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Volumn 7, Issue 1, 2010, Pages 42-47

Neuregulin signaling and heart failure

Author keywords

Heart failure; NRG 1; Signaling

Indexed keywords

ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE; CARDIAC MYOSIN; EPIDERMAL GROWTH FACTOR RECEPTOR; FOCAL ADHESION KINASE; MYOSIN LIGHT CHAIN KINASE; NEU DIFFERENTIATION FACTOR; PLACEBO; TRASTUZUMAB;

EID: 77949272136     PISSN: 15469530     EISSN: 15469549     Source Type: Journal    
DOI: 10.1007/s11897-010-0003-y     Document Type: Review
Times cited : (28)

References (53)
  • 1
    • 34247863773 scopus 로고    scopus 로고
    • The neuregulin-I/ErbB signaling system in development and disease
    • 10.1007/978-3-540-37107-6-1 17432114
    • S Britsch 2007 The neuregulin-I/ErbB signaling system in development and disease Adv Anat Embryol Cell Biol 190 1 65 10.1007/978-3-540-37107-6-1 17432114
    • (2007) Adv Anat Embryol Cell Biol , vol.190 , pp. 1-65
    • Britsch, S.1
  • 2
    • 0030830869 scopus 로고    scopus 로고
    • Isoform-specific expression and function of neuregulin
    • 1:CAS:528:DyaK2sXmvVWgsb4%3D 9342050
    • D Meyer T Yamaai A Garratt, et al. 1997 Isoform-specific expression and function of neuregulin Development 124 3575 3586 1:CAS:528:DyaK2sXmvVWgsb4%3D 9342050
    • (1997) Development , vol.124 , pp. 3575-3586
    • Meyer, D.1    Yamaai, T.2    Garratt, A.3
  • 3
    • 0037429649 scopus 로고    scopus 로고
    • Neuregulins: Functions, forms, and signaling strategies
    • DOI 10.1016/S0014-4827(02)00102-7
    • DL Falls 2003 Neuregulins: functions, forms, and signaling strategies Exp Cell Res 284 14 30 10.1016/S0014-4827(02)00102-7 1:CAS:528:DC%2BD3sXitVyltr8%3D 12648463 (Pubitemid 36335807)
    • (2003) Experimental Cell Research , vol.284 , Issue.1 , pp. 14-30
    • Falls, D.L.1
  • 4
    • 33847718214 scopus 로고    scopus 로고
    • The EGF receptor family: Spearheading a merger of signaling and therapeutics
    • DOI 10.1016/j.ceb.2007.02.008, PII S0955067407000221
    • EM Bublil Y Yarden 2007 The EGF receptor family: spearheading a merger of signaling and therapeutics Curr Opin Cell Biol 19 124 134 10.1016/j.ceb.2007. 02.008 1:CAS:528:DC%2BD2sXjt1Slu7w%3D 17314037 (Pubitemid 46386405)
    • (2007) Current Opinion in Cell Biology , vol.19 , Issue.2 , pp. 124-134
    • Bublil, E.M.1    Yarden, Y.2
  • 5
    • 62649116580 scopus 로고    scopus 로고
    • The role of Neuregulin-1beta/ErbB signaling in the heart
    • This article reviews recent advances in understanding the role of NRG-1 in the cardiac development and maintenance of heart function
    • • Pentassuglia L, Sawyer DB: The role of Neuregulin-1beta/ErbB signaling in the heart. Exp Cell Res 2009, 315:627-637. This article reviews recent advances in understanding the role of NRG-1 in the cardiac development and maintenance of heart function.
