메뉴 건너뛰기




Volumn 24, Issue 2, 2004, Pages 112-123

Everolimus: Immunosuppression with antilymphoproliferative therapy;Everolimus: Un inmunosupresor con propiedades antiproliferativas

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN; CYCLOSPORIN A; CYTOCHROME P450 3A; EVEROLIMUS; RAPAMYCIN; TSUKUBAENOLIDE; DRUG DERIVATIVE; FK 506 BINDING PROTEIN; IMMUNOSUPPRESSIVE AGENT;

EID: 3142718792     PISSN: 02116995     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (6)

References (77)
  • 1
    • 4544333768 scopus 로고    scopus 로고
    • http://optn.org/latestData/rptData.asp
  • 2
    • 4544307702 scopus 로고    scopus 로고
    • http://msc.es/ont/esp/estadisticas
  • 3
    • 0032408063 scopus 로고    scopus 로고
    • Tratamiento inmunosupresor inicial en trasplante renal
    • Pascual J: Tratamiento inmunosupresor inicial en trasplante renal. Nefrología 18 (Supl. 6): 104-108, 1998.
    • (1998) Nefrología , vol.18 , Issue.6 SUPPL. , pp. 104-108
    • Pascual, J.1
  • 5
    • 0037087542 scopus 로고    scopus 로고
    • A long-term comparison of tacrolimus (FK506) and cyclosporine in kidney transplantation: Evidence for improved allograft survival at five years
    • Vincenti F, Jensik SC, Filo RS, Millar J, Pirsch J: A long-term comparison of tacrolimus (FK506) and cyclosporine in kidney transplantation: evidence for improved allograft survival at five years. Transplantation 73: 775-782, 2002.
    • (2002) Transplantation , vol.73 , pp. 775-782
    • Vincenti, F.1    Jensik, S.C.2    Filo, R.S.3    Millar, J.4    Pirsch, J.5
  • 6
    • 0035956745 scopus 로고    scopus 로고
    • A worldwide, phase III, randmized, controlles safety and efficacy study of a sirolimus/cyclosporine regimen for prevention of acute rejection in recipients of primery mismatched renal allografts
    • The Rapamune Global Study Group
    • MacDonald AS: The Rapamune Global Study Group. A worldwide, phase III, randmized, controlles safety and efficacy study of a sirolimus/cyclosporine regimen for prevention of acute rejection in recipients of primery mismatched renal allografts. Transplantation 71: 271-2, 2000.
    • (2000) Transplantation , vol.71 , pp. 271-272
    • MacDonald, A.S.1
  • 7
    • 0035973067 scopus 로고    scopus 로고
    • Nuevos inmunodepresores de inducción en trasplante renal
    • Pascual J, Ortuño J: Nuevos inmunodepresores de inducción en trasplante renal. Med Clin (Barc) 117: 147-157, 2001.
    • (2001) Med Clin (Barc) , vol.117 , pp. 147-157
    • Pascual, J.1    Ortuño, J.2
  • 8
    • 0037433703 scopus 로고    scopus 로고
    • Interleukin-2 receptor monoclonal antibodies in renal transplantation: Meta-analysis of randomised trials
    • Adu D, Cockwell P, Ives NJ, Shaw J, Wheatley K: Interleukin-2 receptor monoclonal antibodies in renal transplantation: meta-analysis of randomised trials. BMJ 326: 789-793, 2003.
    • (2003) BMJ , vol.326 , pp. 789-793
    • Adu, D.1    Cockwell, P.2    Ives, N.J.3    Shaw, J.4    Wheatley, K.5
  • 9
    • 0030832514 scopus 로고    scopus 로고
    • SDZ RAD, a new rapamycin derivative. Pharmacological properties in vitro and in vivo
    • Schuler W, Sedrani R, Cottens S y cols.: SDZ RAD, a new rapamycin derivative. Pharmacological properties in vitro and in vivo. Transplantation 64: 36-42, 1997.
    • (1997) Transplantation , vol.64 , pp. 36-42
    • Schuler, W.1    Sedrani, R.2    Cottens, S.3
  • 10
    • 0031657020 scopus 로고    scopus 로고
    • Chemical modification of rapamycin: The discovery of SDZ RAD
    • Sedrani R, Cottens S, Kallen J, Schuler W: Chemical modification of rapamycin: the discovery of SDZ RAD. Transplant Proc 30: 2192-2194, 1998.
