Age-related changes in the epithelial and stromal compartments of the mammary gland in normocalcemic mice lacking the vitamin D3 receptor

PLoS ONE

Volumn 6, Issue 1, 2011, Pages

  Welsh, JoEllen ^a   Zinser, Lindsay N ^b   Mianecki Morton, Laurel ^c   Martin, Jamie ^d   Waltz, Susan E ^e,f   James, Howard ^f   Zinser, Glendon M ^e  

^a STATE UNIVERSITY OF NEW YORK   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d HASBRO CHILDREN'S HOSPITAL   (United States)

^e UNIVERSITY OF CINCINNATI   (United States)

^f Cincinnati Shriner's Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CASPASE 3; COLECALCIFEROL RECEPTOR; ESTRADIOL; LEPTIN; PROTEIN BAX; CALCITRIOL RECEPTOR; CALCIUM; STEROID;

AGED; AGING; ANIMAL TISSUE; ARTICLE; BRANCHING MORPHOGENESIS; BREAST ATROPHY; BREAST DEVELOPMENT; BREAST DUCT ECTASIA; BREAST EPITHELIUM; CALCIUM BLOOD LEVEL; CELL COMPARTMENTALIZATION; CONTROLLED STUDY; ENERGY METABOLISM; ENZYME ACTIVATION; ESTRADIOL BLOOD LEVEL; FEMALE; GENE INACTIVATION; MAMMARY GLAND; MOUSE; NONHUMAN; OVARY INSUFFICIENCY; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE; STROMA CELL; WHITE ADIPOSE TISSUE; WILD TYPE; AGE; ANIMAL; ATROPHY; CYTOLOGY; EPITHELIUM CELL; GROWTH, DEVELOPMENT AND AGING; MORPHOGENESIS; MOUSE MUTANT; UDDER;

MUS;

ADIPOSE TISSUE, WHITE; AGE FACTORS; AGING; ANIMALS; ATROPHY; CALCIUM; EPITHELIAL CELLS; ESTRADIOL; MAMMARY GLANDS, ANIMAL; MICE; MICE, KNOCKOUT; MORPHOGENESIS; RECEPTORS, CALCITRIOL; SIGNAL TRANSDUCTION; STEROIDS; STROMAL CELLS;

EID: 79551505430     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0016479     Document Type: Article

References (43)

