Three-dimensional plotted scaffolds with controlled pore size gradients: Effect of scaffold geometry on mechanical performance and cell seeding efficiency

Acta Biomaterialia

Volumn 7, Issue 3, 2011, Pages 1009-1018

  Sobral, Jorge M ^a   Caridade, Sofia G ^a   Sousa, Rui A ^a   Mano, João F ^a   Reis, Rui L ^a  

^a UNIVERSITY OF MINHO   (Portugal)

Author keywords

Porosity gradient; Regenerative medicine; Seeding efficiency; Three dimensional plotting; Tissue engineering

Indexed keywords

CELL ENGINEERING; CELLS; COMPRESSION TESTING; COMPUTERIZED TOMOGRAPHY; CYTOLOGY; DYNAMIC MECHANICAL ANALYSIS; EFFICIENCY; PORE SIZE; REGENERATIVE MEDICINE; SCAFFOLDS (BIOLOGY); TISSUE;

CELL SEEDING; GRADIENT EFFECT; MECHANICAL PERFORMANCE; PORE ARCHITECTURE; POROSITY GRADIENTS; RAPID-PROTOTYPING; REGENERATIVE MEDICINE; SEEDING EFFICIENCY; THREE-DIMENSIONAL PLOTTING; TISSUES ENGINEERINGS;

SCANNING ELECTRON MICROSCOPY;

POLYCAPROLACTONE; TISSUE SCAFFOLD;

ARTICLE; BIOMECHANICS; COMPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; MICRO-COMPUTED TOMOGRAPHY; OSTEOBLAST; POROSITY; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; TISSUE ENGINEERING;

EID: 79251617418     PISSN: 17427061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actbio.2010.11.003     Document Type: Article

References (75)

