메뉴 건너뛰기




Volumn 31, Issue 1, 2011, Pages 27-34

Clinical evidence on the use of anti-mTOR drugs in renal transplantation;Evidencias clínicas sobre el uso de los fármacos anti-mTOR en el trasplante renal

Author keywords

Anti mTOR drugs; Everolimus; Proliferation signal inhibitors; Renal transplantation; Sirolimus

Indexed keywords

CALCINEURIN; DRUG DERIVATIVE; EVEROLIMUS; IMMUNOSUPPRESSIVE AGENT; MTOR PROTEIN, HUMAN; RAPAMYCIN; TARGET OF RAPAMYCIN KINASE;

EID: 79751504331     PISSN: 02116995     EISSN: None     Source Type: Journal    
DOI: 10.3265/Nefrologia.pre2010.Jul.10512     Document Type: Review
Times cited : (30)

References (73)
  • 1
    • 1442338509 scopus 로고    scopus 로고
    • Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era
    • Meier-Kriesche HU, Schold JD, Srinivas TR, Kaplan B. Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era. Am J Transplant 2004;4:378-83.
    • (2004) Am J Transplant , vol.4 , pp. 378-383
    • Meier-Kriesche, H.U.1    Schold, J.D.2    Srinivas, T.R.3    Kaplan, B.4
  • 2
    • 72049105867 scopus 로고    scopus 로고
    • The role of the mammalian target of rapamycin (mTOR) in renal disease
    • Lieberthal W, Levine JS. The role of the mammalian target of rapamycin (mTOR) in renal disease. J Am Soc Nephrol 2009;20:2493-502.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 2493-2502
    • Lieberthal, W.1    Levine, J.S.2
  • 3
    • 0345161813 scopus 로고    scopus 로고
    • Sirolimus (rapamycin)-based therapy in human renal transplantation: similar efficacy and different toxicity compared with cyclosporine. Sirolimus European Renal Transplant Study Group
    • Groth CG, Backman L, Morales JM, Calne R, Kreis H, Lang P, et al. Sirolimus (rapamycin)-based therapy in human renal transplantation: similar efficacy and different toxicity compared with cyclosporine. Sirolimus European Renal Transplant Study Group. Transplantation 1999;67:1036-42.
    • (1999) Transplantation , vol.67 , pp. 1036-1042
    • Groth, C.G.1    Backman, L.2    Morales, J.M.3    Calne, R.4    Kreis, H.5    Lang, P.6
  • 4
    • 18244427344 scopus 로고    scopus 로고
    • Sirolimus in association with mycophenolate mofetil induction for the prevention of acute graft rejection in renal allograft recipients
    • Kreis H, Cisterne JM, Land W, Wramner L, Squifflet JP, Abramowicz D, et al. Sirolimus in association with mycophenolate mofetil induction for the prevention of acute graft rejection in renal allograft recipients. Transplantation 2000;69:1252-60.
    • (2000) Transplantation , vol.69 , pp. 1252-1260
    • Kreis, H.1    Cisterne, J.M.2    Land, W.3    Wramner, L.4    Squifflet, J.P.5    Abramowicz, D.6
  • 5
    • 0033770939 scopus 로고    scopus 로고
    • Avoidance of cyclosporine in renal transplantation: effects of daclizumab, mycophenolate mofetil, and steroids
    • Tran HT, Acharya MK, McKay DB, Sayegh MH, Carpenter CB, Auchincloss H, et al. Avoidance of cyclosporine in renal transplantation: effects of daclizumab, mycophenolate mofetil, and steroids. J Am Soc Nephrol 2000;11:1903-9.
    • (2000) J Am Soc Nephrol , vol.11 , pp. 1903-1909
    • Tran, H.T.1    Acharya, M.K.2    McKay, D.B.3    Sayegh, M.H.4    Carpenter, C.B.5    Auchincloss, H.6
  • 6
    • 0035872742 scopus 로고    scopus 로고
    • Multicenter trial exploring calcineurin inhibitors avoidance in renal transplantation
    • Vincenti F, Ramos E, Brattstrom C, Cho S, Ekberg H, Grinyo J, et al. Multicenter trial exploring calcineurin inhibitors avoidance in renal transplantation. Transplantation 2000;71:1282-7.
    • (2000) Transplantation , vol.71 , pp. 1282-1287
    • Vincenti, F.1    Ramos, E.2    Brattstrom, C.3    Cho, S.4    Ekberg, H.5    Grinyo, J.6
  • 7
    • 0037184316 scopus 로고    scopus 로고
    • Kidney transplantation without calcineurin inhibitor drugs: a prospective, randomized trial of sirolimus versus cyclosporine
    • Flechner SM, Goldfarb D, Modlin C, Feng J, Krishnamurthi V, Mastroianni B, et al. Kidney transplantation without calcineurin inhibitor drugs: a prospective, randomized trial of sirolimus versus cyclosporine. Transplantation 2002;74:1070-6.
    • (2002) Transplantation , vol.74 , pp. 1070-1076
    • Flechner, S.M.1    Goldfarb, D.2    Modlin, C.3    Feng, J.4    Krishnamurthi, V.5    Mastroianni, B.6
  • 8
    • 0345098542 scopus 로고    scopus 로고
    • Calcineurin inhibitor-free immunosuppression based on antithymocyte globulin and mycophenolate mofetil in cadaveric kidney transplantation: results after 5 years
    • Grinyo JM, Gil-Vernet S, Cruzado JM, Caldés A, Riera L, Serón D, et al. Calcineurin inhibitor-free immunosuppression based on antithymocyte globulin and mycophenolate mofetil in cadaveric kidney transplantation: results after 5 years. Transpl Int 2003;16:820-7.
