Impact of estrogen receptor gene polymorphisms and mRNA levels on obesity and lipolysis - A cohort study

BMC Medical Genetics

Volumn 8, Issue , 2007, Pages

  Nilsson, Maria ^a   Dahlman, Ingrid ^a   Jiao, Hong ^a   Gustafsson, Jan Åke ^a   Arner, Peter ^a   Dahlman Wright, Karin ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR; ISOPRENALINE; MESSENGER RNA; NORADRENALIN; ESR1 PROTEIN, HUMAN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ADULT; AGE DISTRIBUTION; ARTICLE; BODY MASS; CHI SQUARE TEST; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENOTYPE; HAPLOTYPE; HUMAN; HUMAN CELL; HUMAN TISSUE; LIPOGENESIS; LIPOLYSIS; MAJOR CLINICAL STUDY; MALE; OBESITY; REGRESSION ANALYSIS; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; ALLELE; GENETIC PREDISPOSITION; GENETICS; METABOLISM; MIDDLE AGED; PHENOTYPE;

ADIPOSE TISSUE; ADULT; ALLELES; COHORT STUDIES; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; LIPOGENESIS; LIPOLYSIS; MALE; MIDDLE AGED; OBESITY; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RNA, MESSENGER;

EID: 39049146551     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-8-73     Document Type: Article

References (39)

