Discovery of genes related to diabetic nephropathy in various animal models by current techniques

Contributions to Nephrology

Volumn 169, Issue , 2011, Pages 161-174

  Wada, Jun ^a   Sun, Lin ^b   Kanwar, Yashpal S ^b  

^a OKAYAMA UNIVERSITY   (Japan)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; ARTICLE; DIABETIC NEPHROPATHY; DISEASE MODEL; DNA MICROARRAY; GENETIC SCREENING; GENETICS; HUMAN; MOUSE; PROTEOMICS; RAT; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALS; DIABETIC NEPHROPATHIES; DISEASE MODELS, ANIMAL; GENETIC TESTING; HUMANS; MICE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEOMICS; RATS;

EID: 79551484955     PISSN: 03025144     EISSN: None     Source Type: Book Series    
DOI: 10.1159/000313951     Document Type: Article

References (78)

1. Balakumar P, Arora MK, Reddy J, Anand- Srivastava MB: Pathophysiology of diabetic nephropathy: involvement of multifaceted signaling mechanism. J Cardiovasc Pharmacol 2009;54:129-138.
2. Reddy AS: Diabetic Nephropathy: Theory and Practice. East Hanover, College Book Publishers, 2004, pp 1- 563, 2004.
3. Kikkawa R, Koya D, Haneda M: Progression of diabetic nephropathy. Am J Kidney Dis 2003;41(3 Suppl 1):S19-S21.
4. Sugimoto H, Shikata K, Hirata K, Akiyama K, Matsuda M, Kushiro M, Shikata Y, Miyatake N, Miyasaka M, Makino H: Increased expression of intercellular adhesion molecule- 1 (ICAM- 1) in diabetic rat glomeruli: glomerular hyperfiltration is a potential mechanism of ICAM- 1 upregulation. Diabetes 1997;46:2075-2081.
5. Koya D, Haneda M, Nakagawa H, Isshiki K, Sato H, Maeda S, Sugimoto T, Yasuda H, Kashiwagi A, Ways DK, King GL, Kikkawa R: Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes. FASEB J 2000;14:439-447.
6. Sharma K, McCue P, Dunn SR: Diabetic kidney disease in the db/db mouse. Am J Physiol Renal Physiol 2003;284:F1138-F1144.
7. Chung AC, Zhang H, Kong YZ, Tan JJ, Huang XR, Kopp JB, Lan HY: Advanced glycation end- products induce tubular CTGF via TGF- beta- Independent Smad3 Signaling. J Am Soc Nephrol 2010;21:249-260.
8. Alderson NL, Chachich ME, Youssef NN, Beattie RJ, Nachtigal M, Thorpe SR, Baynes JW: The AGE inhibitor pyridoxamine inhibits lipemia and development of renal and vascular disease in Zucker obese rats. Kidney Int 2003;63:2123-2133.
9. Figarola JL, Loera S, Weng Y, Shanmugam N, Natarajan R, Rahbar S: LR- 90 prevents dyslipidaemia and diabetic nephropathy in the Zucker diabetic fatty rat. Diabetologia 2008; 51:882-891.
10. Kim YS, Kim J, Kim CS, Sohn EJ, Lee YM, Jeong IH, Kim H, Jang DS, Kim JS: KIOM- 79, an inhibitor of AGEs- protein cross- linking, prevents progression of nephropathy in Zucker diabetic fatty rats. Evid Based Complement Alternat Med 2009, E- pub ahead of print.
11. Satoh M, Fujimoto S, Haruna Y, Arakawa S, Horike H, Komai N, Sasaki T, Tsujioka K, Makino H, Kashihara N: NAD(P)H oxidase and uncoupled nitric oxide synthase are major sources of glomerular superoxide in rats with experimental diabetic nephropathy. Am J Physiol Renal Physiol 2005;288: F1144-F1152.
12. Asaba K, Tojo A, Onozato ML, Goto A, Quinn MT, Fujita T, Wilcox CS: Effects of NADPH oxidase inhibitor in diabetic nephropathy. Kidney Int 2005;67:1890-1898.
13. Wolf G: New insights into the pathophysiology of diabetic nephropathy: From hemodynamics to molecular pathology. Eur J Clin Invest 2004;34:785-796.