    • (2003) Transpl Int , vol.16 , pp. 820-827
    • Grinyo, J.M.1    Gil-Vernet, S.2    Cruzado, J.M.3    Caldés, A.4    Riera, L.5    Serón, D.6
  • 9
    • 2342596401 scopus 로고    scopus 로고
    • Comparison of sirolimus-based calcineurin inhibitor-sparing and caloriginales inhibitor-free regimens in cadaveric renal transplantation
    • Lo A, Egidi MF, Gaber LW, Amiri HS, Vera S, Nezakatgoo N, et al. Comparison of sirolimus-based calcineurin inhibitor-sparing and caloriginales inhibitor-free regimens in cadaveric renal transplantation. Transplantation 2004;77:1228-35.
    • (2004) Transplantation , vol.77 , pp. 1228-1235
    • Lo, A.1    Egidi, M.F.2    Gaber, L.W.3    Amiri, H.S.4    Vera, S.5    Nezakatgoo, N.6
  • 10
    • 27744512787 scopus 로고    scopus 로고
    • Evidencias en la inmunosupresión de mantenimiento en el trasplante renal
    • Hernández D, González-Posada JM. Evidencias en la inmunosupresión de mantenimiento en el trasplante renal. Nefrologia 2005;25:369-80.
    • (2005) Nefrologia , vol.25 , pp. 369-380
    • Hernández, D.1    González-Posada, J.M.2
  • 11
    • 3142718792 scopus 로고    scopus 로고
    • Everolimus: immunosuppression with antilymphoproliferative therapy
    • Pascual J. Everolimus: immunosuppression with antilymphoproliferative therapy. Nefrologia 2004;24:112-23.
    • (2004) Nefrologia , vol.24 , pp. 112-123
    • Pascual, J.1
  • 12
    • 7244220158 scopus 로고    scopus 로고
    • De novo kidney transplantation without use of calcineurin inhibitors preserves renal structure and function at two years
    • Flechner SM, Kurian SM, Solez K, Cook DJ, Burke JT, Rollin H, et al. De novo kidney transplantation without use of calcineurin inhibitors preserves renal structure and function at two years. Am J Transplant 2004;4:1776-85.
    • (2004) Am J Transplant , vol.4 , pp. 1776-1785
    • Flechner, S.M.1    Kurian, S.M.2    Solez, K.3    Cook, D.J.4    Burke, J.T.5    Rollin, H.6
  • 13
    • 77954088420 scopus 로고    scopus 로고
    • Thymoglobulin induction and sirolimus versus tacrolimus in kidney transplant recipients receiving mycophenolate mofetil and steroids
    • Glotz D, Charpentier B, Abramovicz D, Lang P, Rostaing I, Rifle G, et al. Thymoglobulin induction and sirolimus versus tacrolimus in kidney transplant recipients receiving mycophenolate mofetil and steroids. Transplantation 2010;89:1511-7.
    • (2010) Transplantation , vol.89 , pp. 1511-1517
    • Glotz, D.1    Charpentier, B.2    Abramovicz, D.3    Lang, P.4    Rostaing, I.5    Rifle, G.6
  • 15
    • 77953806817 scopus 로고    scopus 로고
    • Preferential increase in memory and regulatory subsets during T-lymphocyte immune reconstitution after Thymoglobulin induction therapy with maintenance sirolimus vs cyclosporine
    • Morelon E, Lefrançois N, Besson C, Prévautel J, Brunet M, Touraine JL, et al. Preferential increase in memory and regulatory subsets during T-lymphocyte immune reconstitution after Thymoglobulin induction therapy with maintenance sirolimus vs cyclosporine. Transpl Immunol 2010;23:53-8.
    • (2010) Transpl Immunol , vol.23 , pp. 53-58
    • Morelon, E.1    Lefrançois, N.2    Besson, C.3    Prévautel, J.4    Brunet, M.5    Touraine, J.L.6
  • 16
    • 33745801296 scopus 로고    scopus 로고
    • Everolimus in clinical practice renal transplantation
    • Pascual J. Everolimus in clinical practice renal transplantation. Nephrol Dial Transplant 2006;21(Suppl 3):iii18-23.
    • (2006) Nephrol Dial Transplant , vol.21 , Issue.SUPPL. 3
    • Pascual, J.1
  • 17
    • 16244378141 scopus 로고    scopus 로고
    • Everolimus versus mycophenolate mofetil in the prevention of rejection in de novo renal transplant recipients: a 3-year randomized, multicenter, phase III study
    • Lorber MI, Mulgaonkar S, Butt KM, Elkhammas E, Mendez R, Rajagopalan PR, et al. Everolimus versus mycophenolate mofetil in the prevention of rejection in de novo renal transplant recipients: a 3-year randomized, multicenter, phase III study. Transplantation 2005;80:244-52.
