메뉴 건너뛰기




Volumn 84, Issue 2, 2011, Pages 144-150

The influence of N-desmethylclozapine and clozapine on recognition memory and BDNF expression in hippocampus

Author keywords

Brain derived neurotrophic factor (BDNF); Clozapine; Memory; N desmethylclozapine (NDMC); Schizophrenia

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CLOZAPINE; DIZOCILPINE; NORCLOZAPINE;

EID: 79451473008     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2010.11.014     Document Type: Article
Times cited : (14)

References (68)
  • 1
    • 0034659811 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor and tyrosine kinase receptor TrkB in rat brain are significantly altered after haloperidol and risperidone administration
    • Angelucci F., Mathe A.A., Aloe L. Brain-derived neurotrophic factor and tyrosine kinase receptor TrkB in rat brain are significantly altered after haloperidol and risperidone administration. J. Neurosci. Res. 2000, 60:783-794.
    • (2000) J. Neurosci. Res. , vol.60 , pp. 783-794
    • Angelucci, F.1    Mathe, A.A.2    Aloe, L.3
  • 2
    • 16844382943 scopus 로고    scopus 로고
    • BDNF in schizophrenia, depression and corresponding animal models
    • Angelucci F., Brene S., Mathe A.A. BDNF in schizophrenia, depression and corresponding animal models. Mol. Psychiatry 2005, 10:345-352.
    • (2005) Mol. Psychiatry , vol.10 , pp. 345-352
    • Angelucci, F.1    Brene, S.2    Mathe, A.A.3
  • 3
    • 0037215386 scopus 로고    scopus 로고
    • Expression of BDNF m RNA in rat hippocampus after treatmnet with antipsychotic drugs
    • Bai O., Chlan-Fourney J., Bowen R., Keegan D., Li X.M. Expression of BDNF m RNA in rat hippocampus after treatmnet with antipsychotic drugs. J. Neurosci. Res. 2003, 71:127-131.
    • (2003) J. Neurosci. Res. , vol.71 , pp. 127-131
    • Bai, O.1    Chlan-Fourney, J.2    Bowen, R.3    Keegan, D.4    Li, X.M.5
  • 4
    • 43049170318 scopus 로고    scopus 로고
    • Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments
    • Balu D.T., Hoshaw B.A., Malberg J.E., Rosenzweig-Lipson S., Schechter L.E., Lucki I. Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments. Brain Res. 2008, 1211:37-43.
    • (2008) Brain Res. , vol.1211 , pp. 37-43
    • Balu, D.T.1    Hoshaw, B.A.2    Malberg, J.E.3    Rosenzweig-Lipson, S.4    Schechter, L.E.5    Lucki, I.6
  • 5
    • 33747886054 scopus 로고    scopus 로고
    • The object recognition task in rats and mice: a simple and rapid model in safety pharmacology to detect amnesic properties of a new chemical entity
    • Bertaina-Anglade V., Enjuanes E., Morillon D., Drieu la Rochelle C. The object recognition task in rats and mice: a simple and rapid model in safety pharmacology to detect amnesic properties of a new chemical entity. J. Pharmacol. Toxicol. Methods 2006, 54:99-105.
    • (2006) J. Pharmacol. Toxicol. Methods , vol.54 , pp. 99-105
    • Bertaina-Anglade, V.1    Enjuanes, E.2    Morillon, D.3    Drieu la Rochelle, C.4
  • 6
    • 34347215149 scopus 로고    scopus 로고
    • Object recognition in rats and mice: a one trial none-matching to sample learning task to study recognition memory
    • Bevins R.A., Besheer J. Object recognition in rats and mice: a one trial none-matching to sample learning task to study recognition memory. Nat. Protoc. 2006, 1:1306-1322.
    • (2006) Nat. Protoc. , vol.1 , pp. 1306-1322
    • Bevins, R.A.1    Besheer, J.2
  • 7
    • 40349114504 scopus 로고    scopus 로고
    • Role of the brain derived neurotrophic factor at glutamatergic synapses
    • Carvalho A.L., Caldeira M.V., Santos S.D., Duarte C.B. Role of the brain derived neurotrophic factor at glutamatergic synapses. Br. J. Pharmacol. 2008, 153:310-324.
