Involvement of receptor-bound prorenin in development of nephropathy in diabetic db/db mice

Journal of the American Society of Hypertension

Volumn 2, Issue 5, 2008, Pages 332-340

  Ichihara, Atsuhiro ^a   Sakoda, Mariyo ^a   Kurauchi Mito, Asako ^a   Nishiyama, Akira ^b   Itoh, Hiroshi ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KAGAWA UNIVERSITY   (Japan)

Author keywords

Albuminuria; angiotensin; glomerulosclerosis; type 2 diabetes

Indexed keywords

ANGIOTENSIN I; ANGIOTENSIN II; MITOGEN ACTIVATED PROTEIN KINASE 1; PRORENIN; RENIN;

ANGIOTENSIN BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETIC NEUROPATHY; GLOMERULOSCLEROSIS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MICROALBUMINURIA; MOUSE; MOUSE STRAIN; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION;

EID: 51449113656     PISSN: 19331711     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jash.2008.04.009     Document Type: Article

References (36)

1. Danser A.H., and Deinum J. Renin, prorenin, and the putative (pro)renin receptor. Hypertension 46 (2005) 1069-1076
2. Nguyen G. Renin/prorenin receptors. Kidney Int 69 (2006) 1503-1506
3. Danser A.H. Prorenin: back into the arena. Hypertension 47 (2006) 824-826
4. Nguyen G., Delarue F., Burckle C., Bouzhir L., Giller T., and Sraer J.-D. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest 109 (2002) 1417-1427
5. Nabi A.H.M.N., Kageshima A., Uddin M., Nakagawa T., Park E., and Suzuki F. Binding properties of rat prorenin and renin to the recombinant rat renin/prorenin receptor prepared by a baculovirus expression system. Int J Mol Med 18 (2006) 483-488
6. Schefe J.H., Funke-Kaiser H., Jost A., and Unger T. Signal transduction of the renin/prorenin receptor. [Abstract]. J Hypertens 23 (2005) S354
7. Derkx F., and Schalekamp M. Human prorenin: pathophysiology and clinical implications. Clin Exp Hypertens A10 (1988) 1213-1225
8. Wilson D., and Leutscher J.A. Plasma prorenin activity and complications in children with insulin-dependent diabetes mellitus. N Engl J Med 323 (1990) 1101-1106
9. Deinum J., Rønn B., Mathiesen E., Derkx F.H.M., Hop W.C.J., and Schalekamp M.A.D.H. Increase in serum prorenin precedes onset of microalbuminuria in patients with insulin-dependent diabetes mellitus. Diabetologia 42 (1999) 1006-1010
10. Ichihara A., Hayashi M., Kaneshiro Y., Suzuki F., Nakagawa T., Tada Y., et al. Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for non-proteolytic activation of prorenin. J Clin Invest 114 (2004) 1128-1135
11. Ichihara A., Suzuki F., Nakagawa T., Kaneshiro Y., Takemitsu T., Sakoda M., et al. Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor deficient mice. J Am Soc Nephrol 17 (2006) 1950-1961
12. Takahashi H., Ichihara A., Kaneshiro Y., Inomata K., Sakoda M., Takemitsu T., et al. Regression of nephropathy developed in diabetes by (pro)renin receptor blockade. J Am Soc Nephrol 18 (2007) 2054-2061
13. Suzuki F., Hayakawa M., Nakagawa T., Nasir U.M., Ebihara A., Iwasawa A., et al. Human prorenin has "gate and handle" regions for its non-proteolytic activation. J Biol Chem 278 (2003) 22217-22222
14. El-Nahas A.M., Bassett A.H., Cope G.H., and Carpentier J.E. Role of growth hormone in the development of experimental renal scarring. Kidney Int 40 (1991) 29-34
15. Takii Y., Figueiredo A.F.S., and Inagami T. Application of immunochemical methods to the identification and characterization of rat kidney inactive renin. Hypertension 7 (1985) 236-243
16. Inagami T., Murakami T., Higuchi K., and Nakajo S. Roles of renal and vascular renin in spontaneous hypertension and switching of the mechanism upon nephrectomy. Am J Hypertens 4 (1991) 15S-22S
17. Iwai N., Inagami T., Ohmichi N., and Kinoshita M. Renin is expressed in rat macrophage/monocyte cells. Hypertension 27 (1996) 399-403
18. Hirota N., Ichihara A., Koura Y., Hayashi M., and Saruta T. Phospholipase D contributes to transmural pressure control of prorenin processing in juxtaglomerular cell. Hypertension 39 (2002) 363-367