    • (1998) Transplant Proc , vol.30 , pp. 2192-2194
    • Sedrani, R.1    Cottens, S.2    Kallen, J.3    Schuler, W.4
  • 11
    • 0034667904 scopus 로고    scopus 로고
    • Increased impact of acute rejection in recent era
    • Meier-Kriesche HU, Ojo AO, Hanson JA y cols.: Increased impact of acute rejection in recent era. Transplantation 70: 1098-1100, 2000.
    • (2000) Transplantation , vol.70 , pp. 1098-1100
    • Meier-Kriesche, H.U.1    Ojo, A.O.2    Hanson, J.A.3
  • 12
    • 0032844172 scopus 로고    scopus 로고
    • Chronic allograft nephropathy: An update
    • Paul LC: Chronic allograft nephropathy: an update. Kidney Int 56: 783-793, 1999.
    • (1999) Kidney Int , vol.56 , pp. 783-793
    • Paul, L.C.1
  • 13
    • 0036523936 scopus 로고    scopus 로고
    • Call for revolution: A new approach to describing allograft deterioration
    • Halloran PF: Call for revolution: a new approach to describing allograft deterioration. Am J Transplant 2: 195-200, 2002.
    • (2002) Am J Transplant , vol.2 , pp. 195-200
    • Halloran, P.F.1
  • 14
    • 0030065639 scopus 로고    scopus 로고
    • Chronic renal allograft rejection: Immunologic and nonimunologic risk factors
    • Massy ZA, Guijarro C, Wiederkehr R y cols.: Chronic renal allograft rejection: immunologic and nonimunologic risk factors. Kidney Int 49: 518-524, 1996.
    • (1996) Kidney Int , vol.49 , pp. 518-524
    • Massy, Z.A.1    Guijarro, C.2    Wiederkehr, R.3
  • 15
    • 0033611066 scopus 로고    scopus 로고
    • Immunologie factors-the major risk for long-term renal allograft survival
    • Humar A, Kandaswamy R, Hassoun AA y cols.: Immunologie factors-the major risk for long-term renal allograft survival. Transplantation 68: 1842-1846, 1999.
    • (1999) Transplantation , vol.68 , pp. 1842-1846
    • Humar, A.1    Kandaswamy, R.2    Hassoun, A.A.3
  • 16
    • 0032952860 scopus 로고    scopus 로고
    • Current thinking on chronic renal allograft rejection: Issues, concerns and recommendations from a 1997 roundtable discussion
    • Monaco AP, Burke JF Jr, Ferguson RM y cols.: Current thinking on chronic renal allograft rejection: issues, concerns and recommendations from a 1997 roundtable discussion. Am J Kidney Dis 33: 150-160, 1999.
    • (1999) Am J Kidney Dis , vol.33 , pp. 150-160
    • Monaco, A.P.1    Burke Jr., J.F.2    Ferguson, R.M.3
  • 17
    • 0033610454 scopus 로고    scopus 로고
    • Features of acute rejection that increase risk for chronic rejection
    • Humar A, Kerr S, Gillingham KJ, Matas AJ: Features of acute rejection that increase risk for chronic rejection. Transplantation 68: 1200-1203, 1999.
    • (1999) Transplantation , vol.68 , pp. 1200-1203
    • Humar, A.1    Kerr, S.2    Gillingham, K.J.3    Matas, A.J.4
  • 18
    • 0033513026 scopus 로고    scopus 로고
    • Decreased acute rejection in kidney transplant recipients is associated with decreased chronic rejection
    • Matas AJ, Humar A, Payne WD y cols.: Decreased acute rejection in kidney transplant recipients is associated with decreased chronic rejection. Ann Surg 230: 493-500, 1999.
    • (1999) Ann Surg , vol.230 , pp. 493-500
    • Matas, A.J.1    Humar, A.2    Payne, W.D.3
  • 20
    • 0343962625 scopus 로고    scopus 로고
    • The clinical impact of nephrotoxicity in renal transplantation
    • Johnson RWG: The clinical impact of nephrotoxicity in renal transplantation. Transplantation 69: SS14-SS17, 2000.
    • (2000) Transplantation , vol.69
    • Johnson, R.W.G.1
  • 21
    • 4544286194 scopus 로고    scopus 로고
    • Calcineurin inhibitors and chronic renal allograft dysfunction: Not enough or too much?