    • (2008) Br. J. Pharmacol. , vol.153 , pp. 310-324
    • Carvalho, A.L.1    Caldeira, M.V.2    Santos, S.D.3    Duarte, C.B.4
  • 8
    • 0027454035 scopus 로고
    • Differential effects of MK-801 on BDNF mRNA levels in different regions of the rat brain
    • Castren E., Berzaghi M.P., Lindholm D., Thoenen H. Differential effects of MK-801 on BDNF mRNA levels in different regions of the rat brain. Exp. Neurol. 1993, 122:244-252.
    • (1993) Exp. Neurol. , vol.122 , pp. 244-252
    • Castren, E.1    Berzaghi, M.P.2    Lindholm, D.3    Thoenen, H.4
  • 9
    • 0036839413 scopus 로고    scopus 로고
    • Differential regulation of hippocampal BDNF mRNA by typical and atypical antipsychotic administration
    • Chlan-Fourney J., Ashe P., Nylen K., Juorio A.V., Li X.M. Differential regulation of hippocampal BDNF mRNA by typical and atypical antipsychotic administration. Brain Res. 2002, 954:11-20.
    • (2002) Brain Res. , vol.954 , pp. 11-20
    • Chlan-Fourney, J.1    Ashe, P.2    Nylen, K.3    Juorio, A.V.4    Li, X.M.5
  • 10
    • 4444229040 scopus 로고    scopus 로고
    • Clozapine increases both acetylcholine and dopamine release in rat ventral hippocampus: role of 5-HT1A receptor agonism
    • Chung Y.C., Li Z., Dai J., Meltzer H.Y., Ichikawa J. Clozapine increases both acetylcholine and dopamine release in rat ventral hippocampus: role of 5-HT1A receptor agonism. Brain Res. 2004, 1023:54-63.
    • (2004) Brain Res. , vol.1023 , pp. 54-63
    • Chung, Y.C.1    Li, Z.2    Dai, J.3    Meltzer, H.Y.4    Ichikawa, J.5
  • 11
    • 4944221818 scopus 로고    scopus 로고
    • Pre- or post-training administration of the NMDA receptor blocker MK-801 impairs object recognition memory in rats
    • de Lima M.N., Laranja D.C., Bromberg E., Roesler R., Schroder N.A. Pre- or post-training administration of the NMDA receptor blocker MK-801 impairs object recognition memory in rats. Behav. Brain Res. 2005, 156:139-143.
    • (2005) Behav. Brain Res. , vol.156 , pp. 139-143
    • de Lima, M.N.1    Laranja, D.C.2    Bromberg, E.3    Roesler, R.4    Schroder, N.A.5
  • 12
    • 34247574175 scopus 로고    scopus 로고
    • The pharmacology, neuroanatomy and neurogenetics of one-trial object recognition in rodents
    • Dere E., Huston J.P., De Souza Silva M.A. The pharmacology, neuroanatomy and neurogenetics of one-trial object recognition in rodents. Neurosci. Biobehav. Rev. 2007, 31:673-704.
    • (2007) Neurosci. Biobehav. Rev. , vol.31 , pp. 673-704
    • Dere, E.1    Huston, J.P.2    De Souza Silva, M.A.3
  • 13
    • 33745979179 scopus 로고    scopus 로고
    • Sertindole, in contrast to clozapine and olanzapine, does not disrupt water maze performance after acute or chronic treatment
    • Didriksen M., Kreilgaard M., Arnt J. Sertindole, in contrast to clozapine and olanzapine, does not disrupt water maze performance after acute or chronic treatment. Eur. J. Pharmacol. 2006, 542:108-115.
    • (2006) Eur. J. Pharmacol. , vol.542 , pp. 108-115
    • Didriksen, M.1    Kreilgaard, M.2    Arnt, J.3
  • 14
    • 67349131573 scopus 로고    scopus 로고
    • Antiapoptotic and neurotrophic effects of antidepressants: a review of clinical and experimental studies
    • Drzyga L.R., Marcinowska A., Obuchowics E. Antiapoptotic and neurotrophic effects of antidepressants: a review of clinical and experimental studies. Brain Res. Bull. 2009, 79:248-257.
    • (2009) Brain Res. Bull. , vol.79 , pp. 248-257
    • Drzyga, L.R.1    Marcinowska, A.2    Obuchowics, E.3
  • 16
    • 0023691166 scopus 로고
    • A novel one-trial test for neurobiological studies of memory in rats. 1. Behavioral data
    • Ennaceur A., Delacour J. A novel one-trial test for neurobiological studies of memory in rats. 1. Behavioral data. Behav. Brain Res. 1988, 31:47-59.
