Angiogenic activity of an enamel matrix derivative (EMD) and EMD-derived proteins: An experimental study in mice

Journal of Clinical Periodontology

Volumn 38, Issue 3, 2011, Pages 253-260

  Thoma, Daniel S ^a   Villar, Cristina C ^b   Carnes, David L ^b   Dard, Michel ^c   Patricia Chun, Yong Hee ^b   Cochran, David L ^b  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c INSTITUT STRAUMANN AG   (Switzerland)

Author keywords

amelogenin; angiogenesis; enamel matrix proteins; fibroblast growth factor; periodontal regeneration; vascular endothelial growth factor

Indexed keywords

AMELOGENIN; ANGIOGENIC FACTOR; BOVINE SERUM ALBUMIN; DEXTRAN; DIAGNOSTIC AGENT; DRUG DERIVATIVE; ENAMEL MATRIX PROTEINS; ENAMEL PROTEIN; FIBROBLAST GROWTH FACTOR; FLUORESCEIN ISOTHIOCYANATE; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; FLUORESCENT DYE; VASCULOTROPIN A;

ANGIOGENESIS; ANIMAL; ANIMAL MODEL; ARTICLE; COMPARATIVE STUDY; DIFFUSION CHAMBER; DOSE RESPONSE; DRUG EFFECT; ENDOTHELIUM CELL; FEMALE; MOUSE; NUDE MOUSE; PATHOLOGY; SUBCUTANEOUS TISSUE; VASCULAR ENDOTHELIUM; VASCULARIZATION;

AMELOGENIN; ANGIOGENESIS INDUCING AGENTS; ANIMALS; DENTAL ENAMEL PROTEINS; DEXTRANS; DIFFUSION CHAMBERS, CULTURE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FEMALE; FIBROBLAST GROWTH FACTORS; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT DYES; MICE; MICE, NUDE; MODELS, ANIMAL; NEOVASCULARIZATION, PHYSIOLOGIC; SERUM ALBUMIN, BOVINE; SUBCUTANEOUS TISSUE; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 79551663351     PISSN: 03036979     EISSN: 1600051X     Source Type: Journal    
DOI: 10.1111/j.1600-051X.2010.01656.x     Document Type: Article

References (37)

