Hedgehog signal inhibitor forskolin suppresses cell proliferation and tumor growth of human rhabdomyosarcoma xenograft

Journal of Pediatric Surgery

Volumn 46, Issue 2, 2011, Pages 320-325

  Yamanaka, Hiroaki ^a   Oue, Takaharu ^a   Uehara, Shuichiro ^a   Fukuzawa, Masahiro ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

Forskolin; Gli1; Hedgehog signaling pathway; Rhabdomyosarcoma; Xenograft

Indexed keywords

FORSKOLIN; MESSENGER RNA;

ARTICLE; CANCER GROWTH; CELL PROLIFERATION; DRUG ACTIVITY; GENE TARGETING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHABDOMYOSARCOMA; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DELIVERY SYSTEMS; FORSKOLIN; HEDGEHOG PROTEINS; HUMANS; MICE; MICE, NUDE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHABDOMYOSARCOMA; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSPLANTATION, HETEROLOGOUS;

EID: 79551580687     PISSN: 00223468     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpedsurg.2010.11.010     Document Type: Article

References (24)

1. Crist W.M., and Kun L.E. Common solid tumors of childhood N Engl J Med 324 1991 461 471
2. Newton W.A., Gehan E.A., and Webber B.L. Classification of rhabdomyosarcomas and related sarcomas. Pathologic aspects and proposal for a new classification -an intergroup rhabdomyosarcoma study Cancer 76 1995 1073 1085
3. Crist W.M., Anderson J.R., and Meza J.L. Intergroup rhabdomyosarcoma study-IV: results for patients with nonmetastatic disease J Clin Oncol 19 2001 3091 3102
4. Ingham P.W., and McMahon A.P. Hedgehog signaling in animal development: paradigms and principles Genes Dev 15 2001 3059 3087
5. Ruiz i Altaba A., Sanchez P., and Dahmane N. Gli and hedgehog in cancer: tumors, embryos and stem cells Nat Rev Cancer 2 2002 361 372
6. Varjosaro M., and Taipale J. Hedgehog: functions and mechanisms Genes Dev 22 2008 2454 2472
7. Berman D.M., Karhadkar S.S., and Hallahan A.R. Medulloblastoma growth inhibition by hedgehog pathway blockade Science 297 2002 1559 1561
8. Berman D.M., Karhadkar S.S., and Maitra A. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumors Nature 425 2003 846 851
9. Thayer S.P., di Magliano M.P., and Heiser P.W. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis Nature 425 2003 851 856
10. Tostar U., Malm C.J., and Meis-Kindblom J.M. Deregulation of the hedgehog signaling pathway: a possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development J Pathol 208 2006 17 25
11. Taipale J., Chen J.K., and Cooper M.K. Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine Nature 406 2000 1005 1009
12. Incardona J.P., Gaffield W., and Kapur R.P. The teratogenic veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction Development 125 1998 3553 3562
13. Kubo M., Nakamura M., and Tasaki A. Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer Cancer Res 64 2004 6071 6074
14. Ma X., Chen K., and Huang S. Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas Carcinogenesis 26 2005 1698 1705
15. Oue T., Yoneda A., and Uehara S. Increased expression of the Hedgehog signaling pathway in pediatric solid malignancies J Pediatr Surg 45 2010 387 392
16. Nilsson M., Unden A.B., and Krause D. Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1 Proc Natl Acad Sci USA 97 2000 3438 3443
17. Kimura H., Stephen D., and Joyner A. Gli1 is important for medulloblastoma formation in Ptc1+/-mice Oncogene 24 2005 4026 4036
18. Fan C.M., Porter J.A., and Chiang C. Long-range sclerotome induction by sonic hedgehog: direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway Cell 81 1995 457 465
19. Hynes M., Porter J.A., and Chiang C. Induction of midbrain dopaminergic neurons by sonic hedgehog Neuron 15 1995 35 44
20. Noveen A., Jiang T.X., and Chuong C.M cAMP, an activator of protein kinase A, suppresses the expression of sonic hedgehog Biochem Biophys Res Commun 219 1996 180 185
21. Cobourne M.T., Hardcastle Z., and Sharpe P.T. Sonic hedgehog regulates epithelial proliferation and cell survival in the developing tooth germ J Dent Res 80 2001 1974 1979
22. Yao H.H., and Capel B. Disruption of testis cords by cyclopamine or Forskolin reveals independent cellular pathways in testis organogenesis Dev Biol 246 2002 356 365
23. Von Hoff D.D., LoRusso P.M., and Rudin C.M. Inhibition of the hedgehog pathway in advanced basal-cell carcinoma N Engl J Med 361 2009 1164 1172
24. Scales S.J., and de Sauvage F.J. Mechanisms of Hedgehog pathway activation in cancer and implications for therapy Trends Pharmacol Sci 30 2009 303 312