    • (1988) Behav. Brain Res. , vol.31 , pp. 47-59
    • Ennaceur, A.1    Delacour, J.2
  • 17
    • 36249000612 scopus 로고    scopus 로고
    • Lurasidone reverses MK-801-induced impairment of learning and memory in the Morris water maze and radial-arm maze tests in rats
    • Enomoto T., Ishibashi T., Tokuda K., Ishiyama T., Toma S., Ito A. Lurasidone reverses MK-801-induced impairment of learning and memory in the Morris water maze and radial-arm maze tests in rats. Behav. Brain Res. 2008, 186:197-207.
    • (2008) Behav. Brain Res. , vol.186 , pp. 197-207
    • Enomoto, T.1    Ishibashi, T.2    Tokuda, K.3    Ishiyama, T.4    Toma, S.5    Ito, A.6
  • 18
    • 0033528692 scopus 로고    scopus 로고
    • Hippocampal neurotrophin and trk receptor mRNA levels are altered by local administration of nicotine, carbachol and pilocarpine
    • French S.J., Humby T., Horner C.H., Sofroniew M.V., Rattray M. Hippocampal neurotrophin and trk receptor mRNA levels are altered by local administration of nicotine, carbachol and pilocarpine. Mol. Brain Res. 1999, 67:124-136.
    • (1999) Mol. Brain Res. , vol.67 , pp. 124-136
    • French, S.J.1    Humby, T.2    Horner, C.H.3    Sofroniew, M.V.4    Rattray, M.5
  • 20
    • 4644252709 scopus 로고    scopus 로고
    • Quetiapine regulates FGF-2 and BDNF expression in the hippocampus of animals treated with MK-801
    • Fumagalli F., Molteni R., Bedogni F., Gennarelli M., Perez J., Racagni G., Riva M.A. Quetiapine regulates FGF-2 and BDNF expression in the hippocampus of animals treated with MK-801. Neuroreport 2004, 15:2109-2112.
    • (2004) Neuroreport , vol.15 , pp. 2109-2112
    • Fumagalli, F.1    Molteni, R.2    Bedogni, F.3    Gennarelli, M.4    Perez, J.5    Racagni, G.6    Riva, M.A.7
  • 21
    • 34548621479 scopus 로고    scopus 로고
    • Atypical antipsychotics attenuate a sub-chronic PCP-induced cognitive deficit in the novel object recognition task in the rat
    • Grayson B., Idris N.F., Neill J.C. Atypical antipsychotics attenuate a sub-chronic PCP-induced cognitive deficit in the novel object recognition task in the rat. Behav. Brain Res. 2007, 184:31-38.
    • (2007) Behav. Brain Res. , vol.184 , pp. 31-38
    • Grayson, B.1    Idris, N.F.2    Neill, J.C.3
  • 22
    • 33750735357 scopus 로고    scopus 로고
    • Reduced serum BDNF levels in schizophrenic patients on clozapine or typical antipsychotics
    • Grillo R.W., Ottoni G.L., Leke R., Souza D.O., Portela L.V., Lara D.R. Reduced serum BDNF levels in schizophrenic patients on clozapine or typical antipsychotics. J. Psychiat. Res. 2007, 41:31-35.
    • (2007) J. Psychiat. Res. , vol.41 , pp. 31-35
    • Grillo, R.W.1    Ottoni, G.L.2    Leke, R.3    Souza, D.O.4    Portela, L.V.5    Lara, D.R.6
  • 23
    • 0027379995 scopus 로고
    • Activation of NMDA receptors increases brain-derived neurotrophic factor (Bdnf) messenger-rna expression in the hippocampal-formation
    • Gwag B.J., Spri{dotless}nger J.E. Activation of NMDA receptors increases brain-derived neurotrophic factor (Bdnf) messenger-rna expression in the hippocampal-formation. Neuroreport 1993, 5:125-128.
    • (1993) Neuroreport , vol.5 , pp. 125-128
    • Gwag, B.J.1    Springer, J.E.2
  • 24
    • 0027524707 scopus 로고
    • Improvement in cognitive functions and psychiatric symptoms in treatment-refractory schizophrenic patients receiving clozapine
    • Hagger C., Buckley P., Kenny J.T., Friedman L., Ubogy D., Meltzer H.Y. Improvement in cognitive functions and psychiatric symptoms in treatment-refractory schizophrenic patients receiving clozapine. Biol. Psychiatry 1993, 34:702-712.
