Molecular mechanisms underlying the inhibition of IFN-γ-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs

Journal of Cellular Biochemistry

Volumn 112, Issue 2, 2011, Pages 675-683

  Li, Na ^a   Salter, Rebecca C ^a   Ramji, Dipak P ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

IFN ; LXR; macrophages; PPAR; simvastatin; STAT1; transcriptional inhibition

Indexed keywords

GAMMA INTERFERON; LIVER X RECEPTOR; N (2,2,2 TRIFLUOROETHYL) N [4 (2,2,2 TRIFLUORO 1 HYDROXY 1 TRIFLUOROMETHYLETHYL)PHENYL]BENZENESULFONAMIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; ROSIGLITAZONE; SIMVASTATIN; STAT1 PROTEIN;

ARTICLE; DNA BINDING; DRUG MECHANISM; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MACROPHAGE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

BLOTTING, WESTERN; BUTYRIC ACIDS; CELL LINE; CELLS, CULTURED; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HUMANS; HYDROCARBONS, FLUORINATED; INTERFERON-GAMMA; MACROPHAGES; ORPHAN NUCLEAR RECEPTORS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; PHENYLUREA COMPOUNDS; SIMVASTATIN; STAT1 TRANSCRIPTION FACTOR; SULFONAMIDES; THIAZOLIDINEDIONES; TRANSFECTION;

EID: 79251618714     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.22976     Document Type: Article

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