The protective effects of chitooligosaccharides against glucose deprivation-induced cell apoptosis in cultured cortical neurons through activation of PI3K/Akt and MEK/ERK1/2 pathways

Brain Research

Volumn 1375, Issue , 2011, Pages 49-58

  Xu, Yanyan ^a   Zhang, Qi ^a   Yu, Shu ^a   Yang, Yumin ^a   Ding, Fei ^a  

^a NANTONG UNIVERSITY   (China)

Author keywords

Apoptosis; Chitooligosaccharide (COS); Cortical neuron; Glucose deprivation (GD); Neuroprotection

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; ADENOSINE; CASPASE 3; CHITOOLIGOSACCHARIDE DERIVATIVE; GLUCOSE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OLIGOSACCHARIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN NERVE CELL; CELL ASSAY; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; MICROPHOTOGRAPHY; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR STABILITY; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; STAINING;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CASPASE 3; CELLS, CULTURED; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLUCOSE; IN SITU NICK-END LABELING; MEMBRANE POTENTIALS; MITOCHONDRIAL MEMBRANES; MITOGEN-ACTIVATED PROTEIN KINASES; NEUROPROTECTIVE AGENTS; OLIGOSACCHARIDES; ONCOGENE PROTEIN V-AKT; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TETRAZOLIUM SALTS; THIAZOLES;

EID: 79651473128     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2010.12.029     Document Type: Article

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