Candidate pathway polymorphisms in one-carbon metabolism and risk of rectal tumor mutations

International Journal of Molecular Epidemiology and Genetics

Volumn 2, Issue 1, 2011, Pages 1-8

  Curtin, Karen ^a   Ulrich, Cornelia M ^b,c   Samowitz, Wade S ^d   Wolff, Roger K ^a   Duggan, David J ^e   Makar, Karen W ^b   Caan, Bette J ^f   Slattery, Martha L ^a  

^a UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

^b USA   (United States)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^d UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^e TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

^f KAISER PERMANENTE   (United States)

Author keywords

CpG island methylator phenotype (CIMP); Folate mediated one carbon metabolism (FOCM); KRAS2; Rectal cancer; Single nucleotide polymorphism; TP53

Indexed keywords

5 METHYLTETRAHYDROFOLATE HOMOCYSTEINE METHYLTRANSFERASE; 5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); DNA (CYTOSINE 5) METHYLTRANSFERASE; GLYCINE HYDROXYMETHYLTRANSFERASE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE; PROTEIN P53; REDUCED FOLATE CARRIER; THYMINE DNA GLYCOSYLASE;

ADULT; AGED; ARTICLE; CANCER RISK; CARBON METABOLISM; CONTROLLED STUDY; CPG ISLAND; GENE MUTATION; GENETIC VARIABILITY; HOMOZYGOSITY; HUMAN; HUMAN TISSUE; ONCOGENE K RAS; PHENOTYPE; RECTUM TUMOR; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 79251552584     PISSN: None     EISSN: 19481756     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Jass JR, Whitehall VL, Young J and Leggett BA. Emerging concepts in colorectal neoplasia. Gas-troenterology 2002; 123: 862-876.
2. Slattery ML, Curtin K, Wolff RK, Boucher KM, Sweeney C, Edwards S, Caan BJ and Samowitz W. A comparison of colon and rectal somatic DNA alterations. Dis Colon Rectum 2009; 52: 1304-1311.
3. Issa JP, Shen L and Toyota M. CIMP, at last. Gas-troenterology 2005; 129: 1121-1124.
4. Samowitz WS. The CpG island methylator pheno-type in colorectal cancer. J Mol Diagn 2007; 9: 281-283.
5. Samowitz WS, Albertsen H, Herrick J, Levin TR, Sweeney C, Murtaugh MA, Wolff RK and Slattery ML. Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer. Gastroenterology 2005; 129: 837-845.
6. Ogino S, Nosho K, Kirkner GJ, Kawasaki T, Mey-erhardt JA, Loda M, Giovannucci EL and Fuchs CS. CpG island methylator phenotype, microsa-tellite instability, BRAF mutation and clinical outcome in colon cancer. Gut 2009; 58: 90-96.
7. Laird PW and Jaenisch R. The role of DNA methy-lation in cancer genetic and epigenetics. Annu Rev Genet 1996; 30: 441-464.
8. Ulrich CM. Nutrigenetics in cancer research--folate metabolism and colorectal cancer. J Nutr 2005; 135: 2698-2702.
9. James SJ, Melnyk S, Pogribna M, Pogribny IP and Caudill MA. Elevation in S-adenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology. J Nutr 2002; 132: 2361S-2366S.
10. Curtin K, Bigler J, Slattery ML, Caan B, Potter JD and Ulrich CM. MTHFR C677T and A1298C polymorphisms: diet, estrogen, and risk of colon cancer. Cancer Epidemiol Biomarkers Prev 2004; 13: 285-292.
11. Murtaugh MA, Curtin K, Sweeney C, Wolff RK, Holubkov R, Caan BJ and Slattery ML. Dietary intake of folate and co-factors in folate metabolism, MTHFR polymorphisms, and reduced rectal cancer. Cancer Causes Control 2007; 18: 153-163.
12. Ulrich CM, Curtin K, Potter JD, Bigler J, Caan B and Slattery ML. Polymorphisms in the reduced folate carrier, thymidylate synthase, or methion-ine synthase and risk of colon cancer. Cancer Epidemiol Biomarkers Prev 2005; 14: 2509-2516.
13. Little J, Sharp L, Duthie S and Narayanan S. Colon cancer and genetic variation in folate metabolism: the clinical bottom line. J Nutr 2003; 133: 3758S-3766S.
14. Ulrich CM. Folate and cancer prevention--where to next? Counterpoint. Cancer Epidemiol Bio-markers Prev 2008; 17: 2226-2230.
15. Ulrich CM, Reed MC and Nijhout HF. Modeling folate, one-carbon metabolism, and DNA methy-lation. Nutr Rev 2008; 66 Suppl 1: S27-30.
16. Curtin K, Slattery ML, Ulrich CM, Bigler J, Levin TR, Wolff RK, Albertsen H, Potter JD and Samowitz WS. Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet. Carcino-genesis 2007; 28: 1672-1679.
17. Oyama K, Kawakami K, Maeda K, Ishiguro K and Watanabe G. The association between methyl-enetetrahydrofolate reductase polymorphism and promoter methylation in proximal colon cancer. Anticancer Res 2004; 24: 649-654.