14. Tesch GH: Role of macrophages in complications of type 2 diabetes. Clin Exp Pharmacol Physiol 2007;34:1016-1019.
15. Usui HK, Shikata K, Sasaki M, Okada S, Matsuda M, Shikata Y, Ogawa D, Kido Y, Nagase R, Yozai K, Ohga S, Tone A, Wada J, Takeya M, Horiuchi S, Kodama T, Makino H: Macrophage scavenger receptor- A- deficient mice are resistant against diabetic nephropathy through amelioration of microinflammation. Diabetes 2007;56:363-372.
16. Ziyadeh FN, Hoffman BB, Han DC, Iglesias- De La Cruz MC, Hong SW, Isono M, Chen S, McGowan TA, Sharma K: Long- term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor- beta antibody in db/db diabetic mice. Proc Natl Acad Sci USA 2000;97:8015-8020.
17. Gaede P, Vedel P, Parving HH, Pedersen O: Intensified multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria: the Steno type 2 randomized study. Lancet 1999;353:617-622.
18. Gaede P, Vedel P, Larsen N, Jensen GV, Parving HH, Pedersen O: Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes. N Engl J Med 2003;348:383-393. (Pubitemid 36159355)
19. Gaede P, Lund- Andersen H, Parving HH, Pedersen O: Effect of a multifactorial intervention on mortality in type 2 diabetes. N Engl J Med 2008;358:580-591.
20. Hosono N, Kubo M, Tsuchiya Y, Sato H, Kitamoto T, Saito S, Ohnishi Y, Nakamura Y: Multiplex PCR- based real- time invader assay (mPCRRETINA): a novel SNP- based method for detecting allelic asymmetries within copy number variation regions. Hum Mutat 2008;29:182-189.
21. Ohnishi Y, Tanaka T, Ozaki K, Yamada R, Suzuki H, Nakamura Y: A high- throughput SNP typing system for genome- wide association studies. J Hum Genet 2001;46:471-477.
22. The international HapMap project. Nature 2003;426:789-796.
23. Mueller PW, Rogus JJ, Cleary PA, Zhao Y, Smiles AM, Steffes MW, Bucksa J, Gibson TB, Cordovado SK, Krolewski AS, Nierras CR, Warram JH: Genetics of Kidneys in Diabetes (GoKinD) study: a genetics collection available for identifying genetic susceptibility factors for diabetic nephropathy in type 1 diabetes. J Am Soc Nephrol 2006;17:1782-1790.
24. Greene CN, Keong LM, Cordovado SK, Mueller PW: Sequence variants in the PLEKHH2 region are associated with diabetic nephropathy in the GoKinD study population. Hum Genet 2008;124:255-262.
25. Maeda S: Genome- wide search for susceptibility gene to diabetic nephropathy by gene- based SNP. Diabetes Res Clin Pract 2004;66 (Suppl 1):S45-S47.
26. Tanaka N, Babazono T, Saito S, Sekine A, Tsunoda T, Haneda M, Tanaka Y, Fujioka T, Kaku K, Kawamori R, Kikkawa R, Iwamoto Y, Nakamura Y, Maeda S: Association of solute carrier family 12 (sodium/ chloride) member 3 with diabetic nephropathy, identified by genome- wide analyses of single nucleotide polymorphisms. Diabetes 2003;52:2848-2853.
27. Shimazaki A, Kawamura Y, Kanazawa A, Sekine A, Saito S, Tsunoda T, Koya D, Babazono T, Tanaka Y, Matsuda M, Kawai K, Iiizumi T, Imanishi M, Shinosaki T, Yanagimoto T, Ikeda M, Omachi S, Kashiwagi A, Kaku K, Iwamoto Y, Kawamori R, Kikkawa R, Nakajima M, Nakamura Y, Maeda S: Genetic variations in the gene encoding ELMO1 are associated with susceptibility to diabetic nephropathy. Diabetes 2005;54:1171-1178. (Pubitemid 40446333)
28. Susztak K, Bottinger E, Novetsky A, Liang D, Zhu Y, Ciccone E, Wu D, Dunn S, McCue P, Sharma K: Molecular profiling of diabetic mouse kidney reveals novel genes linked to glomerular disease. Diabetes 2004;53:784-794.
29. Wada J, Zhang H, Tsuchiyama Y, Hiragushi K, Hida K, Shikata K, Kanwar YS, Makino H. Gene expression profile in streptozotocin- induced diabetic mice kidneys undergoing glomerulosclerosis. Kidney Int 2001;59:1363-1373.
