Lipoic acid protects against reperfusion injury in the early stages of cerebral ischemia

Brain Research

Volumn 1375, Issue , 2011, Pages 128-136

  Connell, Barry J ^a   Saleh, Monique ^a   Khan, Bobby V ^b   Saleh, Tarek M ^a  

^a UNIVERSITY OF PRINCE EDWARD ISLAND   (Canada)

^b EMORY UNIVERSITY   (United States)

Author keywords

ER stress; Lipoic acid; Neuroprotection; Reperfusion injury; Stroke

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; MANGANESE SUPEROXIDE DISMUTASE; N(G) NITROARGININE METHYL ESTER; SODIUM CHLORIDE; THIOCTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD PRESSURE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN PERFUSION; CELL DEATH; CONTROLLED STUDY; HEART RATE; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PREFRONTAL CORTEX; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; STROKE; WESTERN BLOTTING;

ANIMALS; ANTIOXIDANTS; BAROREFLEX; BLOTTING, WESTERN; BRAIN ISCHEMIA; CEREBRAL INFARCTION; CEREBROVASCULAR CIRCULATION; CYTOSOL; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; HEMODYNAMICS; MALE; MIDDLE CEREBRAL ARTERY; MITOCHONDRIA; NEUROPROTECTIVE AGENTS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SUPEROXIDE DISMUTASE; THIOCTIC ACID;

RATTUS;

EID: 79651475501     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2010.12.045     Document Type: Article

References (47)

