The allelic spectra of common diseases may resemble the allelic spectrum of the full genome

Medical Hypotheses

Volumn 63, Issue 4, 2004, Pages 748-751

  Wang, William Y S ^a,b   Pike, Nathan ^c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF SYDNEY   (Australia)

^c ECOLE NORMALE SUPÉRIEURE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; GENE IDENTIFICATION; GENE LOCUS; GENE TARGETING; GENETIC EPIDEMIOLOGY; GENETIC HETEROGENEITY; GENOME; GENOTYPE; HUMAN; ONCOGENE; PRIORITY JOURNAL; PUBLIC HEALTH; REVIEW; STATISTICAL SIGNIFICANCE;

EID: 7944220775     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2003.12.057     Document Type: Article

References (21)

1. Smith D.J., Lusis A.J. The allelic structure of common disease. Hum. Mol. Genet. 11:2002;2455-2461
2. Botstein D., Risch N. Discovering genotypes underlying human phenotypes: past successes for Mendelian disease, future approaches for complex disease. Nat. Genet. Suppl. 33:2003;228-237
3. Altmuller J., Palmer L.J., Fischer G., Scherb H., Wjst M. Genomewide scans of complex human diseases: true linkage is hard to find. Am. J. Hum. Genet. 69:2001;936-950
4. Hirschhorn J.N., Lohmueller K., Byrne E., Hirschhorn K. A comprehensive review of genetic association studies. Genet. Med. 4:2002;45-61
5. Risch N., Merikangas K. The future of genetic studies of complex human diseases. Science. 273:1996;1516-1517
6. Reich D.A., Lander E.S. On the allelic spectrum of human disease. Trends Genet. 17:2001;502-510
7. Pritchard J.K. Are rare variants responsible for susceptibility to complex diseases? Am. J. Hum. Genet. 69:2001;124-137
8. Glatt C.E., DeYoung J.A., Delgado S., Service S.K., Giacomini K.M., Edwards R.H., et al. Screening a large reference sample to identify very low frequency sequence variants: comparisons between two genes. Nat. Genet. 27:2001;435-438
9. dbSNPs. Available from: http://www.ncbi.nlm.nih.gov/SNP/
10. Wang W.Y., Todd J.A. The usefulness of different density SNP maps for disease association studies of common variants. Hum. Mol. Genet.ff. 12:2003;3145-3149
11. Reich D.E., Cargill M., Bolk S., Ireland J., Sabeti P.C., Richter D.J., et al. Linkage disequilibrium in the human genome. Nature. 411:2001;199-204
12. Lohmueller K.E., Pearce C.L., Pike M., Lander E.S., Hirschhorn J.N. Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat. Genet. 33:2003;177-182
13. Haines J.L., Pericak-Vance M.A. Approaches to gene mapping in complex human diseases. 1998;Wiley, New York
14. Risch N. Linkage strategies for genetically complex traits. I. Multilocus models. Am. J. Hum. Genet. 46:1990;222-228
15. OMIM. Online inheritance in man. Available from: http://www.ncbi.nlm.nih. gov/omim/
16. Clark A.G. Finding genes underlying risk of complex disease by linkage disequilibrium mapping. Curr. Opin. Genet. Develop. 13:2003;296-302
17. Todd J.A. Human genetics: tackling common disease. Nature. 411:2001;537-539
18. Rybicki B.A., Elston R.C. The relationship between the sibling recurrence-risk ratio and genotype relative risk. Am. J. Hum. Genet. 66:2000;593-604
19. Wang W.Y., Cordell H.J., Todd J.A. Association mapping of complex diseases in linked regions: estimation of genetic effects and feasibility of testing rare variants. Genet. Epidemiol. 24:2003;36-43
20. HapMap. The haplotype map. Available from: http://www.genome.gov/10005336
21. Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., et al. Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat. Genet. 22:1999;231-238