    • (2009) Exp Cell Res , vol.315 , pp. 627-637
    • Pentassuglia, L.1    Sawyer, D.B.2
  • 6
    • 0028827104 scopus 로고
    • Multiple essential functions of neuregulin in development
    • 10.1038/378386a0 1:CAS:528:DyaK2MXps1ams7o%3D 7477375
    • D Meyer C Birchmeier 1995 Multiple essential functions of neuregulin in development Nature 378 386 390 10.1038/378386a0 1:CAS:528:DyaK2MXps1ams7o%3D 7477375
    • (1995) Nature , vol.378 , pp. 386-390
    • Meyer, D.1    Birchmeier, C.2
  • 7
    • 0028785406 scopus 로고
    • Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor
    • 10.1038/378390a0 1:CAS:528:DyaK2MXps1ams7s%3D 7477376
    • M Gassmann F Casagranda D Orioli, et al. 1995 Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor Nature 378 390 394 10.1038/378390a0 1:CAS:528:DyaK2MXps1ams7s%3D 7477376
    • (1995) Nature , vol.378 , pp. 390-394
    • Gassmann, M.1    Casagranda, F.2    Orioli, D.3
  • 8
    • 0028884413 scopus 로고
    • Requirement for neuregulin receptor erbB2 in neural and cardiac development
    • 10.1038/378394a0 1:CAS:528:DyaK2MXps1ams7g%3D 7477377
    • KF Lee H Simon H Chen, et al. 1995 Requirement for neuregulin receptor erbB2 in neural and cardiac development Nature 378 394 398 10.1038/378394a0 1:CAS:528:DyaK2MXps1ams7g%3D 7477377
    • (1995) Nature , vol.378 , pp. 394-398
    • Lee, K.F.1    Simon, H.2    Chen, H.3
  • 11
    • 0032562770 scopus 로고    scopus 로고
    • Neuregulins promote survival and growth of cardiac myocytes: Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes
    • DOI 10.1074/jbc.273.17.10261
    • YY Zhao DR Sawyer RR Baliga, et al. 1998 Neuregulins promote survival and growth of cardiac myocytes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes J Biol Chem 273 10261 10269 10.1074/jbc.273.17.10261 1:CAS:528:DyaK1cXivFKntro%3D 9553078 (Pubitemid 28227629)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.17 , pp. 10261-10269
    • Zhao, Y.-Y.1    Sawyer, D.R.2    Baliga, R.R.3    Opel, D.J.4    Han, X.5    Marchionni, M.A.6    Kelly, R.A.7
  • 13
    • 67650569135 scopus 로고    scopus 로고
    • Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury
    • This study first reported on NRG-1-induced proliferation of differentiated cardiomyocytes and further emphasized the therapeutic effects of NRG-1 on ischemic heart failure
    • •• Bersell K, Arab S, Haring B, Kühn B: Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury. Cell 2009, 138: 257-270. This study first reported on NRG-1-induced proliferation of differentiated cardiomyocytes and further emphasized the therapeutic effects of NRG-1 on ischemic heart failure.
    • (2009) Cell , vol.138 , pp. 257-270
    • Bersell, K.1    Arab, S.2    Haring, B.3    Kühn, B.4
  • 14
    • 25144465666 scopus 로고    scopus 로고
    • Neuregulin receptors erbB2 and erbB4in failing human myocardium. Depressed expression and attenuated activation
    • DOI 10.1007/s00395-005-0514-4
    • S Rohrbach B Niemann RE Silber J Holtz 2005 Neuregulin receptors erbB2 and erbB4 in failing human myocardium-depressed expression and attenuated activation Basic Res Cardiol 100 240 249 10.1007/s00395-005-0514-4 1:CAS:528:DC%2BD2MXkslKls7s%3D 15685397 (Pubitemid 41348815)
    • (2005) Basic Research in Cardiology , vol.100 , Issue.3 , pp. 240-249
    • Rohrbach, S.1    Niemann, B.2    Silber, R.-E.3    Holtz, J.4
  • 15
    • 34548132413 scopus 로고    scopus 로고
    • Role of neuregulin-1/ErbB signaling in cardiovascular physiology and disease: Implications for therapy of heart failure
    • DOI 10.1161/CIRCULATIONAHA.107.690487, PII 0000301720070821000013
    • K Lemmens K Doggen GW De Keulenaer 2007 Role of neuregulin-1/ErbB signaling in cardiovascular physiology and disease: implications for therapy of heart failure Circulation 116 954 960 10.1161/CIRCULATIONAHA.107.690487 1:CAS:528:DC%2BD2sXovFyhsrk%3D 17709650 (Pubitemid 47300920)
    • (2007) Circulation , vol.116 , Issue.8 , pp. 954-960
    • Lemmens, K.1    Doggen, K.2    De Keulenaer, G.W.3
  • 16
    • 77949261753 scopus 로고    scopus 로고
    • A phase II, randomized, double-blind, multi-center, based on standard therapy, placebo-controlled study of the efficacy and safety of recombinant human neuregulin-1 (rhNRG-1) in patients with chronic heart failure (CHF)
    • (In press). This article provides the first report demonstrating the therapeutic role of NRG-1 for the treatment of chronic heart failure in humans. Recombinant NRG-1 improved the cardiac function of patients with congestive heart failure by increasing left ventricular ejection fraction percentage, and showed a capability of anti-remodeling by decreasing end-systolic volume and end-diastolic volume compared with pretreatment
    • •• Gao R, Zhang J, Cheng L, et al.: A phase II, randomized, double-blind, multi-center, based on standard therapy, placebo-controlled study of the efficacy and safety of recombinant human neuregulin-1 (rhNRG-1) in patients with chronic heart failure (CHF). J Am Coll Cardiol (In press). This article provides the first report demonstrating the therapeutic role of NRG-1 for the treatment of chronic heart failure in humans. Recombinant NRG-1 improved the cardiac function of patients with congestive heart failure by increasing left ventricular ejection fraction percentage, and showed a capability of anti-remodeling by decreasing end-systolic volume and end-diastolic volume compared with pretreatment.