1. Bellahcene, A., Bonjean, K., Fohr, B., Fedarko, N. S., Robey, F. A., Young, M. F., Fisher, L. W., &, Castronovo, V., (2000) Bone sialoprotein mediates human endothelial cell attachment and migration and promotes angiogenesis. Circulation Research 86, 885-891.
2. Boyan, B. D., Weesner, T. C., Lohmann, C. H., Andreacchio, D., Carnes, D. L., Dean, D. D., Cochran, D. L., &, Schwartz, Z., (2000) Porcine fetal enamel matrix derivative enhances bone formation induced by demineralized freeze dried bone allograft in vivo. Journal of Periodontology 71, 1278-1286.
3. Chong, C. H., Carnes, D. L., Moritz, A. J., Oates, T., Ryu, O. H., Simmer, J., &, Cochran, D. L., (2006) Human periodontal fibroblast response to enamel matrix derivative, amelogenin, and platelet-derived growth factor-BB. Journal of Periodontology 77, 1242-1252.
4. Cochran, D. L., Jones, A., Heijl, L., Mellonig, J. T., Schoolfield, J., &, King, G. N., (2003) Periodontal regeneration with a combination of enamel matrix proteins and autogenous bone grafting. Journal of Periodontology 74, 1269-1281. (Pubitemid 37345089)
5. Conway, E. M., Collen, D., &, Carmeliet, P., (2001) Molecular mechanisms of blood vessel growth. Cardiovascular Research 49, 507-521.
6. Foster, B. L., Popowics, T. E., Fong, H. K., &, Somerman, M. J., (2007) Advances in defining regulators of cementum development and periodontal regeneration. Current Topics in Developmental Biology 78, 47-126.
7. Gottlow, J., Nyman, S., Karring, T., &, Lindhe, J., (1984) New attachment formation as the result of controlled tissue regeneration. Journal of Clinical Periodontology 11, 494-503.
8. Gottlow, J., Nyman, S., Lindhe, J., Karring, T., &, Wennstrom, J., (1986) New attachment formation in the human periodontium by guided tissue regeneration. Case reports. Journal of Clinical Periodontology 13, 604-616.
9. Grayson, R. E., Yamakoshi, Y., Wood, E. J., &, Agren, M. S., (2006) The effect of the amelogenin fraction of enamel matrix proteins on fibroblast-mediated collagen matrix reorganization. Biomaterials 27, 2926-2933.
10. Guedez, L., Rivera, A. M., Salloum, R., Miller, M. L., Diegmueller, J. J., Bungay, P. M., &, Stetler-Stevenson, W. G., (2003) Quantitative assessment of angiogenic responses by the directed in vivo angiogenesis assay. American Journal of Pathology 162, 1431-1439.
11. Gutierrez, M. A., Mellonig, J. T., &, Cochran, D. L., (2003) Evaluation of enamel matrix derivative as an adjunct to non-surgical periodontal therapy. Journal of Clinical Periodontology 30, 739-745.
12. Hammarstrom, L., Heijl, L., &, Gestrelius, S., (1997) Periodontal regeneration in a buccal dehiscence model in monkeys after application of enamel matrix proteins. Journal of Clinical Periodontology 24, 669-677.
13. Heard, R. H., Mellonig, J. T., Brunsvold, M. A., Lasho, D. J., Meffert, R. M., &, Cochran, D. L., (2000) Clinical evaluation of wound healing following multiple exposures to enamel matrix protein derivative in the treatment of intrabony periodontal defects. Journal of Periodontology 71, 1715-1721.
14. Jiang, J., Goodarzi, G., He, J., Li, H., Safavi, K. E., Spangberg, L. S., &, Zhu, Q., (2006) Emdogain-gel stimulates proliferation of odontoblasts and osteoblasts. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics 102, 698-702.
15. Johnson, D. L., Carnes, D. L., Steffensen, B., &, Cochran, D. L., (2009) Cellular effects of enamel matrix derivative are associated with different molecular weight fractions following separation by size-exclusion chromatography. Journal of Periodontology 80, 648-656.
16. Kauvar, A. S., Thoma, D. S., Carnes, D. L., &, Cochran, D. L., (2010) In vivo angiogenic activity of enamel matrix derivative. Journal of Periodontology 81, 1196-1201.
17. McGuire, M. K., &, Cochran, D. L., (2003) Evaluation of human recession defects treated with coronally advanced flaps and either enamel matrix derivative or connective tissue. Part 2: histological evaluation. Journal of Periodontology 74, 1126-1135.
18. Mellonig, J. T., (1991) Freeze-dried bone allografts in periodontal reconstructive surgery. Dental Clinics of North America 35, 505-520.