    • (1993) Biol. Psychiatry , vol.34 , pp. 702-712
    • Hagger, C.1    Buckley, P.2    Kenny, J.T.3    Friedman, L.4    Ubogy, D.5    Meltzer, H.Y.6
  • 25
    • 27744572308 scopus 로고    scopus 로고
    • Phencyclidine-induced cognitive deficits in mice are improved by subsequent sub-chronic administration of clozapine, but not haloperidol
    • Hashimoto K., Fujita Y., Shimizu E., Iyo M. Phencyclidine-induced cognitive deficits in mice are improved by subsequent sub-chronic administration of clozapine, but not haloperidol. Eur. J. Pharmacol. 2005, 519:114-117.
    • (2005) Eur. J. Pharmacol. , vol.519 , pp. 114-117
    • Hashimoto, K.1    Fujita, Y.2    Shimizu, E.3    Iyo, M.4
  • 26
    • 33847289217 scopus 로고    scopus 로고
    • Fine tuning of awake prefrontal cortex neurons by clozapine: comparison with haloperidol and N-desmethylclozapine
    • Homayoun H., Moghaddam B. Fine tuning of awake prefrontal cortex neurons by clozapine: comparison with haloperidol and N-desmethylclozapine. Biol. Psychiatry 2007, 61:679-685.
    • (2007) Biol. Psychiatry , vol.61 , pp. 679-685
    • Homayoun, H.1    Moghaddam, B.2
  • 27
    • 0035096016 scopus 로고    scopus 로고
    • 5-HT(2A) and D(2) receptor blockade increases cortical DA release via 5-HT(1A) receptor activation: a possible mechanism of atypical antipsychotic-induced cortical dopamine release
    • Ichikawa J., Ishii H., Bonaccorso S., Fowler W.L., O'Laughlin I.A., Meltzer H.Y. 5-HT(2A) and D(2) receptor blockade increases cortical DA release via 5-HT(1A) receptor activation: a possible mechanism of atypical antipsychotic-induced cortical dopamine release. J. Neurochem. 2001, 76:1521-1531.
    • (2001) J. Neurochem. , vol.76 , pp. 1521-1531
    • Ichikawa, J.1    Ishii, H.2    Bonaccorso, S.3    Fowler, W.L.4    O'Laughlin, I.A.5    Meltzer, H.Y.6
  • 28
    • 0037036059 scopus 로고    scopus 로고
    • 5-HT1A and 5-HT2A receptors minimally contribute to clozapine induced acetylcholine release in rat medial prefrontal cortex
    • Ichikawa J., Dai J., Meltzer H.Y. 5-HT1A and 5-HT2A receptors minimally contribute to clozapine induced acetylcholine release in rat medial prefrontal cortex. Brain Res. 2002, 939:34-42.
    • (2002) Brain Res. , vol.939 , pp. 34-42
    • Ichikawa, J.1    Dai, J.2    Meltzer, H.Y.3
  • 29
    • 33751105543 scopus 로고    scopus 로고
    • The ability of antipsychotics to prevent a sub-chronic pcp-induced cognitive deficit in the novel object recognition task in the rat
    • Idris N.F., Grayson B., Platford E., Neill J.C. The ability of antipsychotics to prevent a sub-chronic pcp-induced cognitive deficit in the novel object recognition task in the rat. Soc. Neurosci. Abstracts 2005, 67:15.
    • (2005) Soc. Neurosci. Abstracts , vol.67 , pp. 15
    • Idris, N.F.1    Grayson, B.2    Platford, E.3    Neill, J.C.4
  • 30
    • 33747368890 scopus 로고    scopus 로고
    • Valproate prevents MK-801 induced changes in brain-derived neurotrophic factor mRNA in the rat brain
    • Jeon G.S., Park S., Lee K., Lee M., Chun B., Shin K. Valproate prevents MK-801 induced changes in brain-derived neurotrophic factor mRNA in the rat brain. Eur. J. Pharmacol. 2006, 545:142-146.
    • (2006) Eur. J. Pharmacol. , vol.545 , pp. 142-146
    • Jeon, G.S.1    Park, S.2    Lee, K.3    Lee, M.4    Chun, B.5    Shin, K.6
  • 31
    • 0023812652 scopus 로고
    • Clozapine for the treatment resistant schizophrenic. A double-blind comparison with chlorpromazine
    • Kane J., Honigfeld G., Singer J., Meltzer H. Clozapine for the treatment resistant schizophrenic. A double-blind comparison with chlorpromazine. Arch. Gen. Psychiatry 1988, 45:789-796.