    • J Am Coll Cardiol
    • Gao, R.1    Zhang, J.2    Cheng, L.3
  • 17
    • 0032714208 scopus 로고    scopus 로고
    • NRG-1-induced cardiomyocyte hypertrophy. Role of PI-3-kinase, p70(S6K), and MEK-MAPK-RSK
    • 1:CAS:528:DyaK1MXns1yrtrc%3D 10564160
    • RR Baliga DR Pimental YY Zhao, et al. 1999 NRG-1-induced cardiomyocyte hypertrophy. Role of PI-3-kinase, p70(S6K), and MEK-MAPK-RSK Am J Physiol 277 H2026 H2037 1:CAS:528:DyaK1MXns1yrtrc%3D 10564160
    • (1999) Am J Physiol , vol.277
    • Baliga, R.R.1    Pimental, D.R.2    Zhao, Y.Y.3
  • 20
    • 0035158546 scopus 로고    scopus 로고
    • Focal adhesion kinase and p130Cas mediate both sarcomeric organization and activation of genes associated with cardiac myocyte hypertrophy
    • 11514617
    • B Kovacic-Milivojević F Roediger EA Almeida, et al. 2001 Focal adhesion kinase and p130Cas mediate both sarcomeric organization and activation of genes associated with cardiac myocyte hypertrophy Mol Biol Cell 12 2290 2307 11514617
    • (2001) Mol Biol Cell , vol.12 , pp. 2290-2307
    • Kovacic-Milivojević, B.1    Roediger, F.2    Almeida, E.A.3
  • 21
    • 1642263252 scopus 로고    scopus 로고
    • Restoration of Resting Sarcomere Length after Uniaxial Static Strain Is Regulated by Protein Kinase Cε and Focal Adhesion Kinase
    • DOI 10.1161/01.RES.0000121101.32286.C8
    • H Mansour PP de Tombe AM Samarel B Russell 2004 Restoration of resting sarcomere length after uniaxial static strain is regulated by protein kinase Cepsilon and focal adhesion kinase Circ Res 94 642 649 10.1161/01.RES. 0000121101.32286.C8 1:CAS:528:DC%2BD2cXitVGksrY%3D 14963000 (Pubitemid 38387747)
    • (2004) Circulation Research , vol.94 , Issue.5 , pp. 642-649
    • Mansour, H.1    De Tombe, P.P.2    Samarel, A.M.3    Russell, B.4
  • 22
    • 33746048823 scopus 로고    scopus 로고
    • Neuregulin activates erbB2-dependent src/FAK signaling and cytoskeletal remodeling in isolated adult rat cardiac myocytes
    • DOI 10.1016/j.yjmcc.2006.04.007, PII S0022282806005347
    • Y Kuramochi X Guo DB Sawyer 2006 Neuregulin activates erbB2-dependent src/FAK signaling and cytoskeletal remodeling in isolated adult rat cardiac myocytes J Mol Cell Cardiol 41 228 235 10.1016/j.yjmcc.2006.04.007 1:CAS:528:DC%2BD28XntlGhs74%3D 16769082 (Pubitemid 44080212)
    • (2006) Journal of Molecular and Cellular Cardiology , vol.41 , Issue.2 , pp. 228-235
    • Kuramochi, Y.1    Guo, X.2    Sawyer, D.B.3
  • 23
    • 0037604598 scopus 로고    scopus 로고
    • Focal complex formation in adult cardiomyocytes is accompanied by the activation of β3 integrin and c-Src
    • DOI 10.1016/S0022-2828(03)00112-3
    • CD Willey S Balasubramanian 2003 Rodríguez Rosas MC, et al.: Focal complex formation in adult cardiomyocytes is accompanied by the activation of beta3 integrin and c-Src J Mol Cell Cardiol 35 671 683 10.1016/S0022-2828(03) 00112-3 1:CAS:528:DC%2BD3sXkt1Gkurc%3D 12788385 (Pubitemid 36677451)
