Comparative study of in vitro and in vivo activities of bombesin pseudopeptide analogs modified on the C-terminal dipeptide fragment

Peptides

Volumn 19, Issue 1, 1998, Pages 57-63

  Azay, J ^a   Nagain, C ^b   Llinares, M ^a   Devin, C ^a   Fehrentz, J A ^a   Bernad, N ^a   Roze, C ^b   Martinez, J ^a  

^a UNIVERSITÉ DE MONTPELLIER   (France)

^b INSERM   (France)

Author keywords

Bombesin receptor antagonists; Pancreatic secretion; Transition state analog

Indexed keywords

AMYLASE; BOMBESIN ANTAGONIST; BOMBESIN DERIVATIVE; BOMBESIN RECEPTOR; DIPEPTIDE; JMV 594; JMV 641; JMV 717; JMV 736; JMV 845; PSEUDOPEPTIDE; UNCLASSIFIED DRUG;

ACINAR CELL; AMYLASE RELEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DOSE RESPONSE; MALE; NONHUMAN; PANCREAS FISTULA; PANCREAS SECRETION; PRIORITY JOURNAL; RAT;

AMYLASES; ANIMALS; BINDING, COMPETITIVE; BOMBESIN; DOSE-RESPONSE RELATIONSHIP, DRUG; GASTRIN-RELEASING PEPTIDE; MALE; PANCREAS; RATS; RATS, WISTAR; RECEPTORS, BOMBESIN;

EID: 0031913006     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-9781(97)00275-1     Document Type: Article

References (29)