    • Paul LC, Sijpkens WJ, De Fijter JW: Calcineurin inhibitors and chronic renal allograft dysfunction: not enough or too much? Transplant Rev 15: 82-92, 2001.
    • (2001) Transplant Rev , vol.15 , pp. 82-92
    • Paul, L.C.1    Sijpkens, W.J.2    De Fijter, J.W.3
  • 22
    • 0037093506 scopus 로고    scopus 로고
    • Clinical validation studies of Neoral C2 monitoring: A review
    • Nashan B, Cole E, Levy G, Thervet E: Clinical validation studies of Neoral C2 monitoring: a review. Transplantation 73: S3-S11, 2002.
    • (2002) Transplantation , vol.73
    • Nashan, B.1    Cole, E.2    Levy, G.3    Thervet, E.4
  • 23
    • 0027965108 scopus 로고
    • Long-term efficacy and safety of cyclosporine in renal-transplant recipients
    • Burke JF, Pirsch JD, Ramos EL y cols.: Long-term efficacy and safety of cyclosporine in renal-transplant recipients. N Engl J Med 331: 358-363, 1994.
    • (1994) N Engl J Med , vol.331 , pp. 358-363
    • Burke, J.F.1    Pirsch, J.D.2    Ramos, E.L.3
  • 24
    • 0029795382 scopus 로고    scopus 로고
    • Benefits of continued cyclosporine through an indigent drug program
    • Sanders CE, Julián BA, Gaston RS y cols.: Benefits of continued cyclosporine through an indigent drug program. Am J Kidney Dis 28: 572-577, 1996.
    • (1996) Am J Kidney Dis , vol.28 , pp. 572-577
    • Sanders, C.E.1    Julián, B.A.2    Gaston, R.S.3
  • 25
    • 0035171392 scopus 로고    scopus 로고
    • Impact of cyclosporine withdrawal on living-related renal transplants: A single center experience
    • Jha V, Muthukumar R, Kohli HS y cols.: Impact of cyclosporine withdrawal on living-related renal transplants: a single center experience. Am J Kidney Dis 37: 160-163, 2001.
    • (2001) Am J Kidney Dis , vol.37 , pp. 160-163
    • Jha, V.1    Muthukumar, R.2    Kohli, H.S.3
  • 26
    • 0031713649 scopus 로고    scopus 로고
    • The in vivo effect of rapamycin derivative SDZ RAD on lymphocyte proliferation
    • Böhler T, Waiser J, Budde K y cols.: The in vivo effect of rapamycin derivative SDZ RAD on lymphocyte proliferation. Transplant Proc 30: 2195-2197, 1998.
    • (1998) Transplant Proc , vol.30 , pp. 2195-2197
    • Böhler, T.1    Waiser, J.2    Budde, K.3
  • 29
    • 0033548071 scopus 로고    scopus 로고
    • The FKBP12-rapamycin-binding domain is required for FKBP12-rapamycin associated protein kinase activity and G1 progression
    • Vilella-Bach M, Nuzzi P, Fang Y, Chen J: The FKBP12-rapamycin-binding domain is required for FKBP12-rapamycin associated protein kinase activity and G1 progression. J Biol Chem 274: 4266-4272, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 4266-4272
    • Vilella-Bach, M.1    Nuzzi, P.2    Fang, Y.3    Chen, J.4
  • 30
    • 0034654046 scopus 로고    scopus 로고
    • Oral efficacy of the macrolide immunosuppressant SDZ RAD and of cyclosporine microemulsion in cynomolgus monkey kidney allotransplantation
    • Schuurman HJ, Ringers J, Schuler W, Slingerland W, Jonker M: Oral efficacy of the macrolide immunosuppressant SDZ RAD and of cyclosporine microemulsion in cynomolgus monkey kidney allotransplantation. Transplantation 69: 737-742, 2000.
    • (2000) Transplantation , vol.69 , pp. 737-742
    • Schuurman, H.J.1    Ringers, J.2    Schuler, W.3    Slingerland, W.4    Jonker, M.5
  • 31
    • 0031716115 scopus 로고    scopus 로고
    • The macrolide SDZ RAD is efficacious in a nonhuman primate model of allotransplantation
    • Schuurman HJ, Schuler W, Ringers J, Jonker M: The macrolide SDZ RAD is efficacious in a nonhuman primate model of allotransplantation. Transplant Proc 30: 2198-2199, 1998.