18. Ogino S, Hazra A, Tranah GJ, Kirkner GJ, Kawasaki T, Nosho K, Ohnishi M, Suemoto Y, Meyer-hardt JA, Hunter DJ and Fuchs CS. MGMT germ-line polymorphism is associated with somatic MGMT promoter methylation and gene silencing in colorectal cancer. Carcinogenesis 2007; 28: 1985-1990.
19. Ulrich CM, Curtin K, Samowitz W, Bigler J, Potter JD, Caan B and Slattery ML. MTHFR variants reduce the risk of G:C->A:T transition mutations within the p53 tumor suppressor gene in colon tumors. J Nutr 2005; 135: 2462-2467.
20. Ulrich C. Genetic variability in folate-mediated one-carbon metabolism and cancer risk. In: Choi SW, Friso S, editors. Nutrient-Gene Interactions in Cancer. Boca Raton, FL: Taylor & Francis Group; 2006. p. 75-91.
21. Curtin K, Samowitz W, Ulrich C, Wolff R, Herrick J, Caan B and Slattery M. Nutrients in folate-mediated, one-carbon metabolism and risk of rectal tumors in men and women. Nutr Cancer 2011; 63: in press.
22. Slattery ML, Edwards S, Curtin K, Schaffer D and Neuhausen S. Associations between smoking, passive smoking, GSTM-1, NAT2, and rectal cancer. Cancer Epidemiol Biomarkers Prev 2003; 12: 882-889.
23. Slattery ML, Wolff RK, Herrick J, Caan BJ and Samowitz W. Tumor markers and rectal cancer: support for an inflammation-related pathway. Int J Cancer 2009; 125: 1698-1704.
24. Edwards S, Slattery ML, Mori M, Berry TD, Caan BJ, Palmer P and Potter JD. Objective system for interviewer performance evaluation for use in epidemiologic studies. Am J Epidemiol 1994; 140: 1020-1028.
25. Slattery ML, Potter J, Caan B, Edwards S, Coates A, Ma KN and Berry TD. Energy balance and colon cancer--beyond physical activity. Cancer Res 1997; 57: 75-80.
26. Liu K, Slattery M, Jacobs D, Jr., Cutter G, McDonald A, Van Horn L, Hilner JE, Caan B, Bragg C, Dyer A and et al. A study of the reliability and comparative validity of the cardia dietary history. Ethn Dis 1994; 4: 15-27.
27. Slattery ML, Caan BJ, Duncan D, Berry TD, Coates A and Kerber R. A computerized diet history questionnaire for epidemiologic studies. J Am Diet Assoc 1994; 94: 761-766.
28. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJ, den Heijer M, Kluijtmans LA, van den Heuvel LP and et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahy-drofolate reductase. Nat Genet 1995; 10: 111-113.
29. van der Put NM, Gabreels F, Stevens EM, Smeit-ink JA, Trijbels FJ, Eskes TK, van den Heuvel LP and Blom HJ. A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects? Am J Hum Genet 1998; 62: 1044-1051.
30. Spirio LN, Samowitz W, Robertson J, Robertson M, Burt RW, Leppert M and White R. Alleles of APC modulate the frequency and classes of mutations that lead to colon polyps. Nat Genet 1998; 20: 385-388.
31. Burton P, Gurrin L and Sly P. Extending the simple linear regression model to account for correlated responses: an introduction to generalized estimating equations and multi-level mixed modelling. Stat Med 1998; 17: 1261-1291.
32. Kuss O and McLerran D. A note on the estimation of the multinomial logistic model with correlated responses in SAS. Comput Methods Programs Biomed 2007; 87: 262-269.
33. Slattery ML, Curtin K, Sweeney C, Levin TR, Potter J, Wolff RK, Albertsen H and Samowitz WS. Diet and lifestyle factor associations with CpG island methylator phenotype and BRAF mutations in colon cancer. Int J Cancer 2007; 120: 656-663.
34. Slattery ML, Curtin KP, Edwards SL and Schaffer DM. Plant foods, fiber, and rectal cancer. Am J Clin Nutr 2004; 79: 274-281.
35. Slattery ML, Sweeney C, Murtaugh M, Ma KN, Wolff RK, Potter JD, Caan BJ and Samowitz W. Associations between ERalpha, ERbeta, and AR genotypes and colon and rectal cancer. Cancer Epidemiol Biomarkers Prev 2005; 14: 2936-2942.
36. Slattery ML, Murtaugh M, Caan B, Ma KN, Neu-hausen S and Samowitz W. Energy balance, insulin-related genes and risk of colon and rectal cancer. Int J Cancer 2005; 115: 148-154.
37. Slattery ML, Neuhausen SL, Hoffman M, Caan B, Curtin K, Ma KN and Samowitz W. Dietary calcium, vitamin D, VDR genotypes and colorectal cancer. Int J Cancer 2004; 111: 750-756.
38. Steck SE, Keku T, Butler LM, Galanko J, Massa B, Millikan RC and Sandler RS. Polymorphisms in methionine synthase, methionine synthase re-ductase and serine hydroxymethyltransferase, folate and alcohol intake, and colon cancer risk. J Nutrigenet Nutrigenomics 2008; 1: 196-204.
39. Levine AJ, Figueiredo JC, Lee W, Conti DV, Kennedy K, Duggan DJ, Poynter JN, Campbell PT, Newcomb P, Martinez ME, Hopper JL, Le Mar-chand L, Baron JA, Limburg PJ, Ulrich CM and Haile RW. A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk. Cancer Epidemiol Bio-markers Prev 2010; 19: 1812-1821.