    • (2003) Journal of Molecular and Cellular Cardiology , vol.35 , Issue.6 , pp. 671-683
    • Willey, C.D.1    Balasubramanian, S.2    Rodriguez Rosas, M.C.3    Ross, R.S.4    Kuppuswamy, D.5
  • 24
    • 64149113543 scopus 로고    scopus 로고
    • Ablation of ventricular myosin regulatory light chain phosphorylation in mice causes cardiac dysfunction in situ and affects neighboring myofilament protein phosphorylation
    • 10.1074/jbc.M807414200 1:CAS:528:DC%2BD1MXhvVSntr4%3D 19106098
    • SB Scruggs AC Hinken A Thawornkaiwong, et al. 2009 Ablation of ventricular myosin regulatory light chain phosphorylation in mice causes cardiac dysfunction in situ and affects neighboring myofilament protein phosphorylation J Biol Chem 284 5097 5106 10.1074/jbc.M807414200 1:CAS:528:DC%2BD1MXhvVSntr4%3D 19106098
    • (2009) J Biol Chem , vol.284 , pp. 5097-5106
    • Scruggs, S.B.1    Hinken, A.C.2    Thawornkaiwong, A.3
  • 26
    • 0033967571 scopus 로고    scopus 로고
    • Myosin light chain kinase mediates sarcomere organization during cardiac hypertrophy in vitro
    • DOI 10.1038/72287
    • H Aoki J Sadoshima S Izumo 2000 Myosin light chain kinase mediates sarcomere organization during cardiac hypertrophy in vitro Nat Med 6 183 188 10.1038/72287 1:CAS:528:DC%2BD3cXosF2jsg%3D%3D 10655107 (Pubitemid 30082363)
    • (2000) Nature Medicine , vol.6 , Issue.2 , pp. 183-188
    • Aoki, H.1    Sadoshima, J.2    Izumo, S.3
  • 27
    • 34948891653 scopus 로고    scopus 로고
    • A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart
    • This study provided the first report on the identification of cMLCK from human myocardia and further demonstrated that knockdown of cMLCK expression in cardiomyocytes results in immature sarcomere structures
    • • Seguchi O, Takashima S, Yamazaki S, et al.: A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart. J Clin Invest 2007, 117:2812-2824. This study provided the first report on the identification of cMLCK from human myocardia and further demonstrated that knockdown of cMLCK expression in cardiomyocytes results in immature sarcomere structures.
    • (2007) J Clin Invest , vol.117 , pp. 2812-2824
    • Seguchi, O.1    Takashima, S.2    Yamazaki, S.3
  • 28
    • 40949106071 scopus 로고    scopus 로고
    • Identification of cardiac-specific myosin light chain kinase
    • This study reports that Nkx2-5 regulated cMLCK expression and further demonstrates that cMLCK modulate MLC2 phosphorylation, sarcomere organization, and cardiomyocytes contraction
    • • Chan JY, Takeda M, Briggs LE, et al.: Identification of cardiac-specific myosin light chain kinase. Circ Res 2008, 102:571-580. This study reports that Nkx2-5 regulated cMLCK expression and further demonstrates that cMLCK modulate MLC2 phosphorylation, sarcomere organization, and cardiomyocytes contraction.
