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Volumn 84, Issue 1, 2011, Pages 29-35

Analysis of IL2/IL21 gene variants in cholestatic liver diseases reveals an association with primary sclerosing cholangitis

Author keywords

Autoimmune disease; IL2; IL21; Polymorphism; Primary biliary cirrhosis; Primary sclerosing cholangitis; Th17 cells; Ulcerative colitis

Indexed keywords

INTERLEUKIN 2; INTERLEUKIN 21;

EID: 79551622962     PISSN: 00122823     EISSN: 14219867     Source Type: Journal    
DOI: 10.1159/000321619     Document Type: Article
Times cited : (10)

References (44)
  • 1
    • 54349125713 scopus 로고    scopus 로고
    • Etiopathogenesis of primary sclerosing cholangitis
    • Chapman R, Cullen S: Etiopathogenesis of primary sclerosing cholangitis. World J Gastroenterol 2008; 14: 3350-3359.
    • (2008) World J. Gastroenterol. , vol.14 , pp. 3350-3359
    • Chapman, R.1    Cullen, S.2
  • 2
    • 39549115685 scopus 로고    scopus 로고
    • The causes of primary biliary cirrhosis: Convenient and inconvenient truths
    • DOI 10.1002/hep.22042
    • Gershwin ME, Mackay IR: The causes of primary biliary cirrhosis: convenient and inconvenient truths. Hepatology 2008; 47: 737-745. (Pubitemid 351280742) (Pubitemid 351280742)
    • (2008) Hepatology , vol.47 , Issue.2 , pp. 737-745
    • Gershwin, M.E.1    Mackay, I.R.2
  • 5
    • 57749193136 scopus 로고    scopus 로고
    • Detecting shared pathogenesis from the shared genetics of immune-related diseases
    • Zhernakova A, van Diemen CC, Wijmenga C: Detecting shared pathogenesis from the shared genetics of immune-related diseases. Nat Rev Genet 2009; 10: 43-55.
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 43-55
    • Zhernakova, A.1    Van Diemen, C.C.2    Wijmenga, C.3
  • 6
    • 67149095289 scopus 로고    scopus 로고
    • Primary biliary cirrhosis associated with HLA IL12A and IL12RB2 variants
    • Hirschfield GM, Liu X, Xu C, et al: Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants. N Engl J Med 2009; 360: 2544-2555.
    • (2009) N. Engl. J. Med. , vol.360 , pp. 2544-2555
    • Hirschfield, G.M.1    Liu, X.2    Xu, C.3
  • 7
    • 77249164222 scopus 로고    scopus 로고
    • Genome- wide association analysis in primary sclerosing cholangitis
    • Karlsen TH, Franke A, Melum E, et al: Genome- wide association analysis in primary sclerosing cholangitis. Gastroenterology 2010; 138: 1102-1111.
    • (2010) Gastroenterology , vol.138 , pp. 1102-1111
    • Karlsen, T.H.1    Franke, A.2    Melum, E.3
  • 8
    • 64549104048 scopus 로고    scopus 로고
    • Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis
    • Festen EA, Goyette P, Scott R, et al: Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis. Gut 2009; 58: 799-804.
    • (2009) Gut. , vol.58 , pp. 799-804
    • Festen, E.A.1    Goyette, P.2    Scott, R.3
  • 9
    • 77951952691 scopus 로고    scopus 로고
    • Consolidation of evidence for association of the KIAA1109-TENR-IL2- IL21 rs6822844 variant with crohns disease response
    • Glas J, Brand S: Consolidation of evidence for association of the KIAA1109-TENR-IL2- IL21 rs6822844 variant with Crohn's disease response. Am J Gastroenterol 2010; 105: 1206-1207.
    • (2010) Am. J. Gastroenterol. , vol.105 , pp. 1206-1207
    • Glas, J.1    Brand, S.2
  • 10
    • 67650421536 scopus 로고    scopus 로고
    • Novel genetic risk markers for ulcerative colitis in the IL2/IL21 region are in epistasis with IL23R and suggest a common genetic background for ulcerative colitis and celiac disease
    • Glas J, Stallhofer J, Ripke S, et al: Novel genetic risk markers for ulcerative colitis in the IL2/IL21 region are in epistasis with IL23R and suggest a common genetic background for ulcerative colitis and celiac disease. Am J Gastroenterol 2009; 104: 1737-1744.