19. Naito Y., Tsujino T., Fujioka Y., Ohyanagi M., and Iwasaki T. Augmented diurnal variations of the cardiac renin-angiotensin system in hypertensive rats. Hypertension 40 (2002) 827-833
20. Huang Y., Wongamorntham S., Kasting J., McQuillan D., Owens R.T., Yu L., et al. Renin increases mesangial cell transforming growth factor-b1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms. Kidney Int 69 (2006) 105-113
21. Huang Y., Noble N., Zhang J., Xu C., and Border W. Renin-stimulated TGF-beta1 expression is regulated by a mitogen-activated protein kinase in mesangial cells. Kidney Int 72 (2007) 42-52
22. Hong S.W., Isono M., Chen S., Iglesias-de-la-Cruz M.C., Han D.C., and Ziyadeh F.N. Increased glomerular and tubular expression of transforming growth factor-s1, its type II receptor, and activation of the smad signaling pathway in the db/db mouse. Am J Pathol 158 (2001) 1653-1663
23. Nabi A.H.M.N., Uddin M., Nakagawa T., Iwata H., Ichihara A., Inagami T., et al. Role of "handle" region of prorenin prosegment in the non-proteolytic activation of prorenin by binding to membrane anchored (pro)renin receptor. Front Biosci 12 (2007) 4810-4817
24. Batenburg W.W., Krop M.K., Garrelds I.M., deVries R., deBruin R.J.A., Burckle C.A., et al. Prorenin is the endogenous agonist of the (pro)renin receptor. Binding kinetics of renin and prorenin in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor. J Hypertens 25 (2007) 2441-2453
25. Feldt S., Batenburg W.W., Mazak I., Maschke U., Wellner M., Kvakan H., et al. Prorenin and renin-induced extracellular signal regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide. Hypertension 51 (2008) 682-688
26. Sakoda M., Ichihara A., Kaneshiro Y., Takemitsu T., Nakazato Y., Migita T., et al. (Pro)renin receptor-mediated activation of mitogen-activated protein kinases in human vascular smooth muscle cells. Hyper Res 30 (2007) 1139-1146
27. Schefe J., Menk M., Reinemund J., Effertz K., Hobbs R., Pandolfi P., et al. A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein. Circ Res 99 (2006) 1355-1366
28. Susic D., Lippton H., Knight M., and Frohlich E.D. Cardiovascular effects of non-proteolytic activation of prorenin. Hypertension 48 (2006) e113
29. Ichihara A., Kaneshiro Y., Takemitsu T., Sakoda M., Suzuki F., Nakagawa T., et al. Non-proteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension. Hypertension 47 (2006) 894-900
30. Ichihara A., Kaneshiro Y., Takemitsu T., Sakoda M., Nakagawa T., Nishiyama A., et al. Contribution of non-proteolytically activated prorenin in glomeruli to hypertensive renal damage. J Am Soc Nephrol 17 (2006) 2495-2503
31. Feldt S., Maschke U., Dechend R., Luft F.C., and Muller D.N. The putative (pro)renin receptor blocker HRP fails to prevent (pro)renin signaling. J Am Soc Nephrol 19 (2008) 743-748
32. Muller D.N., Klanke B., Feldt S., Cordasic N., Hartner A., Schmieder R.E., et al. (Pro)renin receptor peptide inhibitor "handle-region" peptide does not affect hypertensive nephrosclerosis in Goldblatt rats. Hypertension 51 (2008) 676-681
33. Krebs C., Hamming I., Sadaghiani S., Steinmetz O.M., Meyer-Schwesinger C., Fehr S., et al. Antihypertensive therapy upregulates renin and (pro)renin receptor in the clipped kidney of Goldblatt hypertensive rats. Kidney Int 72 (2007) 725-730
34. Achard V., Boullu-Ciocca S., Desbriere R., Nguyen G., and Grino M. Renin receptor expression in human adipose tissue. Am J Physiol 292 (2007) R274-R282
35. Moriyama T., Oka K., Ueda H., and Imai E. Nilvadipine attenuates mesangial expansion and glomerular hypertrophy in diabetic db/db mice, a model for type 2 diabetes. Clin Exp Nephrol 8 (2004) 230-236
36. Kelly D.J., Zhang Y., Moe G., Nail G., and Gilbert R.E. Aliskiren, a novel renin inhibitor, is renoprotective in a model of advanced diabetic nephropathy in rats. Diabetologia 50 (2007) 2398-2404