Lentiviral-mediated RNA interference against TGF-beta receptor type II in renal epithelial and fibroblast cell populations in vitro demonstrates regulated renal fibrogenesis that is more efficient than a nonlentiviral vector

Journal of Biomedicine and Biotechnology

Volumn 2010, Issue , 2010, Pages

  Wei, Ming Q ^e   Yang, Tao ^a   Zhang, Bing ^b,c,d   Pat, Betty K ^a   Gobe, Glenda C ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF WESTERN SYDNEY   (Australia)

^c DEPARTMENT OF EMPLOYMENT ECONOMIC DEVELOPMENT AND INNOVATION   (Australia)

^d University of Alabama at Birmingham   (United States)

^e GRIFFITH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BIOLOGICAL MARKER; COLLAGEN TYPE 3; ENHANCED GREEN FLUORESCENT PROTEIN; FIBRONECTIN; LENTIVIRUS VECTOR; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; ACTIN; GREEN FLUORESCENT PROTEIN; PROTEIN SERINE THREONINE KINASE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA TYPE II RECEPTOR; TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL POPULATION; CELL STRAIN HEK293; COMPETITIVE INHIBITION; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; EXTRACELLULAR MATRIX; FIBROBLAST; FIBROGENESIS; FLUORESCENCE ACTIVATED CELL SORTING; FLUORESCENCE MICROSCOPY; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNOFLUORESCENCE; IN VITRO STUDY; INTERMETHOD COMPARISON; KIDNEY EPITHELIUM; KIDNEY FIBROSIS; KIDNEY TUBULE CELL; LENTIVIRINAE; NONHUMAN; POSTTRANSCRIPTIONAL GENE SILENCING; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; RECOMBINANT PLASMID; REGULATORY MECHANISM; RNA INTERFERENCE; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; WESTERN BLOTTING; ANIMAL; EPITHELIUM CELL; FIBROSIS; GENE REPRESSION; GENE VECTOR; GENETIC TRANSCRIPTION; GENETICS; KIDNEY; METABOLISM; NUCLEOTIDE SEQUENCE; PATHOLOGY;

ACTINS; ANIMALS; BASE SEQUENCE; EPITHELIAL CELLS; FIBROBLASTS; FIBROSIS; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HEK293 CELLS; HUMANS; KIDNEY; LENTIVIRUS; PROTEIN-SERINE-THREONINE KINASES; RATS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RNA INTERFERENCE; SUPPRESSION, GENETIC; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 79251592246     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2010/859240     Document Type: Article

References (32)

