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Volumn 433, Issue 1, 2011, Pages 187-196

Phosphorylation-dependent association of the G4-1/G5PR regulatory subunit with IKKβ negatively modulates NF-κB activation through recruitment of protein phosphatase 5

Author keywords

G4 1 G5PR; Inhibitor of nuclear factor B kinase (IKK); Nuclear factor B (NF B); Protein phosphatase 5

Indexed keywords

I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 2A; PHOSPHOPROTEIN PHOSPHATASE 5; PROTEIN G4 1; PROTEIN SUBUNIT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 79551503555     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20100247     Document Type: Article
Times cited : (8)

References (32)
  • 1
    • 0028978032 scopus 로고
    • Phosphorylation of human IκB-α on serines 32 and 36 controls IκB-α proteolysis and NF-κB activation in response to diverse stimuli
    • Traenckner, E. B., Pahl, H. L., Henkel, T., Schmidt, K. N., Wilk, S. and Baeuerle, P. A. (1995) Phosphorylation of human IκB-α on serines 32 and 36 controls IκB-α proteolysis and NF-κB activation in response to diverse stimuli. EMBO J. 14, 2876-2883
    • (1995) EMBO J. , vol.14 , pp. 2876-2883
    • Traenckner, E.B.1    Pahl, H.L.2    Henkel, T.3    Schmidt, K.N.4    Wilk, S.5    Baeuerle, P.A.6
  • 2
    • 0030004897 scopus 로고    scopus 로고
    • Site-specific phosphorylation of IκBα by a novel ubiquitination-dependent protein kinase activity
    • Chen, Z. J., Parent, L. and Maniatis, T. (1996) Site-specific phosphorylation of IκBα by a novel ubiquitination-dependent protein kinase activity. Cell 84, 853-862
    • (1996) Cell , vol.84 , pp. 853-862
    • Chen, Z.J.1    Parent, L.2    Maniatis, T.3
  • 3
    • 38849199203 scopus 로고    scopus 로고
    • Shared principles in NF-κB signaling
    • Hayden, M. S. and Ghosh, S. (2008) Shared principles in NF-κB signaling. Cell 132, 344-362
    • (2008) Cell , vol.132 , pp. 344-362
    • Hayden, M.S.1    Ghosh, S.2
  • 4
    • 0029670083 scopus 로고    scopus 로고
    • Mapping of the inducible IκB phosphorylation sites that signal its ubiquitination and degradation
    • DiDonato, J., Mercurio, F., Rosette, C., Wu-Li, J., Suyang, H., Ghosh, S. and Karin, M. (1996) Mapping of the inducible IκB phosphorylation sites that signal its ubiquitination and degradation. Mol. Cell. Biol. 16, 1295-1304
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 1295-1304
    • DiDonato, J.1    Mercurio, F.2    Rosette, C.3    Wu-Li, J.4    Suyang, H.5    Ghosh, S.6    Karin, M.7
  • 5
    • 0028986075 scopus 로고
    • Control of IκB-α proteolysis by site-specific, signal-induced phosphorylation
    • Brown, K., Gerstberger, S., Carlson, L., Franzoso, G. and Siebenlist, U. (1995) Control of IκB-α proteolysis by site-specific, signal-induced phosphorylation. Science 267, 1485-1488
    • (1995) Science , vol.267 , pp. 1485-1488
    • Brown, K.1    Gerstberger, S.2    Carlson, L.3    Franzoso, G.4    Siebenlist, U.5
  • 6
    • 4444376712 scopus 로고    scopus 로고
    • Signaling to NF-κB
    • Hayden, M. S. and Ghosh, S. (2004) Signaling to NF-κB. Genes Dev. 18, 2195-2224
    • (2004) Genes Dev. , vol.18 , pp. 2195-2224
    • Hayden, M.S.1    Ghosh, S.2
  • 7
    • 0030613551 scopus 로고    scopus 로고
    • The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for Iκb phosphorylation and NF-κB activation
    • DOI 10.1016/S0092-8674(00)80406-7
    • Zandi, E., Rothwarf, D. M., Delhase, M., Hayakawa, M. and Karin, M. (1997) The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation. Cell 91, 243-252 (Pubitemid 27456391)
    • (1997) Cell , vol.91 , Issue.2 , pp. 243-252
    • Zandi, E.1    Rothwarf, D.M.2    Delhase, M.3    Hayakawa, M.4    Karin, M.5
  • 8
    • 0032541657 scopus 로고    scopus 로고
    • IKK-γ is an essential regulatory subunit of the IκB kinase complex
    • Rothwarf, D. M., Zandi, E., Natoli, G. and Karin, M. (1998) IKK-γ is an essential regulatory subunit of the IκB kinase complex. Nature 395, 297-300
    • (1998) Nature , vol.395 , pp. 297-300