1. Azay J., Gagne D., Devin C., Llinares M., Fehrentz J. A., Martinez J. JMV641 a potent bombesin receptor antagonist that inhibits Swiss 3T3 cell proliferation . Regul. Pept. 65:1996;91-97.
2. 2 or its derivatives. Proc. Natl. Acad. Sci. USA. 91:1994;12664-12668.
3. Carney D. N., Cuttitta F., Moody T. W., Minna J. D. Selective stimulation of small cell lung cancer clonal growth by bombesin and gastrin-releasing peptide. Cancer Res. 47:1987;821-825.
4. Ceska M., Birath K., Brown B. A new rapid method for the clinical determination of amylase activities in human serum and urine. Optimal conditions. Clin. Chim. Acta. 26:1969;437-444.
5. Chariot, J.; Rozé, C. Détermination automatisée de très faibles concentrations de bicarbonates. Application au suc pancréatique. Ann. Biol. Clin. 34:269-272; 197.
6. Coy D. H., Taylor J. E., Jiang N.-Y., Kim S. H., Wang L.-H., Hua S., Moreau J.-P., Gardner J. D., Jensen R. T. Short-chain pseudopeptide bombesin receptor antagonists with enhanced binding affinities for pancreatic acinar and Swiss 3T3 cells display strong antimitotic activity. J. Biol. Chem. 264:1989;14691-14697.
7. Cuttitta F., Carney D. N., Mulshine J., Moody T. W., Fedorko J., Fischler A., Minna J. D. Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer. Nature. 316:1985;823-825.
8. Gardner J. D., Jackson M. J. Regulation of amylase release from dispersed pancreatic acinar cells. J. Physiol. 270:1977;439-454.
9. Norgaard P, Damstrup L., Rygaard K., Spang-Thomsen M., Poulsen H. Acquired TGF beta 1 sensitivity from a single small cell lung cancer patient during clinical progression. Lung Cancer. 14:1996;63-73.
10. Jensen R. T., Moody T. W., Pert C., Rivier J. E., Gardner J. D. Interaction of bombesin and litorin with specific membrane receptors on pancreatic acinar cells. Proc. Natl. Acad. Sci. USA. 75:1978;6139-6143.
11. Jensen R. T., Lemp G. F., Gardner J. D. Interactions of carboxy-terminal fragments of cholecystokinin with receptors on dispersed acini from guinea pig pancreas. J. Biol. Chem. 257:1982;5554-5559.
12. Jensen R. T., Coy D. H., Saeed Z. A., Heinz-Erian P., Mantey S., Gardner J. D. Interaction of bombesin and related peptides with receptors on pancreatic acinar cells. Ann. N.Y. Acad. Sci. 547:1988;138-149.
13. Jensen R. T., Coy D. H. Progress in the development of potent bombesin receptor antagonists. TIPS. 12:1991;13-19.
14. Lebacq-Verheyden, A. M.; Trepel, J.; Sausville, E. A.; Battey, J. F. Peptide growth factors and their receptors. In: Sporn, M. B.; Roberts, A. B., eds. Handbook of experimental pharmacology. Berlin/Heidelberg; Springer-Verlag; 1990:71-124.
15. Llinares, M.; Azay, J.; Devin, C.; Fehrentz, J. A.; Lignon, M. F.; Martinez, J. Rational design and synthesis of bombesin receptor antagonists. Proceedings of the Twenty-Third European Peptide Symposium. 1994:313-314.
16. Llinares, M.; Devin, C.; Azay, J.; Bergé, G.; Fehrentz, J. A.; Martinez, J. Syntheses and biological activities of bombesin analogs modified in the C-terminal dipeptide part. Eur. J. Med. Chem. (in press).
17. Maruno K., Yamaguchi K., Abe K., Suzuki M., Saijo N., Mishima Y., Yanaihara N., Shimosato Y. Immunoreactive gastrin-releasing peptide as a specific tumor marker in patients with small cell lung carcinoma. Cancer Res. 49:1989;629-632.
18. Nagain C., Galas M. C., Lignon M. F., Rodriguez M., Martinez J., Rozé C. Synthetic CCK8 analogs with antagonist activity on pancreatic receptor in vivo study in the rat, compared to non peptidic antagonist . Pancreas. 6:1991;275-281.
19. Peikin S. R., Rottman A. J., Batzri S., Gardner J. D. Kinetics of amylase release by dispersed acini prepared from guinea pig pancreas. Am. J. Physiol. 235:1978;E743-E749.
20. Pinski J., Halmos G., Szepeshazl K., Schally A. V. Antagonists of bombesin/gastrin releasing peptide as adjuncts to agonists of luteinizing releasing hormone in the treatment of experimental prostate cancer. Cancer. 72:1993;3263-3270.
21. Pinski J., Schally A. V., Halmos G., Szepeshazl K., Groot K. Somatostatin analogues and bombesin/gastrin releasing peptide antagonist RC-3095 inhibit the growth of Human glioblastomas in vitro and in vivo. Cancer Res. 54:1994;5895-5901.
22. Radulovic S., Cai R.-Z., Serfoso P., Groot K., Redding T. W., Pinski J., Schally A. V. Biological effects and receptor binding affinities of new pseudononapeptide bombesin/GRP receptor antagonists with N-terminal D-Trp or D-Tpi. Int. J. Pept. Prot. Res. 38:1991;593-600.
23. Rozé, C.; de La Tour, J.; Chariot, J.; Souchard, M.; Debray, C. Technique d'étude de la sécrétion pancréatique externe chez le rat. Biol. Gastroenterol. (Paris) 8:291-295; 1975.
24. Rozengurt E., Sinnett-Smith J. Bombesin stimulation of DNA synthesis and cell division in cultures of Swiss 3T3 cells. Proc. Natl. Acad Sci. USA. 80:1983;2936-2940.
25. Sausville E. A., Lebacq-Verheyden A.-M., Spindel E. R., Cuttitta F., Gazdar A. F., Battey J. F. Expression of the gastrin-releasing peptide gene in human small cell lung cancer. Evidence for alternative processing resulting in three distinct mRNAs. J. Biol. Chem. 261:1986;2451-2457.
26. Sekar M. C., Uemura N., Coy D. H., Hirschowitz B. I., Dickinson K. E. J. Bombesin, neuromedin B and neuromedin C interact with a common rat pancreatic phosphoinositide-coupled receptor, but are differentially regulated by guanine nucleotides. Biochem. J. 280:1991;163-169.
27. 3 reverses intracisternal bombesin-induced inhibition of gastric acid secretion in rats. Peptides. 12:1991;665-667.
28. Tache T., Melchiorri P., Negri L. Bombesin-like peptides in health and disease. Ann. NY Acad. Sci. 547:1988;1-541.
29. Tallarida R. J., Murray R. B. Manual of pharmacologic calculations with computer programs. 1975;14-19 Springer-Verlag, New York.