    • (1988) Arch. Gen. Psychiatry , vol.45 , pp. 789-796
    • Kane, J.1    Honigfeld, G.2    Singer, J.3    Meltzer, H.4
  • 32
    • 77956648156 scopus 로고    scopus 로고
    • N-methyl-d-aspartate (NMDA) receptor dysfunction or dysregulation: the final common pathway on the road to schizophrenia? Brain Res. Bull. doi:10.1016/j.brainresbull.2010.04.006.
    • J.T. Kantrowitz, D.C. Javitt, N-methyl-d-aspartate (NMDA) receptor dysfunction or dysregulation: the final common pathway on the road to schizophrenia? Brain Res. Bull., 2010, doi:10.1016/j.brainresbull.2010.04.006.
    • (2010)
    • Kantrowitz, J.T.1    Javitt, D.C.2
  • 33
    • 36049021794 scopus 로고    scopus 로고
    • D-Serine and a glycine transporter inhibitor improve MK-801-induced cognitive deficits in a novel object recognition test in rats
    • Karasawa J., Hashimoto K., Chaki S. D-Serine and a glycine transporter inhibitor improve MK-801-induced cognitive deficits in a novel object recognition test in rats. Behav. Brain Res. 2008, 186:78-83.
    • (2008) Behav. Brain Res. , vol.186 , pp. 78-83
    • Karasawa, J.1    Hashimoto, K.2    Chaki, S.3
  • 35
    • 0344234416 scopus 로고    scopus 로고
    • Spatial learning is delayed and brain-derived neurotrophic factor mRNA expression inhibited by administration of MK-801 in rats
    • Kesslak J.P., Chuang K.R., Berchtold N.C. Spatial learning is delayed and brain-derived neurotrophic factor mRNA expression inhibited by administration of MK-801 in rats. Neurosci. Lett. 2003, 353:95-98.
    • (2003) Neurosci. Lett. , vol.353 , pp. 95-98
    • Kesslak, J.P.1    Chuang, K.R.2    Berchtold, N.C.3
  • 36
    • 0028266334 scopus 로고
    • Positive feedback between acetylcholine and the neurotrophins nerve growth factor and brain-derived neurotrophic factor in the rat hippocampus
    • Knipper M., da Penha Berzaghi M., Blöchl A., Breer H., Thoenen H., Lindholm D. Positive feedback between acetylcholine and the neurotrophins nerve growth factor and brain-derived neurotrophic factor in the rat hippocampus. Eur. J. Neurosci. 1994, 6:668-671.
    • (1994) Eur. J. Neurosci. , vol.6 , pp. 668-671
    • Knipper, M.1    da Penha Berzaghi, M.2    Blöchl, A.3    Breer, H.4    Thoenen, H.5    Lindholm, D.6
  • 37
    • 26244445560 scopus 로고    scopus 로고
    • N-desmethylclozapine, a major metabolite of clozapine, increases cortical acetylcholine and dopamine release in vivo via stimulation of M1 muscarinic receptors
    • Li Z., Huang M., Ichikawa J., Dai J., Meltzer H.Y. N-desmethylclozapine, a major metabolite of clozapine, increases cortical acetylcholine and dopamine release in vivo via stimulation of M1 muscarinic receptors. Neuropsychopharmacology 2005, 30:1986-1995.
    • (2005) Neuropsychopharmacology , vol.30 , pp. 1986-1995
    • Li, Z.1    Huang, M.2    Ichikawa, J.3    Dai, J.4    Meltzer, H.Y.5
  • 38
    • 0034084010 scopus 로고    scopus 로고
    • Expression of neurotrophins BDNF and NT-3, and their receptors in rat brain after administration of antipsychotic and psychotrophic agents
    • Linden A.M., Vaisanen J., Lakso M., Nawa H., Wong G., Castren E. Expression of neurotrophins BDNF and NT-3, and their receptors in rat brain after administration of antipsychotic and psychotrophic agents. J. Mol. Neurosci. 2000, 14:27-37.