1. Maes HH Neale MC Eaves LJ Genetic and environmental factors in relative body weight and human adiposity Behav Genet 1997, 27:325-351 10.1023/ A:1025635913927 9519560
2. Toth MJ Tchernof A Sites CK Poehlman ET Effect of menopausal status on body composition and abdominal fat distribution Int J Obes Relat Metab Disord 2000, 24:226-231 10.1038/sj.ijo.0801118 10702775
3. Dahlman-Wright K Cavailles V Fuqua SA Jordan VC Katzenellenbogen JA Korach KS Maggi A Muramatsu M Parker MG Gustafsson JA International Union of Pharmacology. LXIV. Estrogen receptors Pharmacol Rev 2006, 58:773-781 10.1124/pr.58.4.8 17132854
4. Heine PA Taylor JA Iwamoto GA Lubahn DB Cooke PS Increased adipose tissue in male and female estrogen receptor-alpha knockout mice Proc Natl Acad Sci U S A 2000, 97:12729-12734 18832 11070086 10.1073/ pnas.97.23.12729
5. Laflamme N Nappi RE Drolet G Labrie C Rivest S Expression and neuropeptidergic characterization of estrogen receptors (ERalpha and ERbeta) throughout the rat brain: Anatomical evidence of distinct roles of each subtype J Neurobiol 1998, 36:357-378 10.1002/ (SICI)1097-4695(19980905)36:3<357::AID-NEU5>3.0.CO;2-V 9733072
6. Pedersen SB Bruun JM Hube F Kristensen K Hauner H Richelsen B Demonstration of estrogen receptor subtypes alpha and beta in human adipose tissue: Influences of adipose cell differentiation and fat depot localization Mol Cell Endocrinol 2001, 182:27-37 10.1016/ S0303-7207(01)00557-3 11500236
7. Liang YQ Akishita M Kim S Ako J Hashimoto M Iijima K Ohike Y Watanabe T Sudoh N Toba K Yoshizumi M Ouchi Y Estrogen receptor beta is involved in the anorectic action of estrogen Int J Obes Relat Metab Disord 2002, 26:1103-1109 10.1038/sj.ijo.0802054 12119576
8. Lindberg UB Crona N Silfverstolpe G Bjorntorp P Rebuffe-Scrive M Regional adipose tissue metabolism in postmenopausal women after treatment with exogenous sex steroids Horm Metab Res 1990, 22:345-351 2116375
9. Pedersen SB Kristensen K Hermann PA Katzenellenbogen JA Richelsen B Estrogen controls lipolysis by up-regulating alpha2A-adrenergic receptors directly in human adipose tissue through the estrogen receptor alpha. Implications for the female fat distribution J Clin Endocrinol Metab 2004, 89:1869-1878 10.1210/jc.2003-031327 15070958
10. Atwood LD Heard-Costa NL Cupples LA Jaquish CE Wilson PW D'Agostino RB Genomewide linkage analysis of body mass index across 28 years of the Framingham Heart Study Am J Hum Genet 2002 71 1044 1050 385083 12355400 10.1086/343822
11. Arya R Lehman D Hunt KJ Schneider J Almasy L Blangero J Stern MP Duggirala R Evidence for bivariate linkage of obesity and HDL-C levels in the Framingham Heart Study BMC Genet 2003, 4(Suppl 1):S52 1866489 14975120 10.1186/1471-2156-4-S1-S52
12. Geller F Dempfle A Gorg T Genome scan for body mass index and height in the Framingham Heart Study BMC Genet 2003, 4(Suppl 1):S91 1866532 14975159 10.1186/1471-2156-4-S1-S91
13. Fox CS Heard-Costa NL Wilson PW Levy D D'Agostino RB Sr Atwood LD Genome-wide linkage to chromosome 6 for waist circumference in the Framingham Heart Study Diabetes 2004, 53:1399-1402 10.2337/ diabetes.53.5.1399 15111512
14. Fox CS Yang Q Cupples LA Guo CY Atwood LD Murabito JM Levy D Mendelsohn ME Housman DE Shearman AM Sex-specific association between estrogen receptor-alpha gene variation and measures of adiposity: The Framingham Heart Study J Clin Endocrinol Metab 2005, 90:6257-6262 10.1210/ jc.2005-0670 16144952
15. Okura T Koda M Ando F Niino N Ohta S Shimokata H Association of polymorphisms in the estrogen receptor alpha gene with body fat distribution Int J Obes Relat Metab Disord 2003, 27:1020-1027 10.1038/ sj.ijo.0802378 12917706
16. Nilsson M Dahlman I Ryden M Nordstrom EA Gustafsson JA Arner P Dahlman-Wright K, Oestrogen receptor alpha gene expression levels are reduced in obese compared to normal weight females Int J Obes (Lond) 2007 17224934
17. Gallagher CJ Langefeld CD Gordon CJ Campbell JK Mychaleckyj JC Bryer-Ash M Rich SS Bowden DW Sale MM Association of the estrogen receptor-alpha gene with the metabolic syndrome and its component traits in African-American families: The Insulin Resistance Atherosclerosis Family Study Diabetes 2007, 56(8):2135-2141 10.2337/db06-1017 17513703
18. Gallagher CJ Keene KL Mychaleckyj JC Langefeld CD Hirschhorn JN Henderson BE Gordon CJ Freedman BI Rich SS Bowden DW Sale MM Investigation of the estrogen receptor-alpha gene with type 2 diabetes and/or nephropathy in African-American and European-American populations Diabetes 2007, 56:675-684 10.2337/db06-0303 17327435
19. Nilsson M Naessen S Dahlman I Linden Hirschberg A Gustafsson JA Dahlman-Wright K Association of estrogen receptor beta gene polymorphisms with bulimic disease in women Mol Psychiatry 2004, 9:28-34 10.1038/sj.mp.4001402 14699439
20. Eastwood H Brown KM Markovic D Pieri LF Variation in the ESR1 and ESR2 genes and genetic susceptibility to anorexia nervosa Mol Psychiatry 2002, 7:86-89 10.1038/sj/mp/4000929 11803451
21. Rosenkranz K Hinney A Ziegler A Hermann H Fichter M Mayer H Siegfried W Young JK Remschmidt H Hebebrand J Systematic mutation screening of the estrogen receptor beta gene in probands of different weight extremes: identification of several genetic variants J Clin Endocrinol Metab 1998, 83:4524-4527 10.1210/jc.83.12.4524 9851804
22. Bell CG Walley AJ Froguel P The genetics of human obesity Nat Rev Genet 2005, 6:221-234 10.1038/nrg1556 15703762
23. QUANTO http://hydra.usc.edu/GxE/
24. Eriksson P Reynisdottir S Lonnqvist F Stemme V Hamsten A Arner P Adipose tissue secretion of plasminogen activator inhibitor-1 in non-obese and obese individuals Diabetologia 1998, 41:65-71 10.1007/s001250050868 9498632
25. Hoffstedt J Arvidsson E Sjolin E Wahlen K Arner P Adipose tissue adiponectin production and adiponectin serum concentration in human obesity and insulin resistance J Clin Endocrinol Metab 2004, 89:1391-1396 10.1210/jc.2003-031458 15001639
26. Bonora E Targher G Alberiche M Bonadonna RC Saggiani F Zenere MB Monauni T Muggeo M Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: Studies in subjects with various degrees of glucose tolerance and insulin sensitivity Diabetes Care 2000, 23:57-63 10.2337/diacare.23.1.57 10857969
27. Kolaczynski JW Morales LM Moore JH Jr Considine RV Pietrzkowski, Z Noto, PF Colberg, J Caro, JF A new technique for biopsy of human abdominal fat under local anaesthesia with Lidocaine Int J Obes Relat Metab Disord 1994, 18:161-166 8186813
28. Reynisdottir S Eriksson M Angelin B Arner P Impaired activation of adipocyte lipolysis in familial combined hyperlipidemia J Clin Invest 1995, 95:2161-2169 295819 7738184
29. Reynisdottir S Ellerfeldt K Wahrenberg H Lithell H Arner P Multiple lipolysis defects in the insulin resistance (metabolic) syndrome J Clin Invest 1994, 93:2590-2599 294492 8200997
30. Reynisdottir S Wahrenberg H Carlstrom K Rossner S Arner P Catecholamine resistance in fat cells of women with upper-body obesity due to decreased expression of beta 2-adrenoceptors Diabetologia 1994, 37:428-435 8063046
31. Arner P Engfeldt P Fasting-mediated alteration studies in insulin action on lipolysis and lipogenesis in obese women Am J Physiol 1987, 253:E193-201 3303967
32. Arvidsson E Blomqvist L Ryden M Depot-specific differences in perilipin mRNA but not protein expression in obesity J Intern Med 2004, 255:595-601 10.1111/j.1365-2796.2004.01314.x 15078502
33. Hapmap http://www.hapmap.org
34. Haploview http://www.broad.mit.edu/mpg/haploview/
35. Fan JB Oliphant A Shen R Kermani BG Garcia F Gunderson KL Hansen M Steemers F Butler SL Deloukas P Galver L Hunt S McBride C Bibikova M Rubano T Chen J Wickham E Doucet D Chang W Campbell D Zhang B Kruglyak S Bentley D Haas J Rigault P Zhou L Stuelpnagel J Chee MS Highly parallel SNP genotyping Cold Spring Harb Symp Quant Biol 2003, 68:69-78 10.1101/ sqb.2003.68.69 15338605
36. SNP technology platform http://www.genotyping.se
37. Jurinke C van den Boom D Cantor CR Koster H Automated genotyping using the DNA MassArray technology Methods Mol Biol 2002, 187:179-192 12013745
38. software, F http://ihg.gsf.de/cgi-bin/hw/hwa1.pl
39. Arner P Human fat cell lipolysis: Biochemistry, regulation and clinical role Best Pract Res Clin Endocrinol Metab 2005, 19:471-482 10.1016/ j.beem.2005.07.004 16311212