1. E.H. Bae, K.S. Lee, J.U. Lee, S.K. Ma, S.H. Kim, K.C. Choi, J. Frokiaer, S. Nielsen, S.Y. Kim, and S.W. Kim Effects of α-lipoic acid on ischemia-reperfusion-induced renal dysfunction in rats Am. J. Physiol. Ren. Physiol. 294 2008 F272 F280
2. G.P. Biewenga, G.R.M. Haenen, and A. Bast The pharmacology of the antioxidant lipoic acid Gen. Pharm. 29 1997 315 331
3. G.E. Billman, T.M. Schwartz, and H.L. Stone Baroreceptor control of heart rate: a predictor of sudden cardiac death Circulation 66 1982 874 880 (Pubitemid 12015075)
4. A. Bilska, and L. Wlodek Lipoic acid-the drug of the future? Pharmacol. Rep. 57 2005 570 577
5. X.H. Cao, and J.W. Phillis The free radical scavenger α-lipoic acid protects against cerebral ischemia-reperfusion injury in gerbils Free Radic. Res. 23 1995 365 370
6. D.F. Cechetto, J.X. Wilson, K. Smith, D. Wolski, and V.C. Hachinski Autonomic and myocardial changes in MCAO: stroke models in the rat Brain Res. 502 1989 296 305 (Pubitemid 19276516)
7. P.H. Chan Mitochondria and neuronal death/survival signaling pathways in cerebral ischemia Neurochem. Res. 29 2004 1943 1949 (Pubitemid 39663875)
8. P.H. Chan Mitochondrial dysfunction and oxidative stress as determinants of cell death/survival Ann. NY Acad. Sci. 1042 2005 203 209 (Pubitemid 40967640)
9. R.T.F. Cheung, T. Diab, and D.F. Cechetto Time-course of neuropeptide changes in the peri-ischemic zone and amygdala following focal ischemia in rats J. Comp. Neurol. 360 1995 101 121
10. G. Chidlow, K.G. Schmidt, J.P.M. Wood, J. Melena, and N.N. Osborne α-lipoic acid protects the retina against ischemia-reperfusion Neuropharmacology 43 2002 1015 1025 (Pubitemid 35341237)
11. W.M. Clark, L.G. Rinker, N.S. Lessov, S.L. Lowery, and M.J. Cipolla Efficacy of antioxidant therapies in transient focal ischemia in mice Stroke 32 2001 1000 1004 (Pubitemid 32285174)
12. B.J. Connell, and T.M. Saleh A novel rodent model of reperfusion injury following occlusion of the middle cerebral artery J. Neurosci. Methods 190 2010 28 33
13. L. Ding-Zhou, C. Marchand-Verrecchia, N. Croci, M. Plotkine, and I. Margaill L-NAME reduces infarction, neurological deficit and blood-brain barrier disruption following cerebral ischemia in mice Eur. J. Pharmacol. 457 2002 137 146 (Pubitemid 35447655)
14. M. Fujimura, Y. Morita-Fujimura, M. Kawase, J.C. Copin, B. Calagui, C.J. Epstein, and P.H. Chan Manganese superoxide dismutase mediates the early release of mitochondrial cytochrome c and subsequent DNA fragmentation after permanent focal cerebral ischemia in mice J. Neurosci. 19 1999 3414 3422 (Pubitemid 29203121)
15. M. Gabowski, B.B. Johansson, and P. Brundin Fetal neocortical grafts placed in brain infarcts do not improve paw-reaching deficits in adult spontaneously hypertensive rats Acta Neurochir. Suppl. 66 1996 68 72 (Pubitemid 126440531)
16. G-nitro-l-arginine methyl ester in conscious, Long Evans rats Br. J. Pharmacol. 101 1990 625 631 (Pubitemid 20357186)
17. M.D. Ginsberg Neuroprotection for ischemic stroke: past, present and future Neuropharmacology 55 2008 363 389
18. S.S. Gross, and M.S. Wolin Nitric oxide: pathophysiological mechanisms Annu. Rev. Physiol. 57 1995 737 769
19. E.D. Hall, R.A. Vaishnav, and A.G. Mustafa Antioxidant therapies for traumatic brain injury J. Am. Soc. Exp. NeuroTher. 7 2010 51 61
20. B.B. Heinisch, M. Francesconi, F. Mittermayer, G. Schaller, G. Gouya, M. Wolzt, and J. Pleiner Alpha-lipoic acid improves vascular endothelial function in patients with type 2 diabetes: a placebo-controlled randomized trial Eur. J. Clin. Invest. 40 2010 148 154
21. T. Heitzer, B. Finckh, S. Albers, K. Krohn, A. Kohlschutter, and T. Meinertz Beneficial effects of α-lipoic acid and ascorbic acid on endothelium-dependent, nitric oxide-mediated vasodilation in diabetic patients: relation to parameters of oxidative stress Free Radical Biol. Med. 31 2001 53 61 (Pubitemid 32568424)
22. H.Y. Jin, S.J. Joung, J.H. Park, H.S. Baek, and T.S. Park The effect of α-lipoic acid on symptoms and skin blood flow in diabetic neuropathy Diabet. Med. 24 2007 1034 1038 (Pubitemid 47301632)
23. J.E. Jung, G.S. Kim, P. Narasimhan, Y.S. Song, and P. Chan Regulation of Mn-Superoxide dismutase activity and neuroprotection of STAT3 in mice after cerebral ischemia J. Neurosci. 29 2009 7003 7014
24. G.W. Kim, T. Kondo, N. Noshita, and P.H. Chan Manganese superoxide dismutase deficiency exacerbates cerebral infarction after focal cerebral ischemia/reperfusion in mice. Implications for the production and role of superoxide radicals Stroke 33 2002 809 815 (Pubitemid 34207703)
