CD8+ cells enhance resistance to pulmonary serotype 3 Streptococcus pneumoniae infection in mice

Journal of Immunology

Volumn 186, Issue 1, 2011, Pages 432-442

  Weber, Sarah E ^a   Tian, Haijun ^a   Pirofski, Liise Anne ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CYTOKINE; CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT; GAMMA INTERFERON; INTERLEUKIN 17; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PERFORIN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL IMMUNITY; BACTERIAL SURVIVAL; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL SURVIVAL; CELLULAR RECRUITMENT; CONTROLLED STUDY; FLUORESCENCE ACTIVATED CELL SORTING; IMMUNOMODULATION; LETHALITY; MOUSE; NEUTROPHIL; NONHUMAN; PHENOTYPE; PNEUMOCOCCAL INFECTION; PNEUMONIA; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SEROTYPE; STREPTOCOCCUS INFECTION; STREPTOCOCCUS PNEUMONIAE; T CELL DEPLETION; TH17 CELL;

ANIMALS; ANTIGENS, CD8; CD8-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; IMMUNITY, INNATE; IMMUNOPHENOTYPING; LUNG; LYMPHOCYTE DEPLETION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; PNEUMONIA, PNEUMOCOCCAL; SEROTYPING; STREPTOCOCCUS PNEUMONIAE;

EID: 79251546707     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1001963     Document Type: Article

References (52)