    • (2000) J. Mol. Neurosci. , vol.14 , pp. 27-37
    • Linden, A.M.1    Vaisanen, J.2    Lakso, M.3    Nawa, H.4    Wong, G.5    Castren, E.6
  • 39
    • 0027970123 scopus 로고
    • Activity-dependent and hormonal regulation of neurotrophin mRNA levels in the brain - implications for neuronal plasticity
    • Lindholm D., Castren E., Berzaghi M., Blochl A., Thoenen H. Activity-dependent and hormonal regulation of neurotrophin mRNA levels in the brain - implications for neuronal plasticity. J. Neurobiol. 1994, 25:1362-1372.
    • (1994) J. Neurobiol. , vol.25 , pp. 1362-1372
    • Lindholm, D.1    Castren, E.2    Berzaghi, M.3    Blochl, A.4    Thoenen, H.5
  • 40
    • 0034907671 scopus 로고    scopus 로고
    • BDNF mRNA expression in rat hippocampus and prefrontal cortex: effects of neonatal ventral hippocampal damage and antipschotic drugs
    • Lipska B.K., Khaing Z.Z., Weickert C.S., Weinberger D.R. BDNF mRNA expression in rat hippocampus and prefrontal cortex: effects of neonatal ventral hippocampal damage and antipschotic drugs. Eur. J. Neurosci. 2001, 14:135-144.
    • (2001) Eur. J. Neurosci. , vol.14 , pp. 135-144
    • Lipska, B.K.1    Khaing, Z.Z.2    Weickert, C.S.3    Weinberger, D.R.4
  • 41
    • 36549042458 scopus 로고    scopus 로고
    • Interaction between BDNF and serotonin: role in mood disorders
    • Martinowich K., Lu B. Interaction between BDNF and serotonin: role in mood disorders. Neuropsychopharmacology 2008, 33:73-83.
    • (2008) Neuropsychopharmacology , vol.33 , pp. 73-83
    • Martinowich, K.1    Lu, B.2
  • 42
    • 0034979408 scopus 로고    scopus 로고
    • Effects of age and gender on the expression of brain derived neurotrophic factor mRNA in rat retrosplenial cortex following administation of dizocilpine
    • Matsuki H., Shirayama Y., Hashimoto K., Tanaka A., Minabe Y. Effects of age and gender on the expression of brain derived neurotrophic factor mRNA in rat retrosplenial cortex following administation of dizocilpine. Neuropsychopharmacology 2001, 25:258-266.
    • (2001) Neuropsychopharmacology , vol.25 , pp. 258-266
    • Matsuki, H.1    Shirayama, Y.2    Hashimoto, K.3    Tanaka, A.4    Minabe, Y.5
  • 44
    • 79451473844 scopus 로고    scopus 로고
    • et al., N-desmethlyclozapine demonstrated pro-cognitive actions in experimental models, International Congress on Schizophrenia Research 2007, Colorado Springs, CO.
    • K. McFarland, R.W. Johnson, T. Son, L. Pounds, K.E. Vanover, S. Bradley, et al., N-desmethlyclozapine demonstrated pro-cognitive actions in experimental models, International Congress on Schizophrenia Research 2007, Colorado Springs, CO.
    • McFarland, K.1    Johnson, R.W.2    Son, T.3    Pounds, L.4    Vanover, K.E.5    Bradley, S.6
  • 45
    • 0024466603 scopus 로고
    • Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin-2 pKi values
    • Meltzer H.Y., Matsubara S., Lee J.C. Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin-2 pKi values. J. Pharmacol. Exp. Ther. 1989, 251:238-246.
    • (1989) J. Pharmacol. Exp. Ther. , vol.251 , pp. 238-246
    • Meltzer, H.Y.1    Matsubara, S.2    Lee, J.C.3
  • 46
    • 0032977410 scopus 로고    scopus 로고
    • The effects of clozapine, risperidone, and olanzapine on cognitive function in schizophrenia
    • Meltzer H.Y., McGurk S.R. The effects of clozapine, risperidone, and olanzapine on cognitive function in schizophrenia. Schizophr. Bull. 1999, 25:233-255.
    • (1999) Schizophr. Bull. , vol.25 , pp. 233-255
    • Meltzer, H.Y.1    McGurk, S.R.2
  • 49
    • 33646677275 scopus 로고    scopus 로고
    • Opposing effects of AMPA and 5 HT1A receptor blockade on passive avoidance and object recognition performance: correlation with AMPA receptor subunit expression in rat hippocampus
    • Schiapparelli L., Simon A.M., Del Rio J., Frechilla D. Opposing effects of AMPA and 5 HT1A receptor blockade on passive avoidance and object recognition performance: correlation with AMPA receptor subunit expression in rat hippocampus. Neuropharmacology 2006, 50:897-907.
