The Soy Isoflavones for Reducing Bone Loss Study: 3-Yr Effects on pQCT Bone Mineral Density and Strength Measures in Postmenopausal Women

Journal of Clinical Densitometry

Volumn 14, Issue 1, 2011, Pages 47-57

  Shedd Wise, Kristine M ^a   Alekel, D Lee ^b   Hofmann, Heike ^c   Hanson, Kathy B ^b   Schiferl, Dan J ^d   Hanson, Laura N ^b   Van Loan, Marta D ^e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b IOWA STATE UNIVERSITY   (United States)

^c Department of Statistics Center for Statistics and Applications in Forensic Evidence Iowa State University 2438 Osborn Dr Ames   (United States)

^d Bone Diagnostics Inc   (United States)

^e U S DEPARTMENT OF AGRICULTURE   (United States)

Author keywords

Bone geometry; Peripheral quantitative computed tomography (pQCT); Soy isoflavone tablets; Strength strain index

Indexed keywords

ISOFLAVONE DERIVATIVE; PLACEBO;

ADULT; ARTICLE; BONE ATROPHY; BONE DENSITY; BONE STRENGTH; COMPUTER ASSISTED TOMOGRAPHY; CORTICAL BONE; DISTAL TIBIA FRACTURE; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; FEMALE; FEMUR SHAFT; HUMAN; MAJOR CLINICAL STUDY; MULTICENTER STUDY; OSTEOLYSIS; PERIOSTEUM; POSTMENOPAUSE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SOYBEAN;

BODY WEIGHTS AND MEASURES; BONE DENSITY; BONE RESORPTION; DOUBLE-BLIND METHOD; FEMALE; FEMUR; HUMANS; ISOFLAVONES; MIDDLE AGED; OSTEOPOROSIS, POSTMENOPAUSAL; PHYTOESTROGENS; PHYTOTHERAPY; PLANT EXTRACTS; SOYBEAN PROTEINS; TABLETS; TIBIA; TOMOGRAPHY, X-RAY COMPUTED; TREATMENT OUTCOME;

EID: 79551478019     PISSN: 10946950     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jocd.2010.11.003     Document Type: Article

References (25)

1. Kuiper G.G., Lemmen J.G., Carlsson B., et al. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 1998, 139:4252-4263.
2. Dip R., Lenz S., Antignac J.P., et al. Global gene expression profiles induced by phytoestrogens in human breast cancer cells. Endocr Relat Cancer 2008, 15:161-173.
3. Potter S.M., Baum J.A., Teng H.T., et al. Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women. Am J Clin Nutr 1998, 68:1375S-1379S.
4. Alekel D.L., St.Germain A., Peterson C.T., et al. Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women. Am J Clin Nutr 2000, 72:844-852.
5. Kenny A.M., Mangano K.M., Abourizk R.H., et al. Soy proteins and isoflavones affect bone mineral density in older women: a randomized controlled trial. Am J Clin Nutr 2009, 90:234-242.
6. Brink E., Coxam V., Robins S., et al. Long-term consumption of isoflavone-enriched foods does not affect bone mineral density, bone metabolism, or hormonal status in early postmenopausal women: a randomized, double-blind, placebo controlled study. Am J Clin Nutr 2008, 87:761-770.
7. Wong W.W., Lewis R.D., Steinberg F.M., et al. Soy isoflavone supplementation and bone mineral density in menopausal women: a 2-y multicenter clinical trial. Am J Clin Nutr 2009, 90:1433-1439.
8. Alekel D.L., Van Loan M.D., Koehler K.J., et al. Soy Isoflavones for Reducing Bone Loss (SIRBL) study: three-year randomized controlled trial to determine efficacy and safety of soy isoflavones to reduce bone loss in postmenopausal women. Am J Clin Nutr 2010, 91:218-230.
9. Breitman P.L., Fonseca D., Cheung A.M., Ward W.E. Isoflavones with supplemental calcium provide greater protection against the loss of bone mass and strength after ovariectomy compared to isoflavones alone. Bone 2003, 33:597-605.
10. Devareddy L., Khalil D.A., Smith B.J., et al. Soy moderately improves microstructural properties without affecting bone mass in an ovariectomized rat model of osteoporosis. Bone 2006, 38:686-693.
11. Fonseca D., Ward W.E. Daidzein together with high calcium preserve bone mass and biomechanical strength at multiple sites in ovariectomized mice. Bone 2004, 35:489-497.
12. Cummings S.R., Bates D., Black D. Clinical use of bone densitometry: scientific review. JAMA 2002, 288:1889-1897.
13. Sarkar S., Reginster J.Y., Crans G.G., et al. Relationship between changes in biomechanical markers of bone turnover and BMD to predict vertebral fracture risk. J Bone Miner Res 2004, 19:394-401.
14. Looker A.C., Wahner H.W., Dunn W.L., et al. Updated data on proximal femur bone mineral levels of US adults. Osteoporos Int 1998, 8:468-489.
15. Food and Nutrition Board Dietary reference intakes for calcium, phosphorus, magnesium, vitamin D, and fluoride 1999, Institute of Medicine, National Academy Press, Washington, DC.
16. Alekel DL. 1993 Contributions of physical activity, body composition, age, and nutritional factors to total and regional bone mass in premenopausal aerobic dancers and exercisers. Doctoral Dissertation, University of Illinois-Urbana.
17. Morabia A., Costanza M.C. International variability in ages at menarche, first live birth, and menopause: World Health Organization collaborative study of neoplasia and steroid contraceptives. Am J Epidemiol 1998, 148:1195-1205.
18. St.Germain A., Peterson C.T., Robinson J., Alekel D.L. Isoflavone-rich or isoflavone-poor soy protein does not reduce menopausal symptoms during 24 weeks of treatment. Menopause 2001, 8:17-26.
19. Kirk P., Patterson R.E., Lampe J. Development of a soy food frequency questionnaire to estimate isoflavone consumption in U.S. adults. J Am Diet Assoc 1999, 99:558-563.
20. Morgan E.F., Bayraktar H.H., Keaveny T.M. Trabecular bone modulus-density relationships depend on anatomic site. J Biomech 2003, 36:897-904.
21. Hayes W.C. Biomechanics of cortical and trabecular bone: implications for assessment of fracture risk. Basic Orthopaedic Biomechanics 1991, Raven Press, New York. V.C. Mow, W.C. Hayes (Eds.).
22. Kemi V.E., Kärkkäinen M.U., Lamberg-Allardt C.J. High phosphorus intakes acutely and negatively affect Ca and bone metabolism in a dose-dependent manner in healthy young females. Br J Nutr 2006, 96:545-552.
23. Moshfegh A., Goldman J., Ahuja J., et al. What we eat in America, NHANES 2005-2006: usual nutrient intakes from food and water compared to 1997 dietary reference intakes for vitamin D, calcium, phosphorus, and magnesium 2009, U.S. Department of Agriculture, Agricultural Research Service, Beltsville, MD.
24. Seeman E. Structural basis of growth-related gain and age-related loss of bone strength. Rheumatology 2008, 47:iv2-iv8.
25. Forwood M.R., Burr D.B. Physical activity and bone mass: exercises in futility?. Bone Miner 1993, 21:89-112.