    • (2005) Transplantation , vol.80 , pp. 244-252
    • Lorber, M.I.1    Mulgaonkar, S.2    Butt, K.M.3    Elkhammas, E.4    Mendez, R.5    Rajagopalan, P.R.6
  • 18
    • 33644696712 scopus 로고    scopus 로고
    • Three-year efficacy and safety results from a study of everolimus versus mycophenolate mofetil in de novo renal transplant patients
    • Vítko S, Margreiter R, Weimar W, Dantal J, Kuypers D, Winkler M, et al. Three-year efficacy and safety results from a study of everolimus versus mycophenolate mofetil in de novo renal transplant patients. Am J Transplant 2005;5:2521-30.
    • (2005) Am J Transplant , vol.5 , pp. 2521-2530
    • Vítko, S.1    Margreiter, R.2    Weimar, W.3    Dantal, J.4    Kuypers, D.5    Winkler, M.6
  • 19
    • 33845672656 scopus 로고    scopus 로고
    • 12-month safety and efficacy of everolimus with reduced exposure cyclosporine in de novo renal transplant recipients
    • Tedesco-Silva H Jr, Vitko S, Pascual J, Eris J, Magee JC, Whelchel J, et al. 12-month safety and efficacy of everolimus with reduced exposure cyclosporine in de novo renal transplant recipients. Transpl Int 2007;20:27-36.
    • (2007) Transpl Int , vol.20 , pp. 27-36
    • Tedesco-Silva Jr., H.1    Vitko, S.2    Pascual, J.3    Eris, J.4    Magee, J.C.5    Whelchel, J.6
  • 20
    • 73849119625 scopus 로고    scopus 로고
    • Everolimus with very low-exposure cyclosporine a in de novo kidney transplantation: a multicenter, randomized, controlled trial
    • Salvadori M, Scolari MP, Bertoni E, Citterio F, Rigotti P, Cossu M, et al. Everolimus with very low-exposure cyclosporine a in de novo kidney transplantation: a multicenter, randomized, controlled trial. Transplantation 2009;88:1194-202.
    • (2009) Transplantation , vol.88 , pp. 1194-1202
    • Salvadori, M.1    Scolari, M.P.2    Bertoni, E.3    Citterio, F.4    Rigotti, P.5    Cossu, M.6
  • 21
    • 77952945224 scopus 로고    scopus 로고
    • Everolimus plus reduced-exposure CsA versus mycophenolic acid plus standard-exposure CsA in renal-transplant recipients
    • Tedesco Silva H Jr, Cibrik D, Johnston T, Lackova E, Mange K, Panis C, et al. Everolimus plus reduced-exposure CsA versus mycophenolic acid plus standard-exposure CsA in renal-transplant recipients. Am J Transplant 2010;10:1401-13.
    • (2010) Am J Transplant , vol.10 , pp. 1401-1413
    • Tedesco Silva Jr., H.1    Cibrik, D.2    Johnston, T.3    Lackova, E.4    Mange, K.5    Panis, C.6
  • 22
    • 77957583305 scopus 로고    scopus 로고
    • Efficacy and safety of de novo or early everolimus with low cyclosporine in deceased-donor kidney transplant recipients at specified risk of delayed graft function: 12-month results of a randomized, multicenter trial
    • May 24, [Epub ahead of print]
    • Dantal J, Berthoux F, Moal MC, Rostaing L, Legendre C, Genin R, et al. Efficacy and safety of de novo or early everolimus with low cyclosporine in deceased-donor kidney transplant recipients at specified risk of delayed graft function: 12-month results of a randomized, multicenter trial. Transpl Int 2010 May 24 [Epub ahead of print].
    • (2010) Transpl Int
    • Dantal, J.1    Berthoux, F.2    Moal, M.C.3    Rostaing, L.4    Legendre, C.5    Genin, R.6
  • 23
    • 41149117599 scopus 로고    scopus 로고
    • Multicenter, randomized study of the use of everolimus with tacrolimus after renal transplantation demonstrates its effectiveness
    • Chan L, Greenstein S, Hardy MA, Hartmann E, Bunnapradist S, Cibrik D, et al. Multicenter, randomized study of the use of everolimus with tacrolimus after renal transplantation demonstrates its effectiveness. Transplantation 2008;85:821-6.
    • (2008) Transplantation , vol.85 , pp. 821-826
    • Chan, L.1    Greenstein, S.2    Hardy, M.A.3    Hartmann, E.4    Bunnapradist, S.5    Cibrik, D.6
  • 24
    • 77951296433 scopus 로고    scopus 로고
    • Interaction between everolimus and tacrolimus in renal transplant recipients: a pharmacokinetic controlled trial
    • Pascual J, Del Castillo D, Cabello M, Pallardó L, Grinyó JM, Fernáncasdez AM, et al. Interaction between everolimus and tacrolimus in renal transplant recipients: a pharmacokinetic controlled trial. Transplantation 2010;89:994-1000.
    • (2010) Transplantation , vol.89 , pp. 994-1000
    • Pascual, J.1    Del Castillo, D.2    Cabello, M.3    Pallardó, L.4    Grinyó, J.M.5    Fernáncasdez, A.M.6
  • 26
    • 67651039979 scopus 로고    scopus 로고
    • Incidence of delayed graft function and wound healing complications after deceased-donor kidney transplantation is not affected by de novo everolimus
    • Albano L, Berthoux F, Moal MC, Rostaing L, Legendre C, Genin R, et al. Incidence of delayed graft function and wound healing complications after deceased-donor kidney transplantation is not affected by de novo everolimus. Transplantation 2009;88:69-76.