1. Grijalva, C. G., J. P. Nuorti, P. G. Arbogast, S. W. Martin, K. M. Edwards, and M. R. Griffin. 2007. Decline in pneumonia admissions after routine childhood immunisation with pneumococcal conjugate vaccine in the USA: a time-series analysis. Lancet 369: 1179-1186.
2. Albrich, W. C., W. Baughman, B. Schmotzer, and M. M. Farley. 2007. Changing characteristics of invasive pneumococcal disease in Metropolitan Atlanta, Georgia, after introduction of a 7-valent pneumococcal conjugate vaccine. Clin. Infect. Dis. 44: 1569-1576.
3. Hicks, L. A., L. H. Harrison, B. Flannery, J. L. Hadler, W. Schaffner, A. S. Craig, D. Jackson, A. Thomas, B. Beall, R. Lynfield, et al. 2007. Incidence of pneumococcal disease due to non-pneumococcal conjugate vaccine (PCV7) serotypes in the United States during the era of widespread PCV7 vaccination, 1998-2004. J. Infect. Dis. 196: 1346-1354.
4. Melegaro, A., and W. J. Edmunds. 2004. The 23-valent pneumococcal polysaccharide vaccine. Part I. Efficacy of PPV in the elderly: a comparison of meta-analyses. Eur. J. Epidemiol. 19: 353-363.
5. Martens, P., S. W. Worm, B. Lundgren, H. B. Konradsen, and T. Benfield. 2004. Serotype-specific mortality from invasive Streptococcus pneumoniae disease revisited. BMC Infect. Dis. 4: 21.
6. Byington, C. L., K. Korgenski, J. Daly, K. Ampofo, A. Pavia, and E. O. Mason. 2006. Impact of the pneumococcal conjugate vaccine on pneumococcal parapneumonic empyema. Pediatr. Infect. Dis. J. 25: 250-254.
7. Poolman, J., P. Kriz, C. Feron, E. Di-Paolo, I. Henckaerts, A. Miseur, D. Wauters, R. Prymula, and L. Schuerman. 2009. Pneumococcal serotype 3 otitis media, limited effect of polysaccharide conjugate immunisation and strain characteristics. Vaccine 27: 3213-3222.
8. Wong, P., and E. G. Pamer. 2003. CD8 T cell responses to infectious pathogens. Annu. Rev. Immunol. 21: 29-70.
9. + T cells in vivo decreases pulmonary clearance of a moderately virulent strain of Cryptococcus neoformans. J. Lab. Clin. Med. 121: 765-773.
10. + T cells are effector cells against pneumocystis in mice. J. Immunol. 172: 1132-1138.
11. + T cells restrict Yersinia pseudotuberculosis infection: bypass of antiphagocytosis by targeting antigen-presenting cells. PLoS Pathog. 5: e1000573.
12. Tian, H., A. Groner, M. Boes, and L. Pirofski. 2007. Pneumococcal capsular polysaccharide vaccine-mediated protection against serotype 3 Streptococcus pneumoniae in immunodeficient mice. Infect. Immun. 75: 1643-1650.
13. Basset, A., C. M. Thompson, S. K. Hollingshead, D. E. Briles, E. W. Ades, M. Lipsitch, and R. Malley. 2007. Antibody-independent, CD4+ T-cell-dependent protection against pneumococcal colonization elicited by intranasal immunization with purified pneumococcal proteins. Infect. Immun. 75: 5460-5464.
14. Zhang, Z., T. B. Clarke, and J. N. Weiser. 2009. Cellular effectors mediating Th17-dependent clearance of pneumococcal colonization in mice. J. Clin. Invest. 119: 1899-1909.
15. + T cells mediate antibody-independent acquired immunity to pneumococcal colonization. Proc. Natl. Acad. Sci. USA 102: 4848-4853.
16. Kadioglu, A., W. Coward, M. J. Colston, C. R. Hewitt, and P. W. Andrew. 2004. CD4-T-lymphocyte interactions with pneumolysin and pneumococci suggest a crucial protective role in the host response to pneumococcal infection. Infect. Immun. 72: 2689-2697.
17. Lu, Y. J., J. Gross, D. Bogaert, A. Finn, L. Bagrade, Q. Zhang, J. K. Kolls, A. Srivastava, A. Lundgren, S. Forte, et al. 2008. Interleukin-17A mediates acquired immunity to pneumococcal colonization. PLoS Pathog. 4: e1000159.
18. Zelante, T., A. De Luca, P. Bonifazi, C. Montagnoli, S. Bozza, S. Moretti, M. L. Belladonna, C. Vacca, C. Conte, P. Mosci, et al. 2007. IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance. Eur. J. Immunol. 37: 2695-2706.
19. Rutitzky, L. I., J. R. Lopes da Rosa, and M. J. Stadecker. 2005. Severe CD4 T cell-mediated immunopathology in murine schistosomiasis is dependent on IL-12p40 and correlates with high levels of IL-17. J. Immunol. 175: 3920-3926.
20. Ghilardi, N., N. Kljavin, Q. Chen, S. Lucas, A. L. Gurney, and F. J. De Sauvage. 2004. Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice. J. Immunol. 172: 2827-2833.
21. Ye, P., F. H. Rodriguez, S. Kanaly, K. L. Stocking, J. Schurr, P. Schwarzenberger, P. Oliver, W. Huang, P. Zhang, J. Zhang, et al. 2001. Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J. Exp. Med. 194: 519-527.
22. Wüthrich, M., H. I. Filutowicz, T. Warner, and B. S. Klein. 2002. Requisite elements in vaccine immunity to Blastomyces dermatitidis: plasticity uncovers vaccine potential in immune-deficient hosts. J. Immunol. 169: 6969-6976.
23. Sun, K., S. L. Salmon, S. A. Lotz, and D. W. Metzger. 2007. Interleukin-12 promotes g interferon-dependent neutrophil recruitment in the lung and improves protection against respiratory Streptococcus pneumoniae infection. Infect. Immun. 75: 1196-1202.
24. Dallaire, F., N. Ouellet, Y. Bergeron, V. Turmel, M. C. Gauthier, M. Simard, and M. G. Bergeron. 2001. Microbiological and inflammatory factors associated with the development of pneumococcal pneumonia. J. Infect. Dis. 184: 292-300.
25. Marks, M., T. Burns, M. Abadi, B. Seyoum, J. Thornton, E. Tuomanen, and L. A. Pirofski. 2007. Influence of neutropenia on the course of serotype 8 pneumococcal pneumonia in mice. Infect. Immun. 75: 1586-1597.
