Impact of field strength and iron oxide nanoparticle concentration on the linearity and diagnostic accuracy of off-resonance imaging

NMR in Biomedicine

Volumn 21, Issue 5, 2008, Pages 453-463

  Farrar, Christian T ^a   Dai, Guangping ^a   Novikov, Mikhail ^b   Rosenzweig, Anthony ^b   Weissleder, Ralph ^a   Rosen, Bruce R ^a   Sosnovik, David E ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Diagnostic accuracy; Magnetic field strength; Monocrystalline iron oxide nanoparticle; Myocardial infarction; Off resonance imaging

Indexed keywords

CONCENTRATION (PROCESS); HEALTH; IMAGING TECHNIQUES; IMPACT STRENGTH; IRON; LINEARIZATION; MAGNETIC FIELDS; NANOPARTICLES; NANOSTRUCTURED MATERIALS; NANOSTRUCTURES; PHOTORESISTS; RESONANCE;

AIR INTERFACE; DIAGNOSTIC ACCURACY; FIELD DEPENDENCES; FIELD STRENGTHS; IMAGING AGENTS; IRON OXIDE NANOPARTICLES; MAGNETIC FIELD STRENGTH; MAGNETIC FIELD STRENGTHS; MONOCRYSTALLINE; MONOCRYSTALLINE IRON OXIDE NANOPARTICLE; MOUSE MODELS; MYOCARDIAL INFARCTION; NON-LINEAR; OFF-RESONANCE; OFF-RESONANCE IMAGING; OXIDE NANO PARTICLES; RESONANCE SHIFTS;

IRON OXIDES;

MONOCRYSTALLINE IRON OXIDE NANOPARTICLE; WATER;

AIR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL INFILTRATION; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DESCENDING AORTA; DIAGNOSTIC ACCURACY; DRUG UPTAKE; FREQUENCY MODULATION; HEART INFARCTION; IN VITRO STUDY; IN VIVO STUDY; LINEAR SYSTEM; MACROPHAGE; MAGNETIC FIELD; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OFF RESONANCE IMAGING; PHANTOM; PRIORITY JOURNAL; RADIODIAGNOSIS; RADIOFREQUENCY; SENSITIVITY AND SPECIFICITY; THORAX WALL;

ANIMALS; DIAGNOSTIC IMAGING; DISEASE MODELS, ANIMAL; ENERGY TRANSFER; FERROSOFERRIC OXIDE; HEART; MACROPHAGES; MAGNETIC RESONANCE SPECTROSCOPY; MAGNETICS; MICE; MYOCARDIAL INFARCTION; NANOPARTICLES; PHANTOMS, IMAGING; REFERENCE VALUES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPIN LABELS; VIBRATION; WATER;

EID: 46049100379     PISSN: 09523480     EISSN: 10991492     Source Type: Journal    
DOI: 10.1002/nbm.1209     Document Type: Article

References (30)