    • (1998) Transplant Proc , vol.30 , pp. 2198-2199
    • Schuurman, H.J.1    Schuler, W.2    Ringers, J.3    Jonker, M.4
  • 33
    • 0032930815 scopus 로고    scopus 로고
    • Supresion of acute rejection in allogenic rat lung transplantation: A study of the efficacy and pharmacokinetics of rapamycin derivative (SDZ RAD) used alone and in combination with a microemulsion combination of cyclosporine
    • Husen B, Boeke K, Berry GJ, Segarra IT, Christians U, Morris RE: Supresion of acute rejection in allogenic rat lung transplantation: a study of the efficacy and pharmacokinetics of rapamycin derivative (SDZ RAD) used alone and in combination with a microemulsion combination of cyclosporine. J Heart Lung Transplant 18: 150-159, 1999.
    • (1999) J Heart Lung Transplant , vol.18 , pp. 150-159
    • Husen, B.1    Boeke, K.2    Berry, G.J.3    Segarra, I.T.4    Christians, U.5    Morris, R.E.6
  • 34
    • 0033561428 scopus 로고    scopus 로고
    • Coadministration of Neoral and the novel rapamyci analog SDZ RAD, to rat lung allograft recipients
    • Hausen B, Boeke K, Berry GJ y cols.: Coadministration of Neoral and the novel rapamyci analog SDZ RAD, to rat lung allograft recipients. Transplantation 67: 956-962, 1999.
    • (1999) Transplantation , vol.67 , pp. 956-962
    • Hausen, B.1    Boeke, K.2    Berry, G.J.3
  • 35
    • 0034032028 scopus 로고    scopus 로고
    • Successful treatment of acute, ongoing rat lung allograft rejection with the novel immunosuppressant SDZ RAD
    • Hausen B, Boecke K, Berry GJ, Christians U, Schuler W, Morris RE: Successful treatment of acute, ongoing rat lung allograft rejection with the novel immunosuppressant SDZ RAD. Ann Thorac Surg 69: 904-909, 2000.
    • (2000) Ann Thorac Surg , vol.69 , pp. 904-909
    • Hausen, B.1    Boecke, K.2    Berry, G.J.3    Christians, U.4    Schuler, W.5    Morris, R.E.6
  • 36
    • 0034650246 scopus 로고    scopus 로고
    • Combined immunosuprression with cyclosporine (Neoral) and SDZ RAD in non-human primate lung transplantation: Systematic pharmacokinetic-based trials to improve efficacy and tolerability
    • Hausen B, Ikonen T, Briffa N y cols.: Combined immunosuprression with cyclosporine (Neoral) and SDZ RAD in non-human primate lung transplantation: systematic pharmacokinetic-based trials to improve efficacy and tolerability. Transplantation 69: 76-86, 2000.
    • (2000) Transplantation , vol.69 , pp. 76-86
    • Hausen, B.1    Ikonen, T.2    Briffa, N.3
  • 37
    • 0033932343 scopus 로고    scopus 로고
    • Tissue distribution and clinical monitoring of the novel macrolide immunosuppressant SDZ-RAD and its metabolites in monkey lung transplant recipients: Interaction with cyclosporine
    • Serkova N, Hausen B, Berry GJ y cols.: Tissue distribution and clinical monitoring of the novel macrolide immunosuppressant SDZ-RAD and its metabolites in monkey lung transplant recipients: interaction with cyclosporine. J Pharmacol Exp Ther 294: 323-332, 2000.
    • (2000) J Pharmacol Exp Ther , vol.294 , pp. 323-332
    • Serkova, N.1    Hausen, B.2    Berry, G.J.3
  • 38
    • 17344391595 scopus 로고    scopus 로고
    • Prevention of acute allograft rejection in non-human primate lung transplant recipients
    • Hausen B, Gummert J, Berry GJ y cols.: Prevention of acute allograft rejection in non-human primate lung transplant recipients. Transplantation 69: 488-496, 2000.
    • (2000) Transplantation , vol.69 , pp. 488-496
    • Hausen, B.1    Gummert, J.2    Berry, G.J.3
  • 39
    • 0034532250 scopus 로고    scopus 로고
    • The novel immunosuppressant FTY720 induces peripheral lymphodepletion of both T-and B-cells in cynomolgus monkeys when given alone, with cyclosporine Neoral or with RAD
    • Quesniaux VFJ, Menninger K, Kunkler A y cols.: The novel immunosuppressant FTY720 induces peripheral lymphodepletion of both T-and B-cells in cynomolgus monkeys when given alone, with cyclosporine Neoral or with RAD. Transplant Immunol 8: 177-187, 2000.