    • (2009) Am. J. Gastroenterol. , vol.104 , pp. 1737-1744
    • Glas, J.1    Stallhofer, J.2    Ripke, S.3
  • 11
    • 68349148370 scopus 로고    scopus 로고
    • Novel association of the interleukin 2-interleukin 21 region with inflammatory bowel disease
    • Marquez A, Orozco G, Martinez A, et al: Novel association of the interleukin 2-interleukin 21 region with inflammatory bowel disease. Am J Gastroenterol 2009; 104: 1968-1975.
    • (2009) Am. J. Gastroenterol. , vol.104 , pp. 1968-1975
    • Marquez, A.1    Orozco, G.2    Martinez, A.3
  • 13
    • 67349199566 scopus 로고    scopus 로고
    • Genome-wide association study and metaanalysis find that over 40 loci affect risk of type 1 diabetes
    • Barrett JC, Clayton DG, Concannon P, et al: Genome-wide association study and metaanalysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet 2009; 41: 703-707.
    • (2009) Nat. Genet. , vol.41 , pp. 703-707
    • Barrett, J.C.1    Clayton, D.G.2    Concannon, P.3
  • 16
    • 66049103935 scopus 로고    scopus 로고
    • Confirmation of STAT4 IL2/IL21 and CTLA4 polymorphisms in rheumatoid arthritis
    • Daha NA, Kurreeman FA, Marques RB, et al: Confirmation of STAT4, IL2/IL21, and CTLA4 polymorphisms in rheumatoid arthritis. Arthritis Rheum 2009; 60: 1255-1260.
    • (2009) Arthritis. Rheum. , vol.60 , pp. 1255-1260
    • Daha, N.A.1    Kurreeman, F.A.2    Marques, R.B.3
  • 17
    • 75749113734 scopus 로고    scopus 로고
    • Confirmation of an association between rs6822844 at the IL2-IL21 region and multiple autoimmune diseases: Evidence of a general susceptibility locus
    • Maiti AK, Kim-Howard X, Viswanathan P, et al: Confirmation of an association between rs6822844 at the IL2-IL21 region and multiple autoimmune diseases: evidence of a general susceptibility locus. Arthritis Rheum 2010; 62: 323-329.
    • (2010) Arthritis. Rheum. , vol.62 , pp. 323-329
    • Maiti, A.K.1    Kim-Howard, X.2    Viswanathan, P.3
  • 18
    • 43249083380 scopus 로고    scopus 로고
    • A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci
    • Liu Y, Helms C, Liao W, et al: A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci. PLoS Genet 2008; 4:e1000041.
    • (2008) PLoS Genet. , vol.4
    • Liu, Y.1    Helms, C.2    Liao, W.3
  • 19
    • 61649121151 scopus 로고    scopus 로고
    • Association of the autoimmunity locus 4q27 with juvenile idiopathic arthritis
    • Albers HM, Kurreeman FA, Stoeken-Rijsbergen G, et al: Association of the autoimmunity locus 4q27 with juvenile idiopathic arthritis. Arthritis Rheum 2009; 60: 901-904.
    • (2009) Arthritis. Rheum. , vol.60 , pp. 901-904
    • Albers, H.M.1    Kurreeman, F.A.2    Stoeken-Rijsbergen, G.3
  • 20
    • 77649340663 scopus 로고    scopus 로고
    • Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis
    • Hinks A, Eyre S, Ke X, et al: Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis. Genes Immun 2010; 11: 194-198.
    • (2010) Genes. Immun. , vol.11 , pp. 194-198
    • Hinks, A.1    Eyre, S.2    Ke, X.3
  • 22
    • 0033755636 scopus 로고    scopus 로고
    • Increased frequency of autoimmune diseases in patients with primary sclerosing cholangitis
    • Saarinen S, Olerup O, Broome U: Increased frequency of autoimmune diseases in patients with primary sclerosing cholangitis. Am J Gastroenterol 2000; 95: 3195-3199.
    • (2000) Am. J. Gastroenterol. , vol.95 , pp. 3195-3199
    • Saarinen, S.1    Olerup, O.2    Broome, U.3
  • 24
    • 25144474552 scopus 로고    scopus 로고
    • Primary biliary cirrhosis
    • DOI 10.1056/NEJMra043898
    • Kaplan MM, Gershwin ME: Primary biliary cirrhosis. N Engl J Med 2005; 353: 1261-1273. (Pubitemid 41345948) (Pubitemid 41345948)
    • (2005) New England Journal of Medicine , vol.353 , Issue.12 , pp. 1261-1273
    • Kaplan, M.M.1    Gershwin, M.E.2
  • 25