    • (2008) Circ Res , vol.102 , pp. 571-580
    • Chan, J.Y.1    Takeda, M.2    Briggs, L.E.3
  • 29
    • 55249104563 scopus 로고    scopus 로고
    • Neuregulin-1 promotes cardiomyocyte differentiation of genetically engineered embryonic stem cell clones
    • 1:CAS:528:DC%2BD1cXhtlyqsr7E 18959815
    • Z Wang G Xu Y Wu, et al. 2008 Neuregulin-1 promotes cardiomyocyte differentiation of genetically engineered embryonic stem cell clones BMB Rep 41 699 704 1:CAS:528:DC%2BD1cXhtlyqsr7E 18959815
    • (2008) BMB Rep , vol.41 , pp. 699-704
    • Wang, Z.1    Xu, G.2    Wu, Y.3
  • 30
    • 58549114851 scopus 로고    scopus 로고
    • Neuregulin-1 enhances differentiation of cardiomyocytes from embryonic stem cells
    • 10.1007/s11517-008-0383-2 18712425
    • Z Wang G Xu Y Wu, et al. 2009 Neuregulin-1 enhances differentiation of cardiomyocytes from embryonic stem cells Med Biol Eng Comput 47 41 48 10.1007/s11517-008-0383-2 18712425
    • (2009) Med Biol Eng Comput , vol.47 , pp. 41-48
    • Wang, Z.1    Xu, G.2    Wu, Y.3
  • 31
    • 0037205320 scopus 로고    scopus 로고
    • Cardiomyocyte cell cycle regulation
    • DOI 10.1161/01.RES.0000020201.44772.67
    • KB Pasumarthi LJ Field 2002 Cardiomyocyte cell cycle regulation Circ Res 90 1044 1054 10.1161/01.RES.0000020201.44772.67 1:CAS:528:DC%2BD38XktlSnsLY%3D 12039793 (Pubitemid 34627902)
    • (2002) Circulation Research , vol.90 , Issue.10 , pp. 1044-1054
    • Pasumarthi, K.B.S.1    Field, L.J.2
  • 32
    • 0035160313 scopus 로고    scopus 로고
    • Cardiotoxicity in signal transduction therapeutics: ErbB2 antibodies and the heart
    • 10.1016/S0093-7754(01)90278-7 1:CAS:528:DC%2BD3MXpt1Wgu7w%3D 11706392
    • JW Schneider AY Chang TP Rocco 2001 Cardiotoxicity in signal transduction therapeutics: erbB2 antibodies and the heart Semin Oncol 28 18 26 10.1016/S0093-7754(01)90278-7 1:CAS:528:DC%2BD3MXpt1Wgu7w%3D 11706392
    • (2001) Semin Oncol , vol.28 , pp. 18-26
    • Schneider, J.W.1    Chang, A.Y.2    Rocco, T.P.3
  • 33
    • 0742305448 scopus 로고    scopus 로고
    • Myocyte contractile activity modulates norepinephrine cytotoxicity and survival effects of neuregulin-1beta
    • 10.1152/ajpcell.00312.2003 1:CAS:528:DC%2BD2cXhsFarsr8%3D 14522821
    • Y Kuramochi CC Lim X Guo, et al. 2004 Myocyte contractile activity modulates norepinephrine cytotoxicity and survival effects of neuregulin-1beta Am J Physiol Cell Physiol 286 C222 C229 10.1152/ajpcell.00312.2003 1:CAS:528:DC%2BD2cXhsFarsr8%3D 14522821
    • (2004) Am J Physiol Cell Physiol , vol.286
    • Kuramochi, Y.1    Lim, C.C.2    Guo, X.3
  • 34
    • 4043110498 scopus 로고    scopus 로고
    • Neuregulins regulate cardiac parasympathetic activity: Muscarinic modulation of β-adrenergic activity in myocytes from mice with neuregulin-1 gene deletion
    • DOI 10.1161/01.CIR.0000138109.32748.80
    • K Okoshi M Nakayama X Yan, et al. 2004 Neuregulins regulate cardiac parasympathetic activity: muscarinic modulation of beta-adrenergic activity in myocytes from mice with neuregulin-1 gene deletion Circulation 110 713 717 10.1161/01.CIR.0000138109.32748.80 1:CAS:528:DC%2BD2cXmtFOgsr4%3D 15289373 (Pubitemid 39056271)
    • (2004) Circulation , vol.110 , Issue.6 , pp. 713-717