    • (2006) Neuropharmacology , vol.50 , pp. 897-907
    • Schiapparelli, L.1    Simon, A.M.2    Del Rio, J.3    Frechilla, D.4
  • 50
    • 11844271434 scopus 로고    scopus 로고
    • Impairing effects of chronic haloperidol and clozapine treatment on recognition memory: possible relation to oxidative stres
    • Schröder N., de Lima M.N., Quevedo J., Dal Pizzol F., Roesler R. Impairing effects of chronic haloperidol and clozapine treatment on recognition memory: possible relation to oxidative stres. Schizophr. Res. 2005, 73:377-378.
    • (2005) Schizophr. Res. , vol.73 , pp. 377-378
    • Schröder, N.1    de Lima, M.N.2    Quevedo, J.3    Dal Pizzol, F.4    Roesler, R.5
  • 51
    • 34247866389 scopus 로고    scopus 로고
    • Different effects of chronic phencyclidine on brain-derived neurotrophic factor in neonatal and adult rat brains
    • Semba J., Wakuta M., Suhara T. Different effects of chronic phencyclidine on brain-derived neurotrophic factor in neonatal and adult rat brains. Addict. Biol. 2006, 11:126-130.
    • (2006) Addict. Biol. , vol.11 , pp. 126-130
    • Semba, J.1    Wakuta, M.2    Suhara, T.3
  • 52
    • 16844374541 scopus 로고    scopus 로고
    • The possible role of neurotrophins in the pathogenesis and therapy of schizophrenia
    • Shoval G., Weizman A. The possible role of neurotrophins in the pathogenesis and therapy of schizophrenia. Eur. Neuropsychopharmacol. 2005, 15:319-329.
    • (2005) Eur. Neuropsychopharmacol. , vol.15 , pp. 319-329
    • Shoval, G.1    Weizman, A.2
  • 53
    • 0030007496 scopus 로고    scopus 로고
    • Differential effect of antipsychotics on place navigation of rats in the Morris water maze
    • Skarsfeldt T. Differential effect of antipsychotics on place navigation of rats in the Morris water maze. Psychopharmacology (Berl) 1996, 124:126-133.
    • (1996) Psychopharmacology (Berl) , vol.124 , pp. 126-133
    • Skarsfeldt, T.1
  • 54
    • 76749163673 scopus 로고    scopus 로고
    • Attenuation of phencyclidine-induced object recognition deficits by the combination of atypical antipsychotic drugs and pimavanserin (ACP 103), a 5-hydroxytryptamine(2A) receptor inverse agonist
    • Snigdha S., Horiguchi M., Huang M., Li Z., Shahid M., Neill J.C., Meltzer H.Y. Attenuation of phencyclidine-induced object recognition deficits by the combination of atypical antipsychotic drugs and pimavanserin (ACP 103), a 5-hydroxytryptamine(2A) receptor inverse agonist. J. Pharmacol. Exp. Ther. 2010, 332:622-631.
    • (2010) J. Pharmacol. Exp. Ther. , vol.332 , pp. 622-631
    • Snigdha, S.1    Horiguchi, M.2    Huang, M.3    Li, Z.4    Shahid, M.5    Neill, J.C.6    Meltzer, H.Y.7
  • 57
    • 0142136406 scopus 로고    scopus 로고
    • The C270T polymorphism of the brain-derived neurotrophic factor gene is associated with schizophrenia
    • Szekeres G., Juhasz A., Rimanoczy A., Keri S., Janka Z. The C270T polymorphism of the brain-derived neurotrophic factor gene is associated with schizophrenia. Schizophr. Res. 2003, 65:15-18.
    • (2003) Schizophr. Res. , vol.65 , pp. 15-18
    • Szekeres, G.1    Juhasz, A.2    Rimanoczy, A.3    Keri, S.4    Janka, Z.5
  • 58
    • 19444386373 scopus 로고    scopus 로고
    • Decreased BDNF in serum of patients with chronic schizophrenia on long-term treatment with antipsychotics
    • Tan Y.L., Zhou D.F., Cao L.Y., Zou Y.Z., Zhang X.Y. Decreased BDNF in serum of patients with chronic schizophrenia on long-term treatment with antipsychotics. Neurosci. Lett. 2005, 382:27-32.