30. Hsieh TJ, Chen R, Zhang SL, Liu F, Brezniceanu ML, Whiteside CI, Fantus IG, Ingelfinger JR, Hamet P, Chan JS: Upregulation of osteopontin gene expression in diabetic rat proximal tubular cells revealed by microarray profiling. Kidney Int 2006;69: 1005-1015.
31. Wilson KH, McIndoe RA, Eckenrode S, Morel L, Agarwal A, Croker BP, She JX: Alterations of renal phenotype and gene expression profiles due to protein overload in NODrelated mouse strains. BMC Nephrol 2005;6:17.
32. Naito, Uchiyama K, Kuroda M, Mizushima K, Aoi W, Kokura S, Ichikawa H, Yoshida N, Yoshikawa T: Laser capture microdissection/ GeneChip analysis of gene expression in glomerular cells in diabetic db/db mice. Redox Rep 2004;9:307-312.
33. Makino H, Miyamoto Y, Sawai K, Mori K, Mukoyama M, Nakao K, Yoshimasa Y, Suga S. Altered gene expression related to glomerulogenesis and podocyte structure in early diabetic nephropathy of db/db mice and its restoration by pioglitazone. Diabetes 2006;55:2747-2756.
34. Fan Q, Shike T, Shigihara T, Tanimoto M, Gohda T, Makita Y, Wang LN, Horikoshi S, Tomino Y: Gene expression profile in diabetic KK/Ta mice. Kidney Int 2003;64:1978-1985.
35. Ko GJ, Kang YS, Han SY, Lee MH, Song HK, Han KH, Kim HK, Han JY, Cha DR: Pioglitazone attenuates diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats. Nephrol Dial Transplant 2008;23:2750-2760.
36. Inagi R, Yamamoto Y, Nangaku M, Usuda N, Okamato H, Kurokawa K, van Ypersele de Strihou C, Yamamoto H, Miyata T: A severe diabetic nephropathy model with early development of nodule- like lesions induced by megsin overexpression in RAGE/ iNOS transgenic mice. Diabetes 2006;55:356-366.
37. Cheng DW, Jiang Y, Shalev A, Kowluru R, Crook ED, Singh LP: An analysis of high glucose and glucosamine- induced gene expression and oxidative stress in renal mesangial cells. Arch Physiol Biochem 2006;112:189-218.
38. Han SH, Yang S, Jung DS, Li JJ, Kim JJ, Kwak SJ, Kim DK, Moon SJ, Lee JE, Han DS, Kang SW: Gene expression patterns in glucose- stimulated podocytes. Biochem Biophys Res Commun 2008;370:514-518.
39. Qi W, Chen X, Zhang Y, Holian J, Mreich E, Gilbert RE, Kelly DJ, Pollock CA: High glucose induces macrophage inflammatory protein- 3 alpha in renal proximal tubule cells via a transforming growth factor- beta 1 dependent mechanism. Nephrol Dial Transplant 2007;22:3147-3153.
40. Qi W, Chen X, Gilbert RE, Zhang Y, Waltham M, Schache M, Kelly DJ, Pollock CA: High glucoseinduced thioredoxin- interacting protein in renal proximal tubule cells is independent of transforming growth factor- beta1. Am J Pathol 2007;171:744-754. (Pubitemid 47440974)
41. Moczulski DK, Fojcik H, Wielgorecki A, Trautsolt W, Gawlik B, Kosiorz- Gorczynska S, Oczko- Wojciechowska M, Wiench M, Strojek K, Zukowska- Szczechowska E, Grzeszczak W: Expression pattern of genes in peripheral blood mononuclear cells in diabetic nephropathy. Diabet Med 2007;24:266-271.
42. Baelde HJ, Eikmans M, Doran PP, Lappin DW, de Heer E, Bruijn JA: Gene expression profiling in glomeruli from human kidneys with diabetic nephropathy. Am J Kidney Dis 2004;43:636-650.
43. Szeto CC, Lai KB, Chow KM, Szeto CY, Yip TW, Woo KS, Li PK, Lai FM: Messenger RNA expression of glomerular podocyte markers in the urinary sediment of acquired proteinuric diseases. Clin Chim Acta 2005; 361:182-190.
44. Liang P, Pardee AB: Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science 1992;257:967-971.
45. Song Y, Ailenberg M, Silverman M: Cloning of a novel gene in the human kidney homologous to rat munc13s: its potential role in diabetic nephropathy. Kidney Int 1998;53:1689-1695.