    • (2009) Transplantation , vol.88 , pp. 69-76
    • Albano, L.1    Berthoux, F.2    Moal, M.C.3    Rostaing, L.4    Legendre, C.5    Genin, R.6
  • 27
    • 33749601684 scopus 로고    scopus 로고
    • Retrospective analysis of surgical complications following cadaveric kidney transplantation in the modern transplant era
    • Hernández D, Rufino M, Armas S, González A, Gutiérrez P, Barbero P, et al. Retrospective analysis of surgical complications following cadaveric kidney transplantation in the modern transplant era. Nephrol Dial Transplant 2006;21:2908-15.
    • (2006) Nephrol Dial Transplant , vol.21 , pp. 2908-2915
    • Hernández, D.1    Rufino, M.2    Armas, S.3    González, A.4    Gutiérrez, P.5    Barbero, P.6
  • 28
    • 74949094555 scopus 로고    scopus 로고
    • KDIGO clinical practice guideline for the care of kidney transplant recipients
    • Kidney Disease: Improving Global Outcomes (KDIGO) Transplant Work Group
    • Kidney Disease: Improving Global Outcomes (KDIGO) Transplant Work Group. KDIGO clinical practice guideline for the care of kidney transplant recipients. Am J Transplant 2009;9(Suppl 3):S1-155.
    • (2009) Am J Transplant , vol.9 , Issue.SUPPL. 3
  • 29
    • 21344467016 scopus 로고    scopus 로고
    • Calcineurin inhibitor withdrawal from sirolimus-based therapy in kidney transplantation: a systematic review of randomized trials
    • Mulay AV, Hussain N, Fergusson D, Knoll GA. Calcineurin inhibitor withdrawal from sirolimus-based therapy in kidney transplantation: a systematic review of randomized trials. Am J Transplant 2005;5:1748-56.
    • (2005) Am J Transplant , vol.5 , pp. 1748-1756
    • Mulay, A.V.1    Hussain, N.2    Fergusson, D.3    Knoll, G.A.4
  • 30
    • 77954952597 scopus 로고    scopus 로고
    • Renal function, efficacy, and safety of sirolimus and mycophenolate mofetil after short-term calcineurin inhibitor-based quadruple therapy in de novo renal transplant patients: one-year analysis of a randomized multicenter trial
    • SMART-Study Group
    • Guba M, Pratschke J, Hugo C, Krämer BK, Nohr-Westphal C, Brockmann J, SMART-Study Group. Renal function, efficacy, and safety of sirolimus and mycophenolate mofetil after short-term calcineurin inhibitor-based quadruple therapy in de novo renal transplant patients: one-year analysis of a randomized multicenter trial. Transplantation 2010; 90 :175-83.
    • (2010) Transplantation , vol.90 , pp. 175-183
    • Guba, M.1    Pratschke, J.2    Hugo, C.3    Krämer, B.K.4    Nohr-Westphal, C.5    Brockmann, J.6
  • 31
    • 52449098695 scopus 로고    scopus 로고
    • Improved renal function, with similar proteinuria, after two years of early tacrolimus withdrawal from a regimen of sirolimus plus tacrolimus
    • Morales JM, Grinyó JM, Campistol JM, García-Martínez J, Arias M, Paul J, et al. Improved renal function, with similar proteinuria, after two years of early tacrolimus withdrawal from a regimen of sirolimus plus tacrolimus. Transplantation 2008;86:620-2.
    • (2008) Transplantation , vol.86 , pp. 620-622
    • Morales, J.M.1    Grinyó, J.M.2    Campistol, J.M.3    García-Martínez, J.4    Arias, M.5    Paul, J.6
  • 32
    • 77951687018 scopus 로고    scopus 로고
    • Intrarenal vascular resistance parameters in kidney transplant patients receiving calcineurin inhibitor-based or sirolimus-based regimens
    • Lee PC, Lee CY, Hu RH, Lo C, Tsai MK, Lee PH. Intrarenal vascular resistance parameters in kidney transplant patients receiving calcineurin inhibitor-based or sirolimus-based regimens. Nephrol Dial Transplant 2010;25:1675-80.
    • (2010) Nephrol Dial Transplant , vol.25 , pp. 1675-1680
    • Lee, P.C.1    Lee, C.Y.2    Hu, R.H.3    Lo, C.4    Tsai, M.K.5    Lee, P.H.6
  • 33
    • 59649126728 scopus 로고    scopus 로고
    • Conversion from calcineurin inhibitors to sirolimus maintenance therapy in renal allograft recipients: 24-month efficacy and safety results from the CONVERT trial
    • Schena FP, Pascoe MD, Alberu J, del Carmen Rial M, Oberbauer R, Brennan DC, et al. Conversion from calcineurin inhibitors to sirolimus maintenance therapy in renal allograft recipients: 24-month efficacy and safety results from the CONVERT trial. Transplantation 2009;87:233-42.
    • (2009) Transplantation , vol.87 , pp. 233-242
    • Schena, F.P.1    Pascoe, M.D.2    Alberu, J.3    del Carmen Rial, M.4    Oberbauer, R.5    Brennan, D.C.6
  • 34
    • 65249134974 scopus 로고    scopus 로고
    • Efficacy on renal function of early conversion from cyclosporine to sirolimus 3 months after renal transplantation: concept study
    • Lebranchu Y, Thierry A, Toupance O, Westeel PF, Etienne I, Thervet E, et al. Efficacy on renal function of early conversion from cyclosporine to sirolimus 3 months after renal transplantation: concept study. Am J Transplant 2009;9:1115-23.