    • (2000) Transplant Immunol , vol.8 , pp. 177-187
    • Quesniaux, V.F.J.1    Menninger, K.2    Kunkler, A.3
  • 40
    • 0033828090 scopus 로고    scopus 로고
    • The peripheral lymphocyte count predicts graft survival in DA to Lewis heart transplantation treated with FTY720 and SDZ RAD
    • Niklova Z, Hof A, Baumlin Y, Hof RP: The peripheral lymphocyte count predicts graft survival in DA to Lewis heart transplantation treated with FTY720 and SDZ RAD. Transplant Immunol 8: 115-124, 2000.
    • (2000) Transplant Immunol , vol.8 , pp. 115-124
    • Niklova, Z.1    Hof, A.2    Baumlin, Y.3    Hof, R.P.4
  • 41
    • 0034055332 scopus 로고    scopus 로고
    • SDZ-RAD prevents manifestation of chronic rejection in rat renal allografts
    • Viklicky O, Zou H, Muller V, Lacha J, Szabo A, Herman U: SDZ-RAD prevents manifestation of chronic rejection in rat renal allografts. Transplantation 69: 497-502, 2000.
    • (2000) Transplantation , vol.69 , pp. 497-502
    • Viklicky, O.1    Zou, H.2    Muller, V.3    Lacha, J.4    Szabo, A.5    Herman, U.6
  • 42
    • 0042968648 scopus 로고    scopus 로고
    • Apoptosis and treatment of chronic allograft nephropathy with everolimus
    • Lutz J, Zou H, Liu S, Antus B, Heemann U: Apoptosis and treatment of chronic allograft nephropathy with everolimus. Transplantation 76: 508-515, 2003.
    • (2003) Transplantation , vol.76 , pp. 508-515
    • Lutz, J.1    Zou, H.2    Liu, S.3    Antus, B.4    Heemann, U.5
  • 43
    • 0031684549 scopus 로고    scopus 로고
    • Effect of SDZ RAD on transplant arteriosclerosis in the rat aortic model
    • Cole OJ, Shehata M, Riggs KM: Effect of SDZ RAD on transplant arteriosclerosis in the rat aortic model. Transplant Proc 30: 2200-2203, 1998.
    • (1998) Transplant Proc , vol.30 , pp. 2200-2203
    • Cole, O.J.1    Shehata, M.2    Riggs, K.M.3
  • 47
    • 0035131411 scopus 로고    scopus 로고
    • 40-O(2-Hydroxyethyl)-rapamycin attenuates pulmonary arterial hypertension and neointimal formation in rats
    • Nishimura T, Faul JL, Berry GJ, Veve I, Pearl RG , Kao PN: 40-O(2-Hydroxyethyl)-rapamycin attenuates pulmonary arterial hypertension and neointimal formation in rats. Am J Respir Crit Care Med 163: 498-502, 2001.
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 498-502
    • Nishimura, T.1    Faul, J.L.2    Berry, G.J.3    Veve, I.4    Pearl, R.G.5    Kao, P.N.6
  • 48
    • 0034636055 scopus 로고    scopus 로고
    • The immunosuppressive macrolide RAD inhibits growth of the human Epstein-Barr virus-transformed B lymphocytes in vitro and in vivo: A potential approach to prevention and treatment of postrasplant lymphoproliferative disorders
    • Majewski M, Korecka M, Kossev P, Li S, Goldman J, Moore J, Sliberstein LE, Nowell PC, Schuler W, Shaw LM, Vasik MA: The immunosuppressive macrolide RAD inhibits growth of the human Epstein-Barr virus-transformed B lymphocytes in vitro and in vivo: a potential approach to prevention and treatment of postrasplant lymphoproliferative disorders. Proc Natl Acad Sci USA 97: 4285-4290, 2000.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 4285-4290
    • Majewski, M.1    Korecka, M.2    Kossev, P.3    Li, S.4    Goldman, J.5    Moore, J.6    Sliberstein, L.E.7    Nowell, P.C.8    Schuler, W.9    Shaw, L.M.10    Vasik, M.A.11
  • 49
    • 0038054547 scopus 로고    scopus 로고
    • Immunosuppressive TOR kinase inhibitor everolimus (RAD) suppresses growth of cells derived from postrasplant lymphoproliferative disorder at allograft-protecting doses
    • Majewski M, Korecka M, Joergensen J, Fields L, Kossev P, Schuler W, Shaw L, Wasik MA: Immunosuppressive TOR kinase inhibitor everolimus (RAD) suppresses growth of cells derived from postrasplant lymphoproliferative disorder at allograft-protecting doses. Transplantation 75: 1710-7, 2003.