    • Rothwarf, D.M.1    Zandi, E.2    Natoli, G.3    Karin, M.4
  • 9
    • 0027168948 scopus 로고
    • The p65 subunit of NF-κB regulates IκB by two distinct mechanisms
    • Scott, M. L., Fujita, T., Liou, H. C., Nolan, G. P. and Baltimore, D. (1993) The p65 subunit of NF-κB regulates IκB by two distinct mechanisms. Genes Dev. 7, 1266-1276
    • (1993) Genes Dev. , vol.7 , pp. 1266-1276
    • Scott, M.L.1    Fujita, T.2    Liou, H.C.3    Nolan, G.P.4    Baltimore, D.5
  • 10
    • 0000564581 scopus 로고    scopus 로고
    • The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-κB activation
    • Song, H. Y., Rothe, M. and Goeddel, D. V. (1996) The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-κB activation. Proc. Natl. Acad. Sci. U.S.A. 93, 6721-6725
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 6721-6725
    • Song, H.Y.1    Rothe, M.2    Goeddel, D.V.3
  • 11
    • 0035839424 scopus 로고    scopus 로고
    • Identification of a novel A20-binding inhibitor of nuclear factor-κB activation termed ABIN-2
    • Van Huffel, S., Delaei, F., Heyninck, K., De Valck, D. and Beyaert, R. (2001) Identification of a novel A20-binding inhibitor of nuclear factor-κB activation termed ABIN-2. J. Biol. Chem. 276, 30216-30223
    • (2001) J. Biol. Chem. , vol.276 , pp. 30216-30223
    • Van Huffel, S.1    Delaei, F.2    Heyninck, K.3    De Valck, D.4    Beyaert, R.5
  • 12
    • 0037219713 scopus 로고    scopus 로고
    • An LKB1-interacting protein negatively regulates TNFα-induced NF-κB activation
    • Liu, W. K., Chien, C. Y., Chou, C. K. and Su, J. Y. (2003) An LKB1-interacting protein negatively regulates TNFα-induced NF-κB activation. J. Biomed. Sci. 10, 242-252
    • (2003) J. Biomed. Sci. , vol.10 , pp. 242-252
    • Liu, W.K.1    Chien, C.Y.2    Chou, C.K.3    Su, J.Y.4
  • 13
    • 1642464042 scopus 로고    scopus 로고
    • The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKγ to block activation of the transcription factor NF-κB and potentiate apoptosis
    • Liu, W. K., Yen, P. F., Chien, C. Y., Fann, M. J., Su, J. Y. and Chou, C. K. (2004) The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKγ to block activation of the transcription factor NF-κB and potentiate apoptosis. Biochem. J. 378, 867-876
    • (2004) Biochem. J. , vol.378 , pp. 867-876
    • Liu, W.K.1    Yen, P.F.2    Chien, C.Y.3    Fann, M.J.4    Su, J.Y.5    Chou, C.K.6
  • 14
    • 32644460310 scopus 로고    scopus 로고
    • Overexpression of ABIN-2, a negative regulator of NF-κB, delays liver regeneration in the ABIN-2 transgenic mice
    • Li, C. C., Chou, C. K., Wang, M. H. and Tsai, T. F. (2006) Overexpression of ABIN-2, a negative regulator of NF-κB, delays liver regeneration in the ABIN-2 transgenic mice. Biochem. Biophys. Res. Commun. 342, 300-309
    • (2006) Biochem. Biophys. Res. Commun. , vol.342 , pp. 300-309
    • Li, C.C.1    Chou, C.K.2    Wang, M.H.3    Tsai, T.F.4
  • 16
    • 0345826130 scopus 로고    scopus 로고
    • Protein phosphatase 2Cβ association with the IκB kinase complex is involved in regulating NF-κB activity
    • Prajapati, S., Verma, U., Yamamoto, Y., Kwak, Y. T. and Gaynor, R. B. (2004) Protein phosphatase 2Cβ association with the IκB kinase complex is involved in regulating NF-κB activity. J. Biol. Chem. 279, 1739-1746
    • (2004) J. Biol. Chem. , vol.279 , pp. 1739-1746
    • Prajapati, S.1    Verma, U.2    Yamamoto, Y.3    Kwak, Y.T.4    Gaynor, R.B.5
  • 18
    • 54049115864 scopus 로고    scopus 로고
    • Identification of PP2A as a crucial regulator of the NF-κB feedback loop: Its inhibition by UVB turns NF-κB into a pro-apoptotic factor
    • Barisic, S., Strozyk, E., Peters, N., Walczak, H. and Kulms, D. (2008) Identification of PP2A as a crucial regulator of the NF-κB feedback loop: its inhibition by UVB turns NF-κB into a pro-apoptotic factor. Cell Death Differ. 15, 1681-1690
    • (2008) Cell Death Differ. , vol.15 , pp. 1681-1690
    • Barisic, S.1    Strozyk, E.2    Peters, N.3    Walczak, H.4    Kulms, D.5
  • 20
