Inhibition of polyomavirus BK-specific t-cell responses by immunosuppressive drugs

Transplantation

Volumn 88, Issue 10, 2009, Pages 1161-1168

  Egli, Adrian ^a,b   Köhli, Sabrina ^a   Dickenmann, Michael ^b   Hirsch, Hans H ^a,b  

^a UNIVERSITY OF BASEL   (Switzerland)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

BKV; Cyclosporine A; Cytomegalovirus; Immunosuppression; Leflunomide.; Polyomavirus; Sirolimus; Tacrolimus; Viral replication

Indexed keywords

CYCLOSPORIN A; GAMMA INTERFERON; IMMUNOSUPPRESSIVE AGENT; MYCOPHENOLIC ACID; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; RAPAMYCIN; TACROLIMUS; TERIFLUNOMIDE; VIRUS LARGE T ANTIGEN;

ADULT; AGED; ANTIGEN SPECIFICITY; ARTICLE; BK VIRUS; CELL EXPANSION; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOMEGALOVIRUS; DRUG BLOOD LEVEL; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; IN VIVO STUDY; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; LIVING DONOR; MALE; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; SURGICAL PATIENT; T LYMPHOCYTE ACTIVATION; VIRUS IMMUNITY;

ADULT; AGED; BK VIRUS; CYCLOSPORINE; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERFERON-GAMMA; ISOXAZOLES; KIDNEY TRANSPLANTATION; MIDDLE AGED; MYCOPHENOLIC ACID; POLYOMAVIRUS INFECTIONS; REFERENCE VALUES; T-LYMPHOCYTES; TACROLIMUS;

EID: 72949094948     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181bca422     Document Type: Article

References (38)