    • (2003) Transplantation , vol.75 , pp. 1710-1717
    • Majewski, M.1    Korecka, M.2    Joergensen, J.3    Fields, L.4    Kossev, P.5    Schuler, W.6    Shaw, L.7    Wasik, M.A.8
  • 50
    • 0034881393 scopus 로고    scopus 로고
    • Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain
    • Serkova N, Jacobsen W, Niemann CU, Litt L, Benet LZ, Leifritz D, Christians U: Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain. Br J Pharmacol 133: 875-885, 2001.
    • (2001) Br J Pharmacol , vol.133 , pp. 875-885
    • Serkova, N.1    Jacobsen, W.2    Niemann, C.U.3    Litt, L.4    Benet, L.Z.5    Leifritz, D.6    Christians, U.7
  • 51
    • 0033729567 scopus 로고    scopus 로고
    • Pharmacokinetics of SDZ RAD and cyclosporine including their metabolites in seven kidney graft patients after the first dose of SDZ RAD
    • Kirchner GI, Winkler M, Mueller L y cols.: Pharmacokinetics of SDZ RAD and cyclosporine including their metabolites in seven kidney graft patients after the first dose of SDZ RAD. Br J Clin Pharmacol 50: 449-454, 2000.
    • (2000) Br J Clin Pharmacol , vol.50 , pp. 449-454
    • Kirchner, G.I.1    Winkler, M.2    Mueller, L.3
  • 54
    • 0034746371 scopus 로고    scopus 로고
    • Longitudinal assessment of everolimus in de novo renal transplant recipients over the first postrasplant year: Pharmacokinetics, exposure-response, relationship and influence on cylosporine
    • Kovarik JM, Kahan BD, Kaplan B, Lorber M, Winkler M, Rouilly M, Gerbeau C, Cambon N, Boger R, Rordorf C: Longitudinal assessment of everolimus in de novo renal transplant recipients over the first postrasplant year: Pharmacokinetics, exposure-response, relationship and influence on cylosporine. Clin Pharmacol Ther 69: 48-56, 2001.
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 48-56
    • Kovarik, J.M.1    Kahan, B.D.2    Kaplan, B.3    Lorber, M.4    Winkler, M.5    Rouilly, M.6    Gerbeau, C.7    Cambon, N.8    Boger, R.9    Rordorf, C.10
  • 56
    • 0003336529 scopus 로고    scopus 로고
    • Influence of renal and hepatic impairment on everolimus pharmacokinetics: Are dose adjustments necessary?
    • Kovarik JM, Sabia H, Rouilly M y cols.: Influence of renal and hepatic impairment on everolimus pharmacokinetics: are dose adjustments necessary? Am J Transplant 1 (Supl. 1): 989, 2001.
    • (2001) Am J Transplant , vol.1 , Issue.1 SUPPL. , pp. 989
    • Kovarik, J.M.1    Sabia, H.2    Rouilly, M.3
  • 57
    • 0035862975 scopus 로고    scopus 로고
    • Pharmacokinetics and tolerability of 40-0-[2-hydroxiethyl]rapamycin in de novo liver transplant recipients
    • Levy GA, Grant D, Paradis K, Campestrini J, Smith T, Kovarik JM: Pharmacokinetics and tolerability of 40-0-[2-hydroxiethyl]rapamycin in de novo liver transplant recipients. Transplantation 171: 160-163, 2001.
    • (2001) Transplantation , vol.171 , pp. 160-163
    • Levy, G.A.1    Grant, D.2    Paradis, K.3    Campestrini, J.4    Smith, T.5    Kovarik, J.M.6
  • 59
    • 0033060549 scopus 로고    scopus 로고
    • LC/ESI-MS allows simultaneous and specific quantification of SDZ RAD and cyclosporine, including groups of their metabolities, in human blood
    • Kirchner GI, Vidal C, Winkler M y cols.: LC/ESI-MS allows simultaneous and specific quantification of SDZ RAD and cyclosporine, including groups of their metabolities, in human blood. Ther Drug Monitor 21: 116-122, 1999.