    • Okoshi, K.1    Nakayama, M.2    Yan, X.3    Okoshi, M.P.4    Schuldt, A.J.T.5    Marchionni, M.A.6    Lorell, B.H.7
  • 36
    • 0034517548 scopus 로고    scopus 로고
    • Intracoronary, adenovirus-mediated Akt gene transfer in heart limits infarct size following ischemia-reperfusion injury in vivo
    • DOI 10.1006/jmcc.2000.1283
    • W Miao Z Luo RN Kitsis K Walsh 2000 Intracoronary, adenovirus-mediated Akt gene transfer in heart limits infarct size following ischemia-reperfusion injury in vivo J Mol Cell Cardiol 32 2397 2402 10.1006/jmcc.2000.1283 1:CAS:528:DC%2BD3cXos1KhsrY%3D 11113015 (Pubitemid 32039789)
    • (2000) Journal of Molecular and Cellular Cardiology , vol.32 , Issue.12 , pp. 2397-2402
    • Miao, W.1    Luo, Z.2    Kitsis, R.N.3    Walsh, K.4
  • 37
    • 0034651983 scopus 로고    scopus 로고
    • Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart
    • 1:CAS:528:DC%2BD3cXhtlGntLs%3D 10673259
    • Y Fujio T Nguyen D Wencker, et al. 2000 Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart Circulation 101 660 667 1:CAS:528:DC%2BD3cXhtlGntLs%3D 10673259
    • (2000) Circulation , vol.101 , pp. 660-667
    • Fujio, Y.1    Nguyen, T.2    Wencker, D.3
  • 41
    • 0028809084 scopus 로고
    • Differential regulation of two types of intracellular calcium release channels during end-stage heart failure
    • 10.1172/JCI117739 1:CAS:528:DyaK2MXjsV2rsbo%3D 7860772
    • LO Go MC Moschella J Watras, et al. 1995 Differential regulation of two types of intracellular calcium release channels during end-stage heart failure J Clin Invest 95 888 894 10.1172/JCI117739 1:CAS:528:DyaK2MXjsV2rsbo%3D 7860772
    • (1995) J Clin Invest , vol.95 , pp. 888-894
    • Go, L.O.1    Moschella, M.C.2    Watras, J.3
  • 43
    • 0037195427 scopus 로고    scopus 로고
    • 2+ release, but normal ryanodine receptors, in canine and human heart failure
    • DOI 10.1161/01.RES.0000043663.08689.05
    • MT Jiang AJ Lokuta EF Farrell, et al. 2002 Abnormal Ca2+ release, but normal ryanodine receptors, in canine and human heart failure Circ Res 91 1015 1022 10.1161/01.RES.0000043663.08689.05 1:CAS:528:DC%2BD38XoslOqt70%3D 12456487 (Pubitemid 35416638)
    • (2002) Circulation Research , vol.91 , Issue.11 , pp. 1015-1022
    • Jiang, M.T.1    Lokuta, A.J.2    Farrell, E.F.3    Wolff, M.R.4    Haworth, R.A.5    Valdivia, H.H.6
  • 44
    • 0026016543 scopus 로고
    • Identification of the major protein phosphatases in mammalian cardiac muscle which dephosphorylate phospholamban
    • 10.1111/j.1432-1033.1991.tb15871.x 1:CAS:528:DyaK3MXitVChsLs%3D 1849481
    • LK MacDougall LR Jones P Cohen 1991 Identification of the major protein phosphatases in mammalian cardiac muscle which dephosphorylate phospholamban Eur J Biochem 196 725 734 10.1111/j.1432-1033.1991.tb15871.x 1:CAS:528: DyaK3MXitVChsLs%3D 1849481
    • (1991) Eur J Biochem , vol.196 , pp. 725-734
    • MacDougall, L.K.1    Jones, L.R.2    Cohen, P.3
  • 45
    • 0026794257 scopus 로고
    • Functional difference between SERCA2a and SERCA2b Ca2+ pumps and their modulation by phospholamban
    • 1:CAS:528:DyaK38Xls1Kjtro%3D 1326945
