Alterations in Wnt pathway activity in mouse serum and kidneys during lupus development

Arthritis and Rheumatism

Volumn 63, Issue 2, 2011, Pages 513-522

  Tveita, Anders Aune ^a   Rekvig, Ole Petter ^a  

^a UNIVERSITY OF TROMSØ   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; DICKKOPF 1 PROTEIN; WNT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BAGG ALBINO MOUSE; CONTROLLED STUDY; DISEASE COURSE; EXTRACELLULAR MATRIX; FEMALE; GENE EXPRESSION; KIDNEY TUBULE CELL; LUPUS ERYTHEMATOSUS NEPHRITIS; MESANGIUM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANIMALS; ANTIBODIES, ANTINUCLEAR; APOPTOSIS; BETA CATENIN; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DNA; FEMALE; GENE EXPRESSION; GLOMERULAR MESANGIUM; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY; LUPUS NEPHRITIS; MICE; MICE, INBRED BALB C; MICE, INBRED NZB; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 79551676333     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.30116     Document Type: Article

References (39)

1. MacDonald BT, Tamai K, He X,. Wnt/β-catenin signaling: components, mechanisms, and diseases. Dev Cell 2009; 17: 9-26.
2. Semenov MV, Tamai K, Brott BK, Kuhl M, Sokol S, He X,. Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. Curr Biol 2001; 11: 951-61.
3. Surendran K, McCaul SP, Simon TC,. A role for Wnt-4 in renal fibrosis. Am J Physiol Renal Physiol 2002; 282: F431-41.
4. He W, Dai C, Li Y, Zeng G, Monga SP, Liu Y,. Wnt/β-catenin signaling promotes renal interstitial fibrosis. J Am Soc Nephrol 2009; 20: 765-76.
5. Hwang I, Seo EY, Ha H,. Wnt/β-catenin signaling: a novel target for therapeutic intervention of fibrotic kidney disease. Arch Pharm Res 2009; 32: 1653-62.
6. Wu B, Crampton SP, Hughes CC,. Wnt signaling induces matrix metalloproteinase expression and regulates T cell transmigration. Immunity 2007; 26: 227-39.
7. Sonderegger S, Haslinger P, Sabri A, Leisser C, Otten JV, Fiala C, et al. Wingless (Wnt)-3A induces trophoblast migration and matrix metalloproteinase-2 secretion through canonical Wnt signaling and protein kinase B/AKT activation. Endocrinology 2010; 151: 211-20.
8. Tveita A, Rekvig OP, Zykova SN,. Glomerular matrix metalloproteinases and their regulators in the pathogenesis of lupus nephritis. Arthritis Res Ther 2008; 10: 229.
9. Dai C, Stolz DB, Kiss LP, Monga SP, Holzman LB, Liu Y,. Wnt/β-catenin signaling promotes podocyte dysfunction and albuminuria. J Am Soc Nephrol 2009; 20: 1997-2008.
10. Gaipl US, Munoz LE, Grossmayer G, Lauber K, Franz S, Sarter K, et al. Clearance deficiency and systemic lupus erythematosus (SLE). J Autoimmun 2007; 28: 114-21.
11. Herrmann M, Voll R, Zoller O, Hagenhofer M, Ponner B, Kalden J,. Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus. Arthritis Rheum 1998; 41: 1241-50.
12. Gaipl US, Voll RE, Sheriff A, Franz S, Kalden JR, Herrmann M,. Impaired clearance of dying cells in systemic lupus erythematosus. Autoimmun Rev 2005; 4: 189-94. (Pubitemid 40704701)
13. Tveita AA,. The danger model in deciphering autoimmunity. Rheumatology (Oxford) 2010; 49: 632-9.
14. Charles PJ,. Defective waste disposal: does it induce autoantibodies in SLE? Ann Rheum Dis 2003; 62: 1-3.
15. Lin CL, Wang JY, Huang YT, Kuo YH, Surendran K, Wang FS,. Wnt/β-catenin signaling modulates survival of high glucose-stressed mesangial cells. J Am Soc Nephrol 2006; 17: 2812-20.
16. Lin CL, Cheng H, Tung CW, Huang WJ, Chang PJ, Yang JT, et al. Simvastatin reverses high glucose-induced apoptosis of mesangial cells via modulation of Wnt signaling pathway. Am J Nephrol 2008; 28: 290-7.
17. Rekvig OP, Moens U, Sundsfjord A, Bredholt G, Osei A, Haaheim H, et al. Experimental expression in mice and spontaneous expression in human SLE of polyomavirus T-antigen: a molecular basis for induction of antibodies to DNA and eukaryotic transcription factors. J Clin Invest 1997; 99: 2045-54.
18. Kalaaji M, Sturfelt G, Mjelle JE, Nossent H, Rekvig OP,. Critical comparative analyses of anti-α-actinin and glomerulus-bound antibodies in human and murine lupus nephritis. Arthritis Rheum 2006; 54: 914-26.
