Tapered LSO arrays for small animal PET

Physics in Medicine and Biology

Volumn 56, Issue 1, 2011, Pages 139-153

  Yang, Yongfeng ^a   St James, Sara ^a   Wu, Yibao ^a   Du, Huini ^a   Qi, Jinyi ^a   Farrell, Richard ^b   Dokhale, Purushottam A ^b   Shah, Kanai S ^b   Vaigneur, Keith ^c   Cherry, Simon R ^a  

^a University of California   (United States)

^b RADIATION MONITORING DEVICES INC   (United States)

^c Agile Engineering   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL PET; CRYSTAL ARRAYS; CRYSTAL DIMENSIONS; CRYSTAL REFLECTOR; DEPTH OF INTERACTIONS; DETECTOR MODULE; HIGH SENSITIVITY; HIGH SPATIAL RESOLUTION; LUTETIUM OXYORTHOSILICATE; OPTIMAL CONFIGURATIONS; POSITION SENSITIVE; SCINTILLATOR ARRAYS; SMALL ANIMAL PET; SMALL RINGS; THICK ARRAYS;

ANIMALS; POSITRON EMISSION TOMOGRAPHY; SCINTILLATION; X RAY CAMERAS;

SCANNING;

DIAGNOSTIC AGENT; LUTETIUM; LUTETIUM ORTHOSILICATE; SILICATE;

ANIMAL; ARTICLE; CHEMISTRY; EQUIPMENT DESIGN; EVALUATION; INSTRUMENTATION; METHODOLOGY; POSITRON EMISSION TOMOGRAPHY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY;

ANIMALS; EQUIPMENT DESIGN; LUTETIUM; POSITRON-EMISSION TOMOGRAPHY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SILICATES;

EID: 79551658674     PISSN: 00319155     EISSN: 13616560     Source Type: Journal    
DOI: 10.1088/0031-9155/56/1/009     Document Type: Article

References (34)