46. Lisitsyn N, Wigler M: Cloning the differences between two complex genomes. Science 1993;259:946-951.
47. Hubank M, Schatz DG: Identifying differences in mRNA expression by representational difference analysis of cDNA. Nucleic Acids Res 1994;22:5640-5648.
48. Zhang Y, Wada J, Hashimoto I, Eguchi J, Yasuhara A, Kanwar YS, Shikata K, Makino H: Therapeutic approach for diabetic nephropathy using gene delivery of translocase of inner mitochondrial membrane 44 by reducing mitochondrial superoxide production. J Am Soc Nephrol 2006;17:1090-1101.
49. Matsuoka T, Wada J, Hashimoto I, Zhang Y, Eguchi J, Ogawa N, Shikata K, Kanwar YS, Makino H: Gene delivery of Tim44 reduces mitochondrial superoxide production and ameliorates neointimal proliferation of injured carotid artery in diabetic rats. Diabetes 2005;54:2882-2890.
50. Wada J, Kanwar YS: Characterization of mammalian translocase of inner mito- chondrial membrane (Tim44) isolated from diabetic newborn mouse kidney. Proc Natl Acad Sci USA 1998;95:144-149.
51. Kanwar YS, Akagi S, Nayak B, Sun L, Wada J, Xie P, Thakur A, Chugh SS, Danesh FR: Renal- specific oxidoreductase biphasic expression under high glucose ambience during fetal versus neonatal development. Kidney Int 2005;68:1670-1683.
52. Yang Q, Dixit B, Wada J, Tian Y, Wallner EI, Srivastva SK, Kanwar YS: Identification of a renal- specific oxido- reductase in newborn diabetic mice. Proc Natl Acad Sci USA 2000; 97:9896-9901.
53. Sun L, Pan X, Wada J, Haas CS, Wuthrich RP, Danesh FR, Chugh SS, Kanwar YS: Isolation and functional analysis of mouse UbA52 gene and its relevance to diabetic nephropathy. J Biol Chem 2002;277:29953-29962.
54. Sun L, Xie P, Wada J, Kashihara N, Liu FY, Zhao Y, Kumar D, Chugh SS, Danesh FR, Kanwar YS: Rap1b GTPase ameliorates glucose- induced mitochondrial dysfunction. J Am Soc Nephrol 2008;19:2293-2301.
55. Lin S, Chugh S, Pan X, Wallner EI, Wada J, Kanwar YS: Identification of up- regulated Ras- like GTPase, Rap1b, by suppression subtractive hybridization. Kidney Int 2001;60:2129-2141.
56. McMahon R, Murphy M, Clarkson M, Taal M, Mackenzie HS, Godson C, Martin F, Brady HR: IHG- 2, a mesangial cell gene induced by high glucose, is human gremlin. Regulation by extracellular glucose concentration, cyclic mechanical strain, and transforming growth factor- beta1. J Biol Chem 2000;275:9901-9904.
57. Murphy M, Godson C, Cannon S, Kato S, Mackenzie HS, Martin F, Brady HR: Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells. J Biol Chem 1999;274:5830-5834.
58. Velculescu VE, Zhang L, Vogelstein B, Kinzler KW: Serial analysis of gene expression. Science 1995;270:484-487.
59. Schelling JR, El- Meanawy MA, Barathan S, Dodig T, Iyengar SK, Sedor JR: Generation of kidney transcriptomes using serial analysis of gene expression. Exp Nephrol 2002;10:82-92.
60. Cheval L, Duong Van Huyen JP, Bruneval P, Verbavatz JM, Elalouf JM, Doucet A: Plasticity of mouse renal collecting duct in response to potassium depletion. Physiol Genomics 2004;19:61-73.
61. Sengoelge G, Luo W, Fine D, Perschl AM, Fierlbeck W, Haririan A, Sorensson J, Rehman TU, Hauser P, Trevick JS, Kulak SC, Wegner B, Ballermann BJ: A SAGE- based comparison between glomerular and aortic endothelial cells. Am J Physiol Renal Physiol 2005;288:F1290- 1300.
62. Schena M, Shalon D, Davis R, Brown PO: Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science 1995;270:467-470.
63. Cohen CD, Lindenmeyer MT, Eichinger F, Hahn A, Seifert M, Moll AG, Schmid H, Kiss E, Grone E, Grone HJ, Kretzler M, Werner T, Nelson PJ: Improved elucidation of biological processes linked to diabetic nephropathy by single probe- based microarray data analysis. PLoS One 2008;3:e2937.
