CYP19A1 genetic polymorphisms may be associated with obesity-related phenotypes in Chinese women

International Journal of Obesity

Volumn 31, Issue 3, 2007, Pages 418-423

  Long, J R ^a   Shu, X O ^a   Cai, Q ^a   Wen, W ^a   Kataoka, N ^a   Gao, Y T ^b   Zheng, W ^a  

^a VANDERBILT INGRAM CANCER CENTER   (United States)

^b SHANGHAI CANCER INSTITUTE   (China)

Author keywords

Body mass index; CYP19A1; Genetic polymorphism; Waist to hip ratio

Indexed keywords

ADIPOSE TISSUE; ADULT; ARTICLE; BODY FAT DISTRIBUTION; BREAST CANCER; CHINESE; CONTROLLED STUDY; CYTOCHROME P450 19A1 GENE; FEMALE; GENE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; OBESITY; PHENOTYPE; PREMENOPAUSE; PRIORITY JOURNAL; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL SIGNIFICANCE; WAIST HIP RATIO;

EID: 33847269217     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/sj.ijo.0803439     Document Type: Article

References (26)

1. Kopelman PG. Obesity as a medical problem. Nature 2000; 404: 635-643.
2. Seidell JC. Obesity: a growing problem. Acta Paediatr Suppl 1999; 88: 46-50.
3. Bjorntorp P. Metabolic difference between visceral fat and subcutaneous abdominal fat. Diabetes Metab 2000; 26: 10-12.
4. Liu YJ, Araujo S, Recker RR, Deng HW. Molecular and genetic mechanisms of obesity: implications for future management. Curr Mol Med 2003; 3: 325-340.
5. Nelson TL, Brandon DT, Wiggins SA, Whitfield KE. Genetic and environmental influences on body-fat measures among African-American twins. Obes Res 2002; 10: 733-739.
6. Perusse L, Rankinen T, Zuberi A, Chagnon YC, Weisnagel SJ, Argyropoulos G et al. The human obesity gene map: the 2004 update. Obes Res 2005; 13: 381-490.
7. McTernan PG, Anwar A, Eggo MC, Barnett AH, Stewart PM, Kumar S. Gender differences in the regulation of P450 aromatase expression and activity in human adipose tissue. Int J Obes Relat Metab Disord 2000; 24: 875-881.
8. Armellini F, Zamboni M, Bosello O. Hormones and body composition in humans: clinical studies. Int J Obes Relat Metab Disord 2000; 24 (Suppl 2): S18-S21.
9. Anderson LA, McTernan PG, Barnett AH, Kumar S. The effects of androgens and estrogens on preadipocyte proliferation in human adipose tissue: influence of gender and site. J Clin Endocrinol Metab 2001; 86: 5045-5051.
10. De Pergola G. The adipose tissue metabolism: role of testosterone and dehydroepiandrosterone. Int J Obes Relat Metab Disord 2000; 24 (Suppl 2): S59-S63.
11. Dieudonne MN, Pecquery R, Leneveu MC, Giudicelli Y. Opposite effects of androgens and estrogens on adipogenesis in rat preadipocytes: evidence for sex and site-related specificities and possible involvement of insulin-like growth factor 1 receptor and peroxisome proliferator-activated receptor gamma2. Endocrinology 2000; 141: 649-656.
12. Jones ME, Thorburn AW, Britt KL, Hewitt KN, Wreford NG, Proietto J et al. Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity. Proc Natl Acad Sci USA 2000; 97: 12735-12740.
13. Meyre D, Lecoeur C, Delplanque J, Francke S, Vatin V, Durand E et al. A genome-wide scan for childhood obesity-associated traits in French families shows significant linkage on chromosome 6q22.31-q23.2. Diabetes 2004; 53: 803-811.
14. Martin LJ, Cianflone K, Zakarian R, Nagrani G, Almasy L, Rainwater DL et al. Bivariate linkage between acylation-stimulating protein and BMI and high-density lipoproteins. Obes Res 2004; 12: 669-678.
15. Chagnon YC, Borecki IB, Perusse L, Roy S, Lacaille M, Chagnon M et al. Genome-wide search for genes related to the fat-free body mass in the Quebec family study. Metabolism 2000; 49: 203-207.
16. Gao YT, Shu XO, Dai Q, Potter JD, Brinton LA, Wen W et al. Association of menstrual and reproductive factors with breast cancer risk: results from the Shanghai Breast Cancer Study. Int J Cancer 2000; 87: 295-300.
17. Haiman CA, Stram DO, Pike MC, Kolonel LN, Burtt NP, Altshuler D et al. A comprehensive haplotype analysis of CYP19 and breast cancer risk: the Multiethnic Cohort. Hum Mol Genet 2003; 12: 2679-2692.
18. Stephens M, Smith NJ, Donnelly P. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 2001; 68: 978-989.
19. Tworoger SS, Chubak J, Aiello EJ, Yasui Y, Ulrich CM, Farin FM et al. The effect of CYP19 and COMT polymorphisms on exercise-induced fat loss in postmenopausal women. Obes Res 2004; 12: 972-981.
20. Simpson ER. Aromatase: biologic relevance of tissue-specific expression. Semin Reprod Med 2004; 22: 11-23.
21. Bulun SE, Takayama K, Suzuki T, Sasano H, Yilmaz B, Sebastian S. Organization of the human aromatase p450 (CYP19) gene. Semin Reprod Med 2004; 22: 5-9.
22. Zhao Y, Mendelson CR, Simpson ER. Characterization of the sequences of the human CYP19 (aromatase) gene that mediate regulation by glucocorticoids in adipose stromal cells and fetal hepatocytes. Mol Endocrinol 1995; 9: 340-349.
23. Kristensen VN, Harada N, Yoshimura N, Haraldsen E, Lonning PE, Erikstein B et al. Genetic variants of CYP19 (aromatase) and breast cancer risk. Oncogene 2000; 19: 1329-1333.
24. Killinger DW, Perel E, Daniilescu D, Kharlip L, Lindsay WR. The relationship between aromatase activity and body fat distribution. Steroids 1987; 50: 61-72.
25. Killinger DW, Perel E, Danilescu D, Kharlip L, Lindsay WR. Influence of adipose tissue distribution on the biological activity of androgens. Ann NY Acad Sci 1990; 595: 199-211.
26. Evans CT, Corbin CJ, Saunders CT, Merrill JC, Simpson ER, Mendelson CR. Regulation of estrogen biosynthesis in human adipose stromal cells. Effects of dibutyryl cyclic AMP, epidermal growth factor, and phorbol esters on the synthesis of aromatase cytochrome P-450. J Biol Chem 1987; 262: 6914-6920.