PKCζ-interacting protein ZIP3 is generated by intronic polyadenylation, and is expressed in the brain and retina of the rat

Biochemical Journal

Volumn 433, Issue 1, 2011, Pages 43-50

  Urbanczyk, Andreas ^a   Jünemann, Anselm ^b   Enz, Ralf ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

aminobutyric acid type C (GABAC) receptor; p62; Protein kinase C interacting protein 3 (ZIP3); Retina; Sequestosome 1 (SQSTM1)

Indexed keywords

4 AMINOBUTYRIC ACID C RECEPTOR; ANTISERUM; PROTEIN; PROTEIN KINASE C ZETA; PROTEIN KINASE C ZETA INTERACTING PROTEIN 3; SEQUESTOSOME 1; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN; CELL LABELING; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; GENE SEQUENCE; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HEART; HUMAN; HUMAN CELL; INTRON; KIDNEY; LIVER; MALE; MOUSE; NERVE ENDING; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYADENYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; RETINA; RETINA BIPOLAR GANGLION CELL; SIGNAL TRANSDUCTION; SPLEEN; SYNAPSE;

ANIMALS; BRAIN CHEMISTRY; HEAT-SHOCK PROTEINS; HUMANS; IMMUNE SERA; INTRONS; POLYADENYLATION; PROTEIN KINASE C; RATS; RETINA; RETINAL BIPOLAR CELLS; RNA, MESSENGER; TISSUE DISTRIBUTION;

RATTUS;

EID: 79551501745     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20101111     Document Type: Article

References (22)

1. Moscat, J., Diaz-Meco, M. T. and Wooten, M. W. (2007) Signal integration and diversification through the p62 scaffold protein. Trends Biochem. Sci. 32, 95-100
2. Geetha, T. and Wooten, M. W. (2002) Structure and functional properties of the ubiquitin binding protein p62. FEBS Lett. 512, 19-24
3. Moscat, J. and Diaz-Meco, M. T. (2009) p62 at the crossroads of autophagy, apoptosis, and cancer. Cell 137, 1001-1004
4. Rodriguez, A., Duran, A., Selloum, M., Champy, M. F., Diez-Guerra, F. J., Flores, J. M., Serrano, M., Auwerx, J., Diaz-Meco, M. T. and Moscat, J. (2006) Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62. Cell Metab. 3, 211-222
5. Wooten, M. W., Hu, X., Babu, J. R., Seibenhener, M. L., Geetha, T., Paine, M. G. and Wooten, M. C. (2006) Signaling, polyubiquitination, trafficking, and inclusions: sequestosome 1/p62's role in neurodegenerative disease. J. Biomed. Biotechnol. 2006, 62079
6. Zatloukal, K., Stumptner, C., Fuchsbichler, A., Heid, H., Schnoelzer, M., Kenner, L., Kleinert, R., Prinz, M., Aguzzi, A. and Denk, H. (2002) p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases. Am. J. Pathol. 160, 255-263
7. Ramesh Babu, J., Lamar Seibenhener, M., Peng, J., Strom, A. L., Kemppainen, R., Cox, N., Zhu, H., Wooten, M. C., Diaz-Meco, M. T., Moscat, J. and Wooten, M. W. (2008) Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration. J. Neurochem. 106, 107-120
8. Croci, C., Brandstätter, J. H. and Enz, R. (2003) ZIP3, a new splice variant of the PKC-ζ-interacting protein family, binds to GABAC receptors, PKC-ζ, and Kvaβ2. J. Biol. Chem. 278, 6128-6135
9. Gong, J., Xu, J., Bezanilla, M., van Huizen, R., Derin, R. and Li, M. (1999) Differential stimulation of PKC phosphorylation of potassium channels by ZIP1 and ZIP2. Science 285, 1565-1569 (Pubitemid 29420580)
10. Kim, O. J., Ariano, M. A., Namkung, Y., Marinec, P., Kim, E., Han, J. and Sibley, D. R. (2008) D2 dopamine receptor expression and trafficking is regulated through direct interactions with ZIP. J. Neurochem. 106, 83-95
11. Moscat, J., Diaz-Meco, M. T. and Wooten, M. W. (2009) Of the atypical PKCs, Par-4 and p62: recent understandings of the biology and pathology of a PB1-dominated complex. Cell Death Differ. 16, 1426-1437
12. Puls, A., Schmidt, S., Grawe, F. and Stabel, S. (1997) Interaction of protein kinase Cζ with ZIP, a novel protein kinase C-binding protein. Proc. Natl. Acad. Sci. U.S.A. 94, 6191-6196
13. Tian, B., Pan, Z. and Lee, J. Y. (2007) Widespread mRNA polyadenylation events in introns indicate dynamic interplay between polyadenylation and splicing. Genome Res. 17, 156-165
14. Rose, M., Dütting, E., Schröder, N., Sticht, H., Brandstätter, J. H. and Enz, R. (2008) PNUTS forms a trimeric protein complex with GABAC receptors and protein phosphatase 1. Mol. Cell. Neurosci. 37, 808-819
15. C receptor rho subunits in the mammalian retina. J. Neurosci. 16, 4479-4490
16. Enz, R. and Cutting, G. R. (1999) GABAC receptor rho subunits are heterogeneously expressed in the human CNS and form homo- and heterooligomers with distinct physical properties. Eur. J. Neurosci. 11, 41-50
17. Enz, R., Brandstätter, J. H., Hartveit, E., Wässle, H. and Bormann, J. (1995) Expression of GABA receptor rho 1 and rho 2 subunits in the retina and brain of the rat. Eur. J. Neurosci. 7, 1495-1501
18. Pan, Q., Shai, O., Lee, L. J., Frey, B. J. and Blencowe, B. J. (2008) Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing. Nat. Genet. 40, 1413-1415
19. Cooper, T. A., Wan, L. and Dreyfuss, G. (2009) RNA and disease. Cell 136, 777-793
20. Koscielny, G., Le Texier, V., Gopalakrishnan, C., Kumanduri, V., Riethoven, J. J., Nardone, F., Stanley, E., Fallsehr, C., Hofmann, O., Kull, M. et al. (2009) ASTD: the Alternative Splicing and Transcript Diversity database. Genomics 93, 213-220
21. C receptors on rat retinal bipolar cells. Eur. J. Pharmacol. 288, 97-104
22. Sedelnikova, A. and Weiss, D. S. (2002) Phosphorylation of the recombinant rho1 GABA receptor. Int. J. Dev. Neurosci. 20, 237-246