Molecular imaging of myocardial injury: A magnetofluorescent approach

Current Cardiovascular Imaging Reports

Volumn 2, Issue 1, 2009, Pages 33-39

  Sosnovik, David E ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79751491249     PISSN: 19419066     EISSN: 19419074     Source Type: Journal    
DOI: 10.1007/s12410-009-0005-x     Document Type: Review

References (37)

1. Wu JC, Bengel FM, Gambhir SS: Cardiovascular molecular imaging. Radiology 2007, 244: 337-355.
2. Sosnovik DE, Nahrendorf M, Weissleder R: Molecular magnetic resonance imaging in cardiovascular medicine. Circulation 2007, 115: 2076-2086.
3. Weissleder R, Ntziachristos V: Shedding light onto live molecular targets. Nat Med 2003, 9: 123-128.
4. Sosnovik DE, Nahrendorf M, Weissleder R: Targeted imaging of myocardial damage. Nat Clin Pract Cardiovasc Med 2008, 5(Suppl 2): S63-S70.
5. Louie AY, Huber MM, Ahrens ET, et al.: In vivo visualization of gene expression using magnetic resonance imaging. Nat Biotechnol 2000, 18: 321-325.
6. Perez JM, Josephson L, O'Loughlin T, et al.: Magnetic relaxation switches capable of sensing molecular interactions. Nat Biotechnol 2002, 20: 816-820.
7. Chen J, Tung CH, Allport JR, et al.: Near-infrared fluorescent imaging of matrix metalloproteinase activity after myocardial infarction. Circulation 2005, 111: 1800-1805.
8. Nahrendorf M, Sosnovik DE, Waterman P, et al.: Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarct. Circ Res 2007, 100: 1218-1225.
9. Nahrendorf M, Sosnovik D, Chen JW, et al.: Activatable magnetic resonance imaging agent reports myeloperoxidase activity in healing infarcts and noninvasively detects the antiinflammatory effects of atorvastatin on ischemia-reperfusion injury. Circulation 2008, 117: 1153-1160.
10. Weissleder R, Tung CH, Mahmood U, Bogdanov A Jr: In vivo imaging of tumors with protease-activated near-infrared fluorescent probes. Nat Biotechnol 1999, 17: 375-378.
11. Chen JW, Querol Sans M, Bogdanov A Jr, Weissleder R: Imaging of myeloperoxidase in mice by using novel amplifiable paramagnetic substrates. Radiology 2006, 240: 473-481.
12. Taktak S, Sosnovik D, Cima MJ, et al.: Multiparameter magnetic relaxation switch assays. Anal Chem 2007, 79: 8863-8869.
13. Wunderbaldinger P, Josephson L, Weissleder R: Crosslinked iron oxides (CLIO): a new platform for the development of targeted MR contrast agents. Acad Radiol 2002, 9(Suppl 2): S304-S306.
14. Sosnovik DE, Nahrendorf M, Weissleder R: Magnetic nanoparticles for MR imaging: agents, techniques and cardiovascular applications. Basic Res Cardiol 2008, 103: 122-130.
15. Hofstra L, Liem IH, Dumont EA, et al.: Visualisation of cell death in vivo in patients with acute myocardial infarction. Lancet 2000, 356: 209-212.
16. Berr SS, Roy RJ, French BA, et al.: Black blood gradient echo cine magnetic resonance imaging of the mouse heart. Magn Reson Med 2005, 53: 1074-1079.
17. Sosnovik DE, Nahrendorf M, Deliolanis N, et al.: Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo. Circulation 2007, 115: 1384-1391.
18. Korngold EC, Jaffer FA, Weissleder R, Sosnovik DE: Noninvasive imaging of apoptosis in cardiovascular disease. Heart Fail Rev 2008, 13: 163-173.
19. Kajstura J, Cheng W, Reiss K, et al.: Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats. Lab Invest 1996, 74: 86-107.
20. Kang PM, Izumo S: Apoptosis in heart: basic mechanisms and implications in cardiovascular diseases. Trends Mol Med 2003, 9: 177-182.
21. Boersma HH, Kietselaer BL, Stolk LM, et al.: Past, present, and future of annexin A5: from protein discovery to clinical applications. J Nucl Med 2005, 46: 2035-2050.
22. Dumont EA, Reutelingsperger CP, Smits JF, et al.: Realtime imaging of apoptotic cell-membrane changes at the single-cell level in the beating murine heart. Nat Med 2001, 7: 1352-1355.
23. Narula J, Acio ER, Narula N, et al.: Annexin-V imaging for noninvasive detection of cardiac allograft rejection. Nat Med 2001, 7: 1347-1352.
24. Schellenberger EA, Sosnovik D, Weissleder R, Josephson L: Magneto/optical annexin V, a multimodal protein. Bioconjug Chem 2004, 15: 1062-1067.
25. Schellenberger EA, Bogdanov A Jr, Petrovsky A, et al.: Optical imaging of apoptosis as a biomarker of tumor response to chemotherapy. Neoplasia 2003, 5: 187-192.
26. Sosnovik DE, Schellenberger EA, Nahrendorf M, et al.: Magnetic resonance imaging of cardiomyocyte apoptosis with a novel magneto-optical nanoparticle. Magn Reson Med 2005, 54: 718-724.
27. Hiller KH, Waller C, Nahrendorf M, et al.: Assessment of cardiovascular apoptosis in the isolated rat heart by magnetic resonance molecular imaging. Mol Imaging 2006, 5: 115-121.
28. Zhao M, Li Z, Bugenhagen S: 99mTc-labeled duramycin as a novel phosphatidylethanolamine-binding molecular probe. J Nucl Med 2008, 49: 1345-1352.
29. Khaw BA, Fallon FT, Strauss HW, Haber E: Myocardial infarct imaging of antibodies to canine cardiac myosin with indium-111-diethylenetriamine pentaacetic acid. Science 1980, 209: 295-297.
30. Khaw BA, Gold HK, Yasuda T, et al.: Scintigraphic quantification of myocardial necrosis in patients after intravenous injection of myosin-specific antibody. Circulation 1986, 74: 501-508.
31. Weissleder R, Lee AS, Khaw BA, et al.: Antimyosin-labeled monocrystalline iron oxide allows detection of myocardial infarct: MR antibody imaging. Radiology 1992, 182: 381-385.
32. Weissleder R, Kelly K, Sun EY, et al.: Cell-specific targeting of nanoparticles by multivalent attachment of small molecules. Nat Biotechnol 2005, 23: 1418-1423.
33. Flogel U, Ding Z, Hardung H, et al.: In vivo monitoring of inflammation after cardiac and cerebral ischemia by fluorine magnetic resonance imaging. Circulation 2008, 118: 140-148.
34. Farrar CT, Dai G, Novikov M, et al.: Impact of field strength and iron oxide nanoparticle concentration on the linearity and diagnostic accuracy of off-resonance imaging. NMR Biomed 2008, 21: 453-463.
35. Caravan P, Das B, Dumas S, et al.: Collagen-targeted MRI contrast agent for molecular imaging of fibrosis. Angew Chem Int Ed Engl 2007, 46: 8171-8173.
36. Helm PA, Caravan P, French BA, et al.: Postinfarction myocardial scarring in mice: molecular MR imaging with use of a collagen-targeting contrast agent. Radiology 2008, 247: 788-796.
37. Spuentrup E, Botnar RM, Wiethoff AJ, et al.: MR imaging of thrombi using EP-2104R, a fibrin-specific contrast agent: initial results in patients. Eur Radiol 2008, 18: 1995-2005.