Expression of CYP19 and CYP17 is associated with leg length, weight, and BMI

Obesity

Volumn 19, Issue 2, 2011, Pages 436-441

  Yousefi, Mitra ^a   Karmaus, Wilfried ^a   Mudd, Lanay M ^b   Landgraf, Jeffrey R ^c   Mikucki, Dorota ^b   Haan, Pamela S ^b   Zhang, Jessica ^a   Osuch, Janet R ^b  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATASE; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; RNA 18S; RNA POLYMERASE II; STEROID 17ALPHA MONOOXYGENASE;

ADULT; ANTHROPOMETRY; ARTICLE; BLOOD CELL; BODY COMPOSITION; BODY GROWTH; BODY HEIGHT; BODY MASS; BODY WEIGHT; CIGARETTE SMOKING; COHORT ANALYSIS; CONTROLLED STUDY; EDUCATION; EXERCISE; FEMALE; FOLLOW UP; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION; GENETIC CORRELATION; GENETICS; HISTOLOGY; HUMAN; LEG; LEG LENGTH; MATERNAL AGE; METABOLISM; MIDDLE AGED; PHYSIOLOGY; PROGENY; REPRODUCTIVE HISTORY; TRUNK;

ADULT; AROMATASE; BODY COMPOSITION; BODY MASS INDEX; BODY WEIGHT; COHORT STUDIES; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; LEG; MIDDLE AGED; RECEPTORS, ESTROGEN; STEROID 17-ALPHA-HYDROXYLASE; YOUNG ADULT;

EID: 79551500582     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2010.128     Document Type: Article

References (41)

