Potential competing interests: N.J. Talley: research support from GlaxoSmithKline.
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