1. R. Langer, and J.P. Vacanti Tissue engineering Science 260 1993 920 926
2. R.G. Flemming Effects of synthetic micro- and nano-structured surfaces on cell behavior Biomaterials 20 1999 573 588
3. T.A. Desai Micro-and nanoscale structures for tissue engineering constructs Med Eng Phys 22 2000 595 606
4. H. Andersson, and A. Van den Berg Microfabrication and microfluidics for tissue engineering: state of the art and future opportunities Lab Chip 4 2004 98 103
5. W.Y. Yeong Rapid prototyping in tissue engineering: challenges and potential Trends Biotechnol 22 2004 643 652
6. J. Lee Three-dimensional cell culture matrices: state of the art Tissue Eng Part B Rev 14 2008 61 86
7. D.W. Hutmacher Scaffold-based tissue engineering: Rationale for computer-aided design and solid free-form fabrication systems Trends Biotechnol 22 2004 354 362
8. D.W. Hutmacher, and S. Cool Concepts of scaffold-based tissue engineering-the rationale to use solid free-form fabrication techniques J Cell Mol Med 11 2007 654 669
9. D.W. Hutmacher Scaffolds in tissue engineering bone, cartilage Biomaterials 21 2000 2529 2543
10. I. Zein Fused deposition modeling of novel scaffold architectures for tissue engineering applications Biomaterials 23 2002 1169 1185
11. K.F. Leong Solid freeform fabrication of three-dimensional scaffolds for engineering replacement tissues and organs Biomaterials 24 2003 2363 2378
12. T.B.F. Woodfield Design of porous scaffolds for cartilage tissue engineering using a three-dimensional fiber-deposition technique Biomaterials 25 2004 4149 4161
13. J. Malda The effect of PEGT/PBT scaffold architecture on the composition of tissue engineered cartilage Biomaterials 26 2005 63 72
14. S. Miot Effects of scaffold composition and architecture on human nasal chondrocyte redifferentiation and cartilaginous matrix deposition Biomaterials 26 2005 2479 2489
15. L. Moroni 3D fiber-deposited scaffolds for tissue engineering: Influence of pores geometry and architecture on dynamic mechanical properties Biomaterials 27 2006 974 985
16. A.M. Yousefi Design and fabrication of 3D-plotted polymeric scaffolds in functional tissue engineering Polym Eng Sci 47 2007 608 618
17. N.E. Fedorovich Three-dimensional fiber deposition of cell-laden, viable, patterned constructs for bone tissue printing Tissue Eng Part A 14 2008 127 133
18. A. Pfister Biofunctional rapid prototyping for tissue-engineering applications: 3D bioplotting versus 3D printing J Polym Sci Part A: Polym Chem 42 2004 624 638
19. B.S. Kim Optimizing seeding and culture methods to engineer smooth muscle tissue on biodegradable polymer matrices Biotechnol Bioeng 57 1998 46 54
20. R.L. Carrier Cardiac tissue engineering: cell seeding, cultivation parameters, and tissue construct characterization Biotechnol Bioeng 64 1999 580 589
21. Y.L. Xiao Static and dynamic fibroblast seeding and cultivation in porous PEO/PBT scaffolds J Mater Sci: Mater Med 10 1999 773 777
22. C.E. Holy Engineering three-dimensional bone tissue in vitro using biodegradable scaffolds: investigating initial cell-seeding density and culture period J Biomed Mater Res 51 2000 376 382
23. Y. Li Effects of filtration seeding on cell density, spatial distribution, and proliferation in nonwoven fibrous matrices Biotechnol Prog 17 2001 935 944
24. G. Vunjak-Novakovic, and M. Radisic Cell seeding of polymer scaffolds Methods Mol Biol 238 2004 131 146
25. C.J. Galban, and B.R. Locke Effects of spatial variation of cells, nutrient, product concentrations coupled with product inhibition on cell growth in a polymer scaffold Biotechnol Bioeng 64 1999 633 643
26. P. Yilgor 3D plotted PCL scaffolds for stem cell based bone tissue engineering Macromol Symp 269 2008 92 99
27. R. El-Ayoubi Design and fabrication of 3D porous scaffolds to facilitate cell-based gene therapy Tissue Eng Part A 14 2008 1037 1048
28. J.P. Li Bone ingrowth in porous titanium implants produced by 3D fiber deposition Biomaterials 28 2007 2810 2820
29. L. Moroni Anatomical 3D fiber-deposited scaffolds for tissue engineering: designing a neotrachea Tissue Eng 13 2007 2483 2493
30. R. Detsch 3D-cultivation of bone marrow stromal cells on hydroxyapatite scaffolds fabricated by dispense-plotting and negative mould technique J Mater Sci: Mater Med 19 2008 1491 1496
31. Moroni L., et al. 3D fiber-deposited electrospun integrated scaffolds enhance cartilage tissue formation. Adv Funct Mater. 2008;18 11:53-60.
32. T.B.F. Woodfield Polymer scaffolds fabricated with pore-size gradients as a model for studying the zonal organization within tissue-engineered cartilage constructs Tissue Eng 11 2005 1297 1311
33. B.A. Harley Fabricating tubular scaffolds with a radial pore size gradient by a spinning technique Biomaterials 27 2006 866 874
34. M.M.C.G. Silva The effect of anisotropic architecture on cell and tissue infiltration into tissue engineering scaffolds Biomaterials 27 2006 5909 5917
35. S.H. Oh In vitro and in vivo characteristics of PCL scaffolds with pore size gradient fabricated by a centrifugation method Biomaterials 28 2007 1664 1671
36. G. Kim Hybrid process for fabricating 3D hierarchical scaffolds combining rapid prototyping and electrospinning Macromol Rapid Commun 29 2008 1577 1581
37. A. Martins Hierarchical starch-based fibrous scaffold for bone tissue engineering applications J Tissue Eng Regener Med 3 2009 37 42
38. 2 nanonodular structures in a micro-to-nanoscale hierarchy model Biomaterials 30 2009 5319 5329
39. S. Park 3D polycaprolactone scaffolds with controlled pore structure using a rapid prototyping system J Mater Sci: Mater Med 20 2009 229 234