25. S.A. Lipton Neuronal protection and destruction by NO Cell Death Differ. 6 1999 943 951 (Pubitemid 29520794)
26. C.M. Maier, L. Hsieh, T. Crandall, P. Narasimhan, and P.H. Chan Evaluating therapeutic targets for reperfusion-related brain hemorrhage Ann. NY Acad. Sci. 59 2006 929 938 (Pubitemid 43830925)
27. I. Margaill, M. Allix, R.G. Boulu, and M. Plotkine Dose- and time-dependence of l-NAME neuroprotection in transient focal cerebral ischemia in rats Br. J. Pharmacol. 120 1997 160 163 (Pubitemid 27042575)
28. Y. Mitsui, J.D. Schmelzer, P.J. Zollman, M. Mitsui, H.J. Tritschler, and P.A. Low Alpha-lipoic acid provides neuroprotection from ischemia-reperfusion injury of peripheral nerve J. Neurol. Sci. 163 1999 11 16 (Pubitemid 29155409)
29. E. Murakami, T. Kondo, M. Kawase, Y. Li, S. Sato, S.F. Chen, and P.H. Chan Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency J. Neurosci. 18 1998 205 213 (Pubitemid 28046782)
30. M.G. Myers, J.W. Norris, V.C. Hachinski, and M.J. Sole Cardiac sequelae of acute stroke Stroke 13 1982 833 842
31. S.M. Oppenheimer, D.F. Cechetto, and V.C. Hachinski Cerebrogenic cardiac arrhythmias: cerebral electrocardiographic influences and their role in sudden death Arch. Neurol. 47 1990 513 519 (Pubitemid 20155838)
32. L. Packer, H.J. Tritschler, and K. Wessel Neuroprotection by the metabolic antioxidant α-lipoic acid Free Radic. Biol. Med. 22 1997 359 378
33. J. Pan, A.A. Konstas, B. Bateman, G.A. Ortolano, and J. Pile-Spellman Reperfusion injury following cerebral ischemia: pathophysiology, MR imaging, and potential therapies Neuroradiology 49 2007 93 102 (Pubitemid 46218581)
34. M. Panigrahi, Y. Sadguna, B.R. Shivakumar, S.V.R. Kolluri, S. Roy, L. Packer, and V. Ravindranath α-Lipoic acid protects against reperfusion injury following cerebral ischemia Brain Res. 717 1996 184 188 (Pubitemid 26153450)
35. T.M. Paravicini, S. Chrissobolis, G.R. Drummond, and C.G. Sobey Increased NADPH-oxidase activity and Nox4 expression during chronic hypertension is associated with enhanced cerebral vasodilation to NADPH in vivo Stroke 35 2004 584 589 (Pubitemid 38174454)
36. D.D. Rees, R.M.J. Palmer, R. Schulz, H.F. Hodson, and S. Moncada Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo Br. J. Pharmacol. 101 1990 746 752 (Pubitemid 20357206)
37. T. Reese, R. Porszasz, D. Baumann, D. Bochelen, F. Boumezbeur, K.J. McAllister, A. Sauter, B. Bjelk, and M. Rudin Cytoprotection does not preserve brain functionality in rats during the acute post-stroke phase despite evidence of non-infarction provided by MRI NMR Biomed. 13 2000 361 370
38. T.M. Saleh, and B.J. Connell Central nuclei mediating estrogen-induced changes in autonomic tone and baroreceptor reflex in male rats Brain Res. 961 2003 190 200 (Pubitemid 36071580)
39. T.M. Saleh, A.E. Cribb, and B.J. Connell Estrogen-induced recovery of autonomic function after middle cerebral artery occlusion in male rats Am. J. Physiol. 281 2001 R1531 R1539
40. T.M. Saleh, A.E. Cribb, and B.J. Connell Reduction in infarct size by local estrogen does not prevent autonomic dysfunction after stroke Am. J. Physiol. 281 2001 R2088 R2095
41. M.C. Saleh, B.J. Connell, and T.M. Saleh Ischemic tolerance following low dose NMDA involves modulation of cellular stress proteins Brain Res. 1247 2009 212 220
42. K. Schonheit, L. Gille, and H. Nohl Effect of alpha-lipoic acid and dihydrolipoic acid on ischemia/reperfusion injury of the heart and heart mitochondria Biochim. Biophys. Acta 1271 1995 335 342
43. K.P. Shay, R.F. Moreau, E.J. Smith, and T.M. Hagen Is α-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity Life 60 2008 362 367
44. K.P. Shay, R.F. Moreau, E.J. Smith, A.R. Smith, and T.M. Hagen Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential Biochim. Biophys. Acta 1790 2009 1149 1160
45. A.R. Smith, S.V. Shenvi, M. Widlansky, J.H. Suh, and T. Hagen Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress Curr. Med. Chem. 11 2004 1135 1146 (Pubitemid 38585058)
46. C. Verrecchia, R.G. Boulu, and M. Plotkine Neuroprotective and deleterious effects of nitric oxide on focal cerebral ischemia-induced neuron death Adv. Neuroimmnol. 5 1995 359 378 (Pubitemid 26024132)
47. P. Wolz, and J. Krieglstein Neuroprotective effects of α-lipoic acid and its enantiomers demonstrated in rodent models of focal cerebral ischemia Neuropharmacology 35 1996 369 375 (Pubitemid 26172069)