The effects of the estrogen receptor blocker, Faslodex (ICI 182,780), on estrogen-accelerated bone maturation in mice

Pediatric Research

Volumn 46, Issue 3, 1999, Pages 269-273

  Gunther, Daniel F ^a   Calikoglu, Ali S ^a   Underwood, Louis E ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR; FULVESTRANT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MATURATION; BONE MINERALIZATION; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG MECHANISM; DRUG RECEPTOR BINDING; EPIPHYSIS PLATE; ESTROGEN ACTIVITY; FORELIMB; LUMBAR SPINE; MOUSE; NONHUMAN; PRECOCIOUS PUBERTY; PRIORITY JOURNAL; RECEPTOR BLOCKING; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0032788615     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/00006450-199909000-00004     Document Type: Article

References (17)

1. Bachrach BE, Smith EP 1996 The role of sex steroids in bone growth and development: evolving new concepts. Endocrinologist 6:362-368
2. Smith EP, Korach KS 1996 Oestrogen receptor deficiency: consequences for growth. Acta Paediatr Suppl 417:39-43
3. Baker VL, Jaffe RB 1995 Clinical uses of antiestrogens. Obstet Gynecol Surv 51:45-59
4. Wright CD, Garrahan NJ, Stanton M, Gazet JC, Mansell RE, Compston JE 1994 Effect of long-term tamoxifen therapy on cancellous bone remodeling and structure in women with breast cancer. J Bone Miner Res 9:153-159
5. Eugster EA, Shankar R, Feezle LK, Pescovitz OH 1998 Tamoxifen treatment of progressive precocious puberty in a patient with McCune-Albright syndrome. Pediatr Res 43:74A (abstr)
6. Wakeling AE, Bowler J 1992 ICI 182,780, a new antioestrogen with clinical potential. J Steroid Biochem Mol Biol 43:173-177
7. Wakeling AE, Dukes M, Bowler J 1991 A potent pure antiestrogen with clinical potential. Cancer Res 51:3867-3873
8. Wakeling AE 1993 The future of new pure antiestrogens in clinical breast cancer. Breast Cancer Res Treat 25:1-9
9. Gallagher A, Chambers TJ, Tobias JH 1993 The estrogen antagonist ICI 182,780 reduces cancellous bone volume in female rats. Endocrinology 133:2787-2791
10. Sibonga JD, Dobnig H, Harden RM, Turner TT 1998 Effect of the high-affinity estrogen receptor ligand ICI 182,780 on the rat tibia. Endocrinology 139:3736-3742
11. Howard E 1962 Steroids and bone maturation in infant mice: relative activities of dehydroepiandrosterone and testosterone. Endocrinology 70:131-141
12. Smith EP, Boyd J, Frank GR, Takahashi H, Cohen RM, Specker B, Williams TC, Lubahn DB, Korach KS 1991 Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med 331:1056-1061
13. Shozu M, Akasofu K, Harada T, Kubota Y 1991 A new cause of female pseudohermaphroditism: placental aromatase deficiency. J Clin Endocrinol Metab 72:560-566
14. Ito Y, Fisher CR, Conte FA, Grumbach MM. Simpson ER 1993 Molecular basis of aromatase deficiency in an adult female with sexual infantilism and polycystic ovaries. Proc NaIl Acad Sci USA 90:11673-11677
15. Bilezikian JP, Morishima A, Bell J, Grumbach MM 1998 Increased bone mass as a result of estrogen therapy in a man with aromatase deficiency. N Engl J Med 339:599-603
16. Breyer P, Haider A, Pescovitz OH 1993 Gonadotrophin-releasing hormone agonists in the treatment of girls with central precocious puberty. Clin Obstet Gynecol 36:764-772
17. Nicholson RI, Walker KJ, Bouzubar N, Wills RJ, Gee JM, Rushmere NK, Davies P 1990 Estrogen deprivation in breast cancer: clinical, experimental, and biological aspects. Ann NY Acad Sci 595:316-327