    • H Verboomen F Wuytack H De Smedt, et al. 1992 Functional difference between SERCA2a and SERCA2b Ca2+ pumps and their modulation by phospholamban Biochem J 286 591 595 1:CAS:528:DyaK38Xls1Kjtro%3D 1326945
    • (1992) Biochem J , vol.286 , pp. 591-595
    • Verboomen, H.1    Wuytack, F.2    De Smedt, H.3
  • 46
    • 0344009618 scopus 로고    scopus 로고
    • Cardiac SR-coupled PP1 activity and expression are increased and inhibitor 1 protein expression is decreased in failing hearts
    • 1:CAS:528:DC%2BD2cXhsVSi 14613911
    • RC Gupta S Mishra S Rastogi, et al. 2003 Cardiac SR-coupled PP1 activity and expression are increased and inhibitor 1 protein expression is decreased in failing hearts Am J Physiol Heart Circ Physiol 285 H2373 H2381 1:CAS:528:DC%2BD2cXhsVSi 14613911
    • (2003) Am J Physiol Heart Circ Physiol , vol.285
    • Gupta, R.C.1    Mishra, S.2    Rastogi, S.3
  • 47
    • 0037365794 scopus 로고    scopus 로고
    • Evidence for protein phosphatase inhibitor-1 playing an amplifier role in beta-adrenergic signaling in cardiac myocytes
    • 1:CAS:528:DC%2BD3sXitFaqsbc%3D 12514122
    • A El-Armouche T Rau O Zolk, et al. 2003 Evidence for protein phosphatase inhibitor-1 playing an amplifier role in beta-adrenergic signaling in cardiac myocytes FASEB J 17 437 439 1:CAS:528:DC%2BD3sXitFaqsbc%3D 12514122
    • (2003) FASEB J , vol.17 , pp. 437-439
    • El-Armouche, A.1    Rau, T.2    Zolk, O.3
  • 48
    • 1642458136 scopus 로고    scopus 로고
    • Neuregulin-1 Induces a Negative Inotropic Effect in Cardiac Muscle: Role of Nitric Oxide Synthase
    • DOI 10.1161/01.CIR.0000114521.88547.5E
    • K Lemmens P Fransen SU Sys, et al. 2004 Neuregulin-1 induces a negative inotropic effect in cardiac muscle: role of nitric oxide synthase Circulation 109 324 326 10.1161/01.CIR.0000114521.88547.5E 1:CAS:528:DC%2BD2cXks1Citw%3D%3D 14732742 (Pubitemid 38133898)
    • (2004) Circulation , vol.109 , Issue.3 , pp. 324-326
    • Lemmens, K.1    Fransen, P.2    Sys, S.U.3    Brutsaert, D.L.4    De Keulenaer, G.W.5
  • 49
    • 33644546368 scopus 로고    scopus 로고
    • Tumor endothelial cells express epidermal growth factor receptor (EGFR) but not ErbB3 and are responsive to EGF and to EGFR kinase inhibitors
    • DOI 10.1158/0008-5472.CAN-05-3387
    • DN Amin K Hida DR Bielenberg M Klagsbrun 2006 Tumor endothelial cells express epidermal growth factor receptor (EGFR) but not ErbB3 and are responsive to EGF and to EGFR kinase inhibitors Cancer Res 66 2173 2180 10.1158/0008-5472.CAN-05-3387 1:CAS:528:DC%2BD28XhsFalsrk%3D 16489018 (Pubitemid 43294927)
    • (2006) Cancer Research , vol.66 , Issue.4 , pp. 2173-2180
    • Amin, D.N.1    Hida, K.2    Bielenberg, D.R.3    Klagsbrun, M.4
  • 53
    • 70149110196 scopus 로고    scopus 로고
    • Preventive effects of heregulin-beta1 on macrophage foam cell formation and atherosclerosis
    • 10.1161/CIRCRESAHA.109.193870 1:CAS:528:DC%2BD1MXhtVekt7%2FJ 19644050
    • G Xu T Watanabe Y Iso, et al. 2009 Preventive effects of heregulin-beta1 on macrophage foam cell formation and atherosclerosis Circ Res 105 500 510 10.1161/CIRCRESAHA.109.193870 1:CAS:528:DC%2BD1MXhtVekt7%2FJ 19644050
    • (2009) Circ Res , vol.105 , pp. 500-510
    • Xu, G.1    Watanabe, T.2    Iso, Y.3


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