19. He TC, Chan TA, Vogelstein B, Kinzler KW,. PPARÎ is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell 1999; 99: 335-45.
20. Yan D, Wiesmann M, Rohan M, Chan V, Jefferson AB, Guo L, et al. Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/β-catenin signaling is activated in human colon tumors. Proc Natl Acad Sci U S A 2001; 98: 14973-8.
21. Gonzalez-Sancho JM, Aguilera O, Garcia JM, Pendas-Franco N, Pena C, Cal S, et al. The Wnt antagonist DICKKOPF-1 gene is a downstream target of β-catenin/TCF and is downregulated in human colon cancer. Oncogene 2005; 24: 1098-103.
22. Oltvai ZN, Milliman CL, Korsmeyer SJ,. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993; 74: 609-19.
23. Yang B, Johnson TS, Thomas GL, Watson PF, Wagner B, Furness PN, et al. A shift in the Bax/Bcl-2 balance may activate caspase-3 and modulate apoptosis in experimental glomerulonephritis. Kidney Int 2002; 62: 1301-13.
24. Bengtsson AA, Sturfelt G, Gullstrand B, Truedsson L,. Induction of apoptosis in monocytes and lymphocytes by serum from patients with systemic lupus erythematosus: an additional mechanism to increased autoantigen load? Clin Exp Immunol 2004; 135: 535-43.
25. Tveita A, Rekvig O, Zykova S,. Increased glomerular matrix metalloproteinase activity in murine lupus nephritis. Kidney Int 2008; 74: 1150-8.
26. Wu B, Crampton SP, Hughes CC,. Wnt signaling induces matrix metalloproteinase expression and regulates T cell transmigration. Immunity 2007; 26: 227-39.
27. Wang Z, Havasi A, Gall JM, Mao H, Schwartz JH, Borkan SC,. β-catenin promotes survival of renal epithelial cells by inhibiting Bax. J Am Soc Nephrol 2009; 20: 1919-28.
28. Herrmann M, Voll RE, Zoller OM, Hagenhofer M, Ponner BB, Kalden JR,. Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus. Arthritis Rheum 1998; 41: 1241-50.
29. Chen S, Guttridge DC, You Z, Zhang Z, Fribley A, Mayo MW, et al. Wnt-1 signaling inhibits apoptosis by activating β-catenin/T cell factor-mediated transcription. J Cell Biol 2001; 152: 87-96.
30. Shou J, Ali-Osman F, Multani AS, Pathak S, Fedi P, Srivenugopal KS,. Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA. Oncogene 2002; 21: 878-89.
31. Fenton K, Fismen S, Hedberg A, Seredkina N, Fenton C, Mortensen ES, et al. Anti-dsDNA antibodies promote initiation, and acquired loss of renal Dnase1 promotes progression of lupus nephritis in autoimmune (NZBxNZW)F1 mice. PLoS ONE 2009; 4: e8474.
32. Kalaaji M, Fenton KA, Mortensen ES, Olsen R, Sturfelt G, Alm P, et al. Glomerular apoptotic nucleosomes are central target structures for nephritogenic antibodies in human SLE nephritis. Kidney Int 2007; 71: 664-72.
33. Bengtsson AA, Gullstrand B, Truedsson L, Sturfelt G,. SLE serum induces classical caspase-dependent apoptosis independent of death receptors. Clin Immunol 2008; 126: 57-66.
34. Gollob JA, Sciambi CJ, Huang Z, Dressman HK,. Gene expression changes and signaling events associated with the direct antimelanoma effect of IFN-γ. Cancer Res 2005; 65: 8869-77.
35. Qu JH, Cheng J, Zhang LX, Zhang LY, Zhong YW, Liu Y, et al. Identification of genes upregulated by recombinant interferon-α in HepG2 cells by suppressive subtractive hybridization analysis. Hepatobiliary Pancreat Dis Int 2007; 6: 290-3.
36. Noda T, Nagano H, Takemasa I, Yoshioka S, Murakami M, Wada H, et al. Activation of Wnt/β-catenin signalling pathway induces chemoresistance to interferon-α/5-fluorouracil combination therapy for hepatocellular carcinoma. Br J Cancer 2009; 100: 1647-58.
37. Bennett L, Palucka AK, Arce E, Cantrell V, Borvak J, Banchereau J, et al. Interferon and granulopoiesis signatures in systemic lupus erythematosus blood. J Exp Med 2003; 197: 711-23.
38. Bengtsson AA, Sturfelt G, Truedsson L, Blomberg J, Alm G, Vallin H, et al. Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies. Lupus 2000; 9: 664-71.
39. Wang J, Shou J, Chen X,. Dickkopf-1, an inhibitor of the Wnt signaling pathway, is induced by p53. Oncogene 2000; 19: 1843-8.