    • 40849123925 scopus 로고    scopus 로고
    • The challenges in primary sclerosing cholangitis - Aetiopathogenesis autoimmunity management and malignancy
    • Weismuller TJ, Wedemeyer J, Kubicka S, et al: The challenges in primary sclerosing cholangitis - aetiopathogenesis, autoimmunity, management and malignancy. J Hepatol 2008; 48(suppl 1):S38-S57.
    • (2008) J. Hepatol. , vol.48 , Issue.1
    • Weismuller, T.J.1    Wedemeyer, J.2    Kubicka, S.3
  • 26
    • 13444269543 scopus 로고    scopus 로고
    • Haploview: Analysis and visualization of LD and haplotype maps
    • DOI 10.1093/bioinformatics/bth457
    • Barrett JC, Fry B, Maller J, et al: Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21: 263-265. (Pubitemid 40202029) (Pubitemid 40202029)
    • (2005) Bioinformatics , vol.21 , Issue.2 , pp. 263-265
    • Barrett, J.C.1    Fry, B.2    Maller, J.3    Daly, M.J.4
  • 27
    • 77749291718 scopus 로고    scopus 로고
    • Confidence intervals that match fishers exact or blakers exact tests
    • Fay MP: Confidence intervals that match Fisher's exact or Blaker's exact tests. Biostatistics 2010; 11: 373-374.
    • (2010) Biostatistics , vol.11 , pp. 373-374
    • Fay, M.P.1
  • 28
    • 77049120009 scopus 로고    scopus 로고
    • SNP-tools: A compact tool package for analysis and conversion of genotype data for MSExcel
    • Chen B, Wilkening S, Drechsel M, et al: SNP-tools: a compact tool package for analysis and conversion of genotype data for MSExcel. BMC Res Notes 2009; 2: 214.
    • (2009) BMC Res. Notes. , vol.2 , pp. 214
    • Chen, B.1    Wilkening, S.2    Drechsel, M.3
  • 29
    • 33646817076 scopus 로고    scopus 로고
    • CC-type chemokine receptor 5-Delta32 mutation protects against primary sclerosing cholangitis
    • Henckaerts L, Fevery J, Van Steenbergen W, et al: CC-type chemokine receptor 5-Delta32 mutation protects against primary sclerosing cholangitis. Inflamm Bowel Dis 2006; 12: 272-277.
    • (2006) Inflamm. Bowel. Dis. , vol.12 , pp. 272-277
    • Henckaerts, L.1    Fevery, J.2    Van Steenbergen, W.3
  • 30
    • 40049102828 scopus 로고    scopus 로고
    • Primary sclerosing cholangitis, autoimmune hepatitis and overlap syndromes in inflammatory bowel disease
    • DOI 10.3748/wjg.14.331
    • Saich R, Chapman R: Primary sclerosing cholangitis, autoimmune hepatitis and overlap syndromes in inflammatory bowel disease. World J Gastroenterol 2008; 14: 331-337. (Pubitemid 351320842) (Pubitemid 351320842)
    • (2008) World Journal of Gastroenterology , vol.14 , Issue.3 , pp. 331-337
    • Saich, R.1    Chapman, R.2
  • 31
    • 12444260826 scopus 로고    scopus 로고
    • Increased prevalence of primary sclerosing cholangitis among first-degree relatives
    • DOI 10.1016/j.jhep.2004.10.011, PII S0168827804004751
    • Bergquist A, Lindberg G, Saarinen S, et al: Increased prevalence of primary sclerosing cholangitis among first-degree relatives. J Hepatol 2005; 42: 252-256. (Pubitemid 40143473) (Pubitemid 40143473)
    • (2005) Journal of Hepatology , vol.42 , Issue.2 , pp. 252-256
    • Bergquist, A.1    Lindberg, G.2    Saarinen, S.3    Broome, U.4
  • 32
    • 47949124659 scopus 로고    scopus 로고
    • Increased risk of primary sclerosing cholangitis and ulcerative colitis in first-degree relatives of patients with primary sclerosing cholangitis
    • Bergquist A, Montgomery SM, Bahmanyar S, et al: Increased risk of primary sclerosing cholangitis and ulcerative colitis in first-degree relatives of patients with primary sclerosing cholangitis. Clin Gastroenterol Hepatol 2008; 6: 939-943.
    • (2008) Clin. Gastroenterol. Hepatol. , vol.6 , pp. 939-943
    • Bergquist, A.1    Montgomery, S.M.2    Bahmanyar, S.3
  • 33
    • 56749178234 scopus 로고    scopus 로고