1. Zeisberg M., Strutz F., Mller G. A., Renal fibrosis: an update Current Opinion in Nephrology and Hypertension 2001 10 3 315 320
2. Eddy A. A., Can renal fibrosis be reversed? Pediatric Nephrology 2005 20 10 1369 1375
3. Eddy A. A., Progression in chronic kidney disease Advances in Chronic Kidney Disease 2005 12 353 365
4. Liu Y., Renal fibrosis: new insights into the pathogenesis and therapeutics Kidney International 2006 69 2 213 217
5. Kushibiki T., Nagata-Nakajima N., Sugai M., Shimizu A., Tabata Y., Delivery of plasmid DNA expressing small interference RNA for TGF- type II receptor by cationized gelatin to prevent interstitial renal fibrosis Journal of Controlled Release 2005 105 3 318 331
6. Huang X. R., Chung A. C. K., Wang X. J., Lai K. N., Lan H. Y., Mice overexpressing latent TGF- 1 are protected against renal fibrosis in obstructive kidney disease American Journal of Physiology 2008 295 1 F118 F127
7. Attisano A. L., Wrana J. L., Lopez-Casillas F., Massague J., TGF- receptors and actions Biochimica et Biophysica Acta 1994 1222 1 71 80
8. Wrana J. L., Attisano L., Wieser R., Ventura F., Massagu J., Mechanism of activation of the TGF- receptor Nature 1994 370 6488 341 347
9. Nakao A., Imamura T., Souchelnytskyi S., Kawabata M., Ishisaki A., Oeda E., Tamaki K., Hanai J.-I., Heldin C.-H., Miyazono K., Ten Dijke P., TGF- receptor-mediated signalling through Smad2, Smad3 and Smad4 EMBO Journal 1997 16 17 5353 5362
10. Lavoie P., Robitaille G., Agharazii M., Ledbetter S., Lebel M., Larivire R., Neutralization of transforming growth factor- attenuates hypertension and prevents renal injury in uremic rats Journal of Hypertension 2005 23 10 1895 1903
11. Benigni A., Zoja C., Corna D., Zatelli C., Conti S., Campana M., Gagliardini E., Rottoli D., Zanchi C., Abbate M., Ledbetter S., Remuzzi G., Add-on anti-TGF- antibody to ACE inhibitor arrests progressive diabetic nephropathy in the rat Journal of the American Society of Nephrology 2003 14 7 1816 1824
12. Border W. A., Noble N. A., Yamamoto T., Harper J. R., Yamaguchi Y., Pierschbacher M. D., Ruoslahti E., Natural inhibitor of transforming growth factor- protects against scarring in experimental kidney disease Nature 1992 360 6402 361 364
13. Wu F., Yao H., Bader A., Dong F., Zhu F., Wu N., Wang B., Li H., Brochmeyer N. H., Altmeyer P., Decorin gene transfer inhibited the expression of TGF 1 and ECM in rat mesangial cells European Journal of Medical Research 2007 12 8 360 368
14. Isaka Y., Akagi Y., Ando Y., Tsujie M., Sudo T., Ohno N., Border W. A., Noble N. A., Kaneda Y., Hori M., Imai E., Gene therapy by transforming growth factor- receptor-IgG Fc chimera suppressed extracellular matrix accumulation in experimental glomerulonephritis Kidney International 1999 55 2 465 475
15. Haviv Y. S., Takayama K., Nagi P. A., Tousson A., Cook W., Wang M., Lam J. T., Naito S., Lei X., Carey D. E., Curiel D. T., Modulation of renal glomerular disease using remote delivery of adenoviral-encoded soluble type II TGF- receptor fusion molecule Journal of Gene Medicine 2003 5 10 839 851
16. Nakamuta M., Morizono S., Tsuruta S., Kohjima M., Kotoh K., Enjoji M., Remote delivery and expression of soluble type II TGF-beta receptor in muscle prevents hepatic fibrosis in rats International Journal of Molecular Medicine 2005 16 1 59 64
17. Kushibiki T., Nagata-Nakajima N., Sugai M., Shimizu A., Tabata Y., Targeting of plasmid DNA to renal interstitial fibroblasts by cationized gelatin Biological and Pharmaceutical Bulletin 2005 28 10 2007 2010
18. Gressner A. M., Weiskirchen R., The tightrope of therapeutic suppression of active transforming growth factor- : high enough to fall deeply? Journal of Hepatology 2003 39 5 856 859
19. Naldini L., Blomer U., Gage F. H., Trono D., Verma I. M., Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector Proceedings of the National Academy of Sciences of the United States of America 1996 93 21 11382 11388
20. Sioud M., Targeted delivery of antisense oligonucleotides and siRNAs into mammalian cells Methods in Molecular Biology 2009 487 61 82
21. Gusella G. L., Fedorova E., Hanss B., Marras D., Klotman M. E., Klotman P. E., Lentiviral gene transduction of kidney Human Gene Therapy 2002 13 3 407 414
22. Lin H. Y., Wang X.-F., Ng-Eaton E., Weinberg R. A., Lodish H. F., Expression cloning of the TGF- type II receptor, a functional transmembrane serine/threonine kinase Cell 1992 68 4 775 785. Erratum in Cell, vol. 70, no. 6, pp. 1069, 1992
23. Yu J.-Y., DeRuiter S. L., Turner D. L., RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells Proceedings of the National Academy of Sciences of the United States of America 2002 99 9 6047 6052
24. Zeisberg M., Maeshima Y., Mosterman B., Kalluri R., Renal fibrosis: extracellular matrix microenvironment regulates migratory behavior of activated tubular epithelial cells American Journal of Pathology 2002 160 6 2001 2008
25. Hwang M., Kim H.-J., Noh H.-J., Chang Y.-C., Chae Y.-M., Kim K.-H., Jeon J.-P., Lee T.-S., Oh H.-K., Lee Y.-S., Park K.-K., TGF- 1 siRNA suppresses the tubulointerstitial fibrosis in the kidney of ureteral obstruction Experimental and Molecular Pathology 2006 81 1 48 54
26. Brummelkamp T. R., Bernards R., Agami R., A system for stable expression of short interfering RNAs in mammalian cells Science 2002 296 5567 550 553
27. Donz O., Picard D., RNA interference in mammalian cells using siRNAs synthesized with T7 RNA polymerase Nucleic Acids Research 2002 30 10 e46
28. Elbashir S. M., Lendeckel W., Tuschl T., RNA interference is mediated by 21- and 22-nucleotide RNAs Genes and Development 2001 15 2 188 200
29. Zhang B., Xia H. Q., Cleghorn G., Gobe G., West M., Wei M. Q., A highly efficient and consistent method for harvesting large volumes of high-titre lentiviral vectors Gene Therapy 2001 8 22 1745 1751
30. Abbas-Terki T., Blanco-Bose W., Dglon N., Pralong W., Aebischer P., Lentiviral-mediated RNA interference Human Gene Therapy 2002 13 18 2197 2201
31. Eikmans M., Baelde J. J., de Heer E., Bruijn J. A., ECM homeostasis in renal diseases: a genomic approach Journal of Pathology 2003 200 4 526 536
32. Iwano M., Neilson E. G., Mechanisms of tubulointerstitial fibrosis Current Opinion in Nephrology and Hypertension 2004 13 3 279 284