1. Lamote I, Meyer E, Massart-Leen AM, Burvenich C (2004) Sex steroids and growth factors in the regulation of mammary gland proliferation, differentiation, and involution. Steroids 69: 145-159.
2. Haslam SZ (2005) Experimental mouse model of hormonal therapy effects on the postmenopausal mammary gland. Breast Dis 24: 71-78.
3. Haslam SZ, Osuch JR, Raafat AM, Hofseth LJ (2002) Postmenopausal hormone replacement therapy: effects on normal mammary gland in humans and in a mouse postmenopausal model. J Mammary Gland Biol Neoplasia 7: 93-105.
4. Cooke PS, Heine PA, Taylor JA, Lubahn DB (2001) The role of estrogen and estrogen receptor-alpha in male adipose tissue. Mol Cell Endocrinol 178: 147-154.
5. Neville MC, Medina D, Monks J, Hovey RC (1998) The mammary fat pad. J Mammary Gland Biol Neoplasia 3: 109-116.
6. Landskroner-Eiger S, Park J, Israel D, Pollard JW, Scherer PE () Morphogenesis of the developing mammary gland: stage-dependent impact of adipocytes. Dev Biol 344: 968-978.
7. Rajala MW, Scherer PE (2003) Minireview: The adipocyte-at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology 144: 3765-3773.
8. Kershaw EE, Flier JS (2004) Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 89: 2548-2556.
9. Couldrey C, Moitra J, Vinson C, Anver M, Nagashima K, et al. (2002) Adipose tissue: a vital in vivo role in mammary gland development but not differentiation. Dev Dyn 223: 459-468.
10. Zinser GM, Welsh J (2004) Accelerated mammary gland development during pregnancy and delayed postlactational involution in vitamin D3 receptor null mice. Mol Endocrinol 18: 2208-2223.
11. Lefebvre MF, Guillot C, Crepin M, Saez S (1995) Influence of tumor derived fibroblasts and 1,25-dihydroxyvitamin D3 on growth of breast cancer cell lines. Breast Cancer Res Treat 33: 189-197.
12. Simboli-Campbell M, Narvaez CJ, Tenniswood M, Welsh J (1996) 1,25- Dihydroxyvitamin D3 induces morphological and biochemical markers of apoptosis in MCF-7 breast cancer cells. J Steroid Biochem Mol Biol 58: 367-376.
13. Kanazawa T, Enami J, Kohmoto K (1999) Effects of 1alpha,25-dihydroxycholecalciferol and cortisol on the growth and differentiation of primary cultures of mouse mammary epithelial cells in collagen gel. Cell Biol Int 23: 481-487.
14. Narvaez CJ, Welsh J (2001) Role of mitochondria and caspases in vitamin Dmediated apoptosis of MCF-7 breast cancer cells. J Biol Chem 276: 9101-9107.
15. Zinser G, Packman K, Welsh J (2002) Vitamin D(3) receptor ablation alters mammary gland morphogenesis. Development 129: 3067-3076.
16. Johnson LE, DeLuca HF (2001) Vitamin D receptor null mutant mice fed high levels of calcium are fertile. J Nutr 131: 1787-1791.
17. Li YC, Amling M, Pirro AE, Priemel M, Meuse J, et al. (1998) Normalization of mineral ion homeostasis by dietary means prevents hyperparathyroidism, rickets, and osteomalacia, but not alopecia in vitamin D receptor-ablated mice. Endocrinology 139: 4391-4396.
18. Froicu M, Zhu Y, Cantorna MT (2006) Vitamin D receptor is required to control gastrointestinal immunity in IL-10 knockout mice. Immunology 117: 310-318.
19. Li YC, Kong J, Wei M, Chen ZF, Liu SQ, et al. (2002) 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest 110: 229-238.
20. Narvaez CJ, Matthews D, Broun E, Chan M, Welsh J (2009) Lean phenotype and resistance to diet-induced obesity in vitamin D receptor knockout mice correlates with induction of uncoupling protein-1 in white adipose tissue. Endocrinology 150: 651-661.
21. Wong KE, Szeto FL, Zhang W, Ye H, Kong J, et al. (2009) Involvement of the Vitamin D Receptor in Energy Metabolism: Regulation of Uncoupling Proteins. Am J Physiol Endocrinol Metab.
22. Zinser GM, Suckow M, Welsh J (2005) Vitamin D receptor (VDR) ablation alters carcinogen-induced tumorigenesis in mammary gland, epidermis and lymphoid tissues. J Steroid Biochem Mol Biol 97: 153-164.
23. Eriksen EF, Glerup H (2002) Vitamin D deficiency and aging: implications for general health and osteoporosis. Biogerontology 3: 73-77.
24. Zinser GM, Sundberg JP, Welsh J (2002) Vitamin D(3) receptor ablation sensitizes skin to chemically induced tumorigenesis. Carcinogenesis 23: 2103-2109.
25. Amling M, Priemel M, Holzmann T, Chapin K, Rueger JM, et al. (1999) Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: formal histomorphometric and biomechanical analyses. Endocrinology 140: 4982-4987.
26. Zemel MB, Shi H, Greer B, Dirienzo D, Zemel PC (2000) Regulation of adiposity by dietary calcium. FASEB J 14: 1132-1138.
27. Parra P, Bruni G, Palou A, Serra F (2008) Dietary calcium attenuation of body fat gain during high-fat feeding in mice. J Nutr Biochem 19: 109-117.
28. Metcalfe AD, Gilmore A, Klinowska T, Oliver J, Valentijn AJ, et al. (1999) Developmental regulation of Bcl-2 family protein expression in the involuting mammary gland. J Cell Sci 112(Pt 11): 1771-1783.
29. Wiseman BS, Werb Z (2002) Stromal effects on mammary gland development and breast cancer. Science 296: 1046-1049.
30. Kass L, Erler JT, Dembo M, Weaver VM (2007) Mammary epithelial cell: influence of extracellular matrix composition and organization during development and tumorigenesis. Int J Biochem Cell Biol 39: 1987-1994.
31. Degerman E, Landstrom TR, Wijkander J, Holst LS, Ahmad F, et al. (1998) Phosphorylation and activation of hormone-sensitive adipocyte phosphodiesterase type 3B. Methods 14: 43-53.
32. Johnson JA, Grande JP, Roche PC, Kumar R (1996) Immunohistochemical detection and distribution of the 1,25-dihydroxyvitamin D3 receptor in rat reproductive tissues. Histochem Cell Biol 105: 7-15.
33. Fendrick JL, Raafat AM, Haslam SZ (1998) Mammary gland growth and development from the postnatal period to postmenopause: ovarian steroid receptor ontogeny and regulation in the mouse. J Mammary Gland Biol Neoplasia 3: 7-22.
34. Heine PA, Taylor JA, Iwamoto GA, Lubahn DB, Cooke PS (2000) Increased adipose tissue in male and female estrogen receptor-alpha knockout mice. Proc Natl Acad Sci U S A 97: 12729-12734.
35. Jones ME, Thorburn AW, Britt KL, Hewitt KN, Wreford NG, et al. (2000) Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity. Proc Natl Acad Sci U S A 97: 12735-12740.
36. Bruce D, Whitcomb JP, August A, McDowell MA, Cantorna MT (2009) Elevated non-specific immunity and normal Listeria clearance in young and old vitamin D receptor knockout mice. Int Immunol 21: 113-122.
37. Froicu M, Cantorna MT (2007) Vitamin D and the vitamin D receptor are critical for control of the innate immune response to colonic injury. BMC Immunol 8: 5.
38. Keisala T, Minasyan A, Lou YR, Zou J, Kalueff AV, et al. (2009) Premature aging in vitamin D receptor mutant mice. J Steroid Biochem Mol Biol 115: 91-97.
39. Zou J, Minasyan A, Keisala T, Zhang Y, Wang JH, et al. (2008) Progressive hearing loss in mice with a mutated vitamin D receptor gene. Audiol Neurootol 13: 219-230.
40. Panda DK, Miao D, Bolivar I, Li J, Huo R, et al. (2004) Inactivation of the 25- hydroxyvitamin D 1alpha-hydroxylase and vitamin D receptor demonstrates independent and interdependent effects of calcium and vitamin D on skeletal and mineral homeostasis. J Biol Chem 279: 16754-16766.
41. Erben RG, Zeitz U, Weber K, Stierstorfer B, Wolf G, et al. A non-functioning vitamin D receptor predisposes to leukaemoid reactions in mice. Hematol Oncol.
42. Li YC, Pirro AE, Amling M, Delling G, Baron R, et al. (1997) Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia. Proc Natl Acad Sci U S A 94: 9831-9835.
43. Zinser GM, McEleney K, Welsh J (2003) Characterization of mammary tumor cell lines from wild type and vitamin D3 receptor knockout mice. Mol Cell Endocrinol 200: 67-80.