    • (2009) Am J Transplant , vol.9 , pp. 1115-1123
    • Lebranchu, Y.1    Thierry, A.2    Toupance, O.3    Westeel, P.F.4    Etienne, I.5    Thervet, E.6
  • 35
    • 70350126186 scopus 로고    scopus 로고
    • Interstitial fibrosis quantification in renal transplant recipients randomized to continue cyclosporine or convert to sirolimus
    • Servais A, Meas-Yedid V, Toupance O, Lebranchu Y, Thierry A, Moulin B, et al. Interstitial fibrosis quantification in renal transplant recipients randomized to continue cyclosporine or convert to sirolimus. Am J Transplant 2009;9:2552-60.
    • (2009) Am J Transplant , vol.9 , pp. 2552-2560
    • Servais, A.1    Meas-Yedid, V.2    Toupance, O.3    Lebranchu, Y.4    Thierry, A.5    Moulin, B.6
  • 36
    • 43749098555 scopus 로고    scopus 로고
    • Early, abrupt conversion of de novo renal transplant patients from cyclosporine to everolimus: results of a pilot study
    • Holdaas H, Bentdal O, Pfeffer P, Mjørnstedt L, Solbu D, Midtvedt K. Early, abrupt conversion of de novo renal transplant patients from cyclosporine to everolimus: results of a pilot study. Clin Transplant 2008;22:366-71.
    • (2008) Clin Transplant , vol.22 , pp. 366-371
    • Holdaas, H.1    Bentdal, O.2    Pfeffer, P.3    Mjørnstedt, L.4    Solbu, D.5    Midtvedt, K.6
  • 37
    • 34548689882 scopus 로고    scopus 로고
    • Use of the new proliferation signal inhibitor everolimus in renal transplant patients in Spain: preliminary results of the EVERODATA registry
    • Ruiz JC, Sánchez A, Rengel M, Beneyto I, Plaza JJ, Zárraga S, et al. Use of the new proliferation signal inhibitor everolimus in renal transplant patients in Spain: preliminary results of the EVERODATA registry. Transplant Proc 2007;39:2157-9.
    • (2007) Transplant Proc , vol.39 , pp. 2157-2159
    • Ruiz, J.C.1    Sánchez, A.2    Rengel, M.3    Beneyto, I.4    Plaza, J.J.5    Zárraga, S.6
  • 41
    • 79751496260 scopus 로고    scopus 로고
    • Early everolimus introduction and calcineurine inhibitor withdrawal in renal transplant patients: a multicenter, randomized open-label study (The ERIC study) [abstract]
    • Sánchez-Fructuoso A, Ruiz JC, Hernández D, Sánchez-Plumed J, Fernández A, Pastor Rodríguez A, et al. Early everolimus introduction and calcineurine inhibitor withdrawal in renal transplant patients: a multicenter, randomized open-label study (The ERIC study) [abstract]. Am J Transplant 2010;10(Suppl. 4):506.
    • (2010) Am J Transplant , vol.10 , Issue.SUPPL. 4 , pp. 506
    • Sánchez-Fructuoso, A.1    Ruiz, J.C.2    Hernández, D.3    Sánchez-Plumed, J.4    Fernández, A.5    Pastor Rodríguez, A.6
  • 42
    • 0042968648 scopus 로고    scopus 로고
    • Apoptosis and treatment of chronic allograft nephropathy with everolimus
    • Lutz J, Zou H, Liu S, Antus B, Heemann U. Apoptosis and treatment of chronic allograft nephropathy with everolimus. Transplantation 2003;76:508-15.
    • (2003) Transplantation , vol.76 , pp. 508-515
    • Lutz, J.1    Zou, H.2    Liu, S.3    Antus, B.4    Heemann, U.5
  • 43
    • 33947543050 scopus 로고    scopus 로고
    • Effects of everolimus on cellular and humoral immune processes leading to chronic allograft nephropathy in a rat model with sensitized recipients
    • Koch M, Mengel M, Poehnert D, Nashan B. Effects of everolimus on cellular and humoral immune processes leading to chronic allograft nephropathy in a rat model with sensitized recipients. Transplantation 2007;83:498-50.
    • (2007) Transplantation , vol.83 , pp. 498-550
    • Koch, M.1    Mengel, M.2    Poehnert, D.3    Nashan, B.4
  • 44
    • 2942534405 scopus 로고    scopus 로고
    • Sirolimus-based therapy following early cyclosporine withdrawal provides significantly improved renal histology and function at 3 years
    • Mota A, Arias M, Taskinen EI, Paavonen T, Brault Y, Legendre C, et al. Sirolimus-based therapy following early cyclosporine withdrawal provides significantly improved renal histology and function at 3 years. Am J Transplant 2004;4:953-61.
    • (2004) Am J Transplant , vol.4 , pp. 953-961
    • Mota, A.1    Arias, M.2    Taskinen, E.I.3    Paavonen, T.4    Brault, Y.5    Legendre, C.6
  • 46
    • 68949217712 scopus 로고    scopus 로고
    • Evaluation of the efficacy and safety of conversion to sirolimus in 85 renal transplant recipients
    • Sola E, López V, Gutiérrez C, Cabello M, Burgos D, González Molina M, et al. Evaluation of the efficacy and safety of conversion to sirolimus in 85 renal transplant recipients. Transplant Proc 2009;41:2137-8.