26. Winter, C., W. Herbold, R. Maus, F. Länger, D. E. Briles, J. C. Paton, T. Welte, and U. A. Maus. 2009. Important role for CC chemokine ligand 2-dependent lung mononuclear phagocyte recruitment to inhibit sepsis in mice infected with Streptococcus pneumoniae. J. Immunol. 182: 4931-4937.
27. Norment, A. M., and D. R. Littman. 1988. A second subunit of CD8 is expressed in human T cells. EMBO J. 7: 3433-3439.
28. + Th cell-associated inflammatory lesions during murine mycoplasma respiratory disease. J. Immunol. 168: 3493-3501.
29. Swain, S. D., N. N. Meissner, and A. G. Harmsen. 2006. CD8 T cells modulate CD4 T-cell and eosinophil-mediated pulmonary pathology in pneumocystis pneumonia in B-cell-deficient mice. Am. J. Pathol. 168: 466-475.
30. Knapp, S., J. C. Leemans, S. Florquin, J. Branger, N. A. Maris, J. Pater, N. van Rooijen, and T. van der Poll. 2003. Alveolar macrophages have a protective antiinflammatory role during murine pneumococcal pneumonia. Am. J. Respir. Crit. Care Med. 167: 171-179.
31. Kerr, A. R., L. A. Kirkham, A. Kadioglu, P. W. Andrew, P. Garside, H. Thompson, and T. J. Mitchell. 2005. Identification of a detrimental role for NK cells in pneumococcal pneumonia and sepsis in immunocompromised hosts. Microbes Infect. 7: 845-852.
32. + T cell-dependent late allergic airway responses. J. Allergy Clin. Immunol. 115: 521-526.
33. + T-cell responses to herpes simplex virus type 2-infected human dendritic cells. Viral Immunol. 18: 616-626.
34. Singh, A., W. F. Carson, IV, E. R. Secor, Jr., L. A. Guernsey, R. A. Flavell, R. B. Clark, R. S. Thrall, and C. M. Schramm. 2008. Regulatory role of B cells in a murine model of allergic airway disease. J. Immunol. 180: 7318-7326.
35. Lund, F. E. 2008. Cytokine-producing B lymphocytes-key regulators of immunity. Curr. Opin. Immunol. 20: 332-338.
36. Haas, K. M., J. C. Poe, D. A. Steeber, and T. F. Tedder. 2005. B-1a and B-1b cells exhibit distinct developmental requirements and have unique functional roles in innate and adaptive immunity to S. pneumoniae. Immunity 23: 7-18.
37. Rubins, J. B., and C. Pomeroy. 1997. Role of γ interferon in the pathogenesis of bacteremic pneumococcal pneumonia. Infect. Immun. 65: 2975-2977.
38. Yamamoto, N., K. Kawakami, Y. Kinjo, K. Miyagi, T. Kinjo, K. Uezu, C. Nakasone, M. Nakamatsu, and A. Saito. 2004. Essential role for the p40 subunit of interleukin-12 in neutrophil-mediated early host defense against pulmonary infection with Streptococcus pneumoniae: involvement of interferong. Microbes Infect. 6: 1241-1249.
39. Rijneveld, A. W., F. N. Lauw, M. J. Schultz, S. Florquin, A. A. Te Velde, P. Speelman, S. J. Van Deventer, and T. Van Der Poll. 2002. The role of interferon-γ in murine pneumococcal pneumonia. J. Infect. Dis. 185: 91-97.
40. Cosgrove, D., D. Gray, A. Dierich, J. Kaufman, M. Lemeur, C. Benoist, and D. Mathis. 1991. Mice lacking MHC class II molecules. Cell 66: 1051-1066.
41. Wang, E., M. Simard, N. Ouellet, Y. Bergeron, D. Beauchamp, and M. G. Bergeron. 2000. Modulation of cytokines and chemokines, limited pulmonary vascular bed permeability, and prevention of septicemia and death with ceftriaxone and interleukin-10 in pneumococcal pneumonia. J. Infect. Dis. 182: 1255-1259.
42. + T cells: implications for vaccine development in immune-deficient hosts. J. Exp. Med. 197: 1405-1416.
43. Malley, R., A. Srivastava, M. Lipsitch, C. M. Thompson, C. Watkins, A. Tzianabos, and P. W. Anderson. 2006. Antibody-independent, interleukin-17A- mediated, cross-serotype immunity to pneumococci in mice immunized intranasally with the cell wall polysaccharide. Infect. Immun. 74: 2187-2195.
44. Awasthi, A., and V. K. Kuchroo. 2009. Th17 cells: from precursors to players in inflammation and infection. Int. Immunol. 21: 489-498.
45. Stingele, F., B. Cortheśy, N. Kusy, S. A. Porcelli, D. L. Kasper, and A. O. Tzianabos. 2004. Zwitterionic polysaccharides stimulate T cells with no preferential Vb usage and promote anergy, resulting in protection against experimental abscess formation. J. Immunol. 172: 1483-1490.
46. Joetham, A., K. Takeda, M. Okamoto, C. Taube, H. Matsuda, A. Dakhama, and E. W. Gelfand. 2009. Antigen specificity is not required for modulation of lung allergic responses by naturally occurring regulatory T cells. J. Immunol. 183: 1821-1827.
47. Geng, D., L. Zheng, R. Srivastava, N. Asprodites, C. Velasco-Gonzalez, and E. Davila. 2010. When Toll-like receptor and T-cell receptor signals collide: a mechanism for enhanced CD8 T-cell effectors function. Blood. 116: 3494-504.
48. + T lymphocytes. Crit. Rev. Immunol. 29: 219-239.
49. + T cells are subject to immunomodulation by direct TLR2 or TLR5 stimulation. J. Immunol. 182: 55-62.
50. + T cells improves their cytokine-mediated proliferation and IFN-γ secretion in the absence of Ag. Eur. J. Immunol. 39: 2673-2681.
51. Dessing, M. C., M. Schouten, C. Draing, M. Levi, S. von Aulock, and T. van der Poll. 2008. Role played by Toll-like receptors 2 and 4 in lipoteichoic acid-induced lung inflammation and coagulation. J. Infect. Dis. 197: 245-252.
52. Knapp, S., C. W. Wieland, C. van 't Veer, O. Takeuchi, S. Akira, S. Florquin, and T. van der Poll. 2004. Toll-like receptor 2 plays a role in the early inflammatory response to murine pneumococcal pneumonia but does not contribute to antibacterial defense. J. Immunol. 172: 3132-3138.