RNA interference in mammalian cell systems

Hormone Research in Paediatrics

Volumn 75, Issue 1, 2011, Pages 63-69

  Lochmatter, Didier ^a   Mullis, Primus E ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

MicroRNA; Noncoding RNA; RNA interference; Short interfering RNA

Indexed keywords

MICRORNA; NUCLEIC ACID; SMALL INTERFERING RNA; UNTRANSLATED RNA;

ARTICLE; BIOGENESIS; GENE CONTROL; GENE EXPRESSION; GENETIC VARIABILITY; GENOME; GERM LINE; MAMMAL CELL; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; RNA INTERFERENCE;

ANIMALS; GENE SILENCING; GENE THERAPY; GENE TRANSFER TECHNIQUES; HUMANS; MICRORNAS; MOLECULAR BIOLOGY; OLIGONUCLEOTIDES, ANTISENSE; RNA INTERFERENCE; RNA, SMALL INTERFERING; RNA, UNTRANSLATED;

EID: 79251524944     PISSN: 16632818     EISSN: 16632826     Source Type: Journal    
DOI: 10.1159/000322817     Document Type: Article

References (32)

1. Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC: Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans . Nature 1998; 391: 806-811. (Pubitemid 28099681)
2. Lochmatter D, Strom M, Eble A, Petkovic V, Fluck CE, Bidlingmaier M, Robinson IC, Mullis PE: Isolated GH deficiency type II: knockdown of the harmful Delta3GH recovers wt-GH secretion in rat tumor pituitary cells. Endocrinology 2010;151:4400-4409.
3. Nlend RN, Meyer K, Schumperli D: Repair of pre-mRNA splicing: prospects for a therapy for spinal muscular atrophy. RNA Biol 2010; 7: 430-440.
4. Lee RC, Feinbaum RL, Ambros V: The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993; 75: 843-854.
5. Wightman B, Ha I, Ruvkun G: Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans . Cell 1993; 75: 855-862.
6. Cullen BR: RNAi the natural way. Nat Genet 2005; 37: 1163-1165.
7. Carthew RW, Sontheimer EJ: Origins and mechanisms of miRNAs and siRNAs. Cell 2009; 136: 642-655.
8. Lewis BP, Burge CB, Bartel DP: Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005; 120: 15-20.
9. Hammond SM, Bernstein E, Beach D, Hannon GJ: An RNA-directed nuclease mediates post-transcriptional gene silencing in drosophila cells. Nature 2000; 404: 293-296.
10. Meister G, Tuschl T: Mechanisms of gene silencing by double-stranded RNA. Nature 2004; 431: 343-349.
11. Kim VN, Han J, Siomi MC: Biogenesis of small RNAs in animals. Nat Rev Mol Cell Biol 2009; 10: 126-139.
12. Golden DE, Gerbasi VR, Sontheimer EJ: An inside job for siRNAs. Mol Cell 2008; 31: 309-312.
13. Bernstein E, Caudy AA, Hammond SM, Hannon GJ: Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 2001; 409: 363-366.
14. Rand TA, Ginalski K, Grishin NV, Wang X: Biochemical identification of argonaute 2 as the sole protein required for RNA-induced silencing complex activity. Proc Natl Acad Sci USA 2004; 101: 14385-14389.
15. Matranga C, Tomari Y, Shin C, Bartel DP, Zamore PD: Passenger-strand cleavage facilitates assembly of siRNA into ago2-containing RNAi enzyme complexes. Cell 2005; 123: 607-620.
16. Ameres SL, Martinez J, Schroeder R: Molecular basis for target RNA recognition and cleavage by human RISC. Cell 2007; 130: 101-112.
17. Zhang B, Wang Q, Pan X: MicroRNAs and their regulatory roles in animals and plants. J Cell Physiol 2007; 210: 279-289.
18. Cai X, Hagedorn CH, Cullen BR: Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA 2004; 10: 1957-1966.
19. Filipowicz W, Bhattacharyya SN, Sonenberg N: Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet 2008; 9: 102-114.
20. Brodersen P, Voinnet O: Revisiting the principles of microRNA target recognition and mode of action. Nat Rev Mol Cell Biol 2009; 10: 141-148.
21. Vasudevan S, Tong Y, Steitz JA: Switching from repression to activation: microRNAs can up-regulate translation. Science 2007; 318: 1931-1934.
22. Kim DH, Saetrom P, Snove O Jr, Rossi JJ: MicroRNA- directed transcriptional gene silencing in mammalian cells. Proc Natl Acad Sci USA 2008; 105: 16230-16235.
23. Doench JG, Sharp PA: Specificity of micro- RNA target selection in translational repression. Genes Dev 2004; 18: 504-511.
24. Zeng Y, Wagner EJ, Cullen BR: Both natural and designed microRNAs can inhibit the expression of cognate mRNAs when expressed in human cells. Mol Cell 2002; 9: 1327-1333.
25. Fedorov Y, Anderson EM, Birmingham A, Reynolds A, Karpilow J, Robinson K, Leake D, Marshall WS, Khvorova A: Off-target effects by siRNA can induce toxic phenotype. RNA 2006; 12: 1188-1196.
26. Lin X, Ruan X, Anderson MG, McDowell JA, Kroeger PE, Fesik SW, Shen Y: Sirna-mediated off-target gene silencing triggered by a 7-nt complementation. Nucleic Acids Res 2005; 33: 4527-4535.
27. Meurs E, Chong K, Galabru J, Thomas NS, Kerr IM, Williams BR, Hovanessian AG: Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon. Cell 1990; 62: 379-390.
28. Whitehead KA, Langer R, Anderson DG: Knocking down barriers: advances in si- RNA delivery. Nat Rev Drug Discov 2009; 8: 129-138.
29. Fewell GD, Schmitt K: Vector-based RNAi approaches for stable, inducible and genome- wide screens. Drug Discov Today 2006; 11: 975-982.
30. Grimm D, Streetz KL, Jopling CL, Storm TA, Pandey K, Davis CR, Marion P, Salazar F, Kay MA: Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature 2006; 441: 537-541.
31. Castanotto D, Sakurai K, Lingeman R, Li H, Shively L, Aagaard L, Soifer H, Gatignol A, Riggs A, Rossi JJ: Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC. Nucleic Acids Res 2007; 35: 5154-5164.
32. Chen SH, Zhaori G: Potential clinical applications of siRNA technique: benefits and limitations. Eur J Clin Invest 2010, in press.