    • (1999) Ther Drug Monitor , vol.21 , pp. 116-122
    • Kirchner, G.I.1    Vidal, C.2    Winkler, M.3
  • 60
    • 0036138190 scopus 로고    scopus 로고
    • Differential influence of two cyclosporine formulations on everolimus pharmacokinetics: A clinically relevant pharmacokinetic interction
    • Kovarik JM, Kalbag J, Figueiredo J, Rouilly M, O'Bannon LF, Rordorf C: Differential influence of two cyclosporine formulations on everolimus pharmacokinetics: a clinically relevant pharmacokinetic interction. J Clin Pharmacol 42: 95-99, 2002.
    • (2002) J Clin Pharmacol , vol.42 , pp. 95-99
    • Kovarik, J.M.1    Kalbag, J.2    Figueiredo, J.3    Rouilly, M.4    O'Bannon, L.F.5    Rordorf, C.6
  • 62
    • 0035958104 scopus 로고    scopus 로고
    • RAD in de novo renal transplantation: A comparison of three doses on the incidence and severity of acute rejection
    • Kahan BD, Kaplan B, Sorber MI, Winkler M, Cambon N, Boger RS: RAD in de novo renal transplantation: a comparison of three doses on the incidence and severity of acute rejection. Transplantation 171: 1400-1406, 2001.
    • (2001) Transplantation , vol.171 , pp. 1400-1406
    • Kahan, B.D.1    Kaplan, B.2    Sorber, M.I.3    Winkler, M.4    Cambon, N.5    Boger, R.S.6
  • 63
    • 9244246780 scopus 로고    scopus 로고
    • Everolimus (Certican TM) 12-month safety and efficacy versus mycophenolate mofetil in de novo renal transplant recipients
    • in press
    • Vitko S, Margreiter R, Weimar W y cols.: Everolimus (Certican TM) 12-month safety and efficacy versus mycophenolate mofetil in de novo renal transplant recipients. Transplantation (in press).
    • Transplantation
    • Vitko, S.1    Margreiter, R.2    Weimar, W.3
  • 64
    • 0001115605 scopus 로고    scopus 로고
    • North/South American double-blind, parallel-group study of the safety and efficacy of Certican versus mycophenolate mofetil in combination with Neoral and corticosteroids
    • Kaplan B, Tedesco-Silva H, Méndez R y cols.: North/South American double-blind, parallel-group study of the safety and efficacy of Certican versus mycophenolate mofetil in combination with Neoral and corticosteroids [Abstract]. Am J Transplant 1 (Supl. 1): 475, 2001.
    • (2001) Am J Transplant , vol.1 , Issue.1 SUPPL. , pp. 475
    • Kaplan, B.1    Tedesco-Silva, H.2    Méndez, R.3
  • 65
    • 0000373660 scopus 로고    scopus 로고
    • One year results of a multicenter open-label trial on safety and efficacy of certican (RAD) used in combination with Simulect, corticosteroids, and full or reduce dose Neoral in renal transplantation
    • Curtis J, Nashan B, Ponticelli C, Mourad G, Borger R y cols.: One year results of a multicenter open-label trial on safety and efficacy of certican (RAD) used in combination with Simulect, corticosteroids, and full or reduce dose Neoral in renal transplantation. Am J Transplant 1 (Supl. 1): 474, 2001.
    • (2001) Am J Transplant , vol.1 , Issue.1 SUPPL. , pp. 474
    • Curtis, J.1    Nashan, B.2    Ponticelli, C.3    Mourad, G.4    Borger, R.5
  • 67
    • 0037181426 scopus 로고    scopus 로고
    • Exposure-response relationship for everolimus in de novo kidney transplantation: Defining a therapeutic range
    • Kovarik JM, Kaplan B, Tedesco Silva H y cols.: Exposure-response relationship for everolimus in de novo kidney transplantation: defining a therapeutic range. Transplantation 73: 920-925, 2002.
    • (2002) Transplantation , vol.73 , pp. 920-925
    • Kovarik, J.M.1    Kaplan, B.2    Tedesco Silva, H.3
  • 68
    • 0001666646 scopus 로고    scopus 로고
    • RAD (everolimus) pharmacokinetics are unaltered with full-dose versus reduced-dose cyclosporine
    • Abstract
    • Curtis J, Nashan B, Kovarik JM y cols.: RAD (everolimus) pharmacokinetics are unaltered with full-dose versus reduced-dose cyclosporine. Am J Transplant 1 (Supl. 1): 651 [Abstract], 2001.