    • (2005) Neurosci. Lett. , vol.382 , pp. 27-32
    • Tan, Y.L.1    Zhou, D.F.2    Cao, L.Y.3    Zou, Y.Z.4    Zhang, X.Y.5
  • 59
    • 33645743002 scopus 로고    scopus 로고
    • The impact of atypical antipsychotic medications on long-term memory dysfunction in schizophrenia spectrum disorder: a quantitative review
    • Thornton A.E., Van Snellenberg J.X., Sepehry A.A., Honer W. The impact of atypical antipsychotic medications on long-term memory dysfunction in schizophrenia spectrum disorder: a quantitative review. J. Psychopharmacol. 2006, 20:335-346.
    • (2006) J. Psychopharmacol. , vol.20 , pp. 335-346
    • Thornton, A.E.1    Van Snellenberg, J.X.2    Sepehry, A.A.3    Honer, W.4
  • 60
    • 0037205782 scopus 로고    scopus 로고
    • Decreased levels of brain-derived neurotrophic factor in serum of chronic schizophrenic patients
    • Toyooka K., Asama K., Watanabe Y., Muratake T., Takahashi M., Someya T., Nawa H. Decreased levels of brain-derived neurotrophic factor in serum of chronic schizophrenic patients. Psychiatry Res. 2002, 110:249-257.
    • (2002) Psychiatry Res. , vol.110 , pp. 249-257
    • Toyooka, K.1    Asama, K.2    Watanabe, Y.3    Muratake, T.4    Takahashi, M.5    Someya, T.6    Nawa, H.7
  • 61
    • 0030611192 scopus 로고    scopus 로고
    • 5-HT2A receptor-mediated regulation of brain derived neurotrophic factor mRNA in the hippocampus and the neocortex
    • Vaidya V.A., Marek G.J., Aghajanian G.K., Duman R.S. 5-HT2A receptor-mediated regulation of brain derived neurotrophic factor mRNA in the hippocampus and the neocortex. J. Neurosci. 1997, 17:2785-2795.
    • (1997) J. Neurosci. , vol.17 , pp. 2785-2795
    • Vaidya, V.A.1    Marek, G.J.2    Aghajanian, G.K.3    Duman, R.S.4
  • 64
    • 21244448316 scopus 로고    scopus 로고
    • A meta-analysis of neuropsychological change to clozapine, olanzapine, quetiapine, and risperidone in schizophrenia
    • Woodward N.D., Purdon S.E., Meltzer H.Y., Zald D.H. A meta-analysis of neuropsychological change to clozapine, olanzapine, quetiapine, and risperidone in schizophrenia. Int. J. Neuropsychopharmacol. 2005, 8:457-472.
    • (2005) Int. J. Neuropsychopharmacol. , vol.8 , pp. 457-472
    • Woodward, N.D.1    Purdon, S.E.2    Meltzer, H.Y.3    Zald, D.H.4
  • 65
    • 33845285511 scopus 로고    scopus 로고
    • A meta-analysis of cognitive change with haloperidol in clinical trials of atypical antipsychotics: dose effects and comparison to practice effects
    • Woodward N.D., Purdon S.E., Meltzer H.Y., Zald D.H. A meta-analysis of cognitive change with haloperidol in clinical trials of atypical antipsychotics: dose effects and comparison to practice effects. Schizophr. Res. 2007, 89:211-224.
    • (2007) Schizophr. Res. , vol.89 , pp. 211-224
    • Woodward, N.D.1    Purdon, S.E.2    Meltzer, H.Y.3    Zald, D.H.4
  • 67
    • 0037016553 scopus 로고    scopus 로고
    • Role for brain derived neurotrophic factor in learning and memory
    • Yamada K., Mizuno M., Nabeshima T. Role for brain derived neurotrophic factor in learning and memory. Life Sci. 2002, 70:735-744.
    • (2002) Life Sci. , vol.70 , pp. 735-744
    • Yamada, K.1    Mizuno, M.2    Nabeshima, T.3
  • 68
    • 64249168387 scopus 로고    scopus 로고
    • Using the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia
    • Young J.W., Powell S.B., Risbrough V., Marston H.M., Geyer M.A. Using the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia. Pharmacol. Ther. 2009, 122:150-202.
    • (2009) Pharmacol. Ther. , vol.122 , pp. 150-202
    • Young, J.W.1    Powell, S.B.2    Risbrough, V.3    Marston, H.M.4    Geyer, M.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.