19. Mellonig, J. T., (1999) Enamel matrix derivative for periodontal reconstructive surgery: technique and clinical and histologic case report. International Journal of Periodontics & Restorative Dentistry 19, 8-19.
20. Mellonig, J. T., (2000) Human histologic evaluation of a bovine-derived bone xenograft in the treatment of periodontal osseous defects. International Journal of Periodontics & Restorative Dentistry 20, 19-29.
21. Mirastschijski, U., Konrad, D., Lundberg, E., Lyngstadaas, S. P., Jorgensen, L. N., &, Agren, M. S., (2004) Effects of a topical enamel matrix derivative on skin wound healing. Wound Repair and Regeneration 12, 100-108.
22. Mumulidu, A., Hildebrand, B., Fabi, B., Hammarstrom, L., Cochran, D. L., Dard, M., &, Lemoult, S., (2007) Purification and analysis of a 5 kDa component of enamel matrix derivative. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 857, 210-218.
23. Nabers, C. L., &, O'Leary, T. J., (1965) Autogenous bone transplants in the treatment of osseous defects. Journal of Periodontology 36, 5-14.
24. Nevins, M., Giannobile, W. V., McGuire, M. K., Kao, R. T., Mellonig, J. T., Hinrichs, J. E., McAllister, B. S., Murphy, K. S., McClain, P. K., Nevins, M. L., Paquette, D. W., Han, T. J., Reddy, M. S., Lavin, P. T., Genco, R. J., &, Lynch, S. E., (2005) Platelet-derived growth factor stimulates bone fill and rate of attachment level gain: results of a large multicenter randomized controlled trial. Journal of Periodontology 76, 2205-2215.
25. Nyman, S., Gottlow, J., Karring, T., &, Lindhe, J., (1982) The regenerative potential of the periodontal ligament. An experimental study in the monkey. Journal of Clinical Periodontology 9, 257-265.
26. Plachokova, A. S., van den Dolder, J., &, Jansen, J. A., (2008) The bone-regenerative properties of Emdogain adsorbed onto poly(d, l-lactic-coglycolic acid)/calcium phosphate composites in an ectopic and an orthotopic rat model. Journal of Periodontal Research 43, 55-63.
27. Rincon, J. C., Haase, H. R., &, Bartold, P. M., (2003) Effect of Emdogain on human periodontal fibroblasts in an in vitro wound-healing model. Journal of Periodontal Research 38, 290-295.
28. Risau, W., (1997) Mechanisms of angiogenesis. Nature 386, 671-674.
29. Schlueter, S. R., Carnes, D. L., &, Cochran, D. L., (2007) In vitro effects of enamel matrix derivative on microvascular cells. Journal of Periodontology 78, 141-151.
30. Schwartz, Z., Carnes, D. L. Jr., Pulliam, R., Lohmann, C. H., Sylvia, V. L., Liu, Y., Dean, D. D., Cochran, D. L., &, Boyan, B. D., (2000) Porcine fetal enamel matrix derivative stimulates proliferation but not differentiation of pre-osteoblastic 2T9 cells, inhibits proliferation and stimulates differentiation of osteoblast-like MG63 cells, and increases proliferation and differentiation of normal human osteoblast NHOst cells. Journal of Periodontology 71, 1287-1296.
31. Singer, A. J., &, Clark, R. A., (1999) Cutaneous wound healing. New England Journal of Medicine 341, 738-746.
32. Suzuki, N., Ohyama, M., Maeno, M., Ito, K., &, Otsuka, K., (2001) Attachment of human periodontal ligament cells to enamel matrix-derived protein is mediated via interaction between BSP-like molecules and integrin alpha(v)beta3. Journal of Periodontology 72, 1520-1526.
33. Thoma, D. S., &, Cochran, D. L., (2010) Unlocking the mystery of periodontal regeneration-different tissues, different phenotypes. Journal de Parodontologie et d'Implantologie Orale 17, 23-60.
34. Tonnesen, M. G., Feng, X., &, Clark, R. A., (2000) Angiogenesis in wound healing. Journal of Investigative Dermatology. Symposium Proceedings 5, 40-46.
35. Yancopoulos, G. D., Davis, S., Gale, N. W., Rudge, J. S., Wiegand, S. J., &, Holash, J., (2000) Vascular-specific growth factors and blood vessel formation. Nature 407, 242-248.
36. Yuan, K., Chen, C. L., &, Lin, M. T., (2003) Enamel matrix derivative exhibits angiogenic effect in vitro and in a murine model. Journal of Clinical Periodontology 30, 732-738.
37. Zeldich, E., Koren, R., Nemcovsky, C., &, Weinreb, M., (2007) Enamel matrix derivative stimulates human gingival fibroblast proliferation via ERK. Journal of Dental Research 86, 41-46.