    • Impact of protective IL-2 allelic variants on CD4+ Foxp3+ regulatory T cell function in situ and resistance to autoimmune diabetes in NOD mice
    • Sgouroudis E, Albanese A, Piccirillo CA: Impact of protective IL-2 allelic variants on CD4+ Foxp3+ regulatory T cell function in situ and resistance to autoimmune diabetes in NOD mice. J Immunol 2008; 181: 6283-6292.
    • (2008) J. Immunol. , vol.181 , pp. 6283-6292
    • Sgouroudis, E.1    Albanese, A.2    Piccirillo, C.A.3
  • 35
    • 73349091581 scopus 로고    scopus 로고
    • Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus
    • USA
    • McGuire HM, Vogelzang A, Hill N, et al: Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus. Proc Natl Acad Sci USA 2009; 106: 19438-19443.
    • (2009) Proc. Natl. Acad. Sci. , vol.106 , pp. 19438-19443
    • McGuire, H.M.1    Vogelzang, A.2    Hill, N.3
  • 36
    • 33846923124 scopus 로고    scopus 로고
    • + regulatory T cells and for expansion of these cells
    • Zheng SG, Wang J, Wang P, et al: IL-2 is essential for TGF-beta to convert naïve CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells. J Immunol 2007; 178: 2018-2027. (Pubitemid 46233398) (Pubitemid 46233398)
    • (2007) Journal of Immunology , vol.178 , Issue.4 , pp. 2018-2027
    • Song, G.Z.1    Wang, J.2    Wang, P.3    Gray, J.D.4    Horwitz, D.A.5
  • 38
    • 0027369395 scopus 로고
    • Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
    • DOI 10.1016/0092-8674(93)80067-O
    • Sadlack B, Merz H, Schorle H, et al: Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 1993; 75: 253-261. (Pubitemid 23320289) (Pubitemid 23320289)
    • (1993) Cell , vol.75 , Issue.2 , pp. 253-261
    • Sadlack, B.1    Merz, H.2    Schorle, H.3    Schimpl, A.4    Feller, A.C.5    Horak, I.6
  • 39
    • 0034962227 scopus 로고    scopus 로고
    • Tumour necrosis factor α impairs function of liver derived T lymphocytes and natural killer cells in patients with primary sclerosing cholangitis
    • DOI 10.1136/gut.49.1.131
    • Bo X, Broome U, Remberger M, et al: Tumour necrosis factor alpha impairs function of liver derived T lymphocytes and natural killer cells in patients with primary sclerosing cholangitis. Gut 2001; 49: 131-141. (Pubitemid 32601890) (Pubitemid 32601890)
    • (2001) Gut , vol.49 , Issue.1 , pp. 131-141
    • Bo, X.1    Broome, U.2    Remberger, M.3    Sumitran-Holgersson, S.4
  • 40
    • 41949097030 scopus 로고    scopus 로고
    • The biology of interleukin-2
    • DOI 10.1146/annurev.immunol.26.021607.090357
    • Malek TR: The biology of interleukin-2. Annu Rev Immunol 2008; 26: 453-479. (Pubitemid 351600382) (Pubitemid 351600382)
    • (2008) Annual Review of Immunology , vol.26 , pp. 453-479
    • Malek, T.R.1
  • 41
    • 77649184739 scopus 로고    scopus 로고
    • The regulation of IL-10 production by immune cells
    • Saraiva M, O'Garra A: The regulation of IL- 10 production by immune cells. Nat Rev Immunol 2010; 10: 170-181.
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 170-181
    • Saraiva, M.1    O'Garra, A.2
  • 42
    • 47549112840 scopus 로고    scopus 로고
    • IL-21 and TGF-beta are required for differentiation of human T H 17 cells
    • Yang L, Anderson DE, Baecher-Allan C, et al: IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. Nature 2008; 454: 350-352.
    • (2008) Nature , vol.454 , pp. 350-352
    • Yang, L.1    Anderson, D.E.2    Baecher-Allan, C.3
  • 43
    • 38049120319 scopus 로고    scopus 로고
    • IL-21 mediated foxp3 suppression leads to enhanced generation of antigen- specific CD8+ cytotoxic T lymphocytes
    • Li Y, Yee C: IL-21 mediated Foxp3 suppression leads to enhanced generation of antigen- specific CD8+ cytotoxic T lymphocytes. Blood 2008; 111: 229-235.
    • (2008) Blood , vol.111 , pp. 229-235
    • Li, Y.1    Yee, C.2


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