1. Shen T, Weissleder R, Papisov M, Bogdanov A, Brady TJ. Monocrystalline iron oxide nanocompounds (MION): physicochemical properties. Magn Reson Med. 1993; 29: 599-604.
2. Harisinghani MG, Barentsz J, Hahn PF, Deserno WM, Tabatabaei S, van de Kaa CH, de la Rosette J, Weissleder R. Noninvasive detection of clinically occult lymph-node metastases in prostate cancer. N Engl J Med. 2003; 348: 2491-2499.
3. Sosnovik DE, Weissleder R. Magnetic resonance and fluorescence based molecular imaging technologies. Prog Drug Res. 2005; 62: 83-115.
4. Frank JA, Miller BR, Arbab AS, Zywicke HA, Jordan EK, Lewis BK, Bryant LH, Bulte JW. Clinically applicable labeling of mammalian and stem cells by combining superparamagnetic iron oxides and transfection agents. Radiology. 2003; 228: 480-487.
5. Lewin M, Carlesso N, Tung CH, Tang XW, Cory D, Scadden DT, Weissleder R. Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells. Nat Biotechnol. 2000; 18: 410-414.
6. Sosnovik DE, Nahrendorf M, Deliolanis N, Novikov M, Aikawa E, Josephson L, Rosenzweig A, Weissleder R, Ntziachristos V. Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo. Circulation. 2007; 115: 1384-1391.
7. Nahrendorf M, Sosnovik DE, Waterman P, Swirski FK, Pande A, Aikawa E, Figueiredo JL, Pittet MJ, Weissleder R. Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarct. Circ Res. 2007; 100: 1218-1225.
8. Sosnovik DE, Schellenberger EA, Nahrendorf M, Novikov MS, Matsui T, Dai G, Reynolds F, Grazette L, Rosenzweig A, Weissleder R, Josephson L. Magnetic resonance imaging of cardiomyocyte apoptosis with a novel magneto-optical nanoparticle. Magn Reson Med. 2005; 54: 718-724.
9. Nahrendorf M, Jaffer FA, Kelly KA, Sosnovik DE, Aikawa E, Libby P, Weissleder R. Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atheroselerosis. Circulation. 2006; 114: 1504-1511.
10. Weissleder R, Moore A, Mahmood U, Bhorade R, Benveniste H, Chiocca EA, Basilion JP. In vivo magnetic resonance imaging of transgene expression. Nat Med. 2000; 6: 351-355.
11. Tannous BA, Grimm J, Perry KF, Chen JW, Weissleder R, Breakefield XO. Metabolic biotinylation of cell surface receptors for in vivo imaging. Nat Methods. 2006; 3: 391-396.
12. Foster-Gareau P, Heyn C, Alejski A, Rutt BK. Imaging single mammalian cells with a 1.5 T clinical MRI scanner. Magn Reson Med. 2003; 49: 968-971.
13. Heyn C, Bowen CV, Rutt BK, Foster PJ. Detection threshold of single SPIO-labeled cells with FIESTA. Magn Reson Med. 2005; 53: 312-320.
14. Hogemann-Savellano D, Bos E, Blondet C, Sato F, Abe T, Josephson L, Weissleder R, Gaudet J, Sgroi D, Peters PJ, Basilion JE The transferrin receptor: a potential molceular imaging marker for human cancer. Neoplasia. 2003; 5: 495-506.
15. Seppenwoolde JH, Viergever MA, Bakker CJ. Passive tracking exploiting local signal conservation: the white marker phenomenon. Magn Reson Med. 2003; 50: 784-790.
16. Mani V, Briley-Saebo KC, Itskovich VV, Samber DD, Fayad ZA. Gradient echo acquisition for superparamagnetic particles with positive contrast (GRASP): sequence characterization in membrane and glass superparamagnetic iron oxide phantoms at 1.5 T and 3 T. Magn Reson Med. 2006; 55: 126-135.
17. Mani V, Briley-Saebo KC, Hyafil F, Fayad ZA. Feasibility of in vivo identification of endogenous ferritin with positive contrast MRI in rabbit carotid crush injury using GRASE Magn Reson Med. 2006; 56: 1096-1106.
18. Cunningham CH, Arai T, Yang PC, McConnell MV, Pauly JM, Conolly SM. Positive contrast magnetic resonance imaging of cells labeled with magnetic nanoparticles. Magn Reson Med. 2005; 53: 999-1005.
19. Foltz WD, Cunningham CH, Mutsaers AJ, Conolly SM, Stewart DJ, Dick AJ. Positive-contrast imaging in the rabbit hind-limb of transplanted cells bearing endocytosed superparamagnetic beads. J Cardiovasc Magn Reson. 2006; 8: 817-823.
20. Stuber M, Gilson WD, Schaer M, Bulte JW, Kraitchman DL. Shedding light on the dark spot with IRON - a method that generates positive contrast in the presence of superparamagnetic nanoparticles. Proc Intl Soc Magn Reson Med. 2005; 13: 2608.
21. Korosoglou G, Shah S, Gilson WD, Schar M, Tang L, Terrovitis I, Weiss RG, Weissleder R, Kraitchman DL, Stuber M. Off-resonance angiography: a new method to visualize vessels. J Card Magn Reson. 2007; 9: 209-2211.
22. Zurkiya O, Hu X. Off-resonance saturation as a means of generating contrast with superparamagnetic nanoparticles. Magn Reson Med. 2006; 56: 726-732.
23. Ward KM, Aletras AH, Balaban RS. A new class of contrast agents for MRI based on proton chemical exchange dependent saturation transfer (CEST). J Magn Reson. 2000; 143: 79-87.
24. Perez JM, Josephson L, O'Loughlin T, Hogemann D, Weissleder R. Magnetic relaxation switches capable of sensing molecular interactions. Nat Biotechnol. 2002; 20: 816-820.
25. Simon GH, Bauer J, Saborovski O, Fu Y, Corot C, Wendland MF, Daldrup-Link HE. T1 and T2 relaxivity of intracellular and extracellular USPIO at 1.5 T and 3 T clinical MR scanning. Eur Radiol. 2006; 16: 738-745.
26. Bowen CV, Zhang X, Saab G, Gareau PJ, Rutt BK. Application of the static dephasing regime theory to superparamagnetic iron-oxide loaded cells. Magn Reson Med. 2002; 48: 52-61.
27. Bulte JW, Vymazal J, Brooks RA, Pierpaoli C, Frank JA. Frequency dependence of MR relaxation times. II. Iron oxides. J Magn Reson Imaging. 1993; 3: 641-648.
28. Wunderbaldinger P, Josephson L, Weissleder R. Tat peptide directs enhanced clearance and hepatic permeability of magnetic nanoparticles. Bioconjug Chem. 2002; 13: 264-268.
29. Moffat BA, Reddy GR, McConviIle P, Hall DE, Chenevert TL, Kopelman RR, Philbert M, Weissleder R, Rehemtulla A, Ross BD. A novel polyacrylamide magnetic nanoparticle contrast agent for molecular imaging using MRI. Mol Imaging. 2003; 2: 324-332.
30. Lee JH, Huh YM, Jun YW, Seo JW, Jang JT, Song HT, Kim S, Cho EJ, Yoon HG, Suh JS, Cheon J. Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging. Nat Med. 2007; 13: 95-99.