    • (2009) Transplant Proc , vol.41 , pp. 2137-2138
    • Sola, E.1    López, V.2    Gutiérrez, C.3    Cabello, M.4    Burgos, D.5    González Molina, M.6
  • 47
    • 72949094948 scopus 로고    scopus 로고
    • Inhibition of polyomavirus BK-specific T-Cell responses by immunosuppressive drugs
    • Egli A, Köhli S, Dickenmann M, Hirsch HH. Inhibition of polyomavirus BK-specific T-Cell responses by immunosuppressive drugs. Transplantation 2009;88:1161-8.
    • (2009) Transplantation , vol.88 , pp. 1161-1168
    • Egli, A.1    Köhli, S.2    Dickenmann, M.3    Hirsch, H.H.4
  • 48
    • 34447629364 scopus 로고    scopus 로고
    • BK virus-associated nephropathy in sirolimus-treated renal transplant patients: incidence, course, and clinical outcomes
    • Benavides CA, Pollard VB, Mauiyyedi S, Podder H, Knight R, Kahan BD. BK virus-associated nephropathy in sirolimus-treated renal transplant patients: incidence, course, and clinical outcomes. Transplantation 2007;84:83-8.
    • (2007) Transplantation , vol.84 , pp. 83-88
    • Benavides, C.A.1    Pollard, V.B.2    Mauiyyedi, S.3    Podder, H.4    Knight, R.5    Kahan, B.D.6
  • 49
    • 74449084959 scopus 로고    scopus 로고
    • Tubular toxicity in sirolimus- and cyclosporine-based transplant immunosuppression strategies: an ancillary study from a randomized controlled trial
    • Franz S, Regeniter A, Hopfer H, Mihatsch M, Dickenmann M. Tubular toxicity in sirolimus- and cyclosporine-based transplant immunosuppression strategies: an ancillary study from a randomized controlled trial. Am J Kidney Dis 2010;5:335-43.
    • (2010) Am J Kidney Dis , vol.5 , pp. 335-343
    • Franz, S.1    Regeniter, A.2    Hopfer, H.3    Mihatsch, M.4    Dickenmann, M.5
  • 50
    • 58849162784 scopus 로고    scopus 로고
    • Circulating markers of endothelial dysfunction interact with proteinuria in predicting mortality in renal transplant recipients
    • Van Ree RM, Oterdoom LH, de Vries AP, Homan van der Heide JJ, Van Son WJ, Navis G, et al. Circulating markers of endothelial dysfunction interact with proteinuria in predicting mortality in renal transplant recipients. Transplantation 2008;86:1713-9.
    • (2008) Transplantation , vol.86 , pp. 1713-1719
    • Van Ree, R.M.1    Oterdoom, L.H.2    de Vries, A.P.3    Homan van der Heide, J.J.4    Van Son, W.J.5    Navis, G.6
  • 51
    • 3042608187 scopus 로고    scopus 로고
    • Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload
    • McMullen JR, Sherwood MC, Tarnavski O, Zhang L, Dorfman AL, Shioi T, et al. Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload. Circulation 2004;109:3050-5.
    • (2004) Circulation , vol.109 , pp. 3050-3055
    • McMullen, J.R.1    Sherwood, M.C.2    Tarnavski, O.3    Zhang, L.4    Dorfman, A.L.5    Shioi, T.6
  • 52
    • 33746699629 scopus 로고    scopus 로고
    • Inhibition of mTOR reduces chronic pressure-overload cardiac hypertrophy and fibrosis
    • Gao XM, Wong G, Wang B, Kiriazis H, Moore XL, Su YD, et al. Inhibition of mTOR reduces chronic pressure-overload cardiac hypertrophy and fibrosis. J Hypertens 2006;24:1663-70.
    • (2006) J Hypertens , vol.24 , pp. 1663-1670
    • Gao, X.M.1    Wong, G.2    Wang, B.3    Kiriazis, H.4    Moore, X.L.5    Su, Y.D.6
  • 53
    • 63949083046 scopus 로고    scopus 로고
    • Uremic cardiac hypertrophy is reversed by rapamycin but not by lowering of blood pressure
    • Siedlecki AM, Jin X, Muslin AJ. Uremic cardiac hypertrophy is reversed by rapamycin but not by lowering of blood pressure. Kidney Int 2009;75:800-8.
    • (2009) Kidney Int , vol.75 , pp. 800-808
    • Siedlecki, A.M.1    Jin, X.2    Muslin, A.J.3
  • 54
    • 47349128927 scopus 로고    scopus 로고
    • Effect of sirolimus on left ventricular hypertrophy in kidney transplant recipients: a 1-year nonrandomized controlled trial
    • Paoletti E, Amidone M, Cassottana P, Gherzi M, Marsano L, Cannella G. Effect of sirolimus on left ventricular hypertrophy in kidney transplant recipients: a 1-year nonrandomized controlled trial. Am J Kidney Dis 2008;52:324-30.