    • 37349111560 scopus 로고    scopus 로고
    • RNAi screen in mouse astrocytes identifies phosphatases that regulate NF-κB signaling
    • Li, S., Wang, L., Berman, M. A., Zhang, Y. and Dorf, M. E. (2006) RNAi screen in mouse astrocytes identifies phosphatases that regulate NF-κB signaling. Mol. Cell 24, 497-509
    • (2006) Mol. Cell , vol.24 , pp. 497-509
    • Li, S.1    Wang, L.2    Berman, M.A.3    Zhang, Y.4    Dorf, M.E.5
  • 21
    • 0036668467 scopus 로고    scopus 로고
    • MCM3-binding GANP DNA-primase is associated with a novel phosphatase component G5PR
    • DOI 10.1046/j.1365-2443.2002.00562.x
    • Kono, Y., Maeda, K., Kuwahara, K., Yamamoto, H., Miyamoto, E., Yonezawa, K., Takagi, K. and Sakaguchi, N. (2002) MCM3-binding GANP DNA-primase is associated with a novel phosphatase component G5PR. Genes Cells 7, 821-834 (Pubitemid 34947085)
    • (2002) Genes to Cells , vol.7 , Issue.8 , pp. 821-834
    • Kono, Y.1    Maeda, K.2    Kuwahara, K.3    Yamamoto, H.4    Miyamoto, E.5    Yonezawa, K.6    Takagi, K.7    Sakaguchi, N.8
  • 22
    • 24344443288 scopus 로고    scopus 로고
    • Protein phosphatase subunit G5PR is needed for inhibition of B cell receptor-induced apoptosis
    • Xing, Y., Igarashi, H., Wang, X. and Sakaguchi, N. (2005) Protein phosphatase subunit G5PR is needed for inhibition of B cell receptor-induced apoptosis. J. Exp. Med. 202, 707-719
    • (2005) J. Exp. Med. , vol.202 , pp. 707-719
    • Xing, Y.1    Igarashi, H.2    Wang, X.3    Sakaguchi, N.4
  • 23
    • 29244432173 scopus 로고    scopus 로고
    • BCR-crosslinking induces a transcription of protein phosphatase component G5PR that is required for mature B-cell survival
    • Huq Ronny, F. M., Igarashi, H. and Sakaguchi, N. (2006) BCR-crosslinking induces a transcription of protein phosphatase component G5PR that is required for mature B-cell survival. Biochem. Biophys. Res. Commun. 340, 338-346
    • (2006) Biochem. Biophys. Res. Commun. , vol.340 , pp. 338-346
    • Huq Ronny, F.M.1    Igarashi, H.2    Sakaguchi, N.3
  • 24
    • 38949168868 scopus 로고    scopus 로고
    • Protein phosphatase subunit G5PR that regulates the JNK-mediated apoptosis signal is essential for the survival of CD4 and CD8 double-positive thymocytes
    • Xing, Y., Wang, X., Igarashi, H., Kawamoto, H. and Sakaguchi, N. (2008) Protein phosphatase subunit G5PR that regulates the JNK-mediated apoptosis signal is essential for the survival of CD4 and CD8 double-positive thymocytes. Mol. Immunol. 45, 2028-2037
    • (2008) Mol. Immunol. , vol.45 , pp. 2028-2037
    • Xing, Y.1    Wang, X.2    Igarashi, H.3    Kawamoto, H.4    Sakaguchi, N.5
  • 25
    • 0033537719 scopus 로고    scopus 로고
    • Positive and negative regulation of IκB kinase activity through IKKβ subunit phosphorylation
    • Delhase, M., Hayakawa, M., Chen, Y. and Karin, M. (1999) Positive and negative regulation of IκB kinase activity through IKKβ subunit phosphorylation. Science 284, 309-313
    • (1999) Science , vol.284 , pp. 309-313
    • Delhase, M.1    Hayakawa, M.2    Chen, Y.3    Karin, M.4
  • 27
    • 0029991350 scopus 로고    scopus 로고
    • Transfecting mammalian cells: Optimization of critical parameters affecting calcium-phosphate precipitate formation
    • Jordan, M., Schallhorn, A. and Wurm, F. M. (1996) Transfecting mammalian cells: optimization of critical parameters affecting calcium-phosphate precipitate formation. Nucleic Acids Res. 24, 596-601
    • (1996) Nucleic Acids Res. , vol.24 , pp. 596-601
    • Jordan, M.1    Schallhorn, A.2    Wurm, F.M.3
  • 28
    • 24944489952 scopus 로고    scopus 로고
    • Stimulus specificity of gene expression programs determined by temporal control of IKK activity
    • Werner, S. L., Barken, D. and Hoffmann, A. (2005) Stimulus specificity of gene expression programs determined by temporal control of IKK activity. Science 309, 1857-1861
    • (2005) Science , vol.309 , pp. 1857-1861
    • Werner, S.L.1    Barken, D.2    Hoffmann, A.3


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