1. Li L, Hardy R, Kuh D, Lo Conte R, Power C. Child-to-adult body mass index and height trajectories: a comparison of 2 British birth cohorts. Am J Epidemiol 2008;168:1008-1015.
2. Duval-Beaupère G. [Growth of the trunk and lower limbs after the menarche]. Rev Chir Orthop Reparatrice Appar Mot 1976;62: 501-509.
3. Simpson ER, Misso M, Hewitt KN et al. Estrogen-the good, the bad, and the unexpected. Endocr Rev 2005;26:322-330.
4. Gennari L, Nuti R, Bilezikian J P. Aromatase activity and bone homeostasis in men. J Clin Endocrinol Metab 2004;89:5898-5907.
5. Gambacciani M, Ciaponi M, Cappagli B, Piaggesi L, Genazzani AR. Effects of combined low dose of the isoflavone derivative ipriflavone and estrogen replacement on bone mineral density and metabolism in postmenopausal women. Maturitas 1997;28:75-81.
6. Morishima A, Grumbach MM, Simpson ER, Fisher C, Qin K. Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. J Clin Endocrinol Metab 1995;80:3689-3698.
7. Bilezikian J P. The role of estrogens in male skeletal development. Reprod Fertil Dev 2001;13:253-259.
8. Gunther D F, Calikoglu AS, Underwood LE. The effects of the estrogen receptor blocker, Faslodex (ICI 182,780), on estrogen-accelerated bone maturation in mice. Pediatr Res 1999;46:269-273.
9. Smith E P, Boyd J, Frank GR et al. Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med 1994;331:1056-1061.
10. Cohen PG. The hypogonadal-obesity cycle: role of aromatase in modulating the testosterone-estradiol shunt-a major factor in the genesis of morbid obesity. Med Hypotheses 1999;52:49-51.
11. Baghaei F, Rosmond R, Westberg L et al. The CYP19 gene and associations with androgens and abdominal obesity in premenopausal women. Obes Res 2003;11:578-585.
12. Yang TL, Xiong DH, Guo Y, Recker RR, Deng HW. Association analyses of CYP19 gene polymorphisms with height variation in a large sample of Caucasian nuclear families. Hum Genet 2006;120:119-125.
13. Maffei L, Rochira V, Zirilli L et al. A novel compound heterozygous mutation of the aromatase gene in an adult man: reinforced evidence on the relationship between congenital oestrogen deficiency, adiposity and the metabolic syndrome. Clin Endocrinol (Oxf) 2007;67:218-224.
14. Jones ME, Boon WC, Proietto J, Simpson ER. Of mice and men: the evolving phenotype of aromatase deficiency. Trends Endocrinol Metab 2006;17:55-64.
15. Korach KS, Couse J F, Curtis SW et al. Estrogen receptor gene disruption: molecular characterization and experimental and clinical phenotypes. Recent Prog Horm Res 1996;51:159-186; discussion 186.
16. Okura T, Koda M, Ando F et al. Association of polymorphisms in the estrogen receptor alpha gene with body fat distribution. Int J Obes Relat Metab Disord 2003;27:1020-1027.
17. Ohlsson C, Hellberg N, Parini P et al. Obesity and disturbed lipoprotein profile in estrogen receptor-alpha-deficient male mice. Biochem Biophys Res Commun 2000;278:640-645.
18. Musatov S, Chen W, Pfaff DW et al. Silencing of estrogen receptor alpha in the ventromedial nucleus of hypothalamus leads to metabolic syndrome. Proc Natl Acad Sci USA 2007;104:2501-2506.
19. Nilsson M, Dahlman I, Jiao H et al. Impact of estrogen receptor gene polymorphisms and mRNA levels on obesity and lipolysis-a cohort study. BMC Med Genet 2007;8:73.
20. Jones ME, Thorburn AW, Britt KL et al. Aromatase-deficient (ArKO) mice accumulate excess adipose tissue. J Steroid Biochem Mol Biol 2001;79:3-9.
21. Long JR, Shu XO, Cai Q et al. CYP19A1 genetic polymorphisms may be associated with obesity-related phenotypes in Chinese women. Int J Obes (Lond) 2007;31:418-423.
22. Stygar D, Masironi B, Eriksson H, Sahlin L. Studies on estrogen receptor (ER) alpha and beta responses on gene regulation in peripheral blood leukocytes in vivo using selective ER agonists. J Endocrinol 2007;194:101-119.
23. Deng HW, Li J, Li JL et al. Association of estrogen receptor-alpha genotypes with body mass index in normal healthy postmenopausal Caucasian women. J Clin Endocrinol Metab 2000;85:2748-2751.
24. Nilsson M, Dahlman I, Rydén M et al. Oestrogen receptor alpha gene expression levels are reduced in obese compared to normal weight females. Int J Obes (Lond) 2007;31:900-907.
25. Carani C, Qin K, Simoni M et al. Effect of testosterone and estradiol in a man with aromatase deficiency. N Engl J Med 1997;337:91-95.
26. Cohen PG. Aromatase, adiposity, aging and disease. The hypogonadal-metabolic-atherogenic-disease and aging connection. Med Hypotheses 2001;56:702-708.
27. Deladoëy J, Flück C, Bex M et al. Aromatase deficiency caused by a novel P450arom gene mutation: impact of absent estrogen production on serum gonadotropin concentration in a boy. J Clin Endocrinol Metab 1999;84:4050-4054.
28. Wake DJ, Strand M, Rask E et al. Intra-adipose sex steroid metabolism and body fat distribution in idiopathic human obesity. Clin Endocrinol (Oxf) 2007;66:440-446.
29. Corbould AM, Bawden MJ, Lavranos TC, Rodgers RJ, Judd SJ. The effect of obesity on the ratio of type 3 17beta-hydroxysteroid dehydrogenase mRNA to cytochrome P450 aromatase mRNA in subcutaneous abdominal and intra-abdominal adipose tissue of women. Int J Obes Relat Metab Disord 2002;26:165-175.
30. Wong SL, Shu SG, Tsai CR. Seventeen alpha-hydroxylase deficiency. J Formos Med Assoc 2006;105:177-181.
31. Gorai I, Inada M, Morinaga H et al. CYP17 and COMT gene polymorphisms can influence bone directly, or indirectly through their effects on endogenous sex steroids, in postmenopausal Japanese women. Bone 2007;40:28-36.
32. Zmuda JM, Cauley JA, Kuller LH, Ferrell RE. A common promotor variant in the cytochrome P450c17alpha (CYP17) gene is associated with bioavailability testosterone levels and bone size in men. J Bone Miner Res 2001;16:911-917.
33. Vasiliu O, Muttineni J, Karmaus W. In utero exposure to organochlorines and age at menarche. Hum Reprod 2004;19:1506-1512.
34. Hurtado A, Pinós T, Barbosa-Desongles A et al. Estrogen receptor beta displays cell cycle-dependent expression and regulates the G1 phase through a non-genomic mechanism in prostate carcinoma cells. Cell Oncol 2008;30:349-365.
35. CDC. General Physical Activities Defined By Level of Intensity [Electronic version]. http://www.cdc.gov/nccdphp/dnpa/physical/everyone/ recommendations/index.htm (2008).
36. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001;29:e45.
37. Blom G. Statistical Estimates and Transformed Beta Variables. Wiley: New York, 1958.
38. Liew CC, Ma J, Tang HC, Zheng R, Dempsey AA. The peripheral blood transcriptome dynamically reflects system wide biology: a potential diagnostic tool. J Lab Clin Med 2006;147:126-132.
39. Barnes MG, Aronow BJ, Luyrink LK et al. Gene expression in juvenile arthritis and spondyloarthropathy: pro-angiogenic ELR+ chemokine genes relate to course of arthritis. Rheumatology (Oxford) 2004;43: 973-979.
40. Shin JH, Hur J Y, Seo HS et al. The ratio of estrogen receptor alpha to estrogen receptor beta in adipose tissue is associated with leptin production and obesity. Steroids 2007;72:592-599.
41. Schwab KO, Moisan AM, Homoki J, Peter M, Simard J. 17alpha-hydroxylase/ 17,20-Lyase deficiency due to novel compound heterozygote mutations: treatment for tall stature in a female with male pseudohermaphroditism and spontaneous puberty in her affected sister. J Pediatr Endocrinol Metab 2005;18:403-411.