    • (2008) Am J Kidney Dis , vol.52 , pp. 324-330
    • Paoletti, E.1    Amidone, M.2    Cassottana, P.3    Gherzi, M.4    Marsano, L.5    Cannella, G.6
  • 55
    • 0345161813 scopus 로고    scopus 로고
    • Sirolimus (rapamycin)-based therapy in human renal transplantation: similar efficacy and different toxicity compared with cyclosporine. Sirolimus European Renal Transplant Study Group
    • Groth CG, Bäckman L, Morales JM, Calne R, Kreis H, Lang P, et al. Sirolimus (rapamycin)-based therapy in human renal transplantation: similar efficacy and different toxicity compared with cyclosporine. Sirolimus European Renal Transplant Study Group. Transplantation 1999;67:1036-42.
    • (1999) Transplantation , vol.67 , pp. 1036-1042
    • Groth, C.G.1    Bäckman, L.2    Morales, J.M.3    Calne, R.4    Kreis, H.5    Lang, P.6
  • 56
    • 0038585135 scopus 로고    scopus 로고
    • Protective effect of the immunosuppressant sirolimus against aortic atherosclerosis in apo E-deficient mice
    • Elloso MM, Azrolan N, Sehgal SN, Hsu PL, Phiel KL, Kopec CA, et al. Protective effect of the immunosuppressant sirolimus against aortic atherosclerosis in apo E-deficient mice. Am J Transplant 2003;3:562-9.
    • (2003) Am J Transplant , vol.3 , pp. 562-569
    • Elloso, M.M.1    Azrolan, N.2    Sehgal, S.N.3    Hsu, P.L.4    Phiel, K.L.5    Kopec, C.A.6
  • 57
    • 33747185684 scopus 로고    scopus 로고
    • Role of endothelin-1 and nitric oxide bioavailability in transplant-related vascular injury: comparative effects of rapamycin and cyclosporine
    • Ramzy D, Rao V, Tumiati LC, Xu N, Miriuka S, Delgado D, et al. Role of endothelin-1 and nitric oxide bioavailability in transplant-related vascular injury: comparative effects of rapamycin and cyclosporine. Circulation 2006;114(1 Suppl):I214-9.
    • (2006) Circulation , vol.114 , Issue.1 SUPPL.
    • Ramzy, D.1    Rao, V.2    Tumiati, L.C.3    Xu, N.4    Miriuka, S.5    Delgado, D.6
  • 58
    • 77957572222 scopus 로고    scopus 로고
    • Comparative effects of sirolimus and cyclosporin on conduit arteries endothelial function in kidney recipients
    • Jun 7, [Epub ahead of print]
    • Joannides R, Etienne I, Iacob M, de Ligny BH, Barbier S, Bellien J, et al. Comparative effects of sirolimus and cyclosporin on conduit arteries endothelial function in kidney recipients. Transpl Int 2010 Jun 7. [Epub ahead of print].
    • (2010) Transpl Int
    • Joannides, R.1    Etienne, I.2    Iacob, M.3    de Ligny, B.H.4    Barbier, S.5    Bellien, J.6
  • 59
    • 56049105634 scopus 로고    scopus 로고
    • Switch of immunosuppression from cyclosporine A to everolimus: impact on pulse wave velocity in stable de-novo renal allograft recipients
    • Seckinger J, Sommerer C, Hinkel UP, Hoffmann O, Zeier M, Schwenger V. Switch of immunosuppression from cyclosporine A to everolimus: impact on pulse wave velocity in stable de-novo renal allograft recipients. J Hypertens 2008;26:2213-9.
    • (2008) J Hypertens , vol.26 , pp. 2213-2219
    • Seckinger, J.1    Sommerer, C.2    Hinkel, U.P.3    Hoffmann, O.4    Zeier, M.5    Schwenger, V.6
  • 60
    • 33744473322 scopus 로고    scopus 로고
    • Target of rapamycin inhibitors (sirolimus and everolimus) for primary immunosuppression of kidney transplant recipients: a systematic review and meta-analysis of randomized trials
    • Webster AC, Lee VW, Chapman JR, Craig JC. Target of rapamycin inhibitors (sirolimus and everolimus) for primary immunosuppression of kidney transplant recipients: a systematic review and meta-analysis of randomized trials. Transplantation 2006;81:1234-48.
    • (2006) Transplantation , vol.81 , pp. 1234-1248
    • Webster, A.C.1    Lee, V.W.2    Chapman, J.R.3    Craig, J.C.4
  • 62
    • 13844266265 scopus 로고    scopus 로고
    • Cytomegalovirus infection is associated with elevated interleukin-10 in coronary artery disease
    • Sun Y, Pei W, Welte T, Wu Y, Ye S, Yang Y. Cytomegalovirus infection is associated with elevated interleukin-10 in coronary artery disease. Atherosclerosis 2005;179:133-7.
    • (2005) Atherosclerosis , vol.179 , pp. 133-137
    • Sun, Y.1    Pei, W.2    Welte, T.3    Wu, Y.4    Ye, S.5    Yang, Y.6
  • 63
    • 33747079515 scopus 로고    scopus 로고
    • Cardiovascular events following renal transplantation: role of traditional and transplant-specific risk factors
    • De Mattos AM, Prather J, Olyaei AJ, Shibagaki Y, Keith DS, Mori M, et al. Cardiovascular events following renal transplantation: role of traditional and transplant-specific risk factors. Kidney Int 2006;70:757-64.