64. Naito Y, Uchiyama K, Mizushima K, Kuroda M, Akagiri S, Takagi T, Handa O, Kokura S, Yoshida N, Ichikawa H, Takahashi J, Yoshikawa T: Microarray profiling of gene expression patterns in glomerular cells of astaxanthintreated diabetic mice: a nutrigenomic approach. Int J Mol Med 2006;18:685-695.
65. Thongboonkerd V, Barati MT, McLeish KR, Benarafa C, Remold- ODonnell E, Zheng S, Rovin BH, Pierce WM, Epstein PN, Klein JB: Alterations in the renal elastinelastase system in type 1 diabetic nephropathy identified by proteomic analysis. J Am Soc Nephrol 2004;15:650-662.
66. Tilton RG, Haidacher S, Lejeune W, Zhang X, Zhao Y, Kurosky A, Brasier A, Denner L: Diabetes- induced changes in the renal cortical proteome assessed with 2- dimensional gel electrophoresis and mass spectrometry. Proteomics 2007;7:1729-1742.
67. Sharma K, Lee S, Han S, Francos B, McCue P, Wassell R, Shaw MA, RamachandraRao SP: Twodimensional fluorescence difference gel electrophoresis analysis of the urine proteome in human diabetic nephropathy. Proteomics 2005;5:2648-2655.
68. Dihazi H, Muller GA, Lindner S, Meyer M, Asif AR, Oellerich M, Strutz F: Characterization of diabetic nephropathy by urinary proteomic analysis: identification of a processed ubiquitin form as a differentially excreted protein in diabetic nephropathy patients. Clin Chem 2007;53:1636-1645.
69. Rossing K, Mischak H, Dakna M, Zurbig P, Novak J, Julian BA, Good DM, Coon JJ, Tarnow L, Rossing P: Urinary proteomics in diabetes and CKD. J Am Soc Nephrol 2008; 19:1283-1290.
70. Yang YH, Zhang S, Cui JF, Lu B, Dong XH, Song XY, Liu YK, Zhu XX, Hu RM: Diagnostic potential of serum protein pattern in Type 2 diabetic nephropathy. Diabet Med 2007;24:1386-1392.
71. Kanwar YS, Wada J, Sun L, Xie P, Wallner EI, Chen S, Chugh S, Danesh FR: Diabetic nephropathy: mechanisms of renal disease progression. Exp Biol Med (Maywood) 2008; 233:4-11.
72. Nayak B, Xie P, Akagi S, Yang Q, Sun L, Wada J, Thakur A, Danesh FR, Chugh SS, Kanwar YS: Modulation of renal- specific oxidoreductase/myoinositol oxygenase by high- glucose ambience. Proc Natl Acad Sci USA 2005;102:17952- 17957.
73. Ziyadeh FN, Simmons DA, Snipes ER, Goldfarb S: Effect of myo- inositol on cell proliferation and collagen transcription and secretion in proximal tubule cells cultured in elevated glucose. J Am Soc Nephrol 1991;1: 1220-1229.
74. Lin S, Sahai A, Chugh SS, Pan X, Wallner EI, Danesh FR, Lomasney JW, Kanwar YS: High glucose stimulates synthesis of fibronectin via a novel protein kinase C, Rap1b, and B- Raf signaling pathway. J Biol Chem 2002;277:41725-41735.
75. Meissner A, Mikkelsen TS, Gu H, Wernig M, Hanna J, Sivachenko A, Zhang X, Bernstein B, Nusbaum C, Jaffe D, Gnirke A, Jaenisch R, Lander E: Genome- scale DNA methylation maps of pluripotent and differentiated cells. Nature 2008;454:766-770.
76. Nathan DM, Cleary PA, Backlund JY, Genuth SM, Lachin JM, Orchard TJ, Raskin P, Zinman B: Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med 2005;353:2643-2653.
77. Holmes E, Loo RL, Stamler J, Bictash M, Yap IK, Chan Q, Ebbels T, De Iorio M, Brown IJ, Veselkov KA, Daviglus ML, Kesteloot H, Ueshima H, Zhao L, Nicholson JK, Elliott P: Human metabolic phenotype diversity and its association with diet and blood pressure. Nature 2008;453:396-400.
78. Ebe Y, Kuno A, Uchiyama N, Koseki- Kuno S, Yamada M, Sato T, Narimatsu H, Hirabayashi J: Application of lectin microarray to crude samples: differential glycan profiling of lec mutants. J Biochem 2006;139:323-327.