1. Burr K C, Ivan A, Castleberry D E, LeBlanc J W, Shah K S and Farrell R 2004 Evaluation of a prototype small animal PET detector with depth-of-interaction encoding IEEE Trans. Nucl. Sci. 51 1791-8
2. Chatziioannou A F 2002 Molecular imaging of small animals with dedicated PET tomographs Eur. J. Nucl. Med. 29 98-114
3. Cherry S R 2004 In vivo molecular and genomic imaging: new challenges for imaging physics Phys. Med. Biol. 49 R13-48
4. Cherry S R 2006 The 2006 Henry N Wagner lecture: of mice and men (and positrons) - advances in PET imaging technology J. Nucl. Med. 47 1735-45
5. Dokhale P A, Silverman R W, Shah K S, Grazioso R, Farrell R, Glodo J, McClish M A, Entine G, Tran V H and Cherry S R 2004 Performance measurements of a depth-encoding PET detector module based on positionsensitive avalanche photodiode read-out Phys. Med. Biol. 49 4293-304
6. Du H N, Yang Y F, Glodo J, Wu Y B, Shah K and Cherry S R 2009 Continuous depth-of-interaction encoding using phosphor-coated scintillators Phys. Med. Biol. 54 1757-71
7. Janecek M and Moses WW 2008 Optical reflectance measurements for commonly used reflectors IEEE Trans. Nucl. Sci. 55 2432-7
8. Judenhofer M S, Pichler B J and Cherry S R 2005 Evaluation of high performance data acquisition boards for simultaneous sampling of fast signals from PET detectors Phys. Med. Biol. 50 29-44
9. Larobina M, Brunetti A and SalvatoreM2006 Small animal PET: a review of commercially available imaging systems Curr. Med. Imaging Rev. 2 187-92
10. Lecomte R et al 2006 LabPETtm: a second-generation APD-based digital scanner for high-resolution small animal PET imaging Med. Phys. 33 2671
11. Lerche C W et al 2005 Depth of gamma-ray interaction within continuous crystals from the width of its scintillation light-distribution IEEE Trans. Nucl. Sci. 52 560-72
12. Lewellen T K 2008 Recent developments in PET detector technology Phys. Med. Biol. 53 R287-317
13. Ling T, Lewellen T K and Miyaoka R S 2007 Depth of interaction decoding of a continuous crystal detector module Phys. Med. Biol. 52 2213-28 (Pubitemid 46553647)
14. Moses W W and Derenzo S E 1994 Design studies for a PET detector module using a PIN photodiode to measure depth of interaction IEEE Trans. Nucl. Sci. 41 1441-5
15. Muehllehner G and Karp J S 2006 Positron emission tomography Phys. Med. Biol. 51 R117-37
16. Rowland D J and Cherry S R 2008 Small-animal preclinical nuclear medicine instrumentation and methodology Semin. Nucl. Med. 38 209-22
17. Saoudi A, Pepin C M, Dion F, Bentourkia M, Lecomte R, Andreaco M, Casey M, Nutt R and Dautet H 1999 Investigation of depth-of-interaction by pulse shape discrimination inmulticrystal detectors read out by avalanche photodiodes IEEE Trans. Nucl. Sci. 46 462-7
18. Schafers K P, Reader A J, Kriens M, Knoess C, Schober O and Schafers M 2005 Performance evaluation of the 32-module quadHIDAC small-animal PET scanner J. Nucl. Med. 46 996-1004
19. SchmandM, Eriksson L, CaseyME, AndreacoMS,Melcher C,Wienhard K, Flugge G and Nutt R 1998 Performance results of a new DOI detector block for a high resolution PET-LSO research tomograph HRRT IEEE Trans. Nucl. Sci. 45 3000-6
20. Shah K S, Farrell R, Grazioso R, Harmon E S and Karplus E 2002 Position-sensitive avalanche photodiodes for gamma-ray imaging IEEE Trans. Nucl. Sci. 49 1687-92
21. Shah K S, Grazioso R, Farrell R, Glodo J, McClish M, Entine G, Dokhale P and Cherry S R 2004 Position sensitive APDs for small animal PET imaging IEEE Trans. Nucl. Sci. 51 91-5
22. Shao Y P, Yao R T and Ma T Y 2008 A novel method to calibrate DOI function of a PET detector with a dual-endedscintillator readout Med. Phys. 35 5829-40
23. St James S, Yang Y F, Bowen S L, Qi J Y and Cherry S R 2010 Simulation study of spatial resolution and sensitivity for the tapered depth of interaction PET detectors for small animal imaging Phys. Med. Biol. 55 N63-N74
24. St James S, Yang Y F, Wu Y B, Farrell R, Dokhale P, Shah K S and Cherry S R 2009 Experimental characterization and system simulations of depth of interaction PET detectors using 0.5 mm and 0.7 mm LSO arrays Phys. Med. Biol. 54 4605-19
25. Stickel J R, Qi J Y and Cherry S R 2007 Fabrication and characterization of a 0.5-mm lutetium oxyorthosilicate detector array for high-resolution PET applications J. Nucl. Med. 48 115-21
26. Tai Y C, Chatziioannou A F, Yang Y F, Silverman R W, Meadors K, Siegel S, Newport D F, Stickel J R and Cherry S R 2003 MicroPET II: design, development and initial performance of an improved microPET scanner for small-animal imaging Phys. Med. Biol. 48 1519-37
27. Tai Y C, Ruangma A, Rowland D, Siegel S, Newport D F, Chow P L and Laforest R 2005 Performance evaluation of the microPET focus: a third-generation microPET scanner dedicated to animal imaging J. Nucl. Med. 46 455-63
28. Tsuda T, Murayama H, Kitamura K, Yamaya T, Yoshida E, Omura T, Kawai H, Inadama N and Orita N 2004 A four-layer depth of interaction detector block for small animal PET IEEE Trans. Nucl. Sci. 51 2537-42
29. Wang Y C, Seidel J, Tsui B M W, Vaquero J J and Pomper M G 2006 Performance evaluation of the GE healthcare eXplore VISTA dual-ring small-animal PET scanner J. Nucl. Med. 47 1891-900
30. Yamaya T, Yoshida E, Toramatsu C, Nishimura M, Shimada Y, Inadama N, Shibuya K, Nishikido F and Murayama H 2009 Preliminary study on potential of the jPET-D4 human brain scanner for small animal imaging Ann. Nucl. Med. 23 183-90
31. Yang Y, Tai YC, Siegel S, Newport DF, Bai B, Li QZ, Leahy RM and Cherry S R 2004 Optimization and performance evaluation of the microPET II scanner for in vivo small-animal imaging Phys. Med. Biol. 49 2527-45
32. Yang Y F, Dokhale P A, Silverman R W, Shah K S, McClish M A, Farrell R, Entine G and Cherry S R 2006 Depth of interaction resolution measurements for a high resolution PET detector using position sensitive avalanche photodiodes Phys. Med. Biol. 51 2131-42
33. Yang Y F, Qi J Y, Wu Y B, St James S, Farrell R, Dokhale P A, Shah K S and Cherry S R 2009 Depth of interaction calibration for PET detectors with dual-ended readout by PSAPDs Phys. Med. Biol. 54 433-45
34. Yang Y F, Wu Y B, Qi J, James S T, Du H N, Dokhale P A, Shah K S, Farrell R and Cherry S R 2008 A prototype PET scanner with DOI-encoding detectors J. Nucl. Med. 49 1132-40