    • (2006) Kidney Int , vol.70 , pp. 757-764
    • De Mattos, A.M.1    Prather, J.2    Olyaei, A.J.3    Shibagaki, Y.4    Keith, D.S.5    Mori, M.6
  • 64
    • 32844474879 scopus 로고    scopus 로고
    • Glucose metabolism in renal transplant recipients: effect of calcineurin inhibitor withdrawal and conversion to sirolimus
    • Teutonico A, Schena PF, Di Paolo S. Glucose metabolism in renal transplant recipients: effect of calcineurin inhibitor withdrawal and conversion to sirolimus. J Am Soc Nephrol 2005;16:3128-35.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 3128-3135
    • Teutonico, A.1    Schena, P.F.2    Di Paolo, S.3
  • 65
    • 33746488875 scopus 로고    scopus 로고
    • Chronic inhibition of mammalian target of rapamycin signaling downregulates insulin receptor substrates 1 and 2 and AKT activation: A crossroad between cancer and diabetes?
    • Di Paolo S, Teutonico A, Leogrande D, Capobianco C, Schena PF. Chronic inhibition of mammalian target of rapamycin signaling downregulates insulin receptor substrates 1 and 2 and AKT activation: A crossroad between cancer and diabetes? J Am Soc Nephrol 2006;17:2236-44.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 2236-2244
    • Di Paolo, S.1    Teutonico, A.2    Leogrande, D.3    Capobianco, C.4    Schena, P.F.5
  • 66
    • 48149112155 scopus 로고    scopus 로고
    • Sirolimus is associated with new-onset diabetes in kidney transplant recipients
    • Johnston O, Rose CL, Webster AC, Gill JS. Sirolimus is associated with new-onset diabetes in kidney transplant recipients. J Am Soc Nephrol 2008;19: 1411-8.
    • (2008) J Am Soc Nephrol , vol.19 , pp. 1411-1418
    • Johnston, O.1    Rose, C.L.2    Webster, A.C.3    Gill, J.S.4
  • 67
    • 42449104351 scopus 로고    scopus 로고
    • mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes
    • Fraenkel M, Ketzinel-Gilad M, Ariav Y, Pappo O, Karaca M, Castel J, et al. mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes. Diabetes 2008;57:945-57.
    • (2008) Diabetes , vol.57 , pp. 945-957
    • Fraenkel, M.1    Ketzinel-Gilad, M.2    Ariav, Y.3    Pappo, O.4    Karaca, M.5    Castel, J.6
  • 69
    • 72049105867 scopus 로고    scopus 로고
    • The role of the mammalian target of rapamycin (mTOR) in renal disease
    • Lieberthal W, Levine JS. The role of the mammalian target of rapamycin (mTOR) in renal disease. J Am Soc Nephrol 2009;20:2493-502.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 2493-2502
    • Lieberthal, W.1    Levine, J.S.2
  • 70
    • 27644436740 scopus 로고    scopus 로고
    • Maintenance immunosuppression with target-of-rapamycin inhibitors is associated with a reduced incidence of de novo malignancies
    • Kauffman HM, Cherikh WS, Cheng Y, Hanto DW, Kahan BD. Maintenance immunosuppression with target-of-rapamycin inhibitors is associated with a reduced incidence of de novo malignancies. Transplantation 2005;80:883-9.
    • (2005) Transplantation , vol.80 , pp. 883-889
    • Kauffman, H.M.1    Cherikh, W.S.2    Cheng, Y.3    Hanto, D.W.4    Kahan, B.D.5
  • 71
    • 33645458234 scopus 로고    scopus 로고
    • Sirolimus therapy after early cyclosporine withdrawal reduces the risk for cancer in adult renal transplantation
    • Campistol JM, Eris J, Oberbauer R, Friend P, Hutchison B, Morales JM, et al. Sirolimus therapy after early cyclosporine withdrawal reduces the risk for cancer in adult renal transplantation. J Am Soc Nephrol 2006;17:581-9.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 581-589
    • Campistol, J.M.1    Eris, J.2    Oberbauer, R.3    Friend, P.4    Hutchison, B.5    Morales, J.M.6
  • 72
    • 77952940222 scopus 로고    scopus 로고
    • Switch to a sirolimus-based immunosuppression in long-term renal transplant recipients: reduced rate of (pre-)malignancies and nonmelanoma skin cancer in a prospective, randomized, assessor-blinded, controlled clinical trial
    • Salgo R, Gossmann J, Schöfer H, Kachel HG, Kuck J, Geiger H, et al. Switch to a sirolimus-based immunosuppression in long-term renal transplant recipients: reduced rate of (pre-)malignancies and nonmelanoma skin cancer in a prospective, randomized, assessor-blinded, controlled clinical trial. Am J Transplant 2010;10:1385-93.
    • (2010) Am J Transplant , vol.10 , pp. 1385-1393
    • Salgo, R.1    Gossmann, J.2    Schöfer, H.3    Kachel, H.G.4    Kuck, J.5    Geiger, H.6
  • 73
    • 53449096010 scopus 로고    scopus 로고
    • Changes in the immune responses against human herpesvirus-8 in the disease course of posttransplant Kaposi sarcoma
    • Barozzi P, Bonini C, Potenza L, Masetti M, Cappelli G, Gruarin P, et al. Changes in the immune responses against human herpesvirus-8 in the disease course of posttransplant Kaposi sarcoma. Transplantation 2008;86:738-44.
    • (2008) Transplantation , vol.86 , pp. 738-744
    • Barozzi, P.1    Bonini, C.2    Potenza, L.3    Masetti, M.4    Cappelli, G.5    Gruarin, P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.