    • (2001) Am J Transplant , vol.1 , Issue.1 SUPPL. , pp. 651
    • Curtis, J.1    Nashan, B.2    Kovarik, J.M.3
  • 70
    • 0033565808 scopus 로고    scopus 로고
    • Neoral monitoring by simlified sparse sampling are under the concentration-time curve
    • Mahalati K, Belitsky P, Sketris I, West K, Panek R: Neoral monitoring by simlified sparse sampling are under the concentration-time curve. Transplantation 68: 55-62, 1999.
    • (1999) Transplantation , vol.68 , pp. 55-62
    • Mahalati, K.1    Belitsky, P.2    Sketris, I.3    West, K.4    Panek, R.5
  • 71
    • 0031863345 scopus 로고
    • Two-hour cyclosporine level determination is the appropriate tool to monitor Neoral therapy
    • Cantarovich M, Besner JG, Barkun JS, Elstein E, Loertscher R: Two-hour cyclosporine level determination is the appropriate tool to monitor Neoral therapy. Clin Transplant 12: 243-249, 1988.
    • (1988) Clin Transplant , vol.12 , pp. 243-249
    • Cantarovich, M.1    Besner, J.G.2    Barkun, J.S.3    Elstein, E.4    Loertscher, R.5
  • 72
    • 0036487978 scopus 로고    scopus 로고
    • Cyclosporine microemulsion (Neoral) absorption profiling and sparse-sample predictors during the first 3 months after renal transplantation
    • International Neoral Renal Transplantation Study Group: Cyclosporine microemulsion (Neoral) absorption profiling and sparse-sample predictors during the first 3 months after renal transplantation. Am J Transplant 2: 148-156, 2002.
    • (2002) Am J Transplant , vol.2 , pp. 148-156
  • 73
    • 0036487972 scopus 로고    scopus 로고
    • Randomized, international study of cyclosporine microemulsion absorption profiling in renal transplantation with basiliximab immunoprophylaxis
    • International Neoral Renal Transplantation Study Group: Randomized, international study of cyclosporine microemulsion absorption profiling in renal transplantation with basiliximab immunoprophylaxis. Am J Transplant 2: 157-166, 2002.
    • (2002) Am J Transplant , vol.2 , pp. 157-166
  • 74
    • 1642378081 scopus 로고    scopus 로고
    • Excellent renal function with concentration-controlled everolimus, reduced exposure to neoral and steroids in de novo kidney transplant recipients: Resultad of a 6 months effciacy and safety analysis
    • Abstract
    • Pascual J, Tedesco H, Civati G, Magee J, Haas T, Bernhardt P: Excellent renal function with concentration-controlled everolimus, reduced exposure to neoral and steroids in de novo kidney transplant recipients: resultad of a 6 months effciacy and safety analysis. Nephrol Dial Transplant 18 (Supl. 4): 786, 2003 [Abstract].
    • (2003) Nephrol Dial Transplant , vol.18 , Issue.4 SUPPL. , pp. 786
    • Pascual, J.1    Tedesco, H.2    Civati, G.3    Magee, J.4    Haas, T.5    Bernhardt, P.6
  • 75
    • 4544341683 scopus 로고    scopus 로고
    • Excellent graft function in de novo kidney transplant recipients treated with concentration-controlle everolimus, reduced neoral exposure and basiliximab: 6 months analysis
    • Abstract
    • Kramer BK, Whelchel J, Eris J y cols.: Excellent graft function in de novo kidney transplant recipients treated with concentration-controlle everolimus, reduced neoral exposure and basiliximab: 6 months analysis. Nephrol Dial Transplant 18 (Supl. 4): 786 [Abstract].
    • Nephrol Dial Transplant , vol.18 , Issue.4 SUPPL. , pp. 786
    • Kramer, B.K.1    Whelchel, J.2    Eris, J.3
  • 77
    • 19244366021 scopus 로고    scopus 로고
    • Everolimus for the prevention of allograft rejection and vasculopathy in cardiac transplant recipients
    • Eisen HJ, Tuzcu EM, Dorent R y cols.: Everolimus for the prevention of allograft rejection and vasculopathy in cardiac transplant recipients. N Engl J Med 349: 847-858, 2003.
    • (2003) N Engl J Med , vol.349 , pp. 847-858
    • Eisen, H.J.1    Tuzcu, E.M.2    Dorent, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.