Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 2, 2011, Pages 458-462

  Melero, Roberto ^a,e   Rajagopalan, Sridharan ^b,f   Lázaro, Melisa ^c   Joerger, Andreas C ^b   Brandt, Tobias ^b   Veprintsev, Dmitry B ^b,g   Lasso, Gorka ^c   Gil, David ^c   Scheres, Sjors H W ^a,b   Carazo, José María ^a   Fersht, Alan R ^b   Valle, Mikel ^c,d  

^a CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^c CIC BIOGUNE   (Spain)

^d UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^e CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^f UNIVERSITY OF WASHINGTON   (United States)

^g PAUL SCHERRER INSTITUTE   (Switzerland)

Author keywords

Protein; Recognition; Specificity

Indexed keywords

PROTEIN; PROTEIN P53; TETRAMERIZATION DOMAIN PROTEIN; UNCLASSIFIED DRUG; ALANINE; CYSTINE; DNA; TP53 PROTEIN, HUMAN;

ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DNA BINDING; DNA PROTEIN COMPLEX; DNA SEQUENCE; ELECTRON MICROSCOPY; FLUORESCENCE RESONANCE ENERGY TRANSFER; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN PROCESSING; PROTEIN QUATERNARY STRUCTURE; CHEMISTRY; CONFORMATION; HUMAN; METHODOLOGY; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; TUMOR SUPPRESSOR GENE;

ALANINE; CYSTINE; DNA; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENES, P53; HUMANS; MICROSCOPY, ELECTRON; MUTATION; NUCLEIC ACID CONFORMATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; TUMOR SUPPRESSOR PROTEIN P53;

EID: 79551670110     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1012231108     Document Type: Article

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