40. A.P. Marques Effect of starch-based biomaterials on the in vitro proliferation and viability of osteoblast-like cells J Mater Sci: Mater Med 16 2005 833 842
41. W.J. Li Biological response of chondrocytes cultured in three-dimensional nanofibrous poly(epsilon-caprolactone) scaffolds J Biomed Mater Res, Part A 67 2003 1105 1114
42. C.M. Alves The dynamics, kinetics and reversibility of protein adsorption onto the surface of biodegradable materials Soft Matter 6 2010 4135 4143
43. A.P. Marques An in vivo study of the host response to starch-based polymers and composites subcutaneously implanted in rats Macromol Biosci 5 2005 775 785
44. J.W.M. Vehof Bone formation in CaP-coated and noncoated titanium fiber mesh J Biomed Mater Res, Part A 64 2003 417 426
45. R. Landers, and R. Mulhaupt Desktop manufacturing of complex objects, prototypes and biomedical scaffolds by means of computer-assisted design combined with computer-guided 3D plotting of polymers and reactive oligomers Macromol Mater Eng 282 2000 17 21
46. R. Landers Rapid prototyping of scaffolds derived from thermoreversible hydrogels and tailored for applications in tissue engineering Biomaterials 23 2002 4437 4447
47. J. Meyle Fibroblast anchorage to microtextured surfaces J Biomed Mater Res 27 1993 1553 1557
48. X.M. Liu Influence of substratum surface chemistry/energy and topography on the human fetal osteoblastic cell line hFOB 1.19: phenotypic and genotypic responses observed in vitro Biomaterials 28 2007 4535 4550
49. L. Marcotte, and A. Tabrizian Sensing Surfaces: challenges in studying the cell adhesion process and the cell adhesion forces on biomaterials IRBM 29 2008 77 88
50. O. Bretcanu Simple methods to fabricate Bioglass (R)-derived glass-ceramic scaffolds exhibiting porosity gradient J Mater Sci 43 2008 4127 4134
51. A. Tamayo Gradient pore size distributions in porous silicon oxycarbide materials J Eur Ceram Soc 28 2008 1871 1879
52. H. Wu Fabrication of chitosan-g-polycaprolactone copolymer scaffolds with gradient porous microstructures Mater Lett 62 2008 2733 2736
53. N.M. Alves Microhardness of starch based biomaterials in simulated physiological conditions Acta Biomater 3 2007 69 76
54. D.W. Hutmacher Mechanical properties and cell cultural response of polycaprolactone scaffolds designed and fabricated via fused deposition modeling J Biomed Mater Res 55 2001 203 216
55. V. Guarino Porosity and mechanical properties relationship in PCL porous scaffolds J Appl Biomater Biomech 5 2007 149 157
56. H. Yu Effect of porosity and pore size on microstructures and mechanical properties of poly-epsilon-caprolactone-hydroxyapatite composites J Biomed Mater Res B Appl Biomater 86 2008 541 547
57. A. Sen Creep in injection molded starch/synthetic polymer blends Mater Sci Eng, A 338 2002 60 69
58. O.S. Odusanya Effect of starch predrying on the mechanical properties of starch/poly(epsilon-caprolactone) composites J Appl Polym Sci 87 2003 877 884
59. D. Preechawong Characterization of starch/poly(epsilon-caprolactone) hybrid foams Polym Test 23 2004 651 657
60. M.E. Gomes Starch-poly(epsilon-caprolactone) and starch-poly(lactic acid) fibre-mesh scaffolds for bone tissue engineering applications: structure, Mechanical properties and degradation behaviour J Tissue Eng Regener Med 2 2008 243 252
61. J.F. Mano Dynamic mechanical properties of hydroxyapatite-reinforced and porous starch-based degradable biomaterials J Mater Sci: Mater Med 10 1999 857 862
62. J.F. Mano Effects of moisture and degradation time over the mechanical dynamical performance of starch-based biomaterials J Appl Polym Sci 78 2000 2345 2357
63. I. Espigares New partially degradable and bioactive acrylic bone cements based on starch blends and ceramic fillers Biomaterials 23 2002 1883 1895
64. J.F. Mano, and R.L. Reis Viscoelastic monitoring of starch-based biomaterials in simulated physiological conditions Mater Sci Eng, A 370 2004 321 325
65. S. Ghosh Dynamic mechanical behavior of starch-based scaffolds in dry and physiologically simulated conditions: effect of porosity and pore size Acta Biomater 4 2008 950 959
66. R.A. Sousa Mechanical performance of starch based bioactive composite biomaterials molded with preferred orientation Polym Eng Sci 42 2002 1032 1045
67. J.F. Mano Thermal properties of thermoplastic starch/synthetic polymer blends with potential biomedical applicability J Mater Sci: Mater Med 14 2003 127 135
68. C. Elvira Starch-based biodegradable hydrogels with potential biomedical applications as drug delivery systems Biomaterials 23 2002 1955 1966
69. P.M. Buechner A broadband viscoelastic spectroscopic study of bovine bone: implications for fluid flow Ann Biomed Eng 29 2001 719 728
70. S.H. Hsu Evaluation of the growth of chondrocytes and osteoblasts seeded into precision scaffolds fabricated by fused deposition manufacturing J Biomed Mater Res B Appl Biomater 80 2007 519 527
71. D.J. Mooney, and R.S. Langer Engineering biomaterials for tissue engineering The 10-100 micron size scale J.D. Bronzino, The biomedical engineering handbook Second ed. 2000 CRC Press Boca Raton, FL
72. V. Karageorgiou, and D. Kaplan Porosity of 3D biomaterial scaffolds and osteogenesis Biomaterials 26 2005 5474 5491
73. L. Uebersax Effect of scaffold design on bone morphology in vitro Tissue Eng 12 2006 3417 3429
74. D. Wendt Oscillating perfusion of cell suspensions through three-dimensional scaffolds enhances cell seeding efficiency and uniformity Biotechnol Bioeng 84 2003 205 214
75. D.J. Du Oscillatory perfusion seeding and culturing of osteoblast-like cells on porous beta-tricalcium phosphate scaffolds J Biomed Mater Res, Part A 86 2008 796 803