1. Ramos E, Drachenberg CB, Wali R, et al. The decade of polyomavirus BK-associated nephropathy: State of affairs. Transplantation 2009; 87: 621.
2. Hirsch HH, Brennan DC, Drachenberg CB, et al. Polyomavirus-associated nephropathy in renal transplantation: Interdisciplinary analyses and recommendations. Transplantation 2005; 79: 1277.
3. Binet I, Nickeleit V, Hirsch HH, et al. Polyomavirus disease under new immunosuppressive drugs: A cause of renal graft dysfunction and graft loss. Transplantation 1999; 67: 918.
4. Randhawa PS, Finkelstein S, Scantlebury V, et al. Human polyoma virus-associated interstitial nephritis in the allograft kidney. Transplantation 1999; 67: 103.
5. Brennan DC, Agha I, Bohl DL, et al. Incidence of BK with tacrolimus versus cyclosporine and impact of preemptive immunosuppression reduction. Am J Transplant 2005; 5: 582.
6. Hirsch HH, Friman S, Wiecek A, et al. Prospective study of polyoma-virus BK viruria and viremia in de novo renal transplantation [abstract #77]. Am J Transplant 2007; 7(suppl 5): 150.
7. Dharnidharka VR, Cherikh WS, Abbott KC. An OPTN analysis of national registry data on treatment of BK virus allograft nephropathy in the United States. Transplantation 2009; 87: 1019.
8. Rinaldo CH, Hirsch HH. Antivirals for the treatment of polyomavirus BK replication. Expert Rev Anti Infect Ther 2007; 5: 105.
9. Ramos E, Drachenberg CB, Portocarrero M, et al. BK virus nephropathy diagnosis and treatment: Experience at the University of Maryland Renal Transplant Program. Clin Transpl 2002; 143.
10. Vasudev B, Hariharan S, Hussain SA, et al. BK virus nephritis: Risk factors, timing, and outcome in renal transplant recipients. Kidney Int 2005; 68: 1834.
11. Ginevri F, Azzi A, Hirsch HH, et al. Prospective monitoring of polyomavirus BK replication and impact of pre-emptive intervention in pediatric kidney recipients. Am J Transplant 2007; 7: 2727.
12. Hirsch HH, Knowles W, Dickenmann M, et al. Prospective study of polyomavirus type BK replication and nephropathy in renal-transplant recipients. N Engl J Med 2002; 347: 488.
13. Halloran PF. Immunosuppressive drugs for kidney transplantation. N Engl J Med 2004; 351: 2715.
14. Binggeli S, Egli A, Schaub S, et al. Polyomavirus BK-specific cellular immune response to VP1 and large T-antigen in kidney transplant recipients. Am J Transplant 2007; 7: 1131.
15. Egli A, Binet I, Binggeli S, et al. Cytomegalovirus-specific T-cell responses and viral replication in kidney transplant recipients. J Transl Med 2008; 6: 29.
16. Comoli P, Basso S, Azzi A, et al. Dendritic cells pulsed with polyomavirus BK antigen induce ex vivo polyoma BK virus-specific cytotoxic T-cell lines in seropositive healthy individuals and renal transplant recipients. J Am Soc Nephrol 2003; 14: 3197.
17. Comoli P, Azzi A, Maccario R, et al. Polyomavirus BK-specific immunity after kidney transplantation. Transplantation 2004; 78: 1229.
18. Prosser SE, Orentas RJ, Jurgens L, et al. Recovery of BK virus large T-antigen-specific cellular immune response correlates with resolution of BK virus nephritis. Transplantation 2008; 85: 185.
19. Zhou W, Sharma M, Martinez J, et al. Functional characterization of BK virus-specific CD4(+) T cells with cytotoxic potential in seropositive adults. Viral Immunol 2007; 20: 379.
20. Chen Y, Trofe J, Gordon J, et al. BKV and JCV large T antigen-specific CD8(+) T cell response in HLAA*0201(+) kidney transplant recipients with polyomavirus nephropathy and patients with progressive multifocal leukoencephalopathy. J Clin Virol 2008; 42: 198.
21. Leuenberger D, Andresen PA, Gosert R, et al. Human polyomavirus type 1 (BK virus) agnoprotein is abundantly expressed but immunologically ignored. Clin Vaccine Immunol 2007; 14: 959.
22. Binggeli S, Egli A, Steiger J, et al. BKV-specific cellular immune response to VP1 and large T-antigen after polyomavirus-associated nephropathy [abstract 83]. Transplantation 2006; (S3): 94.
23. Hirsch HH, Suthanthiran M. The natural history, risk factors and outcomes of polyomavirus BK-associated nephropathy after renal transplantation. Nat Clin Pract Nephrol 2006; 2: 240.
24. Funk GA, Gosert R, Comoli P, et al. Polyomavirus BK replication dynamics in vivo and in silico to predict cytopathology and viral clearance in kidney transplants. Am J Transplant 2008; 8: 2368.
25. Ramos E, Drachenberg CB, Papadimitriou JC, et al. Clinical course of polyoma virus nephropathy in 67 renal transplant patients. J Am Soc Nephrol 2002; 13: 2145.
26. Mengel M, Marwedel M, Radermacher J, et al. Incidence of polyomavirus-nephropathy in renal allografts: Influence of modern immunosuppressive drugs. Nephrol Dial Transplant 2003; 18: 1190.
27. Khamash HA, Wadei HM, Mahale AS, et al. Polyomavirus-associated nephropathy risk in kidney transplants: The influence of recipient age and donor gender. Kidney Int 2007; 71: 1302.
28. Cosio FG, Am H, Grande JP, et al. Comparison of low versus high tacrolimus levels in kidney transplantation: Assessment of efficacy by protocol biopsies. Transplantation 2007; 83: 411.
29. Akhlaghi F, Trull AK. Distribution of cyclosporin in organ transplant recipients. Clin Pharmacokinet 2002; 41: 615.
30. Knight SR, Morris PJ. The clinical benefits of cyclosporine C2-level monitoring: A systematic review. Transplantation 2007; 83: 1525.
31. Ozbay A, Karamperis N, Jorgensen KA. A review of the immunosup-pressive activity of cyclosporine metabolites: New insights into an old issue. Curr Clin Pharmacol 2007; 2: 244.
32. Sester U, Gartner BC, Wilkens H, et al. Differences in CMV-specific T-cell levels and long-term susceptibility to CMV infection after kidney, heart and lung transplantation. Am J Transplant 2005; 5: 1483.
33. Volk HD, Kern F. Insights into the specificity and function of alloantigen-reactive T cells. Am J Transplant 2001; 1: 109.
34. Wali RK, Drachenberg C, Hirsch HH, et al. BK virus-associated ne-phropathy in renal allograft recipients: Rescue therapy by sirolimus-based immunosuppression. Transplantation 2004; 78: 1069.
35. Benavides CA, Pollard VB, Mauiyyedi S, et al. BK virus-associated ne-phropathy in sirolimus-treated renal transplant patients: Incidence, course, and clinical outcomes. Transplantation 2007; 84: 83.
36. Willcocks LC, Chaudhry AN, Smith JC, et al. The effect of sirolimus therapy on vaccine responses in transplant recipients. Am J Transplant 2007; 7: 2006.
37. Araki K, Turner AP, Shaffer VO, et al. mTOR regulates memory CD8 T-cell differentiation. Nature 2009; 460: 108.
38. Feldman M, Cohen IR, Wekerle H. T-cell mediated immunity in vitro: An analysis of antigen recognition and